Pub Date : 2024-10-29Epub Date: 2024-10-21DOI: 10.1073/pnas.2407519121
Kryštof Štafl, Martin Trávníček, Anna Janovská, Dana Kučerová, Ľubomíra Pecnová, Zhiqi Yang, Vladimír Stepanec, Lukáš Jech, Madhuri S Salker, Jiří Hejnar, Kateřina Trejbalová
Syncytin-1, a human fusogenic protein of retroviral origin, is crucial for placental syncytiotrophoblast formation. To mediate cell-to-cell fusion, Syncytin-1 requires specific interaction with its cognate receptor. Two trimeric transmembrane proteins, Alanine, Serine, Cysteine Transporters 1 and 2 (ASCT1 and ASCT2), were suggested and widely accepted as Syncytin-1 cellular receptors. To quantitatively assess the individual contributions of human ASCT1 and ASCT2 to the fusogenic activity of Syncytin-1, we developed a model system where the ASCT1 and ASCT2 double knockout was rescued by ectopic expression of either ASCT1 or ASCT2. We demonstrated that ASCT2 was required for Syncytin-1 binding, cellular entry, and cell-to-cell fusion, while ASCT1 was not involved in this receptor interaction. We experimentally validated the ASCT1-ASCT2 heterotrimers as a possible explanation for the previous misidentification of ASCT1 as a receptor for Syncytin-1. This redefinition of receptor specificity is important for proper understanding of Syncytin-1 function in normal and pathological pregnancy.
{"title":"Receptor usage of Syncytin-1: ASCT2, but not ASCT1, is a functional receptor and effector of cell fusion in the human placenta.","authors":"Kryštof Štafl, Martin Trávníček, Anna Janovská, Dana Kučerová, Ľubomíra Pecnová, Zhiqi Yang, Vladimír Stepanec, Lukáš Jech, Madhuri S Salker, Jiří Hejnar, Kateřina Trejbalová","doi":"10.1073/pnas.2407519121","DOIUrl":"https://doi.org/10.1073/pnas.2407519121","url":null,"abstract":"<p><p>Syncytin-1, a human fusogenic protein of retroviral origin, is crucial for placental syncytiotrophoblast formation. To mediate cell-to-cell fusion, Syncytin-1 requires specific interaction with its cognate receptor. Two trimeric transmembrane proteins, Alanine, Serine, Cysteine Transporters 1 and 2 (ASCT1 and ASCT2), were suggested and widely accepted as Syncytin-1 cellular receptors. To quantitatively assess the individual contributions of human ASCT1 and ASCT2 to the fusogenic activity of Syncytin-1, we developed a model system where the <i>ASCT1</i> and <i>ASCT2</i> double knockout was rescued by ectopic expression of either ASCT1 or ASCT2. We demonstrated that ASCT2 was required for Syncytin-1 binding, cellular entry, and cell-to-cell fusion, while ASCT1 was not involved in this receptor interaction. We experimentally validated the ASCT1-ASCT2 heterotrimers as a possible explanation for the previous misidentification of ASCT1 as a receptor for Syncytin-1. This redefinition of receptor specificity is important for proper understanding of Syncytin-1 function in normal and pathological pregnancy.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29Epub Date: 2024-10-21DOI: 10.1073/pnas.2411212121
Sylvia Englund Michel, Xin Lan, John Miller, Pieter Tans, J Reid Clark, Hinrich Schaefer, Peter Sperlich, Gordon Brailsford, Shinji Morimoto, Heiko Moossen, Jianghanyang Li
The growth rate of the atmospheric abundance of methane (CH4) reached a record high of 15.4 ppb yr-1 between 2020 and 2022, but the mechanisms driving the accelerated CH4 growth have so far been unclear. In this work, we use measurements of the 13C:12C ratio of CH4 (expressed as δ13CCH4) from NOAA's Global Greenhouse Gas Reference Network and a box model to investigate potential drivers for the rapid CH4 growth. These measurements show that the record-high CH4 growth in 2020-2022 was accompanied by a sharp decline in δ13CCH4, indicating that the increase in CH4 abundance was mainly driven by increased emissions from microbial sources such as wetlands, waste, and agriculture. We use our box model to reject increasing fossil fuel emissions or decreasing hydroxyl radical sink as the dominant driver for increasing global methane abundance.
