Arlin Rodriguez, Bharath Raj Madhanagopal, Kahini Sarkar, Zohreh Nowzari, Johnsi Mathivanan, Hannah Talbot, Akul Patel, Vinod Morya, Ken Halvorsen, Sweta Vangaveti, J. Andrew Berglund, Arun Richard Chandrasekaran
DNA nanostructures are typically assembled by thermal annealing in buffers containing magnesium. We demonstrate the assembly of DNA nanostructures at constant temperatures ranging from 4° to 50°C in solutions containing different counterions. The choice of counterions and the assembly temperature influence the isothermal assembly of several DNA motifs and designed three-dimensional DNA crystals. Molecular dynamics simulations show more fluctuations of the DNA structure in select monovalent ions (Na + and K + ) compared to divalent ions (Mg 2+ and Ca 2+ ). A key highlight is the successful assembly of DNA motifs in nickel-containing buffer at temperatures below 40°C, otherwise unachievable at higher temperatures or using an annealing protocol. DNA nanostructures isothermally assembled in different ions do not affect the viability of fibroblasts, myoblasts, and myotubes or the immune response in myoblasts. The use of ions other than the typically used magnesium holds key potential in biological and materials science applications that require minimal amounts of magnesium.
{"title":"Counterions influence the isothermal self-assembly of DNA nanostructures","authors":"Arlin Rodriguez, Bharath Raj Madhanagopal, Kahini Sarkar, Zohreh Nowzari, Johnsi Mathivanan, Hannah Talbot, Akul Patel, Vinod Morya, Ken Halvorsen, Sweta Vangaveti, J. Andrew Berglund, Arun Richard Chandrasekaran","doi":"10.1126/sciadv.adu7366","DOIUrl":"https://doi.org/10.1126/sciadv.adu7366","url":null,"abstract":"DNA nanostructures are typically assembled by thermal annealing in buffers containing magnesium. We demonstrate the assembly of DNA nanostructures at constant temperatures ranging from 4° to 50°C in solutions containing different counterions. The choice of counterions and the assembly temperature influence the isothermal assembly of several DNA motifs and designed three-dimensional DNA crystals. Molecular dynamics simulations show more fluctuations of the DNA structure in select monovalent ions (Na <jats:sup>+</jats:sup> and K <jats:sup>+</jats:sup> ) compared to divalent ions (Mg <jats:sup>2+</jats:sup> and Ca <jats:sup>2+</jats:sup> ). A key highlight is the successful assembly of DNA motifs in nickel-containing buffer at temperatures below 40°C, otherwise unachievable at higher temperatures or using an annealing protocol. DNA nanostructures isothermally assembled in different ions do not affect the viability of fibroblasts, myoblasts, and myotubes or the immune response in myoblasts. The use of ions other than the typically used magnesium holds key potential in biological and materials science applications that require minimal amounts of magnesium.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"15 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isla R. Simpson, Tiffany A. Shaw, Paulo Ceppi, Amy C. Clement, Erich Fischer, Kevin M. Grise, Angeline G. Pendergrass, James A. Screen, Robert C. J. Wills, Tim Woollings, Russell Blackport, Joonsuk M. Kang, Stephen Po-Chedley
Anthropogenically forced climate change signals are emerging from the noise of internal variability in observations, and the impacts on society are growing. For decades, Climate or Earth System Models have been predicting how these climate change signals will unfold. While challenges remain, given the growing forced trends and the lengthening observational record, the climate science community is now in a position to confront the signals, as represented by historical trends, in models with observations. This review covers the state of the science on the ability of models to represent historical trends in the climate system. It also outlines robust procedures that should be used when comparing modeled and observed trends and how to move beyond quantification into understanding. Finally, this review discusses cutting-edge methods for identifying sources of discrepancies and the importance of future confrontations.
