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Recurrence of conductive hearing loss after stapes surgery: a narrative review. 镫骨手术后传导性听力损失复发的研究综述。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-suppl.1-43-2023-07
Ignacio Javier Fernandez, Federico Rondini, Livio Presutti, Giulia Molinari
SUMMARY Among the functional failures of stapes surgery is recurrent conductive hearing loss, which can occur after a variable period of hearing improvement, from days/months up to many years after surgery. The most common cause of recurrent conductive hearing loss is prosthesis displacement, while fibrous adhesions or stapedotomy hole/oval window re-obliteration due to otosclerosis, occur less frequently. High resolution computed tomography plays an important role in the identification of the cause of hearing loss recurrence. Parallel to this, intra-operative exploration of the middle ear is crucial to confirm the cause of failure and address its treatment, possibly restoring hearing. While generally worse than after primary surgery, hearing outcomes after revision stapes surgery have improved thanks to advancements in pre-operative assessment, intra-operative view and technical refinements.
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引用次数: 0
Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study. 复发性喉乳头状瘤病:多模式治疗策略。文献回顾及多中心回顾性研究。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-suppl.1-43-2023-14
Giulia Bertino, Fabio Pedretti, Simone Mauramati, Marta Filauro, Alberto Vallin, Francesco Mora, Erika Crosetti, Giovanni Succo, Giorgio Peretti, Marco Benazzo
<p><strong>Objectives: </strong>Recurrent respiratory papillomatosis (RRP) is a benign, rare disease caused by Human Papilloma Virus (HPV) that can be divided into juvenile and adult forms. The course of the disease is variable, but is usually more aggressive in the juvenile form. The standard surgical treatment is represented by CO<sub>2</sub> laser resection, although photoangiolytic lasers represent a valid alternative. Adjuvant therapies have been proposed for disease control in case of frequent surgical resections or spreading into the lower airways. In recent years, the development of immunotherapy led to the use of bevacizumab either intratumorally or intravenously, but the most promising therapeutic development is represented by HPV vaccination. This paper aims to present a narrative review of the literature and the experience of three different University Centres in the treatment of RRP.</p><p><strong>Methods: </strong>A retrospective analysis of the clinical charts of all patients affected by laryngeal papillomatosis and treated in three different University Centres between 2002 and 2022 was performed. The following parameters were collected: sex, age at first evaluation, sites of larynx involved, HPV type, type of first surgical treatment, presence and number of recurrences, surgical treatment of recurrences, adjuvant therapies, side effects and status at last follow-up.</p><p><strong>Results: </strong>Seventy-eight patients were available for evaluation. Of these, 88% had adult onset RRP (Ao-RRP) and 12% juvenile onset RRP (Jo-RRP). The glottis was the most frequently involved subsite; all patients were submitted to surgical resection with CO<sub>2</sub> laser under general anaesthesia. Recurrences appeared in 79% of the patients, the patients who did not recur were all adults. The mean number of recurrences was 9 (range 1-110). Recurrences were more frequent in children (M = 20; range 2-110) than adults (M = 5; range 1-21). Thirty-two (52%) of the 62 patients who recurred were re-treated with CO<sub>2</sub> laser under general anaesthesia, while office-based treatment with a photoangiolytic laser was preferred in the remaining 30 (48%) patients. Adjuvant treatments were applied in 26 patients. The analysis of the course of the disease showed that in the 9 patients with Jo-RRP, 6 (67%) were free of lesions at the last follow-up, while the other 3 (33%) had papillomas. Of the 69 patients with Ao-RRP, 53 (77%) were alive and free of disease at the last visit, 14 (21%) were alive with disease, 1 (1%) was lost at follow-up and 1 (1%) died for other disease. Severe side effects were not observed except for 2 patients, who developed posterior glottic stenosis.</p><p><strong>Conclusions: </strong>Our results confirmed the literature review. RRP is a potentially aggressive disease, especially in juvenile onset. Surgical resection is still first-line treatment, but in case of multiple recurrences the use of adjuvant therapies must be taken int
