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Leishmaniasis - General Aspects of a Stigmatized Disease [Working Title]最新文献

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Use of Cell Biology to Identify Cellular Targets in Drug Development Process against Leishmania Sp. 利用细胞生物学鉴定抗利什曼原虫药物开发过程中的细胞靶点。
Pub Date : 2021-12-30 DOI: 10.5772/intechopen.101662
Gabrielle dos Santos da Silva e Miranda, Joseane Lima Prado Godinho, Sara Teixeira de Macedo-Silva, Brunno Renato Farias Verçoza, Alisson Amaral da Rocha, Milena Barenco Pires de Abreu Sodré, Victor Feliciano dos Santos Ramos, Juliany Cola Fernandes Rodrigues
Leishmaniasis is one of the most important neglected tropical diseases. The chemotherapy for its treatment uses very toxic compounds with a low efficacy rate. Thus, there is an urgent need to develop new chemotherapeutic agents to help countries control this devasting disease. In drug development, different approaches can be used to identify potential cellular targets that allow us to understand better the cell biology of eukaryotic cells. Several groups are dedicated to studying new molecules, searching for promising candidates against Leishmania. Different techniques have been used to characterize the cell biology, biochemistry, and molecular biology alterations induced by the treatments, trying to understand the mechanisms of action. The main goal of this chapter is to describe an overview of the literature exploring the several studies published about the chemotherapy of anti-Leishmania concerning the mechanisms of action of different classes of molecules or therapeutic alternatives.
利什曼病是最重要的被忽视的热带病之一。治疗这种疾病的化学疗法使用毒性很强的化合物,而且有效率很低。因此,迫切需要开发新的化疗药物来帮助各国控制这一毁灭性疾病。在药物开发中,可以使用不同的方法来识别潜在的细胞靶标,使我们能够更好地了解真核细胞的细胞生物学。有几个小组致力于研究新的分子,寻找对抗利什曼原虫的有希望的候选分子。不同的技术已被用于表征细胞生物学,生物化学和分子生物学的变化诱导的治疗,试图了解作用机制。本章的主要目的是概述文献,探讨几项关于抗利什曼原虫化疗的研究,涉及不同类别的分子或治疗方案的作用机制。
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引用次数: 0
Toward New Antileishmanial Compounds: Molecular Targets for Leishmaniasis Treatment 抗利什曼病新化合物:治疗利什曼病的分子靶点
Pub Date : 2021-12-04 DOI: 10.5772/intechopen.101132
H. Istanbullu, Gulsah Bayraktar
The leishmaniases are a group of diseases caused by protozoan parasites—Leishmania sp. Leishmaniasis is classified among the 20 neglected diseases by WHO. Although the disease has been known for more than 120 years, the number of drugs used for the treatment is still limited to 5–6. The first-line drugs against leishmaniasis are pentavalent antimonials, which were introduced to the treatment 70 years ago—despite all their side effects. Molecular targets are becoming increasingly important for efficacy and selectivity in postgenomic drug research studies. In this chapter, we have discussed potential therapeutic targets of antileishmanial drug discovery such as pteridine reductase (PTR1), trypanothione reductase (TR), N-myristoyltransferase (NMT), trypanothione synthetase (TryS), IU-nucleoside hydrolase, and topoisomerases, enzymes and their inhibitors reported in the literature.
利什曼病是由原虫寄生虫引起的一类疾病。利什曼病被世界卫生组织列为20种被忽视的疾病之一。虽然这种疾病已经被发现了120多年,但用于治疗这种疾病的药物数量仍然有限,只有5-6种。治疗利什曼病的一线药物是五价锑,70年前就被引入治疗,尽管它们有很多副作用。在后基因组药物研究中,分子靶点对药物的有效性和选择性越来越重要。在本章中,我们讨论了抗利什曼原虫药物发现的潜在治疗靶点,如蝶啶还原酶(PTR1)、锥虫硫酮还原酶(TR)、n -肉豆醇基转移酶(NMT)、锥虫硫酮合成酶(TryS)、u核苷水解酶、拓扑异构酶、酶及其抑制剂等。
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引用次数: 1
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Leishmaniasis - General Aspects of a Stigmatized Disease [Working Title]
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