Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/16059
E. R. Dempster
Selection of content for a school syllabus is important in achieving progress towards inclusive generalisations which characterise powerful knowledge. Biology as a discipline progresses from knowledge of individual facts to inclusive generalisations such as homeostasis, energy transformations, heredity, and evolution. The present study evaluated the selection of content in the official biology syllabus for the seventh and eighth years of schooling in four diverse jurisdictions: Kenya, South Africa, British Columbia (Canada) and Singapore. The purpose was to determine whether and how content selection enabled progression to inclusive generalisations in biology and to compare selection, sequencing and progression among the four jurisdictions. General Topic Trace Mapping was used to compare each syllabus to a generic reference syllabus structured according to inclusive generalisations. Although there was some agreement in the scope of topics selected, jurisdictions varied in the way it was organised. Kenya included more everyday knowledge than other jurisdictions. British Columbia and Singapore selected content according to unifying themes, whereas South Africa and Kenya did not. South Africa selected content that enabled progression towards inclusive generalisations, but did not explicitly identify the generalisations. This study supports the contention that powerful knowledge in biology may be construed differently in diverse jurisdictions.
{"title":"Selection, sequencing and progression of content in biology in four diverse jurisdictions","authors":"E. R. Dempster","doi":"10.17159/sajs.2024/16059","DOIUrl":"https://doi.org/10.17159/sajs.2024/16059","url":null,"abstract":"Selection of content for a school syllabus is important in achieving progress towards inclusive generalisations which characterise powerful knowledge. Biology as a discipline progresses from knowledge of individual facts to inclusive generalisations such as homeostasis, energy transformations, heredity, and evolution. The present study evaluated the selection of content in the official biology syllabus for the seventh and eighth years of schooling in four diverse jurisdictions: Kenya, South Africa, British Columbia (Canada) and Singapore. The purpose was to determine whether and how content selection enabled progression to inclusive generalisations in biology and to compare selection, sequencing and progression among the four jurisdictions. General Topic Trace Mapping was used to compare each syllabus to a generic reference syllabus structured according to inclusive generalisations. Although there was some agreement in the scope of topics selected, jurisdictions varied in the way it was organised. Kenya included more everyday knowledge than other jurisdictions. British Columbia and Singapore selected content according to unifying themes, whereas South Africa and Kenya did not. South Africa selected content that enabled progression towards inclusive generalisations, but did not explicitly identify the generalisations. This study supports the contention that powerful knowledge in biology may be construed differently in diverse jurisdictions.","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140374673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/17301
Brian A. Austin
The pioneering work done in South Africa in developing radio communications technology for use underground in mines is summarised. Propagation took place, in the main, directly through the rock strata with incidental coupling into power cables, pipes, rails and other conductors. The research established the optimum frequencies for communications as well as the most appropriate antennas. Specialised radio equipment was developed for this task as constrained by the technology of the time. Size and weight were major constraints; ultimately, handheld equipment, using single-sideband modulation, was produced that functioned exceptionally well in numerous situations underground.
{"title":"Radio communications through rock strata – South African mining experience over 50 years","authors":"Brian A. Austin","doi":"10.17159/sajs.2024/17301","DOIUrl":"https://doi.org/10.17159/sajs.2024/17301","url":null,"abstract":"The pioneering work done in South Africa in developing radio communications technology for use underground in mines is summarised. Propagation took place, in the main, directly through the rock strata with incidental coupling into power cables, pipes, rails and other conductors. The research established the optimum frequencies for communications as well as the most appropriate antennas. Specialised radio equipment was developed for this task as constrained by the technology of the time. Size and weight were major constraints; ultimately, handheld equipment, using single-sideband modulation, was produced that functioned exceptionally well in numerous situations underground.","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140373592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/16882
Jonathan Jansen, Cyrill Walters, Alistair White, Greame Mehl
In this research article, we examine why so few of the most promising young scientists in South Africa, those who obtain a P or ‘prestigious’ rating from the South African National Research Foundation, go on to obtain an A rating, i.e. become leading international scholars in their fields. Drawing on in-depth interviews with 36 P-rated scientists in the period 1983 to 2022, we found that personal characteristics (such as work ethic), the right international networks, and strong departmental support are among the key factors that explain the research accomplishments of highly successful achievers.
