Pub Date : 2023-09-06DOI: 10.1080/16583655.2023.2254352
Hazim M Ali, I. Alsohaimi, Mohammad Rizwan Khan, Ibrahim A. Naguib, Rosa Busquets, P. Alam, Bayan E Ainousah, Mohammed Gamal
The aim of the present research was to develop a magnetic coconut carbon composite (Fe2O3/Fe3O4@CNC) as a solid-phase extraction (SPE) sorbent for the analysis of carcinogenic N-nitrosodimethylamine (NDMA) in pharmaceuticals. Coconut composites modified with Fe2O3 and Fe3O4 were prepared and applied as SPE sorbent for the extraction of NDMA in pharmaceuticals. The sorbent was characterized with X-Ray, infrared spectroscopy and nitrogen porosimetry. The best ions for the Gas Chromatography-Mass Spectrometry with Selected Ion Monitoring (GC-MS/SIM) analysis were m/z 74 and 42 for NDMA, and m/z 80 and 46 for NDMA-d6 internal standard. System has offered great method performance in terms of sensitivity limit of quantitation (LOQ) 16 ng kg−1. The developed sorbent has enhanced the sensitivity and speed of analysis. The developed method was applied to authenticate the presence of NDMA in various pharmaceutical samples. Among the analyzed samples, NDMA impurities were relatively identified at high amounts in nizatidine samples. Highlights NDMA was verified in ranitidine, metformin and nizatidine Fe2O3/Fe3O4@CNC composite was used for NDMA identification without pretreatment SPE sorbent enhance sensitivity, reduce analysis time, sustain accuracy & precision High level of NDMA impurity were found in nizatidine pharmaceuticals. GRAPHICAL ABSTRACT
{"title":"Selective and sensitive GC-MS analysis of carcinogenic N-nitrosodimethylamine in pharmaceuticals using a magnetic coconut carbon composite as a solid-phase extraction sorbent","authors":"Hazim M Ali, I. Alsohaimi, Mohammad Rizwan Khan, Ibrahim A. Naguib, Rosa Busquets, P. Alam, Bayan E Ainousah, Mohammed Gamal","doi":"10.1080/16583655.2023.2254352","DOIUrl":"https://doi.org/10.1080/16583655.2023.2254352","url":null,"abstract":"The aim of the present research was to develop a magnetic coconut carbon composite (Fe2O3/Fe3O4@CNC) as a solid-phase extraction (SPE) sorbent for the analysis of carcinogenic N-nitrosodimethylamine (NDMA) in pharmaceuticals. Coconut composites modified with Fe2O3 and Fe3O4 were prepared and applied as SPE sorbent for the extraction of NDMA in pharmaceuticals. The sorbent was characterized with X-Ray, infrared spectroscopy and nitrogen porosimetry. The best ions for the Gas Chromatography-Mass Spectrometry with Selected Ion Monitoring (GC-MS/SIM) analysis were m/z 74 and 42 for NDMA, and m/z 80 and 46 for NDMA-d6 internal standard. System has offered great method performance in terms of sensitivity limit of quantitation (LOQ) 16 ng kg−1. The developed sorbent has enhanced the sensitivity and speed of analysis. The developed method was applied to authenticate the presence of NDMA in various pharmaceutical samples. Among the analyzed samples, NDMA impurities were relatively identified at high amounts in nizatidine samples. Highlights NDMA was verified in ranitidine, metformin and nizatidine Fe2O3/Fe3O4@CNC composite was used for NDMA identification without pretreatment SPE sorbent enhance sensitivity, reduce analysis time, sustain accuracy & precision High level of NDMA impurity were found in nizatidine pharmaceuticals. GRAPHICAL ABSTRACT","PeriodicalId":17100,"journal":{"name":"Journal of Taibah University for Science","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46283547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-04DOI: 10.1080/16583655.2023.2254465
Himanshu Upreti, S. R. Mishra, Alok Kumar Pandey, Navneet Joshi, Bhagwati Prasad Joshi
The theme of this work is to explore the impact of shape factor on magnetized Casson gold-blood nanofluid flow through elongated sheet using fuzzified volume fraction. The impact of Ohmic heating, convective heating and suction/injection on heat transfer rate, is incorporated. The existing ordinary differential equations (ODEs) are transformed into fuzzy differential equations by applying the α-cut technique of fuzzy numbers. The α-cut value ranges from 0 to 1, which determines the level of fuzziness in the TFNs. The results indicate that rise in the Casson parameter leads to a reduction in the boundary layer thickness and an augmentation of shear stress near the sheet. Additionally, among the nanoparticle shapes studied, cylindrical nanoparticles demonstrate the extreme thermal conductivity, followed by platelet and blade-shaped nanoparticles, all contributing to an improvement in the heat transfer rate. The present code is validated numerically with previous works and found in good agreement.