目的:复发性呼吸道乳头状瘤病(RRP)是由人乳头状瘤病毒(HPV)引起的一种罕见的良性疾病,可分为少年型和成年型。这种疾病的病程是多变的,但通常在幼年时更具侵袭性。标准的手术治疗是CO2激光切除,尽管光血管溶解激光是一种有效的替代方法。在频繁手术切除或扩散到下呼吸道的情况下,已经提出了辅助治疗来控制疾病。近年来,免疫疗法的发展导致贝伐单抗在肿瘤内或静脉注射的使用,但最有希望的治疗发展是HPV疫苗接种。本文旨在提出的文献和三个不同的大学中心在治疗RRP的经验的叙述回顾。方法:回顾性分析2002年至2022年间在三所不同的大学中心治疗的喉乳头状瘤病患者的临床资料。收集以下参数:性别、初次评估时的年龄、喉部受累部位、HPV类型、首次手术治疗类型、复发的存在和次数、复发的手术治疗、辅助治疗、副作用和最后随访时的情况。结果:78例患者可用于评估。其中88%为成人起病RRP (Ao-RRP), 12%为青少年起病RRP (Jo-RRP)。声门是最常受累的部位;所有患者均在全身麻醉下行CO2激光手术切除。79%的患者出现复发,未复发的患者均为成人。平均复发次数为9次(范围1-110次)。儿童复发率较高(M = 20;范围2-110)比成人(M = 5;范围21)。62例复发患者中有32例(52%)在全身麻醉下再次接受CO2激光治疗,而其余30例(48%)患者首选以办公室为基础的光溶血管激光治疗。辅助治疗26例。病程分析显示,9例Jo-RRP患者中,6例(67%)末次随访无病变,3例(33%)有乳头状瘤。在69例Ao-RRP患者中,53例(77%)在最后一次访问时存活且无疾病,14例(21%)存活且有疾病,1例(1%)在随访中丢失,1例(1%)因其他疾病死亡。除2例患者出现后声门狭窄外,未见严重副作用。结论:我们的结果证实了文献综述。RRP是一种潜在的侵袭性疾病,尤其是在青少年发病时。手术切除仍是一线治疗方法,但在多次复发的情况下,必须考虑辅助治疗的使用。
{"title":"Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.","authors":"Giulia Bertino,&nbsp;Fabio Pedretti,&nbsp;Simone Mauramati,&nbsp;Marta Filauro,&nbsp;Alberto Vallin,&nbsp;Francesco Mora,&nbsp;Erika Crosetti,&nbsp;Giovanni Succo,&nbsp;Giorgio Peretti,&nbsp;Marco Benazzo","doi":"10.14639/0392-100X-suppl.1-43-2023-14","DOIUrl":"https://doi.org/10.14639/0392-100X-suppl.1-43-2023-14","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Recurrent respiratory papillomatosis (RRP) is a benign, rare disease caused by Human Papilloma Virus (HPV) that can be divided into juvenile and adult forms. The course of the disease is variable, but is usually more aggressive in the juvenile form. The standard surgical treatment is represented by CO&lt;sub&gt;2&lt;/sub&gt; laser resection, although photoangiolytic lasers represent a valid alternative. Adjuvant therapies have been proposed for disease control in case of frequent surgical resections or spreading into the lower airways. In recent years, the development of immunotherapy led to the use of bevacizumab either intratumorally or intravenously, but the most promising therapeutic development is represented by HPV vaccination. This paper aims to present a narrative review of the literature and the experience of three different University Centres in the treatment of RRP.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis of the clinical charts of all patients affected by laryngeal papillomatosis and treated in three different University Centres between 2002 and 2022 was performed. The following parameters were collected: sex, age at first evaluation, sites of larynx involved, HPV type, type of first surgical treatment, presence and number of recurrences, surgical treatment of recurrences, adjuvant therapies, side effects and status at last follow-up.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Seventy-eight patients were available for evaluation. Of these, 88% had adult onset RRP (Ao-RRP) and 12% juvenile onset RRP (Jo-RRP). The glottis was the most frequently involved subsite; all patients were submitted to surgical resection with CO&lt;sub&gt;2&lt;/sub&gt; laser under general anaesthesia. Recurrences appeared in 79% of the patients, the patients who did not recur were all adults. The mean number of recurrences was 9 (range 1-110). Recurrences were more frequent in children (M = 20; range 2-110) than adults (M = 5; range 1-21). Thirty-two (52%) of the 62 patients who recurred were re-treated with CO&lt;sub&gt;2&lt;/sub&gt; laser under general anaesthesia, while office-based treatment with a photoangiolytic laser was preferred in the remaining 30 (48%) patients. Adjuvant treatments were applied in 26 patients. The analysis of the course of the disease showed that in the 9 patients with Jo-RRP, 6 (67%) were free of lesions at the last follow-up, while the other 3 (33%) had papillomas. Of the 69 patients with Ao-RRP, 53 (77%) were alive and free of disease at the last visit, 14 (21%) were alive with disease, 1 (1%) was lost at follow-up and 1 (1%) died for other disease. Severe side effects were not observed except for 2 patients, who developed posterior glottic stenosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our results confirmed the literature review. RRP is a potentially aggressive disease, especially in juvenile onset. Surgical resection is still first-line treatment, but in case of multiple recurrences the use of adjuvant therapies must be taken int","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 Suppl. 1","pages":"S111-S122"},"PeriodicalIF":2.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/68/aoi-2023-02-S111.PMC10159644.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The role of the osteoplastic flap in the endoscopic era: a retrospective multicentre experience on revision surgery. 骨成形术瓣在内镜时代的作用:多中心翻修手术的回顾性经验。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-suppl.1-43-2023-04
Fabio Pagella, Eugenia Maiorano, Mario Turri-Zanoni, Marco Ferrari, Paolo Carena, Cesare Zoia, Camilla Czaczkes, Carlo Conti, Alberto Schreiber, Paolo Battaglia, Enzo Emanuelli, Stefano Pelucchi, Maurizio Bignami, Piero Nicolai, Paolo Castelnuovo

