综合性期刊最新文献

Fast radio bursts (FRBs) are a newly discovered class of extragalactic radio transients characterized by their high energy and short duration (from microseconds to milliseconds)¹. The physical origin of these FRBs remains unknown and is a subject of ongoing research, with magnetars emerging as leading candidates^2,3. Previous studies have used various methodologies to address the problem of FRB origin, including demographic analyses of FRB host galaxies and their local environments^4,5,6, assessments of FRB rate evolution with redshift^7,8,9 and searches for proposed multi-messenger FRB counterparts¹⁰. However, these studies are susceptible to substantial biases stemming from unaccounted radio and optical selection effects. Here we present empirical evidence for a substantial selection bias against detecting FRBs in galaxies with large inclination angles (edge-on) using a sample of hosts identified for FRBs discovered by untargeted surveys. This inclination-related bias probably leads to a significant underestimation (by about a factor of two) of the FRB rates reported in the literature and disfavours globular clusters as the dominant origin of FRB sources, as previously speculated⁶. These conclusions have important implications for FRB progenitor models and targeted FRB follow-up strategies. We further investigate the impact of this bias on the relative rate of FRBs in different host environments. Our analysis suggests that scattering in FRB hosts is probably responsible for the observed bias^11,12. However, a larger sample of localized FRBs is required to robustly quantify the contribution of scattering to the inclination-related selection bias.

We discuss two-photon physics, taking for illustration the particular but topical case of resonance fluorescence. We show that the basic concepts of interferences and correlations provide at the two-photon level an independent and drastically different picture than at the one-photon level, with landscapes of correlations that reveal various processes by spanning over all the possible frequencies at which the system can emit. Such landscapes typically present lines of photon bunching and circles of antibunching. The theoretical edifice to account for these features rests on two pillars: (i) a theory of frequency-resolved photon correlations and (ii) admixing classical and quantum fields. While experimental efforts have been to date concentrated on correlations between spectral peaks, strong correlations exist between photons emitted away from the peaks, which are accessible only through multi-photon observables. These could be exploited for both fundamental understanding of quantum-optical processes as well as applications by harnessing these unsuspected resources. This article is part of the theme issue 'Celebrating the 15th anniversary of the Royal Society Newton International Fellowship'.

Plasmons in two-dimensional electron channels have potential applications in the terahertz frequency range. Equivalent circuit models provide a convenient framework for analysing the plasmons. This article introduces a circuit model for plasmons in the presence of a dc current that flows in a gated channel. It is shown that drifting plasmons can be described by an LC-transmission line with distributed dependent sources. A circuit analogue of the Dyakonov-Shur instability is demonstrated. Then, a lumped-element transmission line with dependent sources is analysed, and non-reciprocity is demonstrated for examples of a right- and a left-handed transmission line. Effects of ohmic loss are discussed. The results could be used for the design of non-reciprocal transmission line devices. This article is part of the theme issue 'Celebrating the 15th anniversary of the Royal Society Newton International Fellowship'.

Concepts and evolution of multi-scale modelling from the perspective of wave-structure interaction have been discussed. In this regard, both domain and functional decomposition approaches have come into being. In domain decomposition, the computational domain is spatially segregated to handle the far-field using potential flow models and the near field using Navier-Stokes equations. In functional decomposition, the velocity field is separated into irrotational and rotational parts to facilitate identification of the free surface. These two approaches have been implemented alongside partitioned or monolithic schemes for modelling the structure. The applicability of multi-scale modelling approaches has been established using both mesh-based and meshless schemes. Owing to said diversity in numerical techniques, massively collaborative research has emerged, wherein comparative numerical studies are being carried out to identify shortcomings of developed codes and establish best-practices in numerical modelling. Machine learning is also being applied to handle large-scale ocean engineering problems. This paper reports on the past, present and future research consolidating the contributions made over the past 20 years. Some of these past as well as future research contributions have and shall be actualized through funding from the Newton International Fellowship as the next generation of researchers inherits the present-day expertise in multi-scale modelling. This article is part of the theme issue 'Celebrating the 15th anniversary of the Royal Society Newton International Fellowship'.