{"title":"Diversified role of fuzzified particle concentration on Casson gold-blood nanofluid flow through an elongating sheet for different shape nanoparticles","authors":"Himanshu Upreti, S. R. Mishra, Alok Kumar Pandey, Navneet Joshi, Bhagwati Prasad Joshi","doi":"10.1080/16583655.2023.2254465","DOIUrl":"https://doi.org/10.1080/16583655.2023.2254465","url":null,"abstract":"The theme of this work is to explore the impact of shape factor on magnetized Casson gold-blood nanofluid flow through elongated sheet using fuzzified volume fraction. The impact of Ohmic heating, convective heating and suction/injection on heat transfer rate, is incorporated. The existing ordinary differential equations (ODEs) are transformed into fuzzy differential equations by applying the α-cut technique of fuzzy numbers. The α-cut value ranges from 0 to 1, which determines the level of fuzziness in the TFNs. The results indicate that rise in the Casson parameter leads to a reduction in the boundary layer thickness and an augmentation of shear stress near the sheet. Additionally, among the nanoparticle shapes studied, cylindrical nanoparticles demonstrate the extreme thermal conductivity, followed by platelet and blade-shaped nanoparticles, all contributing to an improvement in the heat transfer rate. The present code is validated numerically with previous works and found in good agreement.","PeriodicalId":17100,"journal":{"name":"Journal of Taibah University for Science","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44119658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-02DOI: 10.1080/16583655.2023.2250565
Funda Karabağ, S. Ince, H. Demirel
Paracetamol (also known as acetaminophen or APAP) is an analgesic and antipyretic drug that is widely used all over the world. Boron is an element proven by many studies that it has indispensable effects on human health. In light of the information expressed about boron, we investigated whether there are any effects of boron on paracetamol-induced liver damage. We analyzed the 8-hydroxyguanosine (8-OHG), ALT, AST, glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and nitric oxide (NO) levels in serum or erythrocyte and liver tissue. At the same time, TNF-α, IL-1β, IL-18 levels were examined in liver tissues to determine the effect of boron on inflammation caused by paracetamol in serum and liver tissue. In this study to determine the effect of ER stress-mediated apoptosis, signal transducers that lead the cell to ER stress-mediated apoptosis, IRE1, ATF6 and PERK, caspase 1, 3, 8, 9 and 12, which play a role in the apoptotic process, antiapoptotic factors bcl2, bcl-xL mRNA gene expressions were determined and the effect level of boron on ER stress-mediated apoptosis was determined by immunohistochemical methods. This study demonstrate that boric acid protects against paracetamol-induced liver damage in association with the augmentation of biomarkers of oxidative and nitrosative stress, inflammation and the ER stress / apoptosis axis in rats.