Objective: To retrospectively review the experience of five tertiary-care university hospitals on frontal sinus revision surgery with osteoplastic flap (OPF).

Methods: Descriptive analysis of patients who underwent frontal sinus surgery with OPF after one or more endoscopic procedures for benign and inflammatory pathologies from 2000 to 2022. Clinical charts were reviewed for demographics, indications, clinical presentation, previous frontal procedures, OPF technique and outcomes.

Results: Of the 124 patients who underwent an OPF procedure, 33 met inclusion criteria. With a mean of 2.1 previous endoscopic surgeries, Draf III was the most common former procedure. In 30 (91%) cases OPF was part of a combined procedure. The most common indications were inverted papilloma (61%), mucocele (9%) and chronic rhinosinusitis (6%). Frontal outflow stenosis (36%) and mucocele (9%) were the most frequent complications observed. Improvement of overall symptoms and patient satisfaction after the OPF procedure were recorded.

Conclusions: Even in the endoscopic era, OPF still represents a paramount procedure that should be included in the rhino-surgeon's armamentarium, in particular in patients with challenging pathologies and anatomy when previous endoscopic endonasal attempts have failed.

目的:回顾性分析五所大学三级医院采用骨成形术(OPF)进行额窦翻修手术的经验。方法:描述性分析2000年至2022年期间,因良性和炎症病理进行一次或多次内镜手术后接受额窦OPF手术的患者。临床图表回顾了人口统计学,适应症,临床表现,以前的额叶手术,OPF技术和结果。结果:124例接受OPF手术的患者中,33例符合纳入标准。平均2.1次内窥镜手术,draft III是最常见的手术。在30例(91%)病例中,OPF是联合手术的一部分。最常见的适应症是内翻性乳头状瘤(61%)、粘液囊肿(9%)和慢性鼻窦炎(6%)。额流出管狭窄(36%)和粘液囊肿(9%)是最常见的并发症。记录OPF手术后整体症状的改善情况和患者满意度。结论:即使在内窥镜时代,OPF仍然是一项重要的手术,应该包括在鼻外科医生的装备中,特别是对于那些具有挑战性的病理和解剖结构的患者,当以前的内窥镜鼻内尝试失败时。
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引用次数: 0
Recurrent obstructive salivary disease after sialendoscopy. A narrative literature review. 涎镜检查后复发性梗阻性涎腺疾病。叙事性文献综述。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-suppl.1-43-2023-12
Pasquale Capaccio, Michele Gaffuri, Pietro Canzi, Lorenzo Pignataro
SUMMARY Over the last 20 years, interventional sialendoscopy has become the therapy of choice for the management of obstructive salivary disorders, favouring a significant reduction in the number of patients undergoing traditional sialadenectomy. The overall success rate of sialendoscopy is around 90% as reported by the largest case series published; recurrence is expected in about 10% of cases, and the patient should be informed about the possibility to undergo further conservative procedures to improve symptoms. Adequate pre-operative assessment, based on ultrasonography, cone beam 3D CT and MR-sialography, is mandatory to reduce the risk of unsuccessful procedures and, therefore, recurrence of obstructive sialadenitis; moreover, in case of recurrence, the surgeon should be experienced enough to manage these cases and be able to perform additional interventions, such as transoral/transfacial sialendoscopy-assisted procedures and imaging-assisted procedures in case of difficult anatomical situations. Botulinum toxin injection and traditional sialadenectomy would be considered as possible salvage treatments in case of failure of all conservative approaches.
{"title":"Recurrent obstructive salivary disease after sialendoscopy. A narrative literature review.","authors":"Pasquale Capaccio,&nbsp;Michele Gaffuri,&nbsp;Pietro Canzi,&nbsp;Lorenzo Pignataro","doi":"10.14639/0392-100X-suppl.1-43-2023-12","DOIUrl":"https://doi.org/10.14639/0392-100X-suppl.1-43-2023-12","url":null,"abstract":"SUMMARY Over the last 20 years, interventional sialendoscopy has become the therapy of choice for the management of obstructive salivary disorders, favouring a significant reduction in the number of patients undergoing traditional sialadenectomy. The overall success rate of sialendoscopy is around 90% as reported by the largest case series published; recurrence is expected in about 10% of cases, and the patient should be informed about the possibility to undergo further conservative procedures to improve symptoms. Adequate pre-operative assessment, based on ultrasonography, cone beam 3D CT and MR-sialography, is mandatory to reduce the risk of unsuccessful procedures and, therefore, recurrence of obstructive sialadenitis; moreover, in case of recurrence, the surgeon should be experienced enough to manage these cases and be able to perform additional interventions, such as transoral/transfacial sialendoscopy-assisted procedures and imaging-assisted procedures in case of difficult anatomical situations. Botulinum toxin injection and traditional sialadenectomy would be considered as possible salvage treatments in case of failure of all conservative approaches.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 Suppl 1","pages":"S95-S102"},"PeriodicalIF":2.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/5b/aoi-2023-02-S95.PMC10159639.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10596344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current trends on subtotal petrosectomy with cochlear implantation in recalcitrant chronic middle ear disorders. 顽固性慢性中耳疾病的次全岩石切除术联合人工耳蜗植入术的发展趋势。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-suppl.1-43-2023-09
Pietro Canzi, Stefano Berrettini, Andrea Albera, Maurizio Barbara, Luca Bruschini, Andrea Canale, Elena Carlotto, Edoardo Covelli, Domenico Cuda, Francesco Dispenza, Maurizio Falcioni, Francesca Forli, Sebastiano Franchella, Lorenzo Gaini, Salvatore Gallina, Andrea Laborai, Ruggero Lapenna, Francesco Lazzerini, Stefano Malpede, Marco Mandalà, Domenico Minervini, Enrico Pasanisi, Giampietro Ricci, Francesca Viberti, Diego Zanetti, Elisabetta Zanoletti, Marco Benazzo