{"title":"Rapid shift in methane carbon isotopes suggests microbial emissions drove record high atmospheric methane growth in 2020-2022.","authors":"Sylvia Englund Michel, Xin Lan, John Miller, Pieter Tans, J Reid Clark, Hinrich Schaefer, Peter Sperlich, Gordon Brailsford, Shinji Morimoto, Heiko Moossen, Jianghanyang Li","doi":"10.1073/pnas.2411212121","DOIUrl":"https://doi.org/10.1073/pnas.2411212121","url":null,"abstract":"<p><p>The growth rate of the atmospheric abundance of methane (CH<sub>4</sub>) reached a record high of 15.4 ppb yr<sup>-1</sup> between 2020 and 2022, but the mechanisms driving the accelerated CH<sub>4</sub> growth have so far been unclear. In this work, we use measurements of the <sup>13</sup>C:<sup>12</sup>C ratio of CH<sub>4</sub> (expressed as <i>δ</i><sup>13</sup>C<sub>CH4</sub>) from NOAA's Global Greenhouse Gas Reference Network and a box model to investigate potential drivers for the rapid CH<sub>4</sub> growth. These measurements show that the record-high CH<sub>4</sub> growth in 2020-2022 was accompanied by a sharp decline in <i>δ</i><sup>13</sup>C<sub>CH4</sub>, indicating that the increase in CH<sub>4</sub> abundance was mainly driven by increased emissions from microbial sources such as wetlands, waste, and agriculture. We use our box model to reject increasing fossil fuel emissions or decreasing hydroxyl radical sink as the dominant driver for increasing global methane abundance.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29Epub Date: 2024-10-21DOI: 10.1073/pnas.2418528121
Eusondia Arnett, Larry S Schlesinger
{"title":"E-cigs put the squeeze on macrophages.","authors":"Eusondia Arnett, Larry S Schlesinger","doi":"10.1073/pnas.2418528121","DOIUrl":"https://doi.org/10.1073/pnas.2418528121","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29Epub Date: 2024-10-22DOI: 10.1073/pnas.2406434121
Jiawu Wan, Caiqian Wang, Zongmei Wang, Lingli Wang, Haoran Wang, Ming Zhou, Zhen F Fu, Ling Zhao
Antibody responses induced by current vaccines for influenza and SARS-CoV-2 often lack robust cross-reactivity. As hubs where diverse immune cells converge and interact, the alterations in the immune microenvironment within lymph nodes (LNs) are intricately linked to immune responses. Herein, we designed a lipid nanoparticle (LNP) loaded with circular RNA (circRNA) and targeted to LNs, in which CXCL13 was directly integrated into antigen-encoding circRNA strands. We demonstrated that CXCL13 alters the transcriptomic profiles of LNs, especially the upregulation of IL-21 and IL-4. Meanwhile, CXCL13 promotes the formation of germinal center and elicits robust antigen-specific T cell responses. With the codelivery of CXCL13 and the antigen, CXCL13 enhances cross-reactive antibodies against influenza virus and SARS-CoV-2, achieving protection against both homologous and heterologous influenza virus challenges in a mouse model. Notably, the targeted modification of LNP surfaces with antibodies helps address some of the challenges associated with lyophilized LNP vaccines, which is crucial for the long-term storage of LNP-circRNA vaccines. Overall, the circRNA-based antigen-CXCL13 coexpression system developed herein provides a simple and robust platform that enhances the magnitude and breadth of antibody responses against multiple viral glycoproteins, highlighting the potential utility of CXCL13 in inducing broad immune responses.