{"title":"Confronting Earth System Model trends with observations","authors":"Isla R. Simpson, Tiffany A. Shaw, Paulo Ceppi, Amy C. Clement, Erich Fischer, Kevin M. Grise, Angeline G. Pendergrass, James A. Screen, Robert C. J. Wills, Tim Woollings, Russell Blackport, Joonsuk M. Kang, Stephen Po-Chedley","doi":"10.1126/sciadv.adt8035","DOIUrl":"https://doi.org/10.1126/sciadv.adt8035","url":null,"abstract":"Anthropogenically forced climate change signals are emerging from the noise of internal variability in observations, and the impacts on society are growing. For decades, Climate or Earth System Models have been predicting how these climate change signals will unfold. While challenges remain, given the growing forced trends and the lengthening observational record, the climate science community is now in a position to confront the signals, as represented by historical trends, in models with observations. This review covers the state of the science on the ability of models to represent historical trends in the climate system. It also outlines robust procedures that should be used when comparing modeled and observed trends and how to move beyond quantification into understanding. Finally, this review discusses cutting-edge methods for identifying sources of discrepancies and the importance of future confrontations.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"21 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isla R. Simpson, Tiffany A. Shaw, Paulo Ceppi, Amy C. Clement, Erich Fischer, Kevin M. Grise, Angeline G. Pendergrass, James A. Screen, Robert C. J. Wills, Tim Woollings, Russell Blackport, Joonsuk M. Kang, Stephen Po-Chedley
Anthropogenically forced climate change signals are emerging from the noise of internal variability in observations, and the impacts on society are growing. For decades, Climate or Earth System Models have been predicting how these climate change signals will unfold. While challenges remain, given the growing forced trends and the lengthening observational record, the climate science community is now in a position to confront the signals, as represented by historical trends, in models with observations. This review covers the state of the science on the ability of models to represent historical trends in the climate system. It also outlines robust procedures that should be used when comparing modeled and observed trends and how to move beyond quantification into understanding. Finally, this review discusses cutting-edge methods for identifying sources of discrepancies and the importance of future confrontations.
{"title":"Confronting Earth System Model trends with observations","authors":"Isla R. Simpson, Tiffany A. Shaw, Paulo Ceppi, Amy C. Clement, Erich Fischer, Kevin M. Grise, Angeline G. Pendergrass, James A. Screen, Robert C. J. Wills, Tim Woollings, Russell Blackport, Joonsuk M. Kang, Stephen Po-Chedley","doi":"","DOIUrl":"","url":null,"abstract":"<div >Anthropogenically forced climate change signals are emerging from the noise of internal variability in observations, and the impacts on society are growing. For decades, Climate or Earth System Models have been predicting how these climate change signals will unfold. While challenges remain, given the growing forced trends and the lengthening observational record, the climate science community is now in a position to confront the signals, as represented by historical trends, in models with observations. This review covers the state of the science on the ability of models to represent historical trends in the climate system. It also outlines robust procedures that should be used when comparing modeled and observed trends and how to move beyond quantification into understanding. Finally, this review discusses cutting-edge methods for identifying sources of discrepancies and the importance of future confrontations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 11","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt8035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet F. Keleş, Ali Osman Berk Sapci, Casey Brody, Isabelle Palmer, Anuradha Mehta, Shahin Ahmadi, Christin Le, Öznur Taştan, Sündüz Keleş, Mark N. Wu
There is great interest in using genetically tractable organisms such as Drosophila to gain insights into the regulation and function of sleep. However, sleep phenotyping in Drosophila has largely relied on simple measures of locomotor inactivity. Here, we present FlyVISTA, a machine learning platform to perform deep phenotyping of sleep in flies. This platform comprises a high-resolution closed-loop video imaging system, coupled with a deep learning network to annotate 35 body parts, and a computational pipeline to extract behaviors from high-dimensional data. FlyVISTA reveals the distinct spatiotemporal dynamics of sleep and wake-associated microbehaviors at baseline, following administration of the sleep-inducing drug gaboxadol, and with dorsal fan-shaped body drivers. We identify a microbehavior (“haltere switch”) exclusively seen during quiescence that indicates a deeper sleep stage. These results enable the rigorous analysis of sleep in Drosophila and set the stage for computational analyses of microbehaviors in quiescent animals.
