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Flexible Concentration Gradient Droplet Generation via Partitioning–Recombination in a Shear Flow-Driven Multilayer Microfluidic Chip 剪切流驱动多层微流控芯片中通过分离-重组产生柔性浓度梯度液滴
3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-05-26 DOI: 10.3390/sym17060826
Linkai Yu, Qingyang Feng, Yifan Chen, Yongji Wu, Haizhen Sun, Hao Yang, Lining Sun
Concentration gradient generation plays a pivotal role in advancing applications across drug screening, chemical synthesis, and biomolecular studies, yet conventional methods remain constrained by labor-intensive workflows, limited throughput, and inflexible gradient control. This study presents a novel multilayer microfluidic chip leveraging shear flow-driven partitioning–recombination mechanisms to enable the flexible and high-throughput generation of concentration gradient droplets. The chip integrates interactive upper and lower polydimethylsiloxane (PDMS) layers, where sequential fluid distribution and recombination are achieved through circular and radial channels while shear forces from the oil phase induce droplet formation. Numerical simulations validated the dynamic pressure-driven concentration gradient formation, demonstrating linear gradient profiles across multiple outlets under varied flow conditions. The experimental results revealed that the shear flow mode significantly enhances mixing uniformity and droplet generation efficiency compared to continuous flow operations, attributed to intensified interfacial interactions within contraction–expansion serpentine channels. By modulating hydrodynamic parameters such as aqueous- and oil-phase flow rates, this system achieved tunable gradient slopes and droplet sizes, underscoring the intrinsic relationship between flow dynamics and gradient formation. The proposed device eliminates reliance on complex channel networks, offering a compact and scalable platform for parallelized gradient generation. This work provides a robust framework for optimizing microfluidic-based concentration gradient systems, with broad implications for high-throughput screening, combinatorial chemistry, and precision biomolecular assays.
浓度梯度生成在药物筛选、化学合成和生物分子研究领域的应用中发挥着关键作用,但传统方法仍然受到劳动密集型工作流程、有限的吞吐量和不灵活的梯度控制的限制。本研究提出了一种新型的多层微流控芯片,利用剪切流驱动的分区-重组机制,实现了浓度梯度液滴的灵活和高通量生成。该芯片集成了相互作用的上下聚二甲基硅氧烷(PDMS)层,其中流体通过圆形和径向通道依次分布和重组,而来自油相的剪切力诱导液滴形成。数值模拟验证了动态压力驱动浓度梯度地层,显示了不同流动条件下多个出口的线性梯度剖面。实验结果表明,与连续流动相比,剪切流动模式显著提高了混合均匀性和液滴生成效率,这主要归因于收缩-膨胀蛇形通道内的界面相互作用增强。通过调节水相和油相流速等流体动力学参数,该系统实现了可调的梯度斜率和液滴大小,强调了流动动力学与梯度形成之间的内在关系。该装置消除了对复杂通道网络的依赖,为并行梯度生成提供了一个紧凑且可扩展的平台。这项工作为优化基于微流控的浓度梯度系统提供了一个强大的框架,对高通量筛选、组合化学和精确生物分子分析具有广泛的意义。
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引用次数: 1
Artificial Interfacial Layers with Zwitterionic Ion Structure Improves Lithium Symmetric Battery Life and Inhibits Dendrite Growth 具有两性离子结构的人工界面层提高锂对称电池寿命并抑制枝晶生长
3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-04-25 DOI: 10.3390/sym17050652
Haihua Wang, Wei Yuan, Chaoxian Chen, Rui Cao, Huizhu Niu, Ling Song, Jie Wang, Xinyu Shang
Lithium (Li) metal’s exceptional low electrode potential and high specific capacity for next-gen energy storage devices make it a top contender. However, the unregulated and unpredictable proliferation of Li dendrites and the instability of interfaces during repeated Li plating and stripping cycles pose significant challenges to the widespread commercialization of Li metal anodes. We introduce the creation of a hydrogen bond network solid electrolyte interphase (SEI) film that integrates zwitterionic groups, designed to facilitate the stability and longevity of lithium metal batteries (LMBs). Here, we design a PVA/P(SBMA-MBA) hydrogen bond network film (PSM) as an artificial SEI, integrating zwitterions and polyvinyl alcohol (PVA) to synergistically regulate Li⁺ flux. The distinctive zwitterionic effect in the network amplifies the SEI film’s ionic conductivity to 1.14 × 10−4 S cm−1 and attains an impressive Li+ ion transfer number of 0.84. In situ Raman spectroscopy reveals dynamic hydrogen bond reconfiguration under strain, endowing the SEI with self-adaptive mechanical robustness. These properties facilitate a homogeneous Li flux and exceptionally suppress dendritic growth. The advanced Li metal anode may endure over 1200 h at 1 mA cm−2 current density and 1 mAh cm−2 area capacity in a Li|Li symmetric battery. And in full cells paired with LiFePO4 cathodes, 93.8% capacity retention is reached after 300 cycles at 1C. Consequently, this work provides a universal strategy for designing dynamic interphases through molecular dipole engineering, paving the way for safe and durable lithium metal batteries.