Objective: To establish the safety and effectiveness of subtotal petrosectomy with cochlear implantation in patients affected by chronic middle ear disorders to refractory to previous surgical treatments.

Methods: A multicentre, retrospective study was conducted on patients affected by recalcitrant chronic middle ear disorders who underwent cochlear implantation in combination with subtotal petrosectomy. Patients' details were collected from databases of 11 Italian tertiary referral centres. Additionally, a review of the most updated literature was carried out.

Results: 55 patients were included with a mean follow-up time of 44 months. Cholesteatoma was the most common middle ear recurrent pathology and 50.9% of patients had an open cavity. 80% of patients underwent a single stage surgery. One case of explantation for device failure was reported among the 7 patients with post-operative complications.

Conclusions: Subtotal petrosectomy with cochlear implantation is a benchmark for management of patients with recalcitrant chronic middle ear disorders. A single stage procedure is the most recommended strategy. Optimal follow-up is still debated. Further studies are required to investigate the role of this surgery in paediatric patients.

目的:探讨慢性中耳疾病对既往手术治疗难治性的患者行次全岩石切除术联合人工耳蜗植入术的安全性和有效性。方法:对顽固性慢性中耳疾患行人工耳蜗植入联合石油大部切除术的患者进行多中心回顾性研究。患者的详细信息从11个意大利三级转诊中心的数据库中收集。此外,对最新的文献进行了回顾。结果:55例患者入组,平均随访时间44个月。胆脂瘤是最常见的中耳复发病理,50.9%的患者有开放腔。80%的患者接受了单期手术。在7例术后并发症中,报告1例因器械失效而拔出。结论:石油次全切除术联合人工耳蜗植入术是治疗顽固性慢性中耳疾病的一种有效方法。单阶段手术是最推荐的策略。最佳随访仍有争议。需要进一步的研究来调查这种手术在儿科患者中的作用。
{"title":"Current trends on subtotal petrosectomy with cochlear implantation in recalcitrant chronic middle ear disorders.","authors":"Pietro Canzi,&nbsp;Stefano Berrettini,&nbsp;Andrea Albera,&nbsp;Maurizio Barbara,&nbsp;Luca Bruschini,&nbsp;Andrea Canale,&nbsp;Elena Carlotto,&nbsp;Edoardo Covelli,&nbsp;Domenico Cuda,&nbsp;Francesco Dispenza,&nbsp;Maurizio Falcioni,&nbsp;Francesca Forli,&nbsp;Sebastiano Franchella,&nbsp;Lorenzo Gaini,&nbsp;Salvatore Gallina,&nbsp;Andrea Laborai,&nbsp;Ruggero Lapenna,&nbsp;Francesco Lazzerini,&nbsp;Stefano Malpede,&nbsp;Marco Mandalà,&nbsp;Domenico Minervini,&nbsp;Enrico Pasanisi,&nbsp;Giampietro Ricci,&nbsp;Francesca Viberti,&nbsp;Diego Zanetti,&nbsp;Elisabetta Zanoletti,&nbsp;Marco Benazzo","doi":"10.14639/0392-100X-suppl.1-43-2023-09","DOIUrl":"https://doi.org/10.14639/0392-100X-suppl.1-43-2023-09","url":null,"abstract":"<p><strong>Objective: </strong>To establish the safety and effectiveness of subtotal petrosectomy with cochlear implantation in patients affected by chronic middle ear disorders to refractory to previous surgical treatments.</p><p><strong>Methods: </strong>A multicentre, retrospective study was conducted on patients affected by recalcitrant chronic middle ear disorders who underwent cochlear implantation in combination with subtotal petrosectomy. Patients' details were collected from databases of 11 Italian tertiary referral centres. Additionally, a review of the most updated literature was carried out.</p><p><strong>Results: </strong>55 patients were included with a mean follow-up time of 44 months. Cholesteatoma was the most common middle ear recurrent pathology and 50.9% of patients had an open cavity. 80% of patients underwent a single stage surgery. One case of explantation for device failure was reported among the 7 patients with post-operative complications.</p><p><strong>Conclusions: </strong>Subtotal petrosectomy with cochlear implantation is a benchmark for management of patients with recalcitrant chronic middle ear disorders. A single stage procedure is the most recommended strategy. Optimal follow-up is still debated. Further studies are required to investigate the role of this surgery in paediatric patients.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 Suppl. 1","pages":"S67-S75"},"PeriodicalIF":2.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c8/b0/aoi-2023-02-S67.PMC10159642.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10596346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prompt diagnosis and airway management for primary thyroid lymphoma with compromised upper airway: a single-institution case series. 上呼吸道受损的原发性甲状腺淋巴瘤的及时诊断和气道管理:单机构病例系列。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-N2286
Aobo Zhang, Mingzhen Zhao, Yanbo Dong, Shuoqing Yuan, Liangfa Liu

Objectives: Primary thyroid lymphoma (PTL) is a rare malignant tumour. Prompt and accurate diagnosis and optimal airway management are crucial for PTL, especially when complicated with dyspnoea.

Methods: Eight patients with PTL and dyspnoea treated in Beijing Friendship Hospital from January 2015 to December 2021 were retrospectively reviewed.

Results: Three of four patients complicated with mild to moderate dyspnoea underwent chemotherapy after prompt diagnosis by fine needle aspiration cytology (FNAC) combined with cell block immunocytochemistry (CB-ICC) and flow cytometric immunophenotyping (FCI) or core needle biopsy (CNB) combined with immunohistochemistry (IHC) without open surgery. Total thyroidectomy was performed in one patient without other diagnostic methods because the FNAC result was inconclusive. Four patients with moderate to severe dyspnoea underwent tracheostomy and incisional biopsy without severe complications after tracheal intubation under the guidance of a fibreoptic bronchoscope performed without general anaesthesia.

Conclusions: For patients with mild to moderate dyspnoea suspected of PTL, FNAC along with FCI and CB-ICC or CNB along with IHC are recommended, in addition to prompt chemotherapy to avoid prophylactic tracheostomy. Patients with moderate to severe dyspnoea suspected of PTL should undergo tracheal intubation under the guidance of a fibreoptic bronchoscope without general anaesthesia, followed by tracheostomy with simultaneous thyroid incisional biopsy to reduce the risk of asphyxia during treatment.

