Vawda Nafeesa, Banerjee Robyn N, Debenham Brock J, Semaka Amy
{"title":"Clinicopathological Factors in Predicting Outcomes in Patients with Human Papilloma Virus (HPV) Associated Oropharyngeal Carcinoma (OPC) Treated with Primary Surgery","authors":"Vawda Nafeesa, Banerjee Robyn N, Debenham Brock J, Semaka Amy","doi":"10.36959/915/581","DOIUrl":"https://doi.org/10.36959/915/581","url":null,"abstract":"","PeriodicalId":113553,"journal":{"name":"Journal of Oral Cancer and Research","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114498795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral ID® as an Adjunctive Tool for Surgical Margin in Patients with Oral Squamous Cell Carcinoma: A Comparative Study","authors":"Mohamed Yassmin Abdalla","doi":"10.36959/915/580","DOIUrl":"https://doi.org/10.36959/915/580","url":null,"abstract":"","PeriodicalId":113553,"journal":{"name":"Journal of Oral Cancer and Research","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131458761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The presence of nodal metastasis from OSCC is the single most important prognostic feature. Extranodal extension further decreases survival by approximately half. Clinical evaluation of the nodal basin has been found to correlate poorly with pathological nodal status. Objectives: Determine the congruency between clinical and pathological nodal status and the incidence of extranodal extension (ENE). Describe the frequency distribution of age, sex, smoking habits, anatomical location, and histology in a South African population. Methods: Ninety-one consecutive cases of oral squamous cell carcinoma were retrospectively studied and the clinical (cN) and pathological (pN) TNM nodal staging compared using the 8th edition of the AJCC/UICC TNM staging system. Extranodal extension was determined in all patients with OSCC, as well as in the subgroup with clinically nodal negative (cN0) disease. The socio-demographical information was described. Results: The cN and pN were congruent in 41.7% (n = 38/91), upstaged in 35.2% (n = 32/91), and down staged in 23.1% (n = 21/91) of cases. Twenty-two patients (24.2%) had pathological evidence of ENE. Males and females constituted 67% and 33% of the study sample, respectively. The median age at the time of diagnosis was 57.3 years (range 5-85 years). A smoking history was present in 73.6%, absent in 14.3%, and unknown in 12.1% of patients. The tongue (38.4%) and floor of mouth (29.7%) were the most common anatomical subsites for primary tumours. Most tumours were conventional squamous cell carcinomas with poorly differentiated grade (62.6%) Conclusion: There is poor correlation between clinical and pathological nodal status when the 8th TNM staging is used. ENE at the time of diagnosis is common among patients with OSCC.
{"title":"The Correlation between Clinical and Pathological Lymph Node Status in Oral Squamous Cell Carcinoma","authors":"Rabie Evan Roche, Schouwstra Ciska-Mari","doi":"10.36959/915/578","DOIUrl":"https://doi.org/10.36959/915/578","url":null,"abstract":"Introduction: The presence of nodal metastasis from OSCC is the single most important prognostic feature. Extranodal extension further decreases survival by approximately half. Clinical evaluation of the nodal basin has been found to correlate poorly with pathological nodal status. Objectives: Determine the congruency between clinical and pathological nodal status and the incidence of extranodal extension (ENE). Describe the frequency distribution of age, sex, smoking habits, anatomical location, and histology in a South African population. Methods: Ninety-one consecutive cases of oral squamous cell carcinoma were retrospectively studied and the clinical (cN) and pathological (pN) TNM nodal staging compared using the 8th edition of the AJCC/UICC TNM staging system. Extranodal extension was determined in all patients with OSCC, as well as in the subgroup with clinically nodal negative (cN0) disease. The socio-demographical information was described. Results: The cN and pN were congruent in 41.7% (n = 38/91), upstaged in 35.2% (n = 32/91), and down staged in 23.1% (n = 21/91) of cases. Twenty-two patients (24.2%) had pathological evidence of ENE. Males and females constituted 67% and 33% of the study sample, respectively. The median age at the time of diagnosis was 57.3 years (range 5-85 years). A smoking history was present in 73.6%, absent in 14.3%, and unknown in 12.1% of patients. The tongue (38.4%) and floor of mouth (29.7%) were the most common anatomical subsites for primary tumours. Most tumours were conventional squamous cell carcinomas with poorly differentiated grade (62.6%) Conclusion: There is poor correlation between clinical and pathological nodal status when the 8th TNM staging is used. ENE at the time of diagnosis is common among patients with OSCC.","PeriodicalId":113553,"journal":{"name":"Journal of Oral Cancer and Research","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126237629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acetaldehyde, a product of alcohol metabolism, has been recognized a risk factor for carcinogenesis. To clarify the carcinogenic effects of acetaldehyde in the oral cavity and mechanisms involved, normal oral epithelial cells were incubated with several concentrations of acetaldehyde and assays of genetic and epigenetic changes were performed. Acetaldehyde induced malignant transformation of normal oral epithelial cells and demethylation of the erbB2 gene. In addition, regulation of DNA methylation was suppressed when cells were subjected to alternating exposure to medium containing acetaldehyde and medium without acetaldehyde. These findings suggest that habitual alcohol drinking increases the risk of developing oral cancer, and that an appropriate abstinence period may reduce this risk.