{"title":"CXCL13 promotes broad immune responses induced by circular RNA vaccines.","authors":"Jiawu Wan, Caiqian Wang, Zongmei Wang, Lingli Wang, Haoran Wang, Ming Zhou, Zhen F Fu, Ling Zhao","doi":"10.1073/pnas.2406434121","DOIUrl":"https://doi.org/10.1073/pnas.2406434121","url":null,"abstract":"<p><p>Antibody responses induced by current vaccines for influenza and SARS-CoV-2 often lack robust cross-reactivity. As hubs where diverse immune cells converge and interact, the alterations in the immune microenvironment within lymph nodes (LNs) are intricately linked to immune responses. Herein, we designed a lipid nanoparticle (LNP) loaded with circular RNA (circRNA) and targeted to LNs, in which CXCL13 was directly integrated into antigen-encoding circRNA strands. We demonstrated that CXCL13 alters the transcriptomic profiles of LNs, especially the upregulation of IL-21 and IL-4. Meanwhile, CXCL13 promotes the formation of germinal center and elicits robust antigen-specific T cell responses. With the codelivery of CXCL13 and the antigen, CXCL13 enhances cross-reactive antibodies against influenza virus and SARS-CoV-2, achieving protection against both homologous and heterologous influenza virus challenges in a mouse model. Notably, the targeted modification of LNP surfaces with antibodies helps address some of the challenges associated with lyophilized LNP vaccines, which is crucial for the long-term storage of LNP-circRNA vaccines. Overall, the circRNA-based antigen-CXCL13 coexpression system developed herein provides a simple and robust platform that enhances the magnitude and breadth of antibody responses against multiple viral glycoproteins, highlighting the potential utility of CXCL13 in inducing broad immune responses.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29Epub Date: 2024-10-21DOI: 10.1073/pnas.2409583121
Nicholas J Arisco, Cassio Peterka, Cesar Diniz, Burton H Singer, Marcia C Castro
Ecological change in the Brazilian Amazon is closely linked to human mobility and health. Mining, agriculture, logging, and other activities alter highly diverse ecological and demographic contexts and subsequent exposure to diseases such as malaria. Studies that have attempted to quantify the impact of deforestation on malaria in the Brazilian Amazon have produced conflicting results. However, they varied in methodology and data sources. Most importantly, all studies used annual data, neglecting the subannual seasonal dynamics of malaria. Here, we fill the knowledge gap on the subannual relationship between ecological change in the Brazilian Amazon and malaria transmission. Using the highest spatiotemporal resolution available, we estimated the effect of deforestation on malaria cases between 2003 and 2022 using a stratified Bayesian spatiotemporal hierarchical zero-inflated Poisson model fitted with the Integrated Nested Laplace Approximation. The model was also stratified by state. We found that a 1% increase in 1-mo lagged deforestation increased malaria cases in a given month and municipality by 6.3% [95% credible interval (Crl): 6.2, 6.5%]. Based on an interaction term included in the model, the effect of deforestation on malaria was even larger in areas with higher forest cover. We found that the coefficients for deforestation and mobility were highly variable when stratified by state. Our results provide detailed evidence that, on average, deforestation increases malaria transmission, but that the relationship is not spatiotemporally uniform. These results have implications for stratifying malaria control interventions based on ecological dynamics to help Brazil achieve its goal of malaria elimination by 2035.