锂(Li)金属的超低电极电位和高比容量使其成为下一代储能设备的主要竞争者。然而,在重复镀锂和剥离锂循环过程中,锂枝晶的不受控制和不可预测的增殖以及界面的不稳定性对锂金属阳极的广泛商业化构成了重大挑战。我们介绍了一种集成两性离子基团的氢键网络固体电解质界面(SEI)膜的创建,旨在促进锂金属电池(lmb)的稳定性和寿命。在这里,我们设计了PVA/P(SBMA-MBA)氢键网络膜(PSM)作为人工SEI,整合两性离子和聚乙烯醇(PVA),协同调节Li⁺的通量。网络中独特的两性离子效应将SEI薄膜的离子电导率提高到1.14 × 10−4 S cm−1,并获得了令人印象深刻的0.84 Li+离子转移数。原位拉曼光谱显示应变下动态氢键重构,赋予SEI自适应的机械鲁棒性。这些特性促进了均匀的Li通量,并特别抑制了枝晶的生长。在锂|锂对称电池中,先进的锂金属阳极可以在1ma cm - 2电流密度和1mah cm - 2面积容量下持续1200小时以上。在与LiFePO4阴极配对的完整电池中,在1C下循环300次后,容量保持率达到93.8%。因此,这项工作为通过分子偶极子工程设计动态界面提供了一种通用策略,为安全耐用的锂金属电池铺平了道路。
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引用次数: 0
Optimization of SOX2 Expression for Enhanced Glioblastoma Stem Cell Virotherapy. 增强胶质母细胞瘤干细胞病毒治疗中SOX2表达的优化
IF 2.2 3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2024-09-01 Epub Date: 2024-09-10 DOI: 10.3390/sym16091186
Dongwook Kim, Abraham Puig, Faranak Rabiei, Erial J Hawkins, Talia F Hernandez, Chang K Sung

The Zika virus has been shown to infect glioblastoma stem cells via the membrane receptor α v β 5 , which is activated by the stem-specific transcription factor SOX2. Since the expression level of SOX2 is an important predictive marker for successful virotherapy, it is important to understand the fundamental mechanisms of the role of SOX2 in the dynamics of cancer stem cells and Zika viruses. In this paper, we develop a mathematical ODE model to investigate the effects of SOX2 expression levels on Zika virotherapy against glioblastoma stem cells. Our study aimed to identify the conditions under which SOX2 expression level, viral infection, and replication can reduce or eradicate the glioblastoma stem cells. Analytic work on the existence and stability conditions of equilibrium points with respect to the basic reproduction number are provided. Numerical results were in good agreement with analytic solutions. Our results show that critical threshold levels of both SOX2 and viral replication, which change the stability of equilibrium points through population dynamics such as transcritical and Hopf bifurcations, were observed. These critical thresholds provide the optimal conditions for SOX2 expression levels and viral bursting sizes to enhance therapeutic efficacy of Zika virotherapy against glioblastoma stem cells. This study provides critical insights into optimizing Zika virus-based treatment for glioblastoma by highlighting the essential role of SOX2 in viral infection and replication.

