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LOW LEVEL LASER THERAPY REDUCES ANTICANCER POTENTIAL OF COLLOIDAL SILVER THROUGH TRPV1 CHANNELS 低水平激光治疗通过TRPV1通道降低胶体银的抗癌潜力
IF 0.4 4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-05-01 DOI: 10.59671/hje0t
İ. Övey, Yılmaz Güler, Ö. Çelik
Recently there are studies which particularly investigated efficiency of silver on neoplastic diseases. and many other diseases. Low level laser therapy(LLLT) has been shown to modulate biological processes and there are many studies that investigate the effect of LLLT, which is used in the treatment of cancers currently. Methods: Breast(MCF7) and colon(Caco 2) cells were cultured and cells were divided into eleven main groups. Cells were incubated with colloidal silver for 24 hrs. Colloidal silver and LLLT exposure separately and together performed on MCF7 and Caco 2 cell cultures. The effects of colloidal silver and LLLT were invastigated on all molecular pathways of apoptosis. Results: It was found that the levels of apoptosis in colloidal silver group were significantly increased in both cancer cells compared to control group. In both cancer cells, transient receptor protein vanilloid 1 (TRPV1) channel stimulator Cpsin administration resulted in significantly increased apoptosis levels compared to the control group, in colloidal silver + LLLT group the apopitosis level significantly reduced compared to colloidal silver-only group.Conclusions: It has been shown that colloidal silver significantly increases apoptosis in breast and colon cancer cells, however LLLT administration decreases apoptosis in both wavelength and suppressed apoptotic effect of colloidal silver significantly on these cells.
最近有一些研究特别研究了银对肿瘤性疾病的疗效。以及许多其他疾病。低水平激光治疗(LLLT)已被证明可以调节生物过程,并且有许多研究研究了LLLT的作用,LLLT目前用于治疗癌症。方法:培养乳腺(MCF7)和结肠(Caco-2)细胞,将其分为11个主要组。将细胞与胶体银孵育24小时。在MCF7和Caco-2细胞培养物上分别并一起进行胶体银和LLLT暴露。胶体银和LLLT对细胞凋亡的所有分子途径都有影响。结果:与对照组相比,胶体银组癌症细胞凋亡水平明显升高。在两种癌症细胞中,与对照组相比,瞬时受体蛋白香兰素1(TRPV1)通道刺激剂Cpsin给药导致细胞凋亡水平显著升高,在胶体银+LLLT组中,与胶体银单用组相比,细胞凋亡水平显着降低。结论:胶体银显著增加了乳腺癌和结肠癌癌症细胞的凋亡,而LLLT给药在两个波长上都减少了凋亡,并显著抑制了胶体银对这些细胞的凋亡作用。
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引用次数: 0
AZIDAS AROMATICAS. PROPIEDADES FISICOQUIMICAS, REACTIVIDAD Y APLICACIONES EN SINTESIS ORGANICA, BIOQUIMICA Y MEDICINA. AZIDAS AROMATICAS。物理化学性质、反应性及在有机合成、生物化学和医学中的应用。
IF 0.4 4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-01-01 DOI: 10.59671/rksca
S. E. Loredo-Carrillo, E. Leyva, J. Aguilar, Sarai Vega-Rodriguez
Las azidas aromáticas son compuestos altamente reactivos y versátiles debido a sus características fisicoquímicas. De acuerdo a las condiciones de reacción forman varios intermediarios que pueden seguir diferentes rutas para dar productos diversos. Además, son utilizados en la técnica de marcado de fotoafinidad por sus características fotoquímicas y estabilidad. Son precursores en la síntesis de compuestos heterocíclicos con actividad biológica como triazoles, azepinas y benzofuroxanos, además también se usan en la química de materiales. En esta revisión se describen las propiedades fisicoquímicas, químicas y fotoquímicas de la azidas, las condiciones y sustituyentes que favorecen la formación de algunos productos y se mencionan las aplicaciones de este tipo de compuestos.
