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Observation of nonlinear fractal higher order topological insulator 观测非线性分形高阶拓扑绝缘体
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-20 DOI: 10.1038/s41377-024-01611-1
Hua Zhong, Victor O. Kompanets, Yiqi Zhang, Yaroslav V. Kartashov, Meng Cao, Yongdong Li, Sergei A. Zhuravitskii, Nikolay N. Skryabin, Ivan V. Dyakonov, Alexander A. Kalinkin, Sergei P. Kulik, Sergey V. Chekalin, Victor N. Zadkov

Higher-order topological insulators (HOTIs) are unique materials hosting topologically protected states, whose dimensionality is at least by 2 lower than that of the bulk. Topological states in such insulators may be strongly confined in their corners which leads to considerable enhancement of nonlinear processes involving such states. However, all nonlinear HOTIs demonstrated so far were built on periodic bulk lattice materials. Here, we demonstrate the first nonlinear photonic HOTI with the fractal origin. Despite their fractional effective dimensionality, the HOTIs constructed here on two different types of the Sierpiński gasket waveguide arrays, may support topological corner states for unexpectedly wide range of coupling strengths, even in parameter regions where conventional HOTIs become trivial. We demonstrate thresholdless spatial solitons bifurcating from corner states in nonlinear fractal HOTIs and show that their localization can be efficiently controlled by the input beam power. We observe sharp differences in nonlinear light localization on outer and multiple inner corners and edges representative for these fractal materials. Our findings not only represent a new paradigm for nonlinear topological insulators, but also open new avenues for potential applications of fractal materials to control the light flow.