寨卡病毒已被证明通过膜受体α v β 5感染胶质母细胞瘤干细胞,该受体被干细胞特异性转录因子SOX2激活。由于SOX2的表达水平是病毒治疗成功的重要预测指标,因此了解SOX2在癌症干细胞和寨卡病毒动力学中作用的基本机制非常重要。在本文中,我们建立了一个数学ODE模型来研究SOX2表达水平对寨卡病毒治疗胶质母细胞瘤干细胞的影响。我们的研究旨在确定SOX2表达水平、病毒感染和复制能够减少或根除胶质母细胞瘤干细胞的条件。给出了平衡点关于基本再现数的存在性和稳定性条件的解析工作。数值结果与解析解吻合较好。我们的研究结果表明,SOX2和病毒复制的临界阈值水平,通过跨临界和Hopf分岔等群体动力学改变平衡点的稳定性,被观察到。这些临界阈值为SOX2表达水平和病毒爆发大小提供了最佳条件,以提高寨卡病毒治疗胶质母细胞瘤干细胞的疗效。该研究通过强调SOX2在病毒感染和复制中的重要作用,为优化基于寨卡病毒的胶质母细胞瘤治疗提供了重要见解。
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引用次数: 0
Nuclear Shape-Phase Transitions and the Sextic Oscillator 核的形状-相变和六振子
3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-11-14 DOI: 10.3390/sym15112059
Géza Lévai, José M. Arias
This review delves into the utilization of a sextic oscillator within the β degree of freedom of the Bohr Hamiltonian to elucidate critical-point solutions in nuclei, with a specific emphasis on the critical point associated with the β shape variable, governing transitions from spherical to deformed nuclei. To commence, an overview is presented for critical-point solutions E(5), X(5), X(3), Z(5), and Z(4). These symmetries, encapsulated in simple models, all model the β degree of freedom using an infinite square-well (ISW) potential. They are particularly useful for dissecting phase transitions from spherical to deformed nuclear shapes. The distinguishing factor among these models lies in their treatment of the γ degree of freedom. These models are rooted in a geometrical context, employing the Bohr Hamiltonian. The review then continues with the analysis of the same critical solutions but with the adoption of a sextic potential in place of the ISW potential within the β degree of freedom. The sextic oscillator, being quasi-exactly solvable (QES), allows for the derivation of exact solutions for the lower part of the energy spectrum. The outcomes of this analysis are examined in detail. Additionally, various versions of the sextic potential, while not exactly solvable, can still be tackled numerically, offering a means to establish benchmarks for criticality in the transitional path from spherical to deformed shapes. This review extends its scope to encompass related papers published in the field in the past 20 years, contributing to a comprehensive understanding of critical-point symmetries in nuclear physics. To facilitate this understanding, a map depicting the different regions of the nuclide chart where these models have been applied is provided, serving as a concise summary of their applications and implications in the realm of nuclear structure.
这篇综述深入探讨了利用玻尔哈密顿量的β自由度内的六振子来阐明原子核的临界点解,特别强调了与β形状变量相关的临界点,它控制着从球形核到变形核的转变。首先,概述了临界点解E(5)、X(5)、X(3)、Z(5)和Z(4)。这些对称性被封装在简单的模型中,所有模型都使用无限平方阱(ISW)势来模拟β自由度。它们对于解剖从球形到变形核形状的相变特别有用。这些模型之间的区别在于它们对γ自由度的处理。这些模型基于几何背景,采用玻尔哈密顿量。然后继续对相同的临界解进行分析,但在β自由度内采用性势代替ISW势。六分频振荡器是准精确可解的(QES),可以推导出能量谱较低部分的精确解。对这一分析的结果进行了详细的检验。此外,各种版本的性势,虽然不是完全可解的,但仍然可以在数值上解决,提供了一种方法来建立从球形到变形形状过渡路径的临界基准。本综述将其范围扩展到过去20年来在该领域发表的相关论文,有助于全面了解核物理中的临界点对称性。为了促进这种理解,提供了一幅描绘核素图中应用这些模型的不同区域的地图,作为它们在核结构领域的应用和影响的简明总结。
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引用次数: 0
Gravity = Yang–Mills 引力 = 杨-米尔斯
3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-11-14 DOI: 10.3390/sym15112062
Roberto Bonezzi, Christoph Chiaffrino, Felipe Díaz-Jaramillo, Olaf Hohm
This essay’s title is justified by discussing a class of Yang–Mills-type theories of which standard Yang–Mills theories are special cases but which is broad enough to include gravity as a double field theory. We use the framework of homotopy algebras, where conventional Yang–Mills theory is the tensor product K⊗g of a ‘kinematic’ algebra K with a color Lie algebra g. The larger class of Yang–Mills-type theories are given by the tensor product of K with more general Lie-type algebras, of which K itself is an example, up to anomalies that can be canceled for the tensor product with a second copy K¯. Gravity is then given by K⊗K¯.