芳香叠氮化物由于其物理化学特性,是一种反应性强、用途广泛的化合物。根据反应条件,它们会形成几种中间体,这些中间体可以沿着不同的路线产生不同的产物。此外,由于其光化学特性和稳定性,它们被用于光亲和标记技术。它们是合成具有生物活性的杂环化合物的前体,如三唑、氮平和苯并呋喃,也用于材料化学。叠氮化物的物理化学、化学和光化学性质,有利于某些产物形成的条件和取代基,以及这类化合物的应用。
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引用次数: 0
LITERATURA E HISTÓRIA EM TERRAS AMAZÔNICAS: ENTREMEANDO FIOS HISTORIOGRÁFICOS 亚马逊土地上的文学和历史:交织史学线索
4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-01-01 DOI: 10.59671/gyjia
Mirian de Oliveira Bertotti,, Robson Fonseca Simoes
Este estudo, um diálogo com uma pesquisa de doutoramento, junto ao Programa de Pós-graduação Em Educação Escolar, traz para discussão possíveis entrelaçamentos entre a Literatura e a História. Objetiva-se compreender de que forma estes campos desvelam o colonizar das terras da Amazônia ocidental brasileira, especificamente o município de Ariquemes, situado no Vale do Jamari, estado de Rondônia. Numa abordagem qualitativa, optou-se por uma operação historiográfica como investigação metodológica, já que permite o entrecruzar das diversas fontes como experiências e saberes dos sujeitos sociais. Os resultados do estudo mostraram que as fontes literárias complementam as fontes históricas se complementam, já que ao apresentarem as perspectivas dos atores envolvidos por meio de gêneros textuais diversos, podemos entender o processo colonizador para além dos documentos, como ele foi vivido e sentido pelos sujeitos.
这项研究,与学校教育研究生项目的博士研究的对话,提出了文学和历史之间可能的交织的讨论。目的是了解这些领域如何揭示巴西亚马逊西部土地的殖民,特别是位于rondonia州贾马里山谷的Ariquemes市。在定性的方法中,我们选择了史学操作作为方法论研究,因为它允许社会主体的经验和知识等各种来源的交叉。研究结果表明,文学来源与历史来源相辅相成,因为通过不同的文本体裁呈现参与者的视角,我们可以超越文献,理解殖民过程是如何被主体生活和感受的。
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引用次数: 0
Chitosan Stabilised Iron Containing Nanoparticles For Photocatalytic Hydrogen Generation 壳聚糖稳定铁纳米颗粒光催化制氢
4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-01-01 DOI: 10.59671/f7ran
Meenal Joshi, Sadhana S. Rayalu
Metal nonoparticles stabilized by polymers is emerging as a new class of materials having entirely new physico-chemical properties as that of bulk and atom both. Stabilizers play important role in protecting the nanoparticles and also contributes in improvising the overall surface area. Chitosan, a natural polymer is selected as a stabilizer for the synthesis of iron containing nanoparticles. These nonoparticles are thoroughly characterized by using BETsurface area, FTIR, TEM and XPS. TEM image is showing well dispersed nanofibers with average size of 13nm. XPS data supports the formation of Fe2O3 type structure with O1s binding energy at 534.5 eV and Fe 2P3/2 and Fe 2P1/2 binding energies at 712eV and 723.2 eV. BET Surface area value is 36.72m2 /g with pore size of 145.16 and pore volume of 0.1332 cm3 /g. This synthesized nanomaterial was evaluated for photocatalytic hydrogen generation via water splitting reaction. Iron containing nanoparticles are showing excellent photocatalytic activity with hydrogen generation yield of 55.5 mmoles h-1g -1 of photocatalyst. The nanoparticles are magnetically retrievable and hence can be separated effectively from heterogeneous system.