高阶拓扑绝缘体(HOTIs)是承载拓扑保护态的独特材料,其维度比体态至少低 2 倍。此类绝缘体中的拓扑态可能会被强烈限制在其边角处,从而大大增强了涉及此类态的非线性过程。然而,迄今为止展示的所有非线性 HOTI 都是建立在周期性体格材料上的。在这里,我们展示了首个具有分形起源的非线性光子 HOTI。尽管存在分数有效维度,但在两种不同类型的西尔潘斯基垫片波导阵列上构建的 HOTIs 可以在出乎意料的宽耦合强度范围内支持拓扑角态,甚至在传统 HOTIs 变得微不足道的参数区域也是如此。我们展示了从非线性分形 HOTI 中的角态分叉出的无阈值空间孤子,并证明它们的定位可由输入光束功率有效控制。我们观察到,在这些分形材料中,外角和多个内角及边缘的非线性光定位存在明显差异。我们的发现不仅代表了非线性拓扑绝缘体的新范例,还为分形材料在控制光流方面的潜在应用开辟了新途径。
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引用次数: 0
Optical neural networks: progress and challenges. 光学神经网络:进展与挑战。
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-20 DOI: 10.1038/s41377-024-01590-3
Tingzhao Fu,Jianfa Zhang,Run Sun,Yuyao Huang,Wei Xu,Sigang Yang,Zhihong Zhu,Hongwei Chen
Artificial intelligence has prevailed in all trades and professions due to the assistance of big data resources, advanced algorithms, and high-performance electronic hardware. However, conventional computing hardware is inefficient at implementing complex tasks, in large part because the memory and processor in its computing architecture are separated, performing insufficiently in computing speed and energy consumption. In recent years, optical neural networks (ONNs) have made a range of research progress in optical computing due to advantages such as sub-nanosecond latency, low heat dissipation, and high parallelism. ONNs are in prospect to provide support regarding computing speed and energy consumption for the further development of artificial intelligence with a novel computing paradigm. Herein, we first introduce the design method and principle of ONNs based on various optical elements. Then, we successively review the non-integrated ONNs consisting of volume optical components and the integrated ONNs composed of on-chip components. Finally, we summarize and discuss the computational density, nonlinearity, scalability, and practical applications of ONNs, and comment on the challenges and perspectives of the ONNs in the future development trends.
在大数据资源、先进算法和高性能电子硬件的帮助下,人工智能在各行各业大行其道。然而,传统计算硬件在执行复杂任务时效率低下,很大程度上是因为其计算架构中的内存和处理器是分离的,在运算速度和能耗方面表现不足。近年来,光神经网络(ONNs)凭借亚纳秒级延迟、低散热和高并行性等优势,在光计算领域取得了一系列研究进展。ONNs有望在计算速度和能源消耗方面为人工智能的进一步发展提供支持,成为一种新的计算模式。在此,我们首先介绍了基于各种光学元件的 ONN 的设计方法和原理。然后,我们依次回顾了由体积光学元件组成的非集成 ONN 和由片上元件组成的集成 ONN。最后,我们总结并讨论了 ONNs 的计算密度、非线性、可扩展性和实际应用,并对 ONNs 在未来发展趋势中面临的挑战和前景进行了评论。
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引用次数: 0
Rational strategy for power doubling of monolithic multijunction III-V photovoltaics by accommodating attachable scattering waveguides. 通过容纳可附加散射波导实现单片多结 III-V 光电功率倍增的合理策略。
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-20 DOI: 10.1038/s41377-024-01628-6
Shin Hyung Lee,Hyo Jin Kim,Jae-Hyun Kim,Gwang Yeol Park,Sun-Kyung Kim,Sung-Min Lee
While waveguide-based light concentrators offer significant advantages, their application has not been considered an interesting option for assisting multijunction or other two-terminal tandem solar cells. In this study, we present a simple yet effective approach to enhancing the output power of transfer-printed multijunction InGaP/GaAs solar cells. By utilizing a simply combinable waveguide concentrator featuring a coplanar waveguide with BaSO4 Mie scattering elements, we enable the simultaneous absorption of directly illuminated solar flux and indirectly waveguided flux. The deployment of cells is optimized for front-surface photon collection in monofacial cells. Through systematic comparisons across various waveguide parameters, supported by both experimental and theoretical quantifications, we demonstrate a remarkable improvement in the maximum output power of a 26%-efficient cell, achieving an enhancement of ~93% with the integration of the optimal scattering waveguide. Additionally, a series of supplementary tests are conducted to explore the effective waveguide size, validate enhancements in arrayed cell module performance, and assess the drawbacks associated with rear illumination. These findings provide a comprehensive understanding of our proposed approach towards advancing multi-junction photovoltaics.
虽然基于波导的聚光器具有显著优势,但其应用尚未被视为辅助多结或其他双端串联太阳能电池的有趣选择。在本研究中,我们提出了一种简单而有效的方法来提高转移印刷多结 InGaP/GaAs 太阳能电池的输出功率。通过利用一个简单可组合的波导聚光器,即带有 BaSO4 Mie 散射元件的共面波导,我们实现了同时吸收直接照射的太阳光通量和间接波导光通量。我们对电池的部署进行了优化,以便在单面电池中收集前表面光子。在实验和理论量化的支持下,通过对各种波导参数进行系统比较,我们证明 26% 效率电池的最大输出功率有了显著提高,在集成了最佳散射波导后提高了约 93%。此外,我们还进行了一系列补充测试,以探索有效波导尺寸,验证阵列电池模块性能的提升,并评估与后部照明相关的缺点。这些研究结果使人们对我们提出的推进多结光伏技术的方法有了全面的了解。
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引用次数: 0
Measuring, processing, and generating partially coherent light with self-configuring optics 利用自配置光学器件测量、处理和生成部分相干光
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-20 DOI: 10.1038/s41377-024-01622-y
Charles Roques-Carmes, Shanhui Fan, David A. B. Miller