目的:原发性甲状腺淋巴瘤是一种罕见的恶性肿瘤。及时准确的诊断和最佳的气道管理对PTL至关重要,特别是当合并呼吸困难时。方法:回顾性分析2015年1月至2021年12月北京友谊医院收治的8例PTL合并呼吸困难患者。结果:4例合并轻中度呼吸困难的患者中有3例在未开腹手术的情况下,经细针穿刺细胞学(FNAC)联合细胞阻滞免疫细胞化学(CB-ICC)和流式细胞免疫表型(FCI)或核心针活检(CNB)联合免疫组织化学(IHC)及时诊断后接受化疗。由于FNAC结果不确定,在没有其他诊断方法的情况下进行了甲状腺全切除术。4例中度至重度呼吸困难患者在纤维支气管镜指导下气管插管后行气管造口术及切口活检,无严重并发症。结论:对于怀疑PTL的轻中度呼吸困难患者,除及时化疗以避免预防性气管切开外,建议FNAC合并FCI、CB-ICC或CNB合并IHC。怀疑为PTL的中重度呼吸困难患者应在纤维支气管镜指导下行气管插管,不需全身麻醉,然后行气管切开术,同时行甲状腺切口活检,以减少治疗过程中窒息的风险。
{"title":"Prompt diagnosis and airway management for primary thyroid lymphoma with compromised upper airway: a single-institution case series.","authors":"Aobo Zhang,&nbsp;Mingzhen Zhao,&nbsp;Yanbo Dong,&nbsp;Shuoqing Yuan,&nbsp;Liangfa Liu","doi":"10.14639/0392-100X-N2286","DOIUrl":"https://doi.org/10.14639/0392-100X-N2286","url":null,"abstract":"<p><strong>Objectives: </strong>Primary thyroid lymphoma (PTL) is a rare malignant tumour. Prompt and accurate diagnosis and optimal airway management are crucial for PTL, especially when complicated with dyspnoea.</p><p><strong>Methods: </strong>Eight patients with PTL and dyspnoea treated in Beijing Friendship Hospital from January 2015 to December 2021 were retrospectively reviewed.</p><p><strong>Results: </strong>Three of four patients complicated with mild to moderate dyspnoea underwent chemotherapy after prompt diagnosis by fine needle aspiration cytology (FNAC) combined with cell block immunocytochemistry (CB-ICC) and flow cytometric immunophenotyping (FCI) or core needle biopsy (CNB) combined with immunohistochemistry (IHC) without open surgery. Total thyroidectomy was performed in one patient without other diagnostic methods because the FNAC result was inconclusive. Four patients with moderate to severe dyspnoea underwent tracheostomy and incisional biopsy without severe complications after tracheal intubation under the guidance of a fibreoptic bronchoscope performed without general anaesthesia.</p><p><strong>Conclusions: </strong>For patients with mild to moderate dyspnoea suspected of PTL, FNAC along with FCI and CB-ICC or CNB along with IHC are recommended, in addition to prompt chemotherapy to avoid prophylactic tracheostomy. Patients with moderate to severe dyspnoea suspected of PTL should undergo tracheal intubation under the guidance of a fibreoptic bronchoscope without general anaesthesia, followed by tracheostomy with simultaneous thyroid incisional biopsy to reduce the risk of asphyxia during treatment.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 2","pages":"108-113"},"PeriodicalIF":2.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/9f/aoi-2023-02-108.PMC10132482.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9356169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of relapses of benign latero-cervical pathology: a narrative literature review. 良性颈后病变复发的治疗:叙述性文献回顾。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-suppl.1-43-2023-10
Piero Giuseppe Meliante, Andrea Colizza, Massimo Ralli, Antonio Minni, Diletta Angeletti, Francesca Cambria, Marco de Vincentiis
