Pub Date : 2016-01-01DOI: 10.7551/mitpress/4884.003.0025
B. Lemaître
Reference EPFL-ARTICLE-223260View record in Web of Science Record created on 2016-11-21, modified on 2016-11-21
参考文献EPFL-ARTICLE-223260View记录在Web of Science record中创建于2016-11-21,修改于2016-11-21
{"title":"Truth and Power","authors":"B. Lemaître","doi":"10.7551/mitpress/4884.003.0025","DOIUrl":"https://doi.org/10.7551/mitpress/4884.003.0025","url":null,"abstract":"Reference EPFL-ARTICLE-223260View record in Web of Science Record created on 2016-11-21, modified on 2016-11-21","PeriodicalId":49557,"journal":{"name":"Scientist","volume":"30 1","pages":"73-73"},"PeriodicalIF":1.8,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71238970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Law and Order","authors":"Alice Higgs","doi":"10.2307/j.ctt1d9nj7d.13","DOIUrl":"https://doi.org/10.2307/j.ctt1d9nj7d.13","url":null,"abstract":"The first series of legal drama Rake attracted a loyal following. Peter Lavelle takes a closer look at what's in store the second time around.","PeriodicalId":49557,"journal":{"name":"Scientist","volume":"1 1","pages":"42"},"PeriodicalIF":1.8,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68711610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
No tumor is an island. Chemical and physical forces exerted by the diverse cellular populations that surround a tumor - its so-called microenvironment - shape development and progression. Manipulating these 'ecological' factors is increasingly attractive therapeutically, as Mina Bissell and colleagues discuss in the following pages. And just as the cellular neighborhood is diverse, tumors enriched in these environments comprise a variety of cell types. In this heterogeneous mix, increasing evidence points to so-called cancer stem cells as the root of malignancy. Irving Weissman and Michael Clarke discuss the implications for leukemias on page 35, and on page 37 Peter B. Dirks discusses cancer stem cells in the brain.
{"title":"The Ecology of Tumors: By perturbing the microenvironment, wounds and infection may be key to tumor development.","authors":"Paraic A Kenny, Celeste M Nelson, Mina J Bissell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>No tumor is an island. Chemical and physical forces exerted by the diverse cellular populations that surround a tumor - its so-called microenvironment - shape development and progression. Manipulating these 'ecological' factors is increasingly attractive therapeutically, as Mina Bissell and colleagues discuss in the following pages. And just as the cellular neighborhood is diverse, tumors enriched in these environments comprise a variety of cell types. In this heterogeneous mix, increasing evidence points to so-called cancer stem cells as the root of malignancy. Irving Weissman and Michael Clarke discuss the implications for leukemias on page 35, and on page 37 Peter B. Dirks discusses cancer stem cells in the brain.</p>","PeriodicalId":49557,"journal":{"name":"Scientist","volume":"20 4","pages":"30"},"PeriodicalIF":1.8,"publicationDate":"2006-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995893/pdf/nihms235521.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29514366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What's wrong with single hypotheses?: Why it is time for Strong-Inference-PLUS.","authors":"Don L Jewett","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49557,"journal":{"name":"Scientist","volume":"19 21","pages":"10"},"PeriodicalIF":1.8,"publicationDate":"2005-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048741/pdf/nihms30352.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41008879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}