Abstract—The paper presents an attempt to estimate the contribution of thermal processes in the Earth’s crust to earthquake generation. As a case study, the seismically active junction zone of the Chu depression and Kyrgyz ridge of the Northern Tien Shan is considered. The analysis is based on the previously constructed models of temperature, petrophysical characteristics, and elastic moduli. The silica content model derived from seismic tomography data is used to build a lithotype model. The thermal conductivity model is constructed and used in conjunction with the temperature model to create a depth model of the heat flow density. The shear stress and thermoelastic stress models derived from density, elastic moduli, and temperature models are compared with the distribution of earthquake hypocenters in the region. The comparison suggests that on the scale of the seismically active junction zone of the Chu depression and the Kyrgyz ridge of the Northern Tien Shan, seismicity is mainly determined by thermomechanical effect induced by hot ascending flow of acid magma rising from the upper mantle beneath the Muyunkum–Narat median massif.