SUMMARY Benign laterocervical pathologies are not without pitfalls. Many may relapse after many years and, sometimes, they cannot be predicted. The purpose of this review is to describe the surgical measures necessary for the treatment of relapses of the most common benign laterocervical masses. We searched PubMed, Embase and Cochrane Central Register of Controlled Trials databases for articles describing the treatment of the most common benign cervical disease recurrences, and summarised available evidence in this narrative review. We overviewed observations about recurrent benign mixed tumour (pleomorphic adenoma), parapharyngeal space tumours and carotid body paragangliomas, thyroglossal duct anomalies and branchial cleft anomalies. Proper surgical technique is crucial for safely and effectively managing the relapses of benign latero-cervical diseases. Radiotherapy is indicated in several cases of recurrence such as pleomorphic adenoma and unresectable paraganglioma. Long-term follow-up is of utmost importance to promptly recognise and treat recurrencies.
{"title":"Treatment of relapses of benign latero-cervical pathology: a narrative literature review.","authors":"Piero Giuseppe Meliante,&nbsp;Andrea Colizza,&nbsp;Massimo Ralli,&nbsp;Antonio Minni,&nbsp;Diletta Angeletti,&nbsp;Francesca Cambria,&nbsp;Marco de Vincentiis","doi":"10.14639/0392-100X-suppl.1-43-2023-10","DOIUrl":"https://doi.org/10.14639/0392-100X-suppl.1-43-2023-10","url":null,"abstract":"SUMMARY Benign laterocervical pathologies are not without pitfalls. Many may relapse after many years and, sometimes, they cannot be predicted. The purpose of this review is to describe the surgical measures necessary for the treatment of relapses of the most common benign laterocervical masses. We searched PubMed, Embase and Cochrane Central Register of Controlled Trials databases for articles describing the treatment of the most common benign cervical disease recurrences, and summarised available evidence in this narrative review. We overviewed observations about recurrent benign mixed tumour (pleomorphic adenoma), parapharyngeal space tumours and carotid body paragangliomas, thyroglossal duct anomalies and branchial cleft anomalies. Proper surgical technique is crucial for safely and effectively managing the relapses of benign latero-cervical diseases. Radiotherapy is indicated in several cases of recurrence such as pleomorphic adenoma and unresectable paraganglioma. Long-term follow-up is of utmost importance to promptly recognise and treat recurrencies.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 Suppl 1","pages":"S76-S83"},"PeriodicalIF":2.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/06/aoi-2023-02-S76.PMC10159646.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non neoplastic recurrences in otorhinolaryngological diseases. 耳鼻喉科疾病的非肿瘤性复发。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-suppl.1-43-2023
Marco Benazzo
{"title":"Non neoplastic recurrences in otorhinolaryngological diseases.","authors":"Marco Benazzo","doi":"10.14639/0392-100X-suppl.1-43-2023","DOIUrl":"https://doi.org/10.14639/0392-100X-suppl.1-43-2023","url":null,"abstract":"","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 Suppl 1","pages":"S1-S122"},"PeriodicalIF":2.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10596343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid-split tracheostomy: short- and long-term outcomes. 甲状腺分裂气管切开术:短期和长期的结果。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-N2192
Nir Tsur, Ella Segal, Eyal Yosefof, Noam Koch, Idan Zeeman, Ella Reifen, Ory Wiesel, Gideon Bachar, Esmat Najjar

