The open orthopaedics journal最新文献

Ankle Fusion Rates using Composite Peptide-enriched Bone Graft 使用复合肽骨移植的踝关节融合率

The open orthopaedics journal

Pub Date : 2024-02-12 DOI: 10.2174/0118743250283784231211111719

Luke S. McKinnon, Michael J. Symes, Andrew Wines, R. Mittal

Joint fusion is a widely accepted treatment option for debilitating arthritis and deformity in the foot and ankle. Autologous bone grafting has long been accepted as the gold standard form of bone grafting; however, it can still be associated with non-union. This study aims to investigate joint fusion rates using Composite Peptide Enhanced Bone Graft (CPEBG) as an adjunct during ankle fusion surgery. Data was collected retrospectively for patients over the age of 18 years, undergoing ankle fusion between June 2016 and August 2020 with autologous bone graft and CPEBG. All patients had their primary or secondary procedure performed by a single surgeon with follow-up at 6 and 12 months post-operatively. Data included baseline demographic data and procedural characteristics. The primary endpoint was to assess joint union at 6 and 12 months, respectively. Secondary objectives included post-operative pain, mobility and the use of walking aids. Radiographic union rates for the primary group were 40/48 (83%) and 43/48 (90%) at 6 and 12 months and 2/3 (67%) and 3/3 (100%) at 6 and 12 months for the secondary group, respectively. The overall non-union rate for primary ankle fusions was 8%, while no non-unions were observed in the secondary group. CPEBG in foot and ankle fusion procedures yields similar union rates compared to other graft options. Further well-designed randomised control trials are warranted to confirm these findings.

关节融合术是治疗足踝关节炎和畸形的一种广为接受的方法。长期以来，自体骨移植一直被认为是骨移植的金标准，但仍有可能出现不愈合的情况。本研究旨在调查在踝关节融合手术中使用复合肽增强型骨移植（CPEBG）作为辅助手段的关节融合率。研究回顾性收集了2016年6月至2020年8月期间接受自体骨移植和CPEBG踝关节融合术的18岁以上患者的数据。所有患者的主要或次要手术均由一名外科医生完成，并在术后 6 个月和 12 个月进行随访。数据包括基线人口统计学数据和手术特征。主要终点分别是评估6个月和12个月时的关节结合情况。次要目标包括术后疼痛、活动能力和行走辅助工具的使用情况。在6个月和12个月时，初级组的X光片结合率分别为40/48（83%）和43/48（90%）；在6个月和12个月时，次级组的X光片结合率分别为2/3（67%）和3/3（100%）。初次踝关节融合术的总体非愈合率为 8%，而二次组未观察到非愈合。与其他移植物相比，CPEBG 在足踝融合术中的结合率相近。为了证实这些研究结果，有必要进一步开展设计良好的随机对照试验。

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引用次数: 0

Ankle Fusion Rates using Composite Peptide-enriched Bone Graft 使用复合肽骨移植的踝关节融合率

The open orthopaedics journal

Pub Date : 2024-02-12 DOI: 10.2174/0118743250283784231211111719

Luke S. McKinnon, Michael J. Symes, Andrew Wines, R. Mittal

Joint fusion is a widely accepted treatment option for debilitating arthritis and deformity in the foot and ankle. Autologous bone grafting has long been accepted as the gold standard form of bone grafting; however, it can still be associated with non-union. This study aims to investigate joint fusion rates using Composite Peptide Enhanced Bone Graft (CPEBG) as an adjunct during ankle fusion surgery. Data was collected retrospectively for patients over the age of 18 years, undergoing ankle fusion between June 2016 and August 2020 with autologous bone graft and CPEBG. All patients had their primary or secondary procedure performed by a single surgeon with follow-up at 6 and 12 months post-operatively. Data included baseline demographic data and procedural characteristics. The primary endpoint was to assess joint union at 6 and 12 months, respectively. Secondary objectives included post-operative pain, mobility and the use of walking aids. Radiographic union rates for the primary group were 40/48 (83%) and 43/48 (90%) at 6 and 12 months and 2/3 (67%) and 3/3 (100%) at 6 and 12 months for the secondary group, respectively. The overall non-union rate for primary ankle fusions was 8%, while no non-unions were observed in the secondary group. CPEBG in foot and ankle fusion procedures yields similar union rates compared to other graft options. Further well-designed randomised control trials are warranted to confirm these findings.