这篇文章的标题是通过讨论一类杨-米尔斯型理论来证明的,其中标准杨-米尔斯理论是特例,但它足够广泛,可以将重力作为双场理论包括在内。我们使用同伦代数的框架,其中传统的Yang-Mills理论是“运动”代数K与彩色李代数g的张量积K⊗g。更大的一类Yang-Mills型理论由K与更一般的李代数的张量积给出,其中K本身就是一个例子,直到具有第二个副本K¯的张量积可以抵消的异常。重力由K⊗K¯给出。
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引用次数: 1
The Chromatic Entropy of Linear Supertrees and Its Application 线性超树的色熵及其应用
3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-11-14 DOI: 10.3390/sym15112061
Feng Fu, Bo Deng, Liming Dai
Shannon entropy plays an important role in the field of information theory, and various graph entropies, including the chromatic entropy, have been proposed by researchers based on Shannon entropy with different graph variables. The applications of the graph entropies are found in numerous areas such as physical chemistry, medicine, and biology. The present research aims to study the chromatic entropy based on the vertex strong coloring of a linear p-uniform supertree. The maximal and minimal values of the p-uniform supertree are determined. Moreover, in order to investigate the generalization of dendrimers, a new class of p-uniform supertrees called hyper-dendrimers is proposed. In particular, the extremal values of chromatic entropy found in the research for supertrees are applied to explore the behavior of the hyper-dendrimers.
香农熵在信息论中占有重要的地位,研究者在香农熵的基础上提出了不同图变量的图熵,包括色熵。图熵在物理化学、医学和生物学等许多领域都有应用。本文研究了线性p-一致超树的顶点强着色的色熵。确定了p-一致超树的最大值和最小值。此外,为了研究树状大分子的泛化性,提出了一类新的p-均匀超树,称为超树状大分子。特别地,在超树的研究中发现的色熵极值被用于探索超树突状分子的行为。
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引用次数: 0
Development of Compact Bandpass Filter Using Symmetrical Metamaterial Structures for GPS, ISM, Wi-MAX, and WLAN Applications 采用对称超材料结构的紧凑型带通滤波器的开发,用于GPS、ISM、Wi-MAX和WLAN应用
3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-11-14 DOI: 10.3390/sym15112058
Kottapadikal Vinodan Vineetha, Boddapati Taraka Phani Madhav, Munuswamy Siva Kumar, Sudipta Das, Tanvir Islam, Moath Alathbah
This article describes the development of a compact microstrip bandpass filter (BPF) for multiple wireless communication utilizations. The proposed bandpass filter consists of metamaterial unit cells that are symmetrical in shape. The design process involves the placement of four symmetrical split-ring resonators (SRRs) on the top plane of the BPF. It exhibits improved filter characteristics through the implementation of these SRRs. The filter was modeled and fabricated and its performance was evaluated using a Vector Network Analyzer. The designed bandpass filter shows a 5 GHz bandwidth covering the frequency band spanning from 1 to 5.2 GHz, with a quality factor value of 1.85 across 1.9 GHz, 3.3 across 3.3 GHz and 5.1 across 5.1 GHz. The metamaterial analysis was carried out using ANSYS ELECTRONIC DESKTOP. The proposed filter measures 20 × 18 × 1.6 mm3, which is significantly smaller than current filters. The designed bandpass filter occupies 50% of the space of a conventional filter. The designed bandpass filter exhibits a distributed surface current of 84 A/m, and 94 A/m across the wide- and narrow-band operating frequency. The simulated and measured results indicate that the suggested metamaterial filter is well-suited for multiband wireless applications like GPS (1.57 GHz), WLAN (2.4, 3.6, and 5.2 GHz), Wi-MAX (2.3, 2.5, and 3.5 GHz), and ISM (2.5 GHz).