Objective: Compare long-term outcomes of thyroid-split and standard thyroid-retraction tracheostomy in a large cohort.

Methods: The healthcare database of a university-affiliated hospital was searched for past patients over 18 years of age from all of the hospital's wards on whom an ear, nose, and throat specialist performed a tracheostomy in the operating room between 2010 and 2020. Clinical data were extracted from the hospital and outpatient medical records. Life-threatening and non-life-threatening intra-operative and early and late post-operative adverse events in patients who underwent split-thyroid tracheostomy were compared with those who underwent standard tracheostomy.

Results: There was no significant difference in intra-operative and early post-operative complications, hospitalisation length, or early reoperation and death rates between the 140 (28%) thyroid-split tracheostomy patients and the 354 (72%) standard tracheostomy patients, although the thyroid-split group had more non-decannulated patients and a longer operative time.

Conclusions: Thyroid-split tracheostomy is safe and feasible. Compared to the standard procedure, it provides better exposure and a similar rate of complications, although its de-cannulation success rate is lower.

目的:比较大队列中甲状腺分裂气管切开术和标准甲状腺后缩气管切开术的远期疗效。方法:检索某大学附属医院的卫生保健数据库,检索2010年至2020年期间在该医院所有病房进行过耳鼻喉科专家气管切开术的18岁以上患者。临床资料提取自医院和门诊病历。比较甲状腺裂气管切开术患者术中危及生命和非危及生命的不良事件以及术后早期和晚期的不良事件。结果:140例甲裂气管造口术患者(28%)与354例标准气管造口术患者(72%)在术中、术后早期并发症、住院时间、早期再手术及死亡率方面无显著差异,但甲裂气管造口术组非脱管患者较多,手术时间较长。结论:甲状裂气管切开术安全可行。与标准程序相比,它提供了更好的暴露和相似的并发症发生率,尽管其脱管成功率较低。
{"title":"Thyroid-split tracheostomy: short- and long-term outcomes.","authors":"Nir Tsur,&nbsp;Ella Segal,&nbsp;Eyal Yosefof,&nbsp;Noam Koch,&nbsp;Idan Zeeman,&nbsp;Ella Reifen,&nbsp;Ory Wiesel,&nbsp;Gideon Bachar,&nbsp;Esmat Najjar","doi":"10.14639/0392-100X-N2192","DOIUrl":"https://doi.org/10.14639/0392-100X-N2192","url":null,"abstract":"<p><strong>Objective: </strong>Compare long-term outcomes of thyroid-split and standard thyroid-retraction tracheostomy in a large cohort.</p><p><strong>Methods: </strong>The healthcare database of a university-affiliated hospital was searched for past patients over 18 years of age from all of the hospital's wards on whom an ear, nose, and throat specialist performed a tracheostomy in the operating room between 2010 and 2020. Clinical data were extracted from the hospital and outpatient medical records. Life-threatening and non-life-threatening intra-operative and early and late post-operative adverse events in patients who underwent split-thyroid tracheostomy were compared with those who underwent standard tracheostomy.</p><p><strong>Results: </strong>There was no significant difference in intra-operative and early post-operative complications, hospitalisation length, or early reoperation and death rates between the 140 (28%) thyroid-split tracheostomy patients and the 354 (72%) standard tracheostomy patients, although the thyroid-split group had more non-decannulated patients and a longer operative time.</p><p><strong>Conclusions: </strong>Thyroid-split tracheostomy is safe and feasible. Compared to the standard procedure, it provides better exposure and a similar rate of complications, although its de-cannulation success rate is lower.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 2","pages":"99-107"},"PeriodicalIF":2.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/5d/aoi-2023-02-99.PMC10132481.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9356167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skull-vibration-induced nystagmus test in patients who are candidates for intratympanic gentamicin injection. 鼓膜内庆大霉素注射候选患者的颅骨振动诱发眼球震颤试验。
IF 2 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2023-04-01 DOI: 10.14639/0392-100X-N2152
Giacomo Ciacca, Alfredo Di Giovanni, Luigi Califano, Vito Enrico Pettorossi, Giampietro Ricci, Chiara Pelliccia, Mario Faralli