{"title":"Ecological change increases malaria risk in the Brazilian Amazon.","authors":"Nicholas J Arisco, Cassio Peterka, Cesar Diniz, Burton H Singer, Marcia C Castro","doi":"10.1073/pnas.2409583121","DOIUrl":"https://doi.org/10.1073/pnas.2409583121","url":null,"abstract":"<p><p>Ecological change in the Brazilian Amazon is closely linked to human mobility and health. Mining, agriculture, logging, and other activities alter highly diverse ecological and demographic contexts and subsequent exposure to diseases such as malaria. Studies that have attempted to quantify the impact of deforestation on malaria in the Brazilian Amazon have produced conflicting results. However, they varied in methodology and data sources. Most importantly, all studies used annual data, neglecting the subannual seasonal dynamics of malaria. Here, we fill the knowledge gap on the subannual relationship between ecological change in the Brazilian Amazon and malaria transmission. Using the highest spatiotemporal resolution available, we estimated the effect of deforestation on malaria cases between 2003 and 2022 using a stratified Bayesian spatiotemporal hierarchical zero-inflated Poisson model fitted with the Integrated Nested Laplace Approximation. The model was also stratified by state. We found that a 1% increase in 1-mo lagged deforestation increased malaria cases in a given month and municipality by 6.3% [95% credible interval (Crl): 6.2, 6.5%]. Based on an interaction term included in the model, the effect of deforestation on malaria was even larger in areas with higher forest cover. We found that the coefficients for deforestation and mobility were highly variable when stratified by state. Our results provide detailed evidence that, on average, deforestation increases malaria transmission, but that the relationship is not spatiotemporally uniform. These results have implications for stratifying malaria control interventions based on ecological dynamics to help Brazil achieve its goal of malaria elimination by 2035.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29Epub Date: 2024-10-21DOI: 10.1073/pnas.2415892121
Paul S Masters
{"title":"Caution urged for work with newly constructed human coronavirus.","authors":"Paul S Masters","doi":"10.1073/pnas.2415892121","DOIUrl":"https://doi.org/10.1073/pnas.2415892121","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
On 13-15 January 2022, the Hunga Tonga-Hunga Ha'apai underwater volcano erupted. This powerful eruption generated infrasonic waves with amplitudes of thousands of Pascals in the near field. The ground infrasonic stations in China, located approximately 10 000 km from the Hunga volcano, also received waves with frequencies from 0.01 to 0.05 Hz. However, the amplitude reached 17 Pa, which is higher than the predicted amplitude using the absorption model without considering the dispersion effect in the thin thermosphere. At high altitudes, dispersion exists and the sound speed depends on the ratio of the molecular mean collision ratio to sound frequency, which is proportional to the ratio (frequency/pressure). And attenuation coefficients are complex to model. We simulate dispersive sound speeds and attenuation coefficients at different frequencies according to theory and our experimental data. In the thermosphere, the dispersion effect causes noticeable changes of sound speed and then affects wave propagation paths in the far field. The abnormal attenuation coefficient has a smaller impact on thermospheric returns than that of the dispersive sound speed, but it is also not negligible. It explains the large amplitude of thermospheric signals received in our infrasound stations. This article is part of the theme issue 'Celebrating the 15th anniversary of the Royal Society Newton International Fellowship'.
{"title":"Infrasound associated with the eruption of the Hunga volcano.","authors":"Quan Guo, Xinxin Jin, Guanwen Sun, Yuxin Zhang, Hanyin Cui, Xiujuan Feng","doi":"10.1098/rsta.2023.0319","DOIUrl":"https://doi.org/10.1098/rsta.2023.0319","url":null,"abstract":"<p><p>On 13-15 January 2022, the Hunga Tonga-Hunga Ha'apai underwater volcano erupted. This powerful eruption generated infrasonic waves with amplitudes of thousands of Pascals in the near field. The ground infrasonic stations in China, located approximately 10 000 km from the Hunga volcano, also received waves with frequencies from 0.01 to 0.05 Hz. However, the amplitude reached 17 Pa, which is higher than the predicted amplitude using the absorption model without considering the dispersion effect in the thin thermosphere. At high altitudes, dispersion exists and the sound speed depends on the ratio of the molecular mean collision ratio to sound frequency, which is proportional to the ratio (frequency/pressure). And attenuation coefficients are complex to model. We simulate dispersive sound speeds and attenuation coefficients at different frequencies according to theory and our experimental data. In the thermosphere, the dispersion effect causes noticeable changes of sound speed and then affects wave propagation paths in the far field. The abnormal attenuation coefficient has a smaller impact on thermospheric returns than that of the dispersive sound speed, but it is also not negligible. It explains the large amplitude of thermospheric signals received in our infrasound stations. This article is part of the theme issue 'Celebrating the 15th anniversary of the Royal Society Newton International Fellowship'.</p>","PeriodicalId":19879,"journal":{"name":"Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-23Epub Date: 2024-09-09DOI: 10.1098/rsta.2023.0324
J M Londono Monsalve, E Kovalska, M F Craciun, M R Marsico
This study presents an experimental investigation of the mechanical behaviour of recycled rubber pads coated with graphene nanoplatelets. The investigation is part of an effort to develop a novel rubber-based composite that aims to reroute rubber from end-of-life tyres from illegal landfills and incineration back into the market in the form of a novel composite for vibration isolation. Graphene nanoplatelets were deposited on rubber pads via ultrasonic spray coating. The pads were made of a combination of recycled rubber (from tyres) and virgin rubber. A comprehensive analysis of the structural and chemical properties of the graphene coating, ensuring its integrity on the rubber substrate, was performed by combining surface topography, Raman and Fourier-transform infrared (FTIR) spectroscopy. Stacked coated pads were cured and tested dynamically in compression and shear under cyclic loading. Results showed promising improvements in the mechanical properties, in particular, in compressive stiffness and damping of the coated specimens with respect to their uncoated counterparts, laying the foundation for using graphene-enhanced recycled rubber as a novel composite.This article is part of the theme issue 'Celebrating the 15th anniversary of the Royal Society Newton International Fellowship'.