{"title":"Boric acid is associated with the suppression of apoptosis and endoplasmic reticulum stress in rat model of paracetamol -induced hepatotoxicity","authors":"Funda Karabağ, S. Ince, H. Demirel","doi":"10.1080/16583655.2023.2250565","DOIUrl":"https://doi.org/10.1080/16583655.2023.2250565","url":null,"abstract":"Paracetamol (also known as acetaminophen or APAP) is an analgesic and antipyretic drug that is widely used all over the world. Boron is an element proven by many studies that it has indispensable effects on human health. In light of the information expressed about boron, we investigated whether there are any effects of boron on paracetamol-induced liver damage. We analyzed the 8-hydroxyguanosine (8-OHG), ALT, AST, glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and nitric oxide (NO) levels in serum or erythrocyte and liver tissue. At the same time, TNF-α, IL-1β, IL-18 levels were examined in liver tissues to determine the effect of boron on inflammation caused by paracetamol in serum and liver tissue. In this study to determine the effect of ER stress-mediated apoptosis, signal transducers that lead the cell to ER stress-mediated apoptosis, IRE1, ATF6 and PERK, caspase 1, 3, 8, 9 and 12, which play a role in the apoptotic process, antiapoptotic factors bcl2, bcl-xL mRNA gene expressions were determined and the effect level of boron on ER stress-mediated apoptosis was determined by immunohistochemical methods. This study demonstrate that boric acid protects against paracetamol-induced liver damage in association with the augmentation of biomarkers of oxidative and nitrosative stress, inflammation and the ER stress / apoptosis axis in rats.","PeriodicalId":17100,"journal":{"name":"Journal of Taibah University for Science","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46647954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.1080/16583655.2023.2251219
Qinglian Yin, Ben Gao, Zhang Shi
This paper reveals the conformable fractional space-time perturbed Gerdjikov-Ivanov (GI) equation, which is applied to nonlinear fibre optics together with photonic crystal fibres. The foremost intent of our operation is adopting the unified method, the modified F-expansion method and the modified Kudryashov method to hunt for definite solutions to the equation. In addition, by selecting fairish values, fluctuation behaviours of the solutions are drafted.
{"title":"Distinct exact solutions for the conformable fractional derivative Gerdjikov-Ivanov equation via three credible methods","authors":"Qinglian Yin, Ben Gao, Zhang Shi","doi":"10.1080/16583655.2023.2251219","DOIUrl":"https://doi.org/10.1080/16583655.2023.2251219","url":null,"abstract":"This paper reveals the conformable fractional space-time perturbed Gerdjikov-Ivanov (GI) equation, which is applied to nonlinear fibre optics together with photonic crystal fibres. The foremost intent of our operation is adopting the unified method, the modified F-expansion method and the modified Kudryashov method to hunt for definite solutions to the equation. In addition, by selecting fairish values, fluctuation behaviours of the solutions are drafted.","PeriodicalId":17100,"journal":{"name":"Journal of Taibah University for Science","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42069244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.1080/16583655.2023.2249628
E. Ay, A. Caner, Ceylan Özsoy Hepokur, Ferdane Danışman Kalındemirtaş, Güneş ÖZEN EROĞLU, I. Kariper
The aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis on human breast cancer cells using a simple and inexpensive nanoformulation. Various methods were used to characterize the surface and morphology of propolis nanoparticles (NP-Pro), including UV-VIS, FTIR, DLS, and EDX-SEM. The cytotoxic activity of MCF-7, MDA-MB-231 breast cancer cells was measured by XTT technique and compared with healthy cells (MCF-10A). The apoptotic effect of NP-Pro was assessed by flow cytometry using Annexin/PI. The IC50 values of NP-Pro on MCF-7, MDA-MB-231 and MCF-10A cells were 13.67 ± 0.89, 17.89 ± 0.6, 29.9 ± 0.56 µg, respectively. According to these findings, the NP-Pro form we prepared was more cytotoxic on cancer cells than propolis. Cancer cells had much stronger apoptotic activity than healthy cells (p < 0.0001). In this work, NP-Pro was produced through a distinct, straightforward, and low-cost method. In summary, the NP-Pro we synthesized may be a promising potential agent for breast cancer treatment due to its specific cytotoxicity via apoptosis.