{"title":"FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in Drosophila","authors":"Mehmet F. Keleş, Ali Osman Berk Sapci, Casey Brody, Isabelle Palmer, Anuradha Mehta, Shahin Ahmadi, Christin Le, Öznur Taştan, Sündüz Keleş, Mark N. Wu","doi":"","DOIUrl":"","url":null,"abstract":"<div >There is great interest in using genetically tractable organisms such as <i>Drosophila</i> to gain insights into the regulation and function of sleep. However, sleep phenotyping in <i>Drosophila</i> has largely relied on simple measures of locomotor inactivity. Here, we present FlyVISTA, a machine learning platform to perform deep phenotyping of sleep in flies. This platform comprises a high-resolution closed-loop video imaging system, coupled with a deep learning network to annotate 35 body parts, and a computational pipeline to extract behaviors from high-dimensional data. FlyVISTA reveals the distinct spatiotemporal dynamics of sleep and wake-associated microbehaviors at baseline, following administration of the sleep-inducing drug gaboxadol, and with dorsal fan-shaped body drivers. We identify a microbehavior (“haltere switch”) exclusively seen during quiescence that indicates a deeper sleep stage. These results enable the rigorous analysis of sleep in <i>Drosophila</i> and set the stage for computational analyses of microbehaviors in quiescent animals.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 11","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq8131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Invasive infections by encapsulated bacteria are the major cause of human morbidity and mortality. The liver resident macrophages, Kupffer cells, form the hepatic firewall to clear many encapsulated bacteria in the blood circulation but fail to control certain high-virulence capsule types. Here we report that the spleen is the backup immune organ to clear the liver-resistant serotypes of Streptococcus pneumoniae (pneumococcus), a leading human pathogen. Asplenic mice failed to control the growth of the liver-resistant pneumococci in the blood circulation. Immunologic and genetic analyses identified splenic red pulp (RP) macrophages as the major phagocytes for bacterial clearance. Furthermore, the plasma natural antibodies against the cell wall phosphocholine and the complement system were necessary for RP macrophage–mediated immunity. These findings have provided a conceptual framework for the innate defense against blood bacterial infections, a mechanistic explanation for the hyper-susceptibility of asplenic individuals to S. pneumoniae, and a proof of concept for developing vaccines and therapeutic antibodies against encapsulated pathogens.
{"title":"Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice","authors":"Haoran An, Yijia Huang, Zhifeng Zhao, Kunpeng Li, Jingjing Meng, Xueting Huang, Xianbin Tian, Hongyu Zhou, Jiamin Wu, Qionghai Dai, Jing-Ren Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<div >Invasive infections by encapsulated bacteria are the major cause of human morbidity and mortality. The liver resident macrophages, Kupffer cells, form the hepatic firewall to clear many encapsulated bacteria in the blood circulation but fail to control certain high-virulence capsule types. Here we report that the spleen is the backup immune organ to clear the liver-resistant serotypes of <i>Streptococcus pneumoniae</i> (pneumococcus), a leading human pathogen. Asplenic mice failed to control the growth of the liver-resistant pneumococci in the blood circulation. Immunologic and genetic analyses identified splenic red pulp (RP) macrophages as the major phagocytes for bacterial clearance. Furthermore, the plasma natural antibodies against the cell wall phosphocholine and the complement system were necessary for RP macrophage–mediated immunity. These findings have provided a conceptual framework for the innate defense against blood bacterial infections, a mechanistic explanation for the hyper-susceptibility of asplenic individuals to <i>S. pneumoniae</i>, and a proof of concept for developing vaccines and therapeutic antibodies against encapsulated pathogens.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 11","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq6399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander M. Shuppara, Gilberto C. Padron, Anuradha Sharma, Zil Modi, Matthias D. Koch, Joseph E. Sanfilippo
Bacterial populations experience chemical gradients in nature. However, most experimental systems either ignore gradients or fail to capture gradients in mechanically relevant contexts. Here, we use microfluidic experiments and biophysical simulations to explore how host-relevant shear flow affects antimicrobial gradients across communities of the highly resistant pathogen Pseudomonas aeruginosa. We discover that flow patterns gradients of three chemically distinct antimicrobials: hydrogen peroxide, gentamicin, and carbenicillin. Without flow, resistant P. aeruginosa cells generate local gradients by neutralizing all three antimicrobials through degradation or chemical modification. As flow increases, delivery overwhelms neutralization, allowing antimicrobials to penetrate deeper into bacterial populations. By imaging single cells across long microfluidic channels, we observe that upstream cells protect downstream cells, and protection is abolished in higher flow regimes. Together, our results reveal that physical flow can promote antimicrobial effectiveness, which could inspire the incorporation of flow into the discovery, development, and implementation of antimicrobials.
