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US-China cooperation and competition in science and technology. 中美在科技领域的合作与竞争。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.1093/nsr/nwaf001
Mu-Ming Poo
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引用次数: 0
Element cycling by environmental viruses. 环境病毒的元素循环。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2024-12-23 eCollection Date: 2024-12-01 DOI: 10.1093/nsr/nwae459
Di Tong, Jianming Xu
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引用次数: 0
Core factor of NEXT complex, ZCCHC8, governs the silencing of LINE1 during spermatogenesis. NEXT复合体的核心因子ZCCHC8控制着精子发生过程中LINE1的沉默。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2024-12-17 eCollection Date: 2025-01-01 DOI: 10.1093/nsr/nwae407
Rushuang Yan, Meijie Qi, Pengfei Zhang, Bin Shen, Jiqing Yin, Chuan Chen, Silin Tian, Lin Chen, Xingxu Huang, Hong Wang, Shaorong Gao, You Wu, Yawei Gao

The overactivation of transposable elements (TEs) is a significant threat to male reproduction, particularly during the delicate process of spermatogenesis. Here, we report that zinc finger protein ZCCHC8-a key component of the nuclear exosome targeting (NEXT) complex that is involved in ribonucleic acid (RNA) surveillance-is required for TE silencing during spermatogenesis. Loss of ZCCHC8 results in delayed meiotic progression and reduced production of round spermatids (RS). We observed that young long-interspersed nuclear element (LINE1, L1) subfamilies that are targeted by ZCCHC8 were upregulated in both spermatogonial stem cells (SSC) and pachytene spermatocytes (PS) of Zcchc8 null testes. Further study found that a reduced H3K9me3 modification in SSC and elevated H3 lysine 4 trimethylation in the PS of Zcchc8 KO mice occurred upon young L1, especially L1Md_A, which may have contributed to impairment of the chromatin condensation from PS to RS during spermatogenesis. This study highlights the crucial role of RNA surveillance-mediated chromatin repression by the NEXT complex during spermatogenesis.

转座因子（te）的过度激活是对男性生殖的重大威胁，特别是在精子发生的微妙过程中。在这里，我们报道锌指蛋白zcchc8是参与核糖核酸（RNA）监视的核外胞体靶向（NEXT）复合体的关键成分，是精子发生过程中TE沉默所必需的。ZCCHC8的缺失导致减数分裂进程延迟和圆形精子（RS）的产生减少。我们观察到zcch8靶向的年轻长间布核元件（LINE1, L1）亚家族在无zcch8睾丸的精原干细胞（SSC）和粗线精母细胞（PS）中均上调。进一步研究发现，zchchc8 KO小鼠的SSC中H3K9me3修饰减少，PS中H3赖氨酸4三甲基化升高，发生在年轻L1，特别是L1Md_A，这可能是导致精子发生过程中染色质从PS到RS凝聚受损的原因。这项研究强调了RNA监视介导的染色质抑制在精子发生过程中的关键作用。
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引用次数: 0
Regulating local environments towards enhanced electrochemical performance. 调节局部环境以提高电化学性能。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2024-12-16 eCollection Date: 2024-12-01 DOI: 10.1093/nsr/nwae460
Chong Liu, Xiangfeng Duan
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引用次数: 0
Non-linear ion transport in nanopores for the design of ultracapacitive ionic memristors. 纳米孔非线性离子输运用于超电容性离子记忆电阻器的设计。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2024-12-14 eCollection Date: 2025-01-01 DOI: 10.1093/nsr/nwae437
Panlong Li, Stefan Kaskel
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引用次数: 0
Unveiling metal-support interactions through interpretable machine learning. 通过可解释的机器学习揭示金属支持相互作用。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2024-12-14 eCollection Date: 2025-01-01 DOI: 10.1093/nsr/nwae455
Junzhong Xie, Ding Ma
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引用次数: 0
Reply to comment by Compagnoni et al. on "First finding of continental deep subduction in the Sesia Zone of Western Alps and implications for subduction dynamics". 回复Compagnoni等人关于“西阿尔卑斯山脉Sesia带首次发现大陆深俯冲及其俯冲动力学意义”的评论。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2024-12-12 eCollection Date: 2024-12-01 DOI: 10.1093/nsr/nwae457
Yi-Xiang Chen, Kun Zhou, Qiang He, Yong-Fei Zheng, Hans-Peter Schertl, Kun Chen
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引用次数: 0
Comment on "First finding of continental deep subduction in the Sesia Zone of Western Alps and implications for subduction dynamics". 评“西阿尔卑斯山脉塞西亚带首次发现大陆深俯冲及其俯冲动力学意义”。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2024-12-12 eCollection Date: 2024-12-01 DOI: 10.1093/nsr/nwae454
Roberto Compagnoni, Mattia Gilio, Stefano Ghignone, Emanuele Scaramuzzo, Alessia Borghini, Marco Bruno
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引用次数: 0
Non-phosgene route: catalytic carbonylation of amines to form unsymmetrical ureas. 非光气途径：催化胺羰基化形成不对称脲。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2024-12-09 eCollection Date: 2025-01-01 DOI: 10.1093/nsr/nwae450
Shunji Xie, Ye Wang
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引用次数: 0
Chemical transformation of polyurethane into valuable polymers. 将聚氨酯化学转化为有价值的聚合物。
IF 16.3 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
National Science Review
Pub Date : 2024-12-04 eCollection Date: 2025-01-01 DOI: 10.1093/nsr/nwae393
Bo Sun, Jiawei Zou, Weijie Qiu, Shuheng Tian, Maolin Wang, Haoyi Tang, Baotieliang Wang, Shifang Luan, Xiaoyan Tang, Meng Wang, Ding Ma

Polyurethanes are an important class of synthetic polymers, widely used in a variety of applications ranging from everyday items to advanced tools in societal infrastructure. Their inherent cross-linked structure imparts exceptional durability and flexibility, yet this also complicates their degradation and recycling. Here we report a heterogeneous catalytic process that combines methanolysis and hydrogenation with a CO2/H2 reaction medium, effectively breaking down PU waste consisting of urethane and ester bonds into valuable intermediates like aromatic diamines and lactones. These intermediates are then converted into functional polymers: polyimide (PI), noted for its exceptional thermal and electrical insulation, and polylactone (P(BL-co-CL)), a biodegradable alternative to traditional plastics. Both polymers exhibit enhanced performance compared to existing commercial products. This approach not only contributes to the valorization of plastic waste but also opens new avenues for the creation of high-performance materials.

聚氨酯是一类重要的合成聚合物，广泛用于各种应用，从日常用品到社会基础设施的先进工具。它们固有的交联结构赋予了非凡的耐久性和灵活性，但这也使它们的降解和回收变得复杂。在这里，我们报道了一个多相催化过程，将甲醇分解和加氢与CO2/H2反应介质结合，有效地将由聚氨酯和酯键组成的PU废料分解成有价值的中间体，如芳香二胺和内酯。然后将这些中间体转化为功能聚合物：聚酰亚胺（PI），以其优异的隔热和电绝缘性而闻名，以及聚内酯（P(BL-co-CL)），一种传统塑料的可生物降解替代品。与现有的商业产品相比，这两种聚合物的性能都有所提高。这种方法不仅有助于塑料废物的增值，而且为创造高性能材料开辟了新的途径。
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引用次数: 0
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