{"title":"Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells","authors":"E. Ay, A. Caner, Ceylan Özsoy Hepokur, Ferdane Danışman Kalındemirtaş, Güneş ÖZEN EROĞLU, I. Kariper","doi":"10.1080/16583655.2023.2249628","DOIUrl":"https://doi.org/10.1080/16583655.2023.2249628","url":null,"abstract":"The aim of this work was to investigate the antiproliferative and pro-apoptotic effects of propolis on human breast cancer cells using a simple and inexpensive nanoformulation. Various methods were used to characterize the surface and morphology of propolis nanoparticles (NP-Pro), including UV-VIS, FTIR, DLS, and EDX-SEM. The cytotoxic activity of MCF-7, MDA-MB-231 breast cancer cells was measured by XTT technique and compared with healthy cells (MCF-10A). The apoptotic effect of NP-Pro was assessed by flow cytometry using Annexin/PI. The IC50 values of NP-Pro on MCF-7, MDA-MB-231 and MCF-10A cells were 13.67 ± 0.89, 17.89 ± 0.6, 29.9 ± 0.56 µg, respectively. According to these findings, the NP-Pro form we prepared was more cytotoxic on cancer cells than propolis. Cancer cells had much stronger apoptotic activity than healthy cells (p < 0.0001). In this work, NP-Pro was produced through a distinct, straightforward, and low-cost method. In summary, the NP-Pro we synthesized may be a promising potential agent for breast cancer treatment due to its specific cytotoxicity via apoptosis.","PeriodicalId":17100,"journal":{"name":"Journal of Taibah University for Science","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46424463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.1080/16583655.2023.2248651
T. Nagaraju, Sireesha Mantena, R. Gobinath, Sridevi Bonthu, Shaik Subhan Alisha
This paper presents the strength and micro-structural characteristics of high plasticity expansive clay stabilized with ordinary Portland cement (OPC) and geopolymers. Furthermore, sustainability aspects such as cost-efficiency, energy consumption and eco-efficiency of the OPC and geopolymer-stabilized soils were compared. The experimental results revealed that the geopolymer-stabilized soils exhibit higher strength and sustainability performance than the OPC-stabilized soils. This study also explores the developed machine learning prediction models of the geopolymer soils’ unconfined compressive strength (UCS) based on experimental data from current research and previous literature. Linear regression (LR), K-nearest neighbour (KNN), random forest (RF), random forest with random search hyperparameter optimization (BRRF) and random forest with grid search hyperparameter optimization (BGRF) were used as part of ensemble algorithms to predict stabilized soils UCS. Eight parameters such as liquid limit (LL), plasticity index (PI), ground granulated blast furnace slag (S) content, fly ash (FA) content, the molarity of NaOH (M), activator to binder ratio (A/B), Na/Al and Si/Al were used as input to predict UCS of geopolymer soils. The following metrics were used to assess the models’ predictive ability for compressive strength: coefficient of determination (R2), root mean square error (RMSE), mean absolute error (MAE) and mean square error (MSE). The BRRF model has a good potential to predict the UCS of geopolymer soils, according to the findings of its testing (MAE = 0.27, MSE = 0.21, RMSE = 0.46, R2 = 0.99) and training (MAE = 0.78, MSE = 1.48, RMSE = 1.23, R2 = 0.96) phases. According to the RF model's feature importance study, slag content and liquid limit were found to influence forecasting compressive strength, while fly ash content has the least influence.