Optical phenomena always display some degree of partial coherence between their respective degrees of freedom. Partial coherence is of particular interest in multimodal systems, where classical and quantum correlations between spatial, polarization, and spectral degrees of freedom can lead to fascinating phenomena (e.g., entanglement) and be leveraged for advanced imaging and sensing modalities (e.g., in hyperspectral, polarization, and ghost imaging). Here, we present a universal method to analyze, process, and generate spatially partially coherent light in multimode systems by using self-configuring optical networks. Our method relies on cascaded self-configuring layers whose average power outputs are sequentially optimized. Once optimized, the network separates the input light into its mutually incoherent components, which is formally equivalent to a diagonalization of the input density matrix. We illustrate our method with numerical simulations of Mach-Zehnder interferometer arrays and show how this method can be used to perform partially coherent environmental light sensing, generation of multimode partially coherent light with arbitrary coherency matrices, and unscrambling of quantum optical mixtures. We provide guidelines for the experimental realization of this method, including the influence of losses, paving the way for self-configuring photonic devices that can automatically learn optimal modal representations of partially coherent light fields.

光学现象总是在各自的自由度之间表现出某种程度的部分相干性。在多模系统中,部分相干性尤其引人关注,因为空间、偏振和光谱自由度之间的经典和量子相关性可导致引人入胜的现象(如纠缠),并可用于先进的成像和传感模式(如高光谱、偏振和鬼影成像)。在这里,我们提出了一种通用方法,利用自配置光网络在多模系统中分析、处理和生成空间部分相干光。我们的方法依赖于级联自配置层,其平均功率输出依次得到优化。一旦优化,网络就会将输入光分离成互不相干的分量,这在形式上等同于输入密度矩阵的对角化。我们用马赫-泽恩德干涉仪阵列的数值模拟来说明我们的方法,并展示了这种方法如何用于进行部分相干环境光传感、产生具有任意相干矩阵的多模部分相干光以及解扰量子光学混合物。我们为这种方法的实验实现(包括损耗的影响)提供了指导,为能够自动学习部分相干光场的最佳模态表示的自配置光子设备铺平了道路。
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引用次数: 0
Dynamic gain driven mode-locking in GHz fiber laser. GHz 光纤激光器中的动态增益驱动锁模。
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-20 DOI: 10.1038/s41377-024-01613-z
Xuewen Chen,Wei Lin,Xu Hu,Wenlong Wang,Zhaoheng Liang,Lin Ling,Yang Yang,Yuankai Guo,Tao Liu,Dongdan Chen,Xiaoming Wei,Zhongmin Yang
Ultrafast lasers have become powerful tools in various fields, and increasing their fundamental repetition rates to the gigahertz (GHz) level holds great potential for frontier scientific and industrial applications. Among various schemes, passive mode-locking in ultrashort-cavity fiber laser is promising for generating GHz ultrashort pulses (typically solitons), for its simplicity and robustness. However, its pulse energy is far lower than the critical value of the existing theory, leading to open questions on the mode-locking mechanism of GHz fiber lasers. Here, we study the passive mode-locking in GHz fiber lasers by exploring dynamic gain depletion and recovery (GDR) effect, and establish a theoretical model for comprehensively understanding its low-threshold mode-locking mechanism with multi-GHz fundamental repetition rates. Specifically, the GDR effect yields an effective interaction force and thereby binds multi-GHz solitons to form a counterpart of soliton crystals. It is found that the resulting collective behavior of the solitons effectively reduces the saturation energy of the gain fiber and permits orders of magnitude lower pulse energy for continuous-wave mode-locking (CWML). A new concept of quasi-single soliton defined in a strongly correlated length is also proposed to gain insight into the dynamics of soliton assembling, which enables the crossover from the present mode-locking theory to the existing one. Specifically, two distinguishing dynamics of Q-switched mode-locking that respectively exhibit rectangular- and Gaussian-shape envelopes are theoretically indicated and experimentally verified in the mode-locked GHz fiber laser through the measurements using both the standard real-time oscilloscope and emerging time-lens magnification. Based on the proposed criterion of CWML, we finally implement a GDR-mediated mode-locked fiber laser with an unprecedentedly high fundamental repetition rate of up to 21 GHz and a signal-to-noise ratio of 85.9 dB.
超快激光器已成为各个领域的强大工具,而将其基本重复率提高到千兆赫(GHz)级别,则为前沿科学和工业应用带来了巨大潜力。在各种方案中,超短腔光纤激光器中的无源模式锁定因其简单性和鲁棒性而有望产生 GHz 超短脉冲(通常是孤子)。然而,它的脉冲能量远低于现有理论的临界值,导致 GHz 光纤激光器的锁模机制成为未决问题。在此,我们通过探索动态增益损耗和恢复(GDR)效应来研究 GHz 光纤激光器中的无源锁模,并建立了一个理论模型,以全面理解其多 GHz 基本重复率的低阈值锁模机制。具体来说,GDR 效应产生了一种有效的相互作用力,从而将多 GHz 孤子结合在一起,形成对应的孤子晶体。研究发现,由此产生的孤子集体行为可有效降低增益光纤的饱和能量,并使连续波模式锁定(CWML)的脉冲能量降低几个数量级。此外,还提出了一个定义在强相关长度上的准单一孤子的新概念,以深入了解孤子集合的动力学,从而实现从现有模式锁定理论到现有理论的交叉。具体地说,通过使用标准实时示波器和新出现的时间透镜放大镜进行测量,在锁模 GHz 光纤激光器中从理论上指出了分别呈现矩形和高斯形状包络的两种不同的 Q 开关锁模动力学,并在实验中进行了验证。基于所提出的 CWML 准则,我们最终实现了 GDR 介导的锁模光纤激光器,其基频重复率高达 21 GHz,信噪比高达 85.9 dB。
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引用次数: 0
Parity-Time symmetry helps breaking a new limit 奇偶性-时间对称性有助于打破新的极限
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-19 DOI: 10.1038/s41377-024-01577-0
Wenjie Wan, Xiaoshun Jiang