聚合物稳定的金属非颗粒是一种新型材料,具有与体和原子完全不同的物理化学性质。稳定剂在保护纳米颗粒方面起着重要的作用,也有助于提高总表面积。选用天然聚合物壳聚糖作为合成含铁纳米颗粒的稳定剂。利用红外光谱、红外光谱、透射电镜和XPS对这些非颗粒进行了表征。TEM图像显示纳米纤维分散良好,平均尺寸为13nm。XPS数据支持形成Fe2O3型结构,O1s结合能为534.5 eV, fe2p3 /2和fe2p1 /2结合能分别为712eV和723.2 eV。BET表面积值为36.72m2 /g,孔径为145.16,孔体积为0.1332 cm3 /g。对合成的纳米材料进行了水裂解反应光催化制氢性能评价。含铁纳米颗粒表现出优异的光催化活性,光催化剂的产氢率为55.5 mmol h-1g -1。纳米颗粒具有磁性可回收性,因此可以有效地从非均相体系中分离出来。
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引用次数: 0
Evaluation of the CEFR framed English language curriculum in primary and secondary schools in Turkey: teachers` perspectives 评估CEFR框架下的土耳其中小学英语课程:教师视角
IF 0.4 4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-01-01 DOI: 10.59671/alfdo
A. Çebi, Ilkay Gilanlioglu
The current English language curriculum in primary and secondary schools in Turkey has been framed by The Common European Framework of Reference for Languages (CEFR) in an endeavour to bring in a more communication-oriented perspective on language education. This study aimed to evaluate the CEFR framed curriculum from the perspectives of teachers who apply it in the classroom. An exploratory sequential mixed method research design, which encompassed a 40-item questionnaire (100 participants), a 25-item semi-structured interview (6 secondary and 3 primary school teachers), and document analysis, was employed in primary and secondary schools in Sultanbeyli, Umraniye, and Besiktas districts of Istanbul. The results showed that lack of knowledge about the CEFR and the contextual factors such as overcrowded classrooms and limited class contact hours greatly affected the implementation phase of the curriculum. It was also revealed that there is a remarkable mismatch between the language education policy (communication-oriented) and the classroom practices (exam-oriented). The findings of this study implied that teachers need ongoing in-service training about the CEFR framed curriculum to enhance their understanding of the implementation of its principles in the classroom. The implications of the study, most notably the need for well-tailored in-service training, are also discussed.
土耳其中小学目前的英语课程是由《欧洲共同语言参考框架》(CEFR)制定的,目的是在语言教育方面引入一种更加以交流为导向的观点。本研究旨在从教师的角度来评估CEFR框架课程在课堂上的应用。采用探索性顺序混合方法研究设计,包括40项问卷(100名参与者)、25项半结构化访谈(6名中学教师和3名小学教师)和文献分析,在伊斯坦布尔Sultanbeyli、Umraniye和Besiktas地区的中小学进行。结果表明,对CEFR知识的缺乏以及教室拥挤、课堂接触时数有限等情境因素对课程实施阶段的影响较大。研究还发现,语言教育政策(以交流为导向)与课堂实践(以考试为导向)之间存在显著的不匹配。本研究结果暗示教师需要持续的在职培训,以提高他们对CEFR框架课程在课堂上实施原则的理解。本文还讨论了这项研究的影响,最引人注目的是需要量身定制的在职培训。
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引用次数: 0
DENTAL TOURISM POTENTIAL FROM THE PERSPECTIVE OF DENTISTS: THE CASE OF ANTALYA PROVINCE 从牙医的角度看牙科旅游潜力:以安塔利亚省为例
4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-01-01 DOI: 10.59671/emma1
Zeynep Aydin Kilinc, Harun Ucak
Dental tourism is one of the fastest-growing and developing sub-branches of medicaltourism. However, academic research in this field is quite limited. Moreover, the verylimited studies in T�rkiye, where the research was conducted, mainly focus on themotivations and destination preferences of dental tourists. This study is a survey-basedstudy conducted with dentists. The cross-sectional study population includes 310 dentistsat private health institutions in Antalya province, and the data were collected face-to-facebetween 2022-2023. According to the results obtained in the study, it was determined thatdental tourists mostly have implanted veneers, crowns, dental bridges and teeth whiteningprocedures. The study also determined that the dental tourism knowledge of dentists is ata reasonable level.