{"title":"Graphene nanoplatelets on recycled rubber: an experimental study of material properties and mechanical improvements.","authors":"J M Londono Monsalve, E Kovalska, M F Craciun, M R Marsico","doi":"10.1098/rsta.2023.0324","DOIUrl":"10.1098/rsta.2023.0324","url":null,"abstract":"<p><p>This study presents an experimental investigation of the mechanical behaviour of recycled rubber pads coated with graphene nanoplatelets. The investigation is part of an effort to develop a novel rubber-based composite that aims to reroute rubber from end-of-life tyres from illegal landfills and incineration back into the market in the form of a novel composite for vibration isolation. Graphene nanoplatelets were deposited on rubber pads via ultrasonic spray coating. The pads were made of a combination of recycled rubber (from tyres) and virgin rubber. A comprehensive analysis of the structural and chemical properties of the graphene coating, ensuring its integrity on the rubber substrate, was performed by combining surface topography, Raman and Fourier-transform infrared (FTIR) spectroscopy. Stacked coated pads were cured and tested dynamically in compression and shear under cyclic loading. Results showed promising improvements in the mechanical properties, in particular, in compressive stiffness and damping of the coated specimens with respect to their uncoated counterparts, laying the foundation for using graphene-enhanced recycled rubber as a novel composite.This article is part of the theme issue 'Celebrating the 15th anniversary of the Royal Society Newton International Fellowship'.</p>","PeriodicalId":19879,"journal":{"name":"Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-23DOI: 10.1038/s41586-024-08199-x
Len van Deurzen, Eungkyun Kim, Naomi Pieczulewski, Zexuan Zhang, Anna Feduniewicz-Zmuda, Mikolaj Chlipala, Marcin Siekacz, David Muller, Huili Grace Xing, Debdeep Jena, Henryk Turski
Correction to: Nature https://doi.org/10.1038/s41586-024-07983-z Published online 25 September 2024
{"title":"Publisher Correction: Using both faces of polar semiconductor wafers for functional devices","authors":"Len van Deurzen, Eungkyun Kim, Naomi Pieczulewski, Zexuan Zhang, Anna Feduniewicz-Zmuda, Mikolaj Chlipala, Marcin Siekacz, David Muller, Huili Grace Xing, Debdeep Jena, Henryk Turski","doi":"10.1038/s41586-024-08199-x","DOIUrl":"https://doi.org/10.1038/s41586-024-08199-x","url":null,"abstract":"<p>Correction to: <i>Nature</i> https://doi.org/10.1038/s41586-024-07983-z Published online 25 September 2024</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":null,"pages":null},"PeriodicalIF":64.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-23DOI: 10.1038/d41586-024-03411-4
Some of the most inventive changes to health care have started in rural communities around the world.
{"title":"Innovations from Rural Communities Are Improving Health Care","authors":"","doi":"10.1038/d41586-024-03411-4","DOIUrl":"https://doi.org/10.1038/d41586-024-03411-4","url":null,"abstract":"Some of the most inventive changes to health care have started in rural communities around the world.","PeriodicalId":18787,"journal":{"name":"Nature","volume":null,"pages":null},"PeriodicalIF":64.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}