Parity-Time (PT) symmetry is an emerging concept in quantum mechanics where non-Hermitian Hamiltonians can exhibit real eigenvalues. Now, PT symmetric optical microresonators have been demonstrated to break the bandwidth-efficiency limit for nonlinear optical signal processing.

奇偶性-时间(PT)对称是量子力学中的一个新兴概念,在这个概念中,非ermitian Hamiltonians 可以表现出实特征值。现在,PT 对称光学微谐振器已被证明可以打破非线性光学信号处理的带宽-效率限制。
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引用次数: 0
Neural stimulation and modulation with sub-cellular precision by optomechanical bio-dart 利用光机械生物镖实现亚细胞精度的神经刺激和调节
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-19 DOI: 10.1038/s41377-024-01617-9
Guoshuai Zhu, Jianyun Xiong, Xing Li, Ziyi He, Shuhan Zhong, Junlin Chen, Yang Shi, Ting Pan, Li Zhang, Baojun Li, Hongbao Xin

Neural stimulation and modulation at high spatial resolution are crucial for mediating neuronal signaling and plasticity, aiding in a better understanding of neuronal dysfunction and neurodegenerative diseases. However, developing a biocompatible and precisely controllable technique for accurate and effective stimulation and modulation of neurons at the subcellular level is highly challenging. Here, we report an optomechanical method for neural stimulation and modulation with subcellular precision using optically controlled bio-darts. The bio-dart is obtained from the tip of sunflower pollen grain and can generate transient pressure on the cell membrane with submicrometer spatial resolution when propelled by optical scattering force controlled with an optical fiber probe, which results in precision neural stimulation via precisely activation of membrane mechanosensitive ion channel. Importantly, controllable modulation of a single neuronal cell, even down to subcellular neuronal structures such as dendrites, axons, and soma, can be achieved. This bio-dart can also serve as a drug delivery tool for multifunctional neural stimulation and modulation. Remarkably, our optomechanical bio-darts can also be used for in vivo neural stimulation in larval zebrafish. This strategy provides a novel approach for neural stimulation and modulation with sub-cellular precision, paving the way for high-precision neuronal plasticity and neuromodulation.