本文介绍了一种用于多种无线通信的紧凑型微带带通滤波器(BPF)的开发。所提出的带通滤波器由形状对称的超材料单元组成。设计过程包括在BPF的顶部平面上放置四个对称的分环谐振器(srr)。通过这些srr的实现,它表现出改进的滤波器特性。对该滤波器进行了建模和制作,并利用矢量网络分析仪对其性能进行了评价。所设计的带通滤波器显示5 GHz带宽,覆盖1至5.2 GHz频段,质量因子值在1.9 GHz范围内为1.85,在3.3 GHz范围内为3.3,在5.1 GHz范围内为5.1。利用ANSYS ELECTRONIC DESKTOP进行超材料分析。该滤波器尺寸为20 × 18 × 1.6 mm3,明显小于现有滤波器。所设计的带通滤波器占用传统滤波器50%的空间。所设计的带通滤波器在宽带和窄带工作频率上的分布表面电流分别为84 a /m和94 a /m。仿真和实测结果表明,所提出的超材料滤波器非常适合GPS (1.57 GHz)、WLAN(2.4、3.6和5.2 GHz)、Wi-MAX(2.3、2.5和3.5 GHz)和ISM (2.5 GHz)等多频段无线应用。
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引用次数: 0
Multiplicity Dependence of the Freeze-Out Parameters in Symmetric and Asymmetric Nuclear Collisions at Large Hadron Collider Energies 大型强子对撞机能量下对称和非对称核碰撞中冻结参数的多重依赖性
3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-11-14 DOI: 10.3390/sym15112063
Muhammad Ajaz, Abd Haj Ismail, Muhammad Waqas, Abdul Mosawir Quraishi, Jalal Hasan Baker, Antalov Jagnandan, Mohammad Ayaz Ahmad, Shawn Jagnandan, Haifa I. Alrebdi, Elmuez A. Dawi, Murad Badshah
Strange hadron transverse momentum spectra are analyzed in symmetric pp and PbPb and asymmetric pPb collision systems for their dependence on rapidity and event charged-particle multiplicity. The thermodynamically consistent Tsallis models with and without flow velocity are used to reproduce the experimental data, extracting the freeze-out parameters to gain insights into the underlying physics of the collision processes by looking into the parameters change with different multiplicities, particle types, and collision geometries. We found that with an increase in the event multiplicity, the average transverse flow velocity, effective, and kinetic freezeout temperatures increase, with heavier strange particle species exhibiting a more significant increase. The value of the non-extensivity parameter decreases with an increase in the multiplicity of the particles. For heavier particles, larger Teff and T0 and smaller q have been observed, confirming the quick thermalization and equilibrium for massive particles. Furthermore, the differences in parameter values for particle species are more significant in pp and pPb collisions than in PbPb collisions. In addition, in symmetric pp and PbPb collisions, parameter values (q,T0,βT) show more significant shifts for heavier particles compared to the lighter ones. In contrast, in asymmetric pPb collisions, both heavier and lighter particles display uniform linear progression.