在这篇研究文章中，我们探讨了为什么南非最有前途的年轻科学家（即获得南非国家研究基金会 P 级或 "著名 "评级的科学家）中只有极少数人能够继续获得 A 级评级，即成为各自领域的国际顶尖学者。通过对 1983 年至 2022 年期间 36 位 P 级科学家的深入访谈，我们发现，个人特质（如职业道德）、合适的国际网络和强有力的部门支持是解释成就卓著者取得研究成就的关键因素。
{"title":"Why so few Ps become As: The character, choices and challenges of South Africa’s most talented young researchers","authors":"Jonathan Jansen, Cyrill Walters, Alistair White, Greame Mehl","doi":"10.17159/sajs.2024/16882","DOIUrl":"https://doi.org/10.17159/sajs.2024/16882","url":null,"abstract":"In this research article, we examine why so few of the most promising young scientists in South Africa, those who obtain a P or ‘prestigious’ rating from the South African National Research Foundation, go on to obtain an A rating, i.e. become leading international scholars in their fields. Drawing on in-depth interviews with 36 P-rated scientists in the period 1983 to 2022, we found that personal characteristics (such as work ethic), the right international networks, and strong departmental support are among the key factors that explain the research accomplishments of highly successful achievers.","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140376236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/14917
M. du Plessis, C. Fourie, Heloise le Roux, A. Engelbrecht
Breast cancer is the most commonly diagnosed cancer and the second most common cause of cancer death in women. The anthracycline, doxorubicin, is a well-known and highly effective treatment for breast cancer patients; however, many patients present with resistance to chemotherapeutic drugs, which ultimately results in treatment failure and contributes to high mortality rates. It is well established that the mitogen-activated protein kinase phosphatase 1 (MKP-1) mediates the response to chemotherapy, where upregulated MKP-1 is associated with chemoresistance. We investigated whether MKP-1 inhibition or silencing can sensitise triple-negative MDA-MB-231 breast cancer cells to doxorubicin therapy. We found that MKP-1 inhibition and silencing sensitises breast cancer cells to doxorubicin-induced apoptosis. Additionally, the inhibition of MKP-1 in combination with doxorubicin treatment promotes autophagy induction, while doxorubicin and not MKP-1 modulation increased lysosomal acidic compartments. As such, this study demonstrated that MKP-1 inhibition has a potential therapeutic benefit for breast cancer patients by increasing the efficacy of conventional chemotherapy. Therefore, MKP-1 inhibition should be developed as a clinically relevant adjuvant therapy, which could provide a novel avenue for therapeutic intervention in combination with chemotherapy in breast cancer patients.