{"title":"Geopolymer-stabilized soils: influencing factors, strength development mechanism and sustainability","authors":"T. Nagaraju, Sireesha Mantena, R. Gobinath, Sridevi Bonthu, Shaik Subhan Alisha","doi":"10.1080/16583655.2023.2248651","DOIUrl":"https://doi.org/10.1080/16583655.2023.2248651","url":null,"abstract":"This paper presents the strength and micro-structural characteristics of high plasticity expansive clay stabilized with ordinary Portland cement (OPC) and geopolymers. Furthermore, sustainability aspects such as cost-efficiency, energy consumption and eco-efficiency of the OPC and geopolymer-stabilized soils were compared. The experimental results revealed that the geopolymer-stabilized soils exhibit higher strength and sustainability performance than the OPC-stabilized soils. This study also explores the developed machine learning prediction models of the geopolymer soils’ unconfined compressive strength (UCS) based on experimental data from current research and previous literature. Linear regression (LR), K-nearest neighbour (KNN), random forest (RF), random forest with random search hyperparameter optimization (BRRF) and random forest with grid search hyperparameter optimization (BGRF) were used as part of ensemble algorithms to predict stabilized soils UCS. Eight parameters such as liquid limit (LL), plasticity index (PI), ground granulated blast furnace slag (S) content, fly ash (FA) content, the molarity of NaOH (M), activator to binder ratio (A/B), Na/Al and Si/Al were used as input to predict UCS of geopolymer soils. The following metrics were used to assess the models’ predictive ability for compressive strength: coefficient of determination (R2), root mean square error (RMSE), mean absolute error (MAE) and mean square error (MSE). The BRRF model has a good potential to predict the UCS of geopolymer soils, according to the findings of its testing (MAE = 0.27, MSE = 0.21, RMSE = 0.46, R2 = 0.99) and training (MAE = 0.78, MSE = 1.48, RMSE = 1.23, R2 = 0.96) phases. According to the RF model's feature importance study, slag content and liquid limit were found to influence forecasting compressive strength, while fly ash content has the least influence.","PeriodicalId":17100,"journal":{"name":"Journal of Taibah University for Science","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49475016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-25DOI: 10.1080/16583655.2023.2248693
G. Wang, Feng Xu, Wei Fang, Chengcheng Zheng, Yujing Jiang, Wei Han
Understanding the mechanical behaviour of tunnels reinforced by end-anchored bolts and lining with voids behind the lining is crucial in determining the appropriate supporting measures. In this study, we constructed a geometric model for a tunnel with a single or double void. We used the substructure method and point matching method to obtain the elastic analytical solutions for the model. We examined the stress, internal force, and deformation characteristics of the tunnel and support structure under the influence of single and double voids. To validate the analytical model, we established a numerical model using the finite difference method. Additionally, we compared and analyzed the mechanical behaviour of tunnels reinforced by bolts and lining versus lining-only, and determined the contribution factor of the bolts.
{"title":"Analytical solutions for bolted tunnel structures with voids behind the lining","authors":"G. Wang, Feng Xu, Wei Fang, Chengcheng Zheng, Yujing Jiang, Wei Han","doi":"10.1080/16583655.2023.2248693","DOIUrl":"https://doi.org/10.1080/16583655.2023.2248693","url":null,"abstract":"Understanding the mechanical behaviour of tunnels reinforced by end-anchored bolts and lining with voids behind the lining is crucial in determining the appropriate supporting measures. In this study, we constructed a geometric model for a tunnel with a single or double void. We used the substructure method and point matching method to obtain the elastic analytical solutions for the model. We examined the stress, internal force, and deformation characteristics of the tunnel and support structure under the influence of single and double voids. To validate the analytical model, we established a numerical model using the finite difference method. Additionally, we compared and analyzed the mechanical behaviour of tunnels reinforced by bolts and lining versus lining-only, and determined the contribution factor of the bolts.","PeriodicalId":17100,"journal":{"name":"Journal of Taibah University for Science","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44624694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-18DOI: 10.1080/16583655.2023.2247633
Lai Xuan Bach, Thi-Bich-Ngoc Dao, Kim-Long Duong-Ngo, Thanh Nha Tran, Tuan Le Minh, Hiep Nguyen Trong, Cam Tu Hoang Ngoc, C. Panaitescu, Nguyen To Hoai, N. N. Dang