高空间分辨率的神经刺激和调控对于介导神经元信号传导和可塑性至关重要,有助于更好地了解神经元功能障碍和神经退行性疾病。然而,开发一种生物相容性好、可精确控制的技术,在亚细胞水平对神经元进行精确有效的刺激和调控,是一项极具挑战性的工作。在此,我们报告了一种使用光控生物镖在亚细胞水平精确刺激和调节神经元的光学机械方法。这种生物镖取自向日葵花粉粒的顶端,在光纤探针控制的光散射力推动下,可在细胞膜上产生亚微米级空间分辨率的瞬时压力,从而通过精确激活膜机械敏感离子通道实现精确的神经刺激。重要的是,可以实现对单个神经元细胞的可控调制,甚至可以精确到树突、轴突和体节等亚细胞神经元结构。这种生物镖还可以作为药物输送工具,用于多功能神经刺激和调控。值得注意的是,我们的光机械生物镖还可用于对幼体斑马鱼进行体内神经刺激。这种策略为亚细胞精度的神经刺激和调控提供了一种新方法,为高精度神经元可塑性和神经调控铺平了道路。
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引用次数: 0
Phase-change VO2-based thermochromic smart windows 基于相变 VO2 的热致变色智能窗
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-18 DOI: 10.1038/s41377-024-01560-9
Cancheng Jiang, Lanyue He, Qingdong Xuan, Yuan Liao, Jian-Guo Dai, Dangyuan Lei

Thermochromic coatings hold promise in reducing building energy consumption by dynamically regulating the heat gain of windows, which are often regarded as less energy-efficient components, across different seasons. Vanadium dioxide (VO2) stands out as a versatile thermochromic material for smart windows owing to its reversible metal-to-insulator transition (MIT) alongside correlated structural and optical properties. In this review, we delve into recent advancements in the phase-change VO2-based thermochromic coatings for smart windows, spanning from the macroscopic crystal level to the microscopic structural level (including elemental doping and micro/nano-engineering), as well as advances in controllable fabrication. It is notable that hybridizing functional elements/materials (e.g., W, Mo/SiO2, TiN) with VO2 in delicate structural designs (e.g., core-shell, optical cavity) brings new degrees of freedom for controlling the thermochromic properties, including the MIT temperature, luminous transmittance, solar-energy modulation ability and building-relevant multi-functionality. Additionally, we provide an overview of alternative chromogenic materials that could potentially complement or surpass the intrinsic limitations of VO2. By examining the landscape of emerging materials, we aim to broaden the scope of possibilities for smart window technologies. We also offer insights into the current challenges and prospects of VO2-based thermochromic smart windows, presenting a roadmap for advancing this field towards enhanced energy efficiency and sustainable building design. In summary, this review innovatively categorizes doping strategies and corresponding effects of VO2, underscores their crucial NIR-energy modulation ability for smart windows, pioneers a theoretical analysis of inverse core-shell structures, prioritizes practical engineering strategies for solar modulation in VO2 films, and summarizes complementary chromogenic materials, thus ultimately advancing VO2-based smart window technologies with a fresh perspective.