{"title":"Influence of Acetaldehyde on Oral Epithelial Cells","authors":"Miyazaki Yuji, Okuyama Ayako, Hoshino Miyako, Nishimura Michiko, Kikuchi Kentaro","doi":"10.36959/915/577","DOIUrl":"https://doi.org/10.36959/915/577","url":null,"abstract":"Acetaldehyde, a product of alcohol metabolism, has been recognized a risk factor for carcinogenesis. To clarify the carcinogenic effects of acetaldehyde in the oral cavity and mechanisms involved, normal oral epithelial cells were incubated with several concentrations of acetaldehyde and assays of genetic and epigenetic changes were performed. Acetaldehyde induced malignant transformation of normal oral epithelial cells and demethylation of the erbB2 gene. In addition, regulation of DNA methylation was suppressed when cells were subjected to alternating exposure to medium containing acetaldehyde and medium without acetaldehyde. These findings suggest that habitual alcohol drinking increases the risk of developing oral cancer, and that an appropriate abstinence period may reduce this risk.","PeriodicalId":113553,"journal":{"name":"Journal of Oral Cancer and Research","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115838482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Head and neck cancer (HNC) is the seventh most common cancer worldwide [1], with 887,659 new cases in 2018 [2]. The time trends in HNC rates from 1983 to 2002 vary by geography [3]. The 2018 age-standardized rate of oral cavity varies from 1.2 per 100,000 in Western Africa to 12.9 in Southeast Asia [2]. The major risk factors are tobacco and alcohol for all HNC subsites, except for HPV infection which is likely the major cause of oropharyngeal cancer in developed countries.
{"title":"Global Perspective on Understanding the Potential Benefits and Risks of E-Cigarette use on Head and Neck Cancer","authors":"Muscat Joshua E, Wenxue Lin","doi":"10.36959/915/574","DOIUrl":"https://doi.org/10.36959/915/574","url":null,"abstract":"Head and neck cancer (HNC) is the seventh most common cancer worldwide [1], with 887,659 new cases in 2018 [2]. The time trends in HNC rates from 1983 to 2002 vary by geography [3]. The 2018 age-standardized rate of oral cavity varies from 1.2 per 100,000 in Western Africa to 12.9 in Southeast Asia [2]. The major risk factors are tobacco and alcohol for all HNC subsites, except for HPV infection which is likely the major cause of oropharyngeal cancer in developed countries.","PeriodicalId":113553,"journal":{"name":"Journal of Oral Cancer and Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133702374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Gagik, Yessayan Lazar, K. Margarita, Tunyan Gegam, G. Laura, Khachatryn Gagik
84 patients with mild chronic periodontitis were participated in this study who received initial periodontal therapy. All patients underwent a thorough clinical and laborator examination including a determination of the serum osteocalcin content, at the beginning of the study and 1, 3 months after therapy.