Waste matter is an abundant source of recyclable materials. This study presented the corrosion inhibitor role of unripe banana peel extract (UBPE) for carbon steel in acidic environments: 1.0 M HCl, 0.5 M H2SO4, and 0.5 M HCl/0.25 M H2SO4. The aim was to demonstrate the robustness of the HCl-UBPE-steel system with respect to competing ions in the solution, and as such, generalizing its mechanism. The localized corrosion in HCl, general corrosion in H2SO4, and their theoretical midpoint were, respectively, subjected to 95.91%, 83.33%, 91.50% corrosion inhibition efficiency when UBPE was added at 3000 ppm. A protective film on the steel surface was found as the cause by electrochemical characterizations and its behavior was explained via protonation of corrosion inhibitor and rust formation on steel surface undering varying acid conditions. Therefore, the work suggests UBPE as corrosion inhibitor for steel in strongly acidic conditions containing chloride and sulfate ions. Highlights Unripe banana peel – water extract (UBPWE) acts as an eco-friendly effective inhibitor for steel in aggressively acidic environments. Carbon steel exhibits more localized corrosion in HCl solution, but more general corrosion in H2SO4 condition. UBPWE performed 95.91, 83.33, and 91.50% of inhibition efficiency for steel in HCl, H2SO4, and mixed conditions. The effective inhibition performance is assigned to the presence of a protective layer on the steel surface. GRAPHICAL ABSTRACT
{"title":"Inhibitive behaviours of unripe banana peel extract for mitigating electrochemical corrosion of carbon steel in aggressively acidic solutions","authors":"Lai Xuan Bach, Thi-Bich-Ngoc Dao, Kim-Long Duong-Ngo, Thanh Nha Tran, Tuan Le Minh, Hiep Nguyen Trong, Cam Tu Hoang Ngoc, C. Panaitescu, Nguyen To Hoai, N. N. Dang","doi":"10.1080/16583655.2023.2247633","DOIUrl":"https://doi.org/10.1080/16583655.2023.2247633","url":null,"abstract":"Waste matter is an abundant source of recyclable materials. This study presented the corrosion inhibitor role of unripe banana peel extract (UBPE) for carbon steel in acidic environments: 1.0 M HCl, 0.5 M H2SO4, and 0.5 M HCl/0.25 M H2SO4. The aim was to demonstrate the robustness of the HCl-UBPE-steel system with respect to competing ions in the solution, and as such, generalizing its mechanism. The localized corrosion in HCl, general corrosion in H2SO4, and their theoretical midpoint were, respectively, subjected to 95.91%, 83.33%, 91.50% corrosion inhibition efficiency when UBPE was added at 3000 ppm. A protective film on the steel surface was found as the cause by electrochemical characterizations and its behavior was explained via protonation of corrosion inhibitor and rust formation on steel surface undering varying acid conditions. Therefore, the work suggests UBPE as corrosion inhibitor for steel in strongly acidic conditions containing chloride and sulfate ions. Highlights Unripe banana peel – water extract (UBPWE) acts as an eco-friendly effective inhibitor for steel in aggressively acidic environments. Carbon steel exhibits more localized corrosion in HCl solution, but more general corrosion in H2SO4 condition. UBPWE performed 95.91, 83.33, and 91.50% of inhibition efficiency for steel in HCl, H2SO4, and mixed conditions. The effective inhibition performance is assigned to the presence of a protective layer on the steel surface. GRAPHICAL ABSTRACT","PeriodicalId":17100,"journal":{"name":"Journal of Taibah University for Science","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45800230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-14DOI: 10.1080/16583655.2023.2244657
Vanitha Mariappan, M. Barathan, A. K. Zulpa, J. Vadivelu, K. M. Vellasamy
Burkholderia pseudomallei produce small colony variants (SCVs) that can persist in harsh conditions. This study aimed to compare SCV with B. pseudomallei wild-type (WT) in the ability to adhere, invade, survive and produce biofilm. Additionally, proteins responsible for pathogenicity were determined through two-dimensional gel electrophoresis (2-DE) and liquid-chromatography mass-spectrometry (LC-MS). Whole bacterial proteins analysed using 2-DE demonstrated 252 and 323 protein spots in WT and SCV, respectively, with 37 distinctive proteins identified in the SCV. Several isoform proteins (dnaK, groEL1, gapA and tuf), upregulated in SCV, may function as moonlighting proteins. Quantitative proteomic analysis using LC-MS revealed 57 and 99 distinctive proteins in the WT and SCV, respectively. Many distinct proteins communicated by B. pseudomallei SCV were involved in the metabolic pathways and may play a role in the alteration of virulence factors. Thus, the alteration of proteins in SCVs may be an approach of B. pseudomallei to enhance pathogenesis.