关节融合术是治疗足踝关节炎和畸形的一种广为接受的方法。长期以来，自体骨移植一直被认为是骨移植的金标准，但仍有可能出现不愈合的情况。本研究旨在调查在踝关节融合手术中使用复合肽增强型骨移植（CPEBG）作为辅助手段的关节融合率。研究回顾性收集了2016年6月至2020年8月期间接受自体骨移植和CPEBG踝关节融合术的18岁以上患者的数据。所有患者的主要或次要手术均由一名外科医生完成，并在术后 6 个月和 12 个月进行随访。数据包括基线人口统计学数据和手术特征。主要终点分别是评估6个月和12个月时的关节结合情况。次要目标包括术后疼痛、活动能力和行走辅助工具的使用情况。在6个月和12个月时，初级组的X光片结合率分别为40/48（83%）和43/48（90%）；在6个月和12个月时，次级组的X光片结合率分别为2/3（67%）和3/3（100%）。初次踝关节融合术的总体非愈合率为 8%，而二次组未观察到非愈合。与其他移植物相比，CPEBG 在足踝融合术中的结合率相近。为了证实这些研究结果，有必要进一步开展设计良好的随机对照试验。

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引用次数: 0

Long Term Results of Innovative Procedure in Surgical Management of Chronic Lymphedema. 慢性淋巴水肿外科治疗创新手术的长期结果。

The open orthopaedics journal

Pub Date : 2016-11-17 eCollection Date: 2016-01-01 DOI: 10.2174/1874325001610010543

Seyed R Mousavi

Background: Lymphedema is the result of impaired lymphatic drainage by the affected organ. This abnormality can be primary or secondary. Different operative approaches have been introduced to treat chronic lymphedema.

Materials and methods: This retrospective study included 816 patients who were diagnosed with chronic lower extremity lymphedema and did not respond to non-operative management for at least six months. Data was collected over 25 years, between March 1987 and March 2013. Doppler ultrasonography of the deep venous system was routinely undertaken in all patients to confirm patency. The patients underwent surgery and their progress was followed for at least one year postoperatively.

Results: All patients were operated by the suggested technique and long term fallow-up which is a modified form of the Homan's technique. The outcome was excellent, and 89.2% of patients were free of complication and 2% had poor results. The most common complication was wound seroma and wound infection.

Conclusion: The long term results and considering the difficulties associated with the treatment of chronic lymphedema and the variety of surgical options, our method achieved excellent results, and may be proposed for the standard operative procedure for treating intractable forms of this disease.

背景：淋巴水肿是受影响器官的淋巴引流受损的结果。这种异常可以是主要的，也可以是次要的。已经介绍了不同的手术方法来治疗慢性淋巴水肿。材料和方法：这项回顾性研究包括816名被诊断为慢性下肢淋巴水肿的患者，他们对非手术治疗至少六个月没有反应。数据收集时间为1987年3月至2013年3月，历时25年。对所有患者常规进行深静脉系统的多普勒超声检查，以确认其通畅性。患者接受了手术，术后至少随访一年。结果：所有患者均按建议的方法进行了手术，长期随访是Homan技术的改良形式。结果非常好，89.2%的患者没有并发症，2%的患者效果不佳。最常见的并发症是伤口血清瘤和伤口感染。结论：从长期疗效来看，考虑到慢性淋巴水肿治疗的困难和手术选择的多样性，我们的方法取得了良好的效果，可作为治疗该病顽固性的标准手术方法。

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引用次数: 0