窗户通常被认为是能效较低的部件,而热致变色涂料可在不同季节动态调节窗户的得热量,从而有望降低建筑能耗。二氧化钒(VO2)具有可逆的金属-绝缘体转变(MIT)以及相关的结构和光学特性,因此是一种适用于智能窗户的多功能热致变色材料。在本综述中,我们将深入探讨基于相变二氧化钛的智能窗户热致变色涂层的最新进展,包括从宏观晶体水平到微观结构水平(包括元素掺杂和微/纳米工程),以及可控制造方面的进展。值得注意的是,将功能元素/材料(如 W、Mo/SiO2、TiN)与 VO2 混合在微妙的结构设计(如核壳、光腔)中,为控制热致变色特性带来了新的自由度,包括 MIT 温度、透光率、太阳能调制能力以及与建筑相关的多功能性。此外,我们还概述了有可能补充或超越 VO2 固有局限性的其他致色材料。通过对新兴材料的研究,我们旨在拓宽智能窗户技术的可能性范围。我们还深入探讨了基于 VO2 的热致变色智能窗目前面临的挑战和发展前景,提出了推动这一领域朝着提高能效和可持续建筑设计方向发展的路线图。总之,本综述创新性地对 VO2 的掺杂策略和相应效应进行了分类,强调了它们对智能窗户至关重要的近红外能量调节能力,开创性地对逆核壳结构进行了理论分析,优先考虑了 VO2 薄膜中太阳光调节的实用工程策略,并总结了互补的致色材料,从而最终以全新的视角推进了基于 VO2 的智能窗户技术。
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引用次数: 0
Optical fibre based artificial compound eyes for direct static imaging and ultrafast motion detection 基于光纤的人造复眼,用于直接静态成像和超快运动检测
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-18 DOI: 10.1038/s41377-024-01580-5
Heng Jiang, Chi Chung Tsoi, Weixing Yu, Mengchao Ma, Mingjie Li, Zuankai Wang, Xuming Zhang

Natural selection has driven arthropods to evolve fantastic natural compound eyes (NCEs) with a unique anatomical structure, providing a promising blueprint for artificial compound eyes (ACEs) to achieve static and dynamic perceptions in complex environments. Specifically, each NCE utilises an array of ommatidia, the imaging units, distributed on a curved surface to enable abundant merits. This has inspired the development of many ACEs using various microlens arrays, but the reported ACEs have limited performances in static imaging and motion detection. Particularly, it is challenging to mimic the apposition modality to effectively transmit light rays collected by many microlenses on a curved surface to a flat imaging sensor chip while preserving their spatial relationships without interference. In this study, we integrate 271 lensed polymer optical fibres into a dome-like structure to faithfully mimic the structure of NCE. Our ACE has several parameters comparable to the NCEs: 271 ommatidia versus 272 for bark beetles, and 180o field of view (FOV) versus 150–180o FOV for most arthropods. In addition, our ACE outperforms the typical NCEs by ~100 times in dynamic response: 31.3 kHz versus 205 Hz for Glossina morsitans. Compared with other reported ACEs, our ACE enables real-time, 180o panoramic direct imaging and depth estimation within its nearly infinite depth of field. Moreover, our ACE can respond to an angular motion up to 5.6×106 deg/s with the ability to identify translation and rotation, making it suitable for applications to capture high-speed objects, such as surveillance, unmanned aerial/ground vehicles, and virtual reality.

自然选择促使节肢动物进化出具有独特解剖结构的神奇天然复眼(NCE),为人工复眼(ACE)在复杂环境中实现静态和动态感知提供了前景广阔的蓝图。具体来说,每只自然复眼都利用分布在弯曲表面上的成像单元--膜阵列来实现丰富的优点。受此启发,人们利用各种微透镜阵列开发出了许多 ACE,但已报道的 ACE 在静态成像和运动检测方面的性能有限。特别是,如何模仿贴合模式,将曲面上许多微透镜收集到的光线有效地传输到平面成像传感器芯片上,同时保留它们之间的空间关系而不受干扰,是一项挑战。在这项研究中,我们将 271 个透镜聚合物光纤集成到一个圆顶状结构中,以忠实模拟 NCE 的结构。我们的 ACE 有几个参数与 NCE 相当:271 个 mmatidia(而树皮甲虫为 272 个)和 180o 视场(FOV)(而大多数节肢动物为 150-180o FOV)。此外,我们的 ACE 在动态响应方面比典型的 NCE 高出约 100 倍:Glossina morsitans 的动态响应为 31.3 kHz,而我们的 ACE 为 205 Hz。与其他已报道的 ACE 相比,我们的 ACE 可在其近乎无限的景深范围内实现实时、180° 全景直接成像和深度估计。此外,我们的 ACE 能够对高达 5.6×106 度/秒的角运动做出响应,并能识别平移和旋转,因此适用于捕捉高速物体的应用,如监控、无人机/地面车辆和虚拟现实。
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引用次数: 0
Towards next-generation diagnostic pathology: AI-empowered label-free multiphoton microscopy 迈向下一代病理诊断:人工智能赋能的无标记多光子显微技术
3区 医学 Q2 CHEMISTRY, MEDICINAL Pub Date : 2024-09-14 DOI: 10.1038/s41377-024-01597-w
Shu Wang, Junlin Pan, Xiao Zhang, Yueying Li, Wenxi Liu, Ruolan Lin, Xingfu Wang, Deyong Kang, Zhijun Li, Feng Huang, Liangyi Chen, Jianxin Chen