分析了对称pp与PbPb和非对称pPb碰撞系统中奇异强子横向动量谱与速度和事件带电粒子多重性的关系。采用具有和不具有流速的热力学一致的Tsallis模型来重现实验数据,提取冻结参数,通过观察参数随不同数量、粒子类型和碰撞几何形状的变化来深入了解碰撞过程的潜在物理特性。结果表明,随着事件数的增加,平均横向流动速度、有效冻结温度和动力学冻结温度均增加,且重的奇异粒子种类增加更显著。非扩张性参数的值随着粒子数量的增加而减小。对于较重的粒子,观察到较大的Teff和T0和较小的q,证实了大质量粒子的快速热化和平衡。此外,pp和pPb碰撞中粒子种类参数值的差异比PbPb碰撞中更显著。此外,在对称的pp和PbPb碰撞中,相对于轻粒子,重粒子的参数值(q,T0,βT)的变化更为显著。相反,在不对称的pPb碰撞中,较重和较轻的粒子都表现出均匀的线性进展。
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引用次数: 0
Entanglement and Symmetry Structure of N(= 3) Quantum Oscillators with Disparate Coupling Strengths in a Common Quantum Field Bath 不同耦合强度的N(= 3)量子振子在公共量子场浴中的纠缠和对称结构
3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-11-14 DOI: 10.3390/sym15112064
Jen-Tsung Hsiang, Bei-Lok Hu
In this paper, we study the entanglement structure of a system of N quantum oscillators with distinctive coupling strengths, all linearly coupled to a common massless scalar quantum field. This study is helpful in characterizing the notion of an entanglement domain and its symmetry features, which is useful for understanding the interplay between different levels of structure in many-body quantum systems. The effect of the quantum field on the system is derived via the influence functional and the correlation functions are obtained from the solutions of the evolutionary operator of the reduced density matrix. They are then used to construct the covariance matrix, which forms the basis for our analysis of the structure of quantum entanglement in this open system. To make the physical features explicit, we consider a system of three quantum coupled oscillators placed at the vertices of an equilateral triangle with disparate pairwise couplings. We analyze the entanglement between one oscillator and the other two with equal (symmetric) and unequal (asymmetric) coupling strengths. As a physical illustration, we apply the results for these two different configurations to address some basic issues in macroscopic quantum phenomena from the quantum entanglement perspective.
本文研究了具有不同耦合强度的N个量子振子系统的纠缠结构,这些量子振子都与一个普通的无质量标量量子场线性耦合。本研究有助于描述纠缠域的概念及其对称性特征,有助于理解多体量子系统中不同层次结构之间的相互作用。通过影响泛函导出了量子场对系统的影响,并由密度矩阵演化算子的解得到了相关函数。然后用它们来构造协方差矩阵,这是我们分析这个开放系统中量子纠缠结构的基础。为了使物理特征明确,我们考虑一个由三个量子耦合振荡器组成的系统,这些振荡器放置在具有不同成对耦合的等边三角形的顶点上。我们分析了耦合强度相等(对称)和不相等(非对称)的一个振荡器与另外两个振荡器之间的纠缠。作为物理说明,我们应用这两种不同构型的结果,从量子纠缠的角度来解决宏观量子现象中的一些基本问题。
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引用次数: 0
Angular-Momentum Modes in a Bosonic Condensate Trapped in the Inverse-Square Potential 反平方势中玻色子凝聚体中的角动量模式
3区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-11-14 DOI: 10.3390/sym15112060
Hidetsugu Sakaguchi, Boris A. Malomed
In the mean-field approximation, the well-known effect of the critical quantum collapse in a 3D gas of particles pulled to the center by potential U(r)=−U0/2r2 is suppressed by repulsive inter-particle interactions, which create the otherwise non-existing s-wave ground state. Here, we address excited bound states carrying angular momentum, with the orbital and magnetic quantum numbers l and m. They exist above a threshold value of the potential’s strength, U0>l(l+1). The sectoral, tesseral, and zonal modes, which correspond to m=l, 0
在平均场近似中,众所周知的临界量子坍缩效应在被势U(r)= - U0/2r2拉向中心的三维粒子气体中被粒子间的排斥性相互作用所抑制,从而产生了不存在的s波基态。在这里,我们处理携带角动量的激发态,轨道和磁量子数分别为l和m。它们存在于势强度的阈值U0>l(l+1)之上。分别对应于m=l、0<m<l和m=0的扇形、不规则和带状模态,在相对较小的U0−l(l+1)值中以近似解析形式存在。对于p波和d波状态产生了明确的结果,其中l分别=1和2。在一般形式下,用数值方法得到了束缚态,证实了解析近似的准确性。
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引用次数: 0
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Symmetry-Basel
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