{"title":"Shear flow patterns antimicrobial gradients across bacterial populations","authors":"Alexander M. Shuppara, Gilberto C. Padron, Anuradha Sharma, Zil Modi, Matthias D. Koch, Joseph E. Sanfilippo","doi":"","DOIUrl":"","url":null,"abstract":"<div >Bacterial populations experience chemical gradients in nature. However, most experimental systems either ignore gradients or fail to capture gradients in mechanically relevant contexts. Here, we use microfluidic experiments and biophysical simulations to explore how host-relevant shear flow affects antimicrobial gradients across communities of the highly resistant pathogen <i>Pseudomonas aeruginosa</i>. We discover that flow patterns gradients of three chemically distinct antimicrobials: hydrogen peroxide, gentamicin, and carbenicillin. Without flow, resistant <i>P. aeruginosa</i> cells generate local gradients by neutralizing all three antimicrobials through degradation or chemical modification. As flow increases, delivery overwhelms neutralization, allowing antimicrobials to penetrate deeper into bacterial populations. By imaging single cells across long microfluidic channels, we observe that upstream cells protect downstream cells, and protection is abolished in higher flow regimes. Together, our results reveal that physical flow can promote antimicrobial effectiveness, which could inspire the incorporation of flow into the discovery, development, and implementation of antimicrobials.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 11","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads5005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Currently, most cell or tissue transplantations using induced pluripotent stem cells (iPSCs) are anticipated to involve allogeneic iPSCs. However, the immunological properties of iPSCs in an allogeneic setting are not well understood. We previously established a mouse transplantation model of MHC-compatible/minor antigen-mismatched combinations, assuming a hypoimmunogenic iPSC-setting. Here, we found that iPSCs subcutaneously inoculated into MHC-compatible allogeneic host mice resisted rejection and formed teratomas without immunosuppressant administration. Notably, when skin grafts were transplanted onto hosts more than 40 d after the initial iPSCs inoculation, only the skin of the same strain as the initial iPSCs was engrafted. Therefore, donor-specific immune tolerance was induced by a single iPSC inoculation. Diverse analyses, including single-cell RNA-sequencing after transplantation, revealed an increase in regulatory T cell (Treg) population, particularly CD25 + CD103 + effector Tregs within the teratoma and skin grafts. The removal of CD25 + or Foxp3 + cells suppressed the increase in effector Tregs and disrupted graft acceptance, indicating the importance of these cells in the establishment of immune tolerance. Within the teratoma, we observed an increase in TGF-β2 levels, suggesting an association with the increase in effector Tregs. Our results provide important insights for future applications of allogeneic iPSC-based cell or tissue transplantation.