{"title":"Small colony variants of Burkholderia pseudomallei: alteration of the virulence factors","authors":"Vanitha Mariappan, M. Barathan, A. K. Zulpa, J. Vadivelu, K. M. Vellasamy","doi":"10.1080/16583655.2023.2244657","DOIUrl":"https://doi.org/10.1080/16583655.2023.2244657","url":null,"abstract":"Burkholderia pseudomallei produce small colony variants (SCVs) that can persist in harsh conditions. This study aimed to compare SCV with B. pseudomallei wild-type (WT) in the ability to adhere, invade, survive and produce biofilm. Additionally, proteins responsible for pathogenicity were determined through two-dimensional gel electrophoresis (2-DE) and liquid-chromatography mass-spectrometry (LC-MS). Whole bacterial proteins analysed using 2-DE demonstrated 252 and 323 protein spots in WT and SCV, respectively, with 37 distinctive proteins identified in the SCV. Several isoform proteins (dnaK, groEL1, gapA and tuf), upregulated in SCV, may function as moonlighting proteins. Quantitative proteomic analysis using LC-MS revealed 57 and 99 distinctive proteins in the WT and SCV, respectively. Many distinct proteins communicated by B. pseudomallei SCV were involved in the metabolic pathways and may play a role in the alteration of virulence factors. Thus, the alteration of proteins in SCVs may be an approach of B. pseudomallei to enhance pathogenesis.","PeriodicalId":17100,"journal":{"name":"Journal of Taibah University for Science","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44848513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-11DOI: 10.1080/16583655.2023.2245200
A. Qarah, Kahdr Alatawi, A. I. Alalawy, R. Alnoman, Alaa M. Alqahtani, Matokah M. Abualnaja, W. Alamoudi, Nashwa M. El‐Metwaly
The significant biological activity of phenylthiourea derivatives prompted the synthesis of a new phenylthiourea-based heterocyclic ring systems (pyrazole, thiazole, and pyran), and their chemical structures were elucidated by spectral data. The DFT/B3LYP methodology was applied to explore the configuration and energetic features of the FMO’s of the compounds. The derivatives exhibited comparable energy gap, ranging from 2.13 to 2.56 eV, and were arranged in the following order: 5 < 8 < 7 < 6 < 4b < 4a. The antitumor activity of the new phenylthiourea-based derivatives was investigated against diverse cell lines, such as HepG2, HCT-116, MCF-7, PC3, and WI38, using Doxorubicin as a reference drug. The hybrids 5, 6, and 8 revealed strong cytotoxic against HCT-116 (IC50 = 2.29 ± 0.46-9.71 ± 0.34 µM). Furthermore, the molecular docking studies of the compounds indicated that the hybrids 5, 6 and 8 exhibited the greatest docking score values, in accordance to the antitumor activity.
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