{"title":"Monitoring the Effects of Combinatet Treatment Chronic Periodontitis Using Bone Metabolism Biomarker Osteocalcin","authors":"H. Gagik, Yessayan Lazar, K. Margarita, Tunyan Gegam, G. Laura, Khachatryn Gagik","doi":"10.36959/915/575","DOIUrl":"https://doi.org/10.36959/915/575","url":null,"abstract":"84 patients with mild chronic periodontitis were participated in this study who received initial periodontal therapy. All patients underwent a thorough clinical and laborator examination including a determination of the serum osteocalcin content, at the beginning of the study and 1, 3 months after therapy.","PeriodicalId":113553,"journal":{"name":"Journal of Oral Cancer and Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124407489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral cancers are among the 10 most common tumors in Europe and the United States. The major recognized risk factors include smoking and alcohol what is possible explanation for higher incidence among men. The risk of developing a tumor of the oral cavity is 38 times higher in the population that consuming alcohol and cigarettes. Cancer of the oral cavity is a serious disease and only half of the patients survive the next five years. According to the World Health Organization classification, oral cancer includes malignant tumors in the lips area, anterior two thirds tongue, gingiva, bottom of the oral cavity, retromolar triangle, hard palate and mucous membranes of the oral cavity. In spite of the advancement of medicine, оral cancer remains a malignant tumor with a high mortality rate. The reason for this was primarily enhanced by the tumor stage at the time of diagnosis. On the other hand, the oral cancer is a tumor that can be detected by a simple examination of the oral mucosa at an early stage, before it starts to cause symptoms.
{"title":"Oral Cancer: Incidence and Management","authors":"M. Ivan, P. Ana","doi":"10.36959/915/573","DOIUrl":"https://doi.org/10.36959/915/573","url":null,"abstract":"Oral cancers are among the 10 most common tumors in Europe and the United States. The major recognized risk factors include smoking and alcohol what is possible explanation for higher incidence among men. The risk of developing a tumor of the oral cavity is 38 times higher in the population that consuming alcohol and cigarettes. Cancer of the oral cavity is a serious disease and only half of the patients survive the next five years. According to the World Health Organization classification, oral cancer includes malignant tumors in the lips area, anterior two thirds tongue, gingiva, bottom of the oral cavity, retromolar triangle, hard palate and mucous membranes of the oral cavity. In spite of the advancement of medicine, оral cancer remains a malignant tumor with a high mortality rate. The reason for this was primarily enhanced by the tumor stage at the time of diagnosis. On the other hand, the oral cancer is a tumor that can be detected by a simple examination of the oral mucosa at an early stage, before it starts to cause symptoms.","PeriodicalId":113553,"journal":{"name":"Journal of Oral Cancer and Research","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122499945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The cervical lymph node (N) status is an important determinant of the prognosis of oral squamous cell carcinoma (SCC). The treatment strategy administered with regard to the N status of a patient greatly affects prognosis. However, it is difficult to completely diagnose the N status preoperatively and the development of secondary cervical lymph node metastasis.
{"title":"Cervical Lymph Node Metastatic Factors in the Preoperative Diagnosis of Oral Squamous Cell Carcinoma","authors":"Kondo Yuudai, Tagawa Yuri, Tamura Tomohiro, Noumi Kenta, Yamamoto Kouji, K. Takeshi, Suehiro Yuusaku, Yamashita Yoshihiro","doi":"10.36959/915/572","DOIUrl":"https://doi.org/10.36959/915/572","url":null,"abstract":"The cervical lymph node (N) status is an important determinant of the prognosis of oral squamous cell carcinoma (SCC). The treatment strategy administered with regard to the N status of a patient greatly affects prognosis. However, it is difficult to completely diagnose the N status preoperatively and the development of secondary cervical lymph node metastasis.","PeriodicalId":113553,"journal":{"name":"Journal of Oral Cancer and Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122303088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cherkas Elliot, Banoub Rapheal, Tuluc Madalina, Rao Neeta, Khan Majid, Champion Allen, Gates James C
{"title":"Does Clinical or Radiologic Exam Better Predict Carcinomatous Invasion of the Jaw?","authors":"Cherkas Elliot, Banoub Rapheal, Tuluc Madalina, Rao Neeta, Khan Majid, Champion Allen, Gates James C","doi":"10.36959/915/582","DOIUrl":"https://doi.org/10.36959/915/582","url":null,"abstract":"","PeriodicalId":113553,"journal":{"name":"Journal of Oral Cancer and Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131006958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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