{"title":"iPSCs engrafted in allogeneic hosts without immunosuppression induce donor-specific tolerance to secondary allografts","authors":"Tomoki Kamatani, Reiko Kimura, Satoshi Ikeda, Makoto Inoue, Ken-ichiro Seino","doi":"10.1073/pnas.2413398122","DOIUrl":"https://doi.org/10.1073/pnas.2413398122","url":null,"abstract":"Currently, most cell or tissue transplantations using induced pluripotent stem cells (iPSCs) are anticipated to involve allogeneic iPSCs. However, the immunological properties of iPSCs in an allogeneic setting are not well understood. We previously established a mouse transplantation model of MHC-compatible/minor antigen-mismatched combinations, assuming a hypoimmunogenic iPSC-setting. Here, we found that iPSCs subcutaneously inoculated into MHC-compatible allogeneic host mice resisted rejection and formed teratomas without immunosuppressant administration. Notably, when skin grafts were transplanted onto hosts more than 40 d after the initial iPSCs inoculation, only the skin of the same strain as the initial iPSCs was engrafted. Therefore, donor-specific immune tolerance was induced by a single iPSC inoculation. Diverse analyses, including single-cell RNA-sequencing after transplantation, revealed an increase in regulatory T cell (Treg) population, particularly CD25 <jats:sup>+</jats:sup> CD103 <jats:sup>+</jats:sup> effector Tregs within the teratoma and skin grafts. The removal of CD25 <jats:sup>+</jats:sup> or Foxp3 <jats:sup>+</jats:sup> cells suppressed the increase in effector Tregs and disrupted graft acceptance, indicating the importance of these cells in the establishment of immune tolerance. Within the teratoma, we observed an increase in TGF-β2 levels, suggesting an association with the increase in effector Tregs. Our results provide important insights for future applications of allogeneic iPSC-based cell or tissue transplantation.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"57 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tongtong Zhang, Farid Manshaii, Chris R. Bowen, Maoyi Zhang, Weiqi Qian, Chaosheng Hu, Yanan Bai, Zhijie Huang, Ya Yang, Jun Chen
The keyboard, a staple tool for information entry and human-machine interaction, faces demands for enhanced information security due to evolving internet technologies. This study introduces a self-powered flexible intelligent keyboard (SFIK) that harnesses the giant magnetoelastic effect to convert the mechanical pressure from key presses into electrical signals. The sensor boasts a wide sensing range (35 to 600 kPa) and a rapid response time (∼300 ms), allowing it to record and recognize individual keystroke dynamics. Integrated with machine learning, this keyboard enables identity authentication through both fixed- and dynamic-text inputs. It accurately authenticates fixed passwords of eight characters with a 95.3% success rate and dynamic text from 14 sets of double keys with 100% accuracy. Given its capabilities, the SFIK offers promising applications in artificial intelligence, network security, and access control for computers and networks.
{"title":"A flexible pressure sensor array for self-powered identity authentication during typing","authors":"Tongtong Zhang, Farid Manshaii, Chris R. Bowen, Maoyi Zhang, Weiqi Qian, Chaosheng Hu, Yanan Bai, Zhijie Huang, Ya Yang, Jun Chen","doi":"10.1126/sciadv.ads2297","DOIUrl":"https://doi.org/10.1126/sciadv.ads2297","url":null,"abstract":"The keyboard, a staple tool for information entry and human-machine interaction, faces demands for enhanced information security due to evolving internet technologies. This study introduces a self-powered flexible intelligent keyboard (SFIK) that harnesses the giant magnetoelastic effect to convert the mechanical pressure from key presses into electrical signals. The sensor boasts a wide sensing range (35 to 600 kPa) and a rapid response time (∼300 ms), allowing it to record and recognize individual keystroke dynamics. Integrated with machine learning, this keyboard enables identity authentication through both fixed- and dynamic-text inputs. It accurately authenticates fixed passwords of eight characters with a 95.3% success rate and dynamic text from 14 sets of double keys with 100% accuracy. Given its capabilities, the SFIK offers promising applications in artificial intelligence, network security, and access control for computers and networks.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"32 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-12DOI: 10.1038/d41586-025-00783-z
Blue-lined octopuses immobilize their partners with venom to avoid being eaten after sex. Plus, astronomers have discovered 128 new moons orbiting Saturn.
{"title":"Daily briefing: Saturn has 128 new moons","authors":"","doi":"10.1038/d41586-025-00783-z","DOIUrl":"https://doi.org/10.1038/d41586-025-00783-z","url":null,"abstract":"Blue-lined octopuses immobilize their partners with venom to avoid being eaten after sex. Plus, astronomers have discovered 128 new moons orbiting Saturn.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"22 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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