Cortical feedback connections are extremely numerous but the logic of connectivity between higher and lower areas remains poorly understood. Feedback from higher visual areas to primary visual cortex (V1) has been shown to enhance responses on perceptual figures compared to backgrounds, an effect known as figure-background modulation (FBM). A likely source of this feedback are border-ownership (BO) selective cells in mid-tier visual areas (e.g. V4) which represent the location of figures. We examined the connectivity between V4 cells and V1 cells using noise-correlations and micro-stimulation to estimate connectivity strength. We show that connectivity is consistent with a model in which BO-tuned V4 cells send positive feedback in the direction of their preferred figure and negative feedback in the opposite direction. This connectivity scheme can recreate patterns of FBM observed in previous studies. These results provide insights into the cortical connectivity underlying figure-background perception and establish a link between FBM and BO-tuning.

Chromosomal inversions are associated with local adaptation in many species. However, questions regarding how they are formed, maintained and impact various other evolutionary processes remain elusive. Here, using a large genomic dataset of long-read and short-read sequencing, we ask these questions in one of the most abundant vertebrates on Earth, the Atlantic herring. This species has four megabase-sized inversions associated with ecological adaptation that correlate with water temperature. The S and N inversion alleles at these four loci dominate in the southern and northern parts, respectively, of the species distribution in the North Atlantic Ocean. By determining breakpoint coordinates of the four inversions and the structural variations surrounding them, we hypothesize that these inversions are formed by ectopic recombination between duplicated sequences immediately outside of the inversions. We show that these are old inversions (>1 MY), albeit formed after the split between the Atlantic herring and its sister species, the Pacific herring. There is evidence for extensive gene flux between inversion alleles at all four loci. The large Ne of herring combined with the common occurrence of opposite homozygotes across the species distribution has allowed effective purifying selection to prevent the accumulation of genetic load and repeats within the inversions.

Hematopoietic Stem Cell (HSC) gene therapy (GT) may provide lifelong reconstitution of the hematopoietic system with gene-corrected cells¹. However, the effects of underlying genetic diseases, replication stress, and aging on hematopoietic reconstitution and lineage specification remain unclear. In this study, we analyzed hematopoietic reconstitution in 53 patients treated with lentiviral-HSC-GT for diverse conditions such as metachromatic leukodystrophy^2,3 (MLD), Wiskott-Aldrich syndrome^4,5 (WAS), and β-thalassemia⁶ (β-Thal) over a follow-up period of up to 8 years, using vector integration sites as markers of clonal identity. We found that long-term hematopoietic reconstitution was supported by 770 to 35,000 active HSCs. While 50% of transplanted clones demonstrated multilineage potential across all conditions, the remaining clones exhibited a disease-specific preferential lineage output and long-term commitment: myeloid for MLD, lymphoid for WAS, and erythroid for β-Thal, particularly in adult patients. Our results indicate that HSC clonogenic activity, lineage output, long-term lineage commitment, and rates of somatic mutations are influenced by the underlying disease, patient age at the time of therapy, the extent of genetic defect correction, and the hematopoietic stress imposed by the inherited disease. This suggests that HSCs adapt to the pathological condition during hematopoietic reconstitution.

Host–pathogen conflicts are crucibles of molecular innovation^1,2. Selection for immunity to pathogens has driven the evolution of sophisticated immunity mechanisms throughout biology, including in bacterial defence against bacteriophages³. Here we characterize the widely distributed anti-phage defence system CmdTAC, which provides robust defence against infection by the T-even family of phages⁴. Our results support a model in which CmdC detects infection by sensing viral capsid proteins, ultimately leading to the activation of a toxic ADP-ribosyltransferase effector protein, CmdT. We show that newly synthesized capsid protein triggers dissociation of the chaperone CmdC from the CmdTAC complex, leading to destabilization and degradation of the antitoxin CmdA, with consequent liberation of the CmdT ADP-ribosyltransferase. Notably, CmdT does not target a protein, DNA or structured RNA, the known targets of other ADP-ribosyltransferases. Instead, CmdT modifies the N6 position of adenine in GA dinucleotides within single-stranded RNAs, leading to arrest of mRNA translation and inhibition of viral replication. Our work reveals a novel mechanism of anti-viral defence and a previously unknown but broadly distributed class of ADP-ribosyltransferases that target mRNA.