Diagnostic pathology, historically dependent on visual scrutiny by experts, is essential for disease detection. Advances in digital pathology and developments in computer vision technology have led to the application of artificial intelligence (AI) in this field. Despite these advancements, the variability in pathologists’ subjective interpretations of diagnostic criteria can lead to inconsistent outcomes. To meet the need for precision in cancer therapies, there is an increasing demand for accurate pathological diagnoses. Consequently, traditional diagnostic pathology is evolving towards “next-generation diagnostic pathology”, prioritizing on the development of a multi-dimensional, intelligent diagnostic approach. Using nonlinear optical effects arising from the interaction of light with biological tissues, multiphoton microscopy (MPM) enables high-resolution label-free imaging of multiple intrinsic components across various human pathological tissues. AI-empowered MPM further improves the accuracy and efficiency of diagnosis, holding promise for providing auxiliary pathology diagnostic methods based on multiphoton diagnostic criteria. In this review, we systematically outline the applications of MPM in pathological diagnosis across various human diseases, and summarize common multiphoton diagnostic features. Moreover, we examine the significant role of AI in enhancing multiphoton pathological diagnosis, including aspects such as image preprocessing, refined differential diagnosis, and the prognostication of outcomes. We also discuss the challenges and perspectives faced by the integration of MPM and AI, encompassing equipment, datasets, analytical models, and integration into the existing clinical pathways. Finally, the review explores the synergy between AI and label-free MPM to forge novel diagnostic frameworks, aiming to accelerate the adoption and implementation of intelligent multiphoton pathology systems in clinical settings.

病理诊断历来依赖专家的肉眼观察,对疾病检测至关重要。数字病理学的进步和计算机视觉技术的发展促使人工智能(AI)应用于这一领域。尽管取得了这些进步,但病理学家对诊断标准的主观解释存在差异,可能导致结果不一致。为了满足癌症治疗的精确性需求,对准确病理诊断的要求越来越高。因此,传统的病理诊断正朝着 "下一代病理诊断 "的方向发展,优先发展多维度的智能诊断方法。利用光与生物组织相互作用产生的非线性光学效应,多光子显微镜(MPM)可对各种人体病理组织的多种内在成分进行高分辨率无标记成像。人工智能驱动的多光子显微镜进一步提高了诊断的准确性和效率,有望提供基于多光子诊断标准的辅助病理诊断方法。在这篇综述中,我们系统地概述了多光子病理诊断在各种人类疾病病理诊断中的应用,并总结了常见的多光子诊断特征。此外,我们还探讨了人工智能在增强多光子病理诊断中的重要作用,包括图像预处理、精细鉴别诊断和预后判断等方面。我们还讨论了多光子病理诊断与人工智能整合所面临的挑战和前景,包括设备、数据集、分析模型以及与现有临床路径的整合。最后,本综述探讨了人工智能与无标记多光子病理学之间的协同作用,以构建新颖的诊断框架,从而加快智能多光子病理学系统在临床环境中的采用和实施。
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引用次数: 0
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