牙科旅游是医疗旅游中发展最快的分支之一。然而,这方面的学术研究相当有限。此外,在T�rkiye进行的研究非常有限,主要集中在牙科游客的动机和目的地偏好上。这项研究是一项基于调查的研究,由牙医进行。横断面研究人群包括安塔利亚省私人卫生机构的310名牙医,数据在2022-2023年间面对面收集。根据研究得出的结果,牙科游客大多进行了种植贴面、牙冠、牙桥和牙齿美白手术。研究还确定了牙医的牙科旅游知识处于合理水平。
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引用次数: 0
The Effects of Learning Method, Motivation, and Self-Discipline on Students’ Retrospective Perceptions of Online Learning 学习方法、动机和自律对学生在线学习回溯性认知的影响
4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-01-01 DOI: 10.59671/imvn3
Eyal Eckhaus, Nitza Davidovitch
This article examines, for the first time, the relationship between learning style, motivation, and self-discipline, as factors that affect tertiary students’ perceptions of online learning, from a retrospective perspective. The period between 2019 and 2022 was and remains one in which students are rethinking the components of teaching and learning. In addition, from the learners’ perspective, social, cultural, and technological changes to which they were subject, including substantial changes to learning environments and learning methods, heightened learners’ need to reconsider time planning. This study is based on 1,928 students enrolled in several academic institutions. We used a mixed-methods design for this exploratory research, incorporating qualitative and quantitative analysis, to develop the proposed Online Teaching Recommendations (SOTR) model. We used Structural Equation Modeling (SEM) for goodness-of-fit. Findings indicate that with respect to self-discipline, distractions and interruptions at home hinder students’ online learning, but they do not lower students’ assessments of the quality of online teaching. We may assume that students learn how to integrate online teaching in their everyday lives, and the short-term disadvantage may become a positive experience as students persist in their academic studies. Moreover, online teaching demands students’ self-discipline, which also has no effect on perceived teaching quality. However, students’ motivation declines following online teaching, s does self-discipline, which lowers perceived teaching quality. Students are concerned by the decline in social interactions with their class mates, caused by online learning, but this decline does not adversely affect their learning process. Findings of this study may contribute to improving teaching and learning for students who use digital tools for learning, especially in academic institutions where frontal instruction remains relevant and significant. Findings support the importance of the relationship between students’ learning methods, motivation, and self-discipline, which are factors that affect students’ perceptions of online learning. The question is whether academic instructors should enhance students’ motivation to improve their self-discipline skills or whether these factors are related exclusively to students.
本文首次从回顾性的角度考察了学习风格、动机和自律之间的关系,这些因素影响着大学生对在线学习的看法。从2019年到2022年,学生们一直在重新思考教与学的组成部分。此外,从学习者的角度来看,他们所面临的社会、文化和技术变化,包括学习环境和学习方法的重大变化,都加剧了学习者重新考虑时间规划的需要。本研究以1928名就读于几所学术机构的学生为研究对象。我们采用混合方法设计探索性研究,结合定性和定量分析,开发拟议的在线教学建议(SOTR)模型。我们使用结构方程模型(SEM)来计算拟合优度。研究结果表明,在自律方面,在家的干扰和干扰阻碍了学生的在线学习,但它们并没有降低学生对在线教学质量的评价。我们可以假设学生学习如何将在线教学融入他们的日常生活中,并且随着学生坚持学业,短期的劣势可能会成为一种积极的经历。此外,网络教学需要学生的自律,这对感知教学质量也没有影响。然而,在线教学后,学生的积极性下降,自律也下降,从而降低了对教学质量的感知。学生们担心,由于在线学习,他们与同班同学的社交互动减少了,但这种减少并不会对他们的学习过程产生不利影响。本研究的发现可能有助于改善使用数字工具学习的学生的教与学,特别是在正面教学仍然相关且重要的学术机构。研究结果支持了学生的学习方法、动机和自律之间关系的重要性,这是影响学生对在线学习看法的因素。问题是,学术导师是否应该增强学生的动机,以提高他们的自律技能,或者这些因素是否只与学生有关。
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引用次数: 0
Pipe Diameter Optimization and Two-Phase Flow Pressure Drop in Seabed Pipelines: A Genetic Algorithm Approach 海底管道管径优化与两相流压降:一种遗传算法
4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-01-01 DOI: 10.59671/9tuvf