{"title":"Sanguinarine highly sensitises breast cancer cells to doxorubicin-induced apoptosis","authors":"M. du Plessis, C. Fourie, Heloise le Roux, A. Engelbrecht","doi":"10.17159/sajs.2024/14917","DOIUrl":"https://doi.org/10.17159/sajs.2024/14917","url":null,"abstract":"Breast cancer is the most commonly diagnosed cancer and the second most common cause of cancer death in women. The anthracycline, doxorubicin, is a well-known and highly effective treatment for breast cancer patients; however, many patients present with resistance to chemotherapeutic drugs, which ultimately results in treatment failure and contributes to high mortality rates. It is well established that the mitogen-activated protein kinase phosphatase 1 (MKP-1) mediates the response to chemotherapy, where upregulated MKP-1 is associated with chemoresistance. We investigated whether MKP-1 inhibition or silencing can sensitise triple-negative MDA-MB-231 breast cancer cells to doxorubicin therapy. We found that MKP-1 inhibition and silencing sensitises breast cancer cells to doxorubicin-induced apoptosis. Additionally, the inhibition of MKP-1 in combination with doxorubicin treatment promotes autophagy induction, while doxorubicin and not MKP-1 modulation increased lysosomal acidic compartments. As such, this study demonstrated that MKP-1 inhibition has a potential therapeutic benefit for breast cancer patients by increasing the efficacy of conventional chemotherapy. Therefore, MKP-1 inhibition should be developed as a clinically relevant adjuvant therapy, which could provide a novel avenue for therapeutic intervention in combination with chemotherapy in breast cancer patients.","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140376330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/17569
A. Carr, Brian M. Chase, Stephen J. Birkinshaw, Peter J. Holmes, M. Rabumbulu, Brian A. Stewart
Recent research reveals that the arid western interior of South Africa has experienced substantially more humid conditions on several occasions during the last 70 000 years. These findings, likely regional in scope, speak to changes to the resource base available to prehistoric hunter-gatherers. Together with recent archaeological findings from this region, there has emerged a growing recognition that previously archaeologically overlooked areas of South Africa’s arid interior need to be included in models of human history. This presents new challenges for archaeologists and palaeoclimatologists, particularly given the prevalence of surficial, rather than stratified, archaeological evidence throughout much of this region
{"title":"Palaeo-landscapes and hydrology in the South African interior: Implications for human history","authors":"A. Carr, Brian M. Chase, Stephen J. Birkinshaw, Peter J. Holmes, M. Rabumbulu, Brian A. Stewart","doi":"10.17159/sajs.2024/17569","DOIUrl":"https://doi.org/10.17159/sajs.2024/17569","url":null,"abstract":"Recent research reveals that the arid western interior of South Africa has experienced substantially more humid conditions on several occasions during the last 70 000 years. These findings, likely regional in scope, speak to changes to the resource base available to prehistoric hunter-gatherers. Together with recent archaeological findings from this region, there has emerged a growing recognition that previously archaeologically overlooked areas of South Africa’s arid interior need to be included in models of human history. This presents new challenges for archaeologists and palaeoclimatologists, particularly given the prevalence of surficial, rather than stratified, archaeological evidence throughout much of this region","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140376357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/17274
Michael I. Cherry
{"title":"The storms facing higher education have not abated","authors":"Michael I. Cherry","doi":"10.17159/sajs.2024/17274","DOIUrl":"https://doi.org/10.17159/sajs.2024/17274","url":null,"abstract":"","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140376418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/17473
Robyn Pickering, Dipuo W. Kgotleng
{"title":"Preprints, press releases and fossils in space: What is happening in South African human evolution research?","authors":"Robyn Pickering, Dipuo W. Kgotleng","doi":"10.17159/sajs.2024/17473","DOIUrl":"https://doi.org/10.17159/sajs.2024/17473","url":null,"abstract":"","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140374777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/17568
Christopher M. Mabeza
{"title":"And the band played on: Conflict-preneurship and the long history of violence in the Niger Delta","authors":"Christopher M. Mabeza","doi":"10.17159/sajs.2024/17568","DOIUrl":"https://doi.org/10.17159/sajs.2024/17568","url":null,"abstract":"","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140374789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/17475
Q. Karim
{"title":"Hoosen (Jerry) M. Coovadia (1940–2023): Caring paediatrician, excellent scientist, courageous human rights activist and visionary leader","authors":"Q. Karim","doi":"10.17159/sajs.2024/17475","DOIUrl":"https://doi.org/10.17159/sajs.2024/17475","url":null,"abstract":"","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140376290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.17159/sajs.2024/18031
L. Swartz
{"title":"Working across disciplines: Robust debate in a context of trust","authors":"L. Swartz","doi":"10.17159/sajs.2024/18031","DOIUrl":"https://doi.org/10.17159/sajs.2024/18031","url":null,"abstract":"","PeriodicalId":21928,"journal":{"name":"South African Journal of Science","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140376615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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