Objective: This study aims to evaluate the utility of the skull-vibration-induced nystagmus test (SVINT) in the selection of patients with Ménière's disease (MD) for intratympanic injection of gentamicin. To date the indications for this treatment have been based only on subjective elements.

Methods: A retrospective study was performed in 20 patients diagnosed with unilateral MD. SVINT were performed monthly and the evoked responses were evaluated. After 6 months, the results from patients who were candidates for gentamicin treatment (G group) were compared with those who did not need it (nG group). Correlation with Dizziness Handicap Inventory (DHI) score was evaluated.

Results: 120 tests were performed. Positive SVINTs were identified in 52 cases (43.3%) and included excitatory nystagmus in 18 (34.7%), inhibitory nystagmus in 28 (53.8%), and atypical pattern in 6 cases (11.5%). A significant increase excitatory nystagmus was recorded in group G (p = 0.00001). Moreover, there was a significant increase in the DHI score in group G compared with the nG group (p < 0.0001) and in patients with evoked excitatory nystagmus.

Conclusions: The finding of excitatory nystagmus during SVINTs performed on several occasions in the follow-up prior to intratympanic injection of gentamicin strengthens this therapeutic choice.

目的:探讨震动诱发眼球震颤试验(SVINT)在选择鼓膜内注射庆大霉素患者中的应用价值。迄今为止,这种治疗的适应症仅基于主观因素。方法:对20例诊断为单侧MD的患者进行回顾性研究,每月进行SVINT,并评估诱发反应。6个月后,将庆大霉素候选治疗组(G组)与不需要庆大霉素治疗组(nG组)的结果进行比较。评估与头晕障碍量表(DHI)评分的相关性。结果:共进行了120次试验。svint阳性52例(43.3%),其中兴奋性眼球震颤18例(34.7%),抑制性眼球震颤28例(53.8%),非典型眼球震颤6例(11.5%)。G组兴奋性眼球震颤显著增加(p = 0.00001)。此外,与nG组和诱发性兴奋性眼球震颤患者相比,G组的DHI评分显著升高(p < 0.0001)。结论:在鼓室内注射庆大霉素之前进行的几次svint随访中发现兴奋性眼球震颤,加强了这种治疗选择。
{"title":"Skull-vibration-induced nystagmus test in patients who are candidates for intratympanic gentamicin injection.","authors":"Giacomo Ciacca,&nbsp;Alfredo Di Giovanni,&nbsp;Luigi Califano,&nbsp;Vito Enrico Pettorossi,&nbsp;Giampietro Ricci,&nbsp;Chiara Pelliccia,&nbsp;Mario Faralli","doi":"10.14639/0392-100X-N2152","DOIUrl":"https://doi.org/10.14639/0392-100X-N2152","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the utility of the skull-vibration-induced nystagmus test (SVINT) in the selection of patients with Ménière's disease (MD) for intratympanic injection of gentamicin. To date the indications for this treatment have been based only on subjective elements.</p><p><strong>Methods: </strong>A retrospective study was performed in 20 patients diagnosed with unilateral MD. SVINT were performed monthly and the evoked responses were evaluated. After 6 months, the results from patients who were candidates for gentamicin treatment (G group) were compared with those who did not need it (nG group). Correlation with Dizziness Handicap Inventory (DHI) score was evaluated.</p><p><strong>Results: </strong>120 tests were performed. Positive SVINTs were identified in 52 cases (43.3%) and included excitatory nystagmus in 18 (34.7%), inhibitory nystagmus in 28 (53.8%), and atypical pattern in 6 cases (11.5%). A significant increase excitatory nystagmus was recorded in group G (p = 0.00001). Moreover, there was a significant increase in the DHI score in group G compared with the nG group (p < 0.0001) and in patients with evoked excitatory nystagmus.</p><p><strong>Conclusions: </strong>The finding of excitatory nystagmus during SVINTs performed on several occasions in the follow-up prior to intratympanic injection of gentamicin strengthens this therapeutic choice.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 2","pages":"140-148"},"PeriodicalIF":2.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/e3/aoi-2023-02-140.PMC10132480.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9349275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Acta Otorhinolaryngologica Italica
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