Ehsan Khamehchi, Matin Dargi, Matin Imeri, Javad Mahdavi Kalatehno, Mohammad Reza Khaleghi
Industries such as oil, gas, and petrochemicals encounter a multifaceted challenge when it comes to the transportation of diverse substances through pipelines. The process relies heavily on two-phase flow, particularly in the case of seabed pipelines responsible for conveying oil and natural gas. In our study, the intricate dynamics of pressure fluctuations in horizontal seabed pipelines were comprehensively investigated through the use of simulation software. Nevertheless, the software employed had its limitations as it failed to account for economic considerations. To address this limitation, the integration of a genetic algorithm was undertaken, which encompassed constraints related to the initial investment, thereby contributing to the enhancement of cost-effectiveness in pressure drop calculations. Additionally, a novel parameter was introduced into the Baker model, leading to improvements in both technical efficiency and economic viability. It was observed that augmenting the weight of the initial investment constraint resulted in a reduction in the optimal pipeline diameter, following a third-degree curve. Furthermore, the research findings indicated that a 4% increase in water shear led to a 14.76% decrease in frictional pressure drop within vertical pipes and a 3.5% reduction in horizontal pipes. Conversely, as the gas-to-oil ratio was increased, frictional pressure drop surged by 116.87% in vertical pipes and 81.69% in horizontal pipes. This valuable information can be harnessed to optimize pipeline design and operations in the demanding underwater environments commonly encountered in these industries.
石油、天然气和石化等行业在通过管道运输各种物质时遇到了多方面的挑战。该过程严重依赖于两相流,特别是在负责输送石油和天然气的海底管道的情况下。本文利用仿真软件对海底水平管道压力波动的复杂动力学进行了全面研究。然而,所使用的软件有其局限性,因为它没有考虑到经济因素。为了解决这一限制,采用了一种遗传算法,该算法包含了与初始投资有关的限制,从而有助于提高压降计算的成本效益。此外,在Baker模型中引入了一个新的参数,从而提高了技术效率和经济可行性。可以观察到,增加初始投资约束的权重会导致三度曲线下最佳管径的减小。此外,研究结果表明,水剪切增加4%,垂直管道内摩擦压降降低14.76%,水平管道内摩擦压降降低3.5%。相反,随着气油比的增大,垂直管道摩擦压降增加116.87%,水平管道摩擦压降增加81.69%。这些有价值的信息可以用来优化管道设计,并在这些行业中经常遇到的苛刻水下环境中进行操作。
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引用次数: 0
STUDY OF FACTORS INFLUENCING NOTIFICATION OF BOVINE ABORTIONS BY PRACTICING VETERINARIANS ON DAIRY CATTLE FARMS IN EASTERN ALGERIA. 阿尔及利亚东部奶牛养殖场执业兽医通报牛流产的影响因素研究。
4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-01-01 DOI: 10.59671/icfwk
Nadia DJELLATA
Bovine abortion is one of the most important causes of economic losses in Algerian cattle farms and industry. A descriptive epidemiological survey was conducted from November 2021 to November 2022 in eastern Algeria to quantify the extent of this scourge and to evaluate the risk factors for reporting abortions using a questionnaire intended for 150 practising veterinarians randomly distributed in five wilayas of eastern Algeria. The statistical analysis of the different risk factors was carried out using a univariate and then multivariate logistic regression model. The results obtained showed that 83.3% of the veterinarians audited had had an abortion rate of more than 5% during the previous 12 months. In the multivariate logistic regression analysis, one risk factor and one protective factor were identified. Indeed, all the areas studied had a very high risk of bovine abortion cases: Batna (odds ratio [OR] = 24.53; 95% confidence interval [CI]: 1.39 - 278.66), Sétif (OR= 73.08; 95% CI: 4.37-669.68), Mila (OR= 245.22; CI: 18.51 - 2306.71) and Bordj Bou Arreridj (OR= 49.09; CI: 3.57-738.69). However, the summer season (OR= 0.23; 95% CI: 0.06 - 0.48) was considered a protective factor, designated as the period of least reporting of abortions by the audited veterinarians compared to winter and autumn.
牛流产是造成阿尔及利亚养牛场和工业经济损失的最重要原因之一。从2021年11月至2022年11月,在阿尔及利亚东部进行了一项描述性流行病学调查,以量化这一祸害的程度,并使用随机分布在阿尔及利亚东部五个省的150名执业兽医的调查问卷,评估报告堕胎的风险因素。采用单因素和多因素logistic回归模型对不同危险因素进行统计分析。结果显示,83.3%的被审计兽医在过去12个月内流产率超过5%。在多因素logistic回归分析中,确定了一个危险因素和一个保护因素。事实上,所有研究的地区都有非常高的牛流产病例风险:巴特纳(优势比[OR] = 24.53;95%可信区间[CI]: 1.39 - 278.66), ssametf (OR= 73.08;95% CI: 4.37-669.68), Mila (OR= 245.22;CI: 18.51 - 2306.71)和Bordj Bou arveridj (OR= 49.09;置信区间:3.57—-738.69)。然而,夏季(OR= 0.23;95% CI: 0.06 - 0.48)被认为是一个保护因素,指定为与冬季和秋季相比,审计兽医报告的流产最少的时期。
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引用次数: 0
Experimental analysis of Aluminum alloy 8011 using Wire cut Electrical discharge machining 8011铝合金线切割电火花加工试验分析
IF 0.4 4区 综合性期刊 Q3 Multidisciplinary Pub Date : 2023-01-01 DOI: 10.59671/adnjc
Sandeep Kumar, S. Dhanabalan, C. Sathiya Narayanan
The increased demand for miniaturization of complex systems necessitates the production of smaller components, cutting with precision dimensional accuracy. Furthermore, Wire cut electrical discharge machining (WEDM) process is the prominent to the fastest growing industries because of their accuracy, the possibility to obtain complex shapes, close tolerances and economically. Therefore, the aim of this experimental work is to analyze the impact of pulse on time and wire feed rate on performance characteristics namely, kerf width and heat affected zone (HAZ). In this experimental investigation, micro level slot cutting experiments were carried out on aluminum plate of 2 mm thickness by WEDM with response surface design. Multi-criteria decision making Grey relational analysis (GRA) technique has been utilized to find optimal machine settings of process constraints. Polynomial models were developed for output constraints. From results, it is analyzed that the pulse on time has more dominance on kerf width, whereas the wire feed rate has a higher influence on HAZ. The obtained outcomes will expedite the advanced machining industries to enhance machinability and dimensional accuracy.
复杂系统小型化的需求日益增加,需要生产更小的部件,切割具有精密的尺寸精度。此外,线切割电火花加工(WEDM)工艺以其精度,获得复杂形状的可能性,紧密的公差和经济的优势在快速发展的行业中占有突出地位。因此,本实验工作的目的是分析脉冲时间和送丝速度对性能特性,即切口宽度和热影响区(HAZ)的影响。采用响应面设计方法,对厚度为2mm的铝板进行了电火花线切割微水平槽切实验。多准则决策采用灰色关联分析(GRA)技术寻找工艺约束的最优机器设置。建立了输出约束的多项式模型。结果表明,脉冲导通时间对切口宽度的影响更大,而送丝速度对热影响区影响更大。所获得的成果将加速先进加工行业提高可加工性和尺寸精度。
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引用次数: 0
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