A. Ogunmoye, O. ATEWOLARA-ODULE, O. Olubomehin, S. Ogundare, S. Yussuf
Alternanthera pungens Kunth commonly called khaki weed is from the family Amaranthaceae. It is a herbaceous perennial plant that has stems prostrate, rarely rising and about 10-50 cm long. The work was carried out due to the scarcity of information on the volatile constituents from the plant leaves despite works on the flower and other parts. The extraction of the essential oils from the dried leaves was carried out by the hydro distillation method using an all-glass Clevenger apparatus. The extracted oils were then analyzed using gas chromatography-mass spectrometry (GC-MS). A total of twelve constituents' representing 93.39% of A. Pungens oil with a yield of 0.4% (v/w) was obtained. The analysis of the GC-MS results of the leaf oil showed that it was dominated by â-ionone (42.18%) and hexahydrofarnesyl acetone (15.53%), others in trace amounts include; methyl palmitate (6.13%), 1octadecyne (4.72%), undecane (3.73%), para-mentha-1, 3, 8-triene (3.65%), isophytol (3.21%), ?cadinene (3.06%), 1, 2-dimethyl cyclooctene (3.05%), para-cymene (2.96%), phytol (2.67%) and neophytadiene (2.50%). The common classes of compounds present in the leaves oil are aceto monocyclic monoterpenoid (42.18%), sesquiterpenoids (18.59%), hydrocarbons (11.50%), diterpenoids (8.38%), monoterpenes (6.61%) and fatty acids (6.13%).The constituents and the compositional pattern of essential oil identified from the leaves of Alternanthera pungens grown in Nigeria differ quantitatively and qualitatively from previously reported member of the genus and the presence of sesquiterpenoid as one of the major components of the oils justify the traditional use of the plants in treating pains, headaches and inflammations.
{"title":"THE CHEMICAL CONSTITUENTS' OF THE LEAVE ESSENTIAL OIL OF ALTERNANTHERA PUNGENS (KUNTH)","authors":"A. Ogunmoye, O. ATEWOLARA-ODULE, O. Olubomehin, S. Ogundare, S. Yussuf","doi":"10.46881/ajsn.v10i0.185","DOIUrl":"https://doi.org/10.46881/ajsn.v10i0.185","url":null,"abstract":"Alternanthera pungens Kunth commonly called khaki weed is from the family Amaranthaceae. It is a herbaceous perennial plant that has stems prostrate, rarely rising and about 10-50 cm long. The work was carried out due to the scarcity of information on the volatile constituents from the plant leaves despite works on the flower and other parts. The extraction of the essential oils from the dried leaves was carried out by the hydro distillation method using an all-glass Clevenger apparatus. The extracted oils were then analyzed using gas chromatography-mass spectrometry (GC-MS). A total of twelve constituents' representing 93.39% of A. Pungens oil with a yield of 0.4% (v/w) was obtained. The analysis of the GC-MS results of the leaf oil showed that it was dominated by â-ionone (42.18%) and hexahydrofarnesyl acetone (15.53%), others in trace amounts include; methyl palmitate (6.13%), 1octadecyne (4.72%), undecane (3.73%), para-mentha-1, 3, 8-triene (3.65%), isophytol (3.21%), ?cadinene (3.06%), 1, 2-dimethyl cyclooctene (3.05%), para-cymene (2.96%), phytol (2.67%) and neophytadiene (2.50%). The common classes of compounds present in the leaves oil are aceto monocyclic monoterpenoid (42.18%), sesquiterpenoids (18.59%), hydrocarbons (11.50%), diterpenoids (8.38%), monoterpenes (6.61%) and fatty acids (6.13%).The constituents and the compositional pattern of essential oil identified from the leaves of Alternanthera pungens grown in Nigeria differ quantitatively and qualitatively from previously reported member of the genus and the presence of sesquiterpenoid as one of the major components of the oils justify the traditional use of the plants in treating pains, headaches and inflammations.","PeriodicalId":120574,"journal":{"name":"African Journal of Science and Nature","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116989810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Osonuga, T. Adenowo, R. Akindele, Gbolahan O Idowu
P-Alaxin, is an anti-malarial drug that is highly effective in treating malaria all forms of malarial infection including multi drug resistance malaria in areas of high resistance especially in Africa. It is composed of dihydroartemisinin and piperaquine phosphate. This study investigates the effects of therapeutic dose of P-alaxin on fertility and hematological indices in rats. Fifteen male adult Wistar rats weighing between 150 and 220g were divided into three consisting of 5 rats per group. Normal saline was administered to the control group while the test and recovery groups were given 15.4mg/kg body weight of P-Alaxin orally for three days. The recovery group was allowed to recover for three days from the drug's effect. The animals were anaesthetized using diethyl ether. Blood samples were collected through cardiac puncture. Oral administration of P-alaxin (15.4mg/kg body weight) for three days reduced (p<0.05) significantly the sperm motility, sperm count, viability and testosterone as well as the PCV, Hb, WBC and RBC when compared to the control and there was no significant change in values of pH of the tests rats' semen. Allowing the rats to recover from the effects of the drug resulted in gradual restoration of sperm parameters and hematological indices under investigation. From the study it can be safely concluded that oral administration of P-Alaxin caused reduction in the hematological and sperm parameters and serum testosterone and could reduce male Wistar rats' fertility and also lead to anemia in rats
{"title":"THE EFFECTS OF P-ALAXIN ON FERTILITY AND HEMATOLOGICAL PARAMETERS IN MALE ADULT WISTAR RATS","authors":"I. Osonuga, T. Adenowo, R. Akindele, Gbolahan O Idowu","doi":"10.46881/ajsn.v10i0.182","DOIUrl":"https://doi.org/10.46881/ajsn.v10i0.182","url":null,"abstract":"P-Alaxin, is an anti-malarial drug that is highly effective in treating malaria all forms of malarial infection including multi drug resistance malaria in areas of high resistance especially in Africa. It is composed of dihydroartemisinin and piperaquine phosphate. This study investigates the effects of therapeutic dose of P-alaxin on fertility and hematological indices in rats. Fifteen male adult Wistar rats weighing between 150 and 220g were divided into three consisting of 5 rats per group. Normal saline was administered to the control group while the test and recovery groups were given 15.4mg/kg body weight of P-Alaxin orally for three days. The recovery group was allowed to recover for three days from the drug's effect. The animals were anaesthetized using diethyl ether. Blood samples were collected through cardiac puncture. Oral administration of P-alaxin (15.4mg/kg body weight) for three days reduced (p<0.05) significantly the sperm motility, sperm count, viability and testosterone as well as the PCV, Hb, WBC and RBC when compared to the control and there was no significant change in values of pH of the tests rats' semen. Allowing the rats to recover from the effects of the drug resulted in gradual restoration of sperm parameters and hematological indices under investigation. From the study it can be safely concluded that oral administration of P-Alaxin caused reduction in the hematological and sperm parameters and serum testosterone and could reduce male Wistar rats' fertility and also lead to anemia in rats","PeriodicalId":120574,"journal":{"name":"African Journal of Science and Nature","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130332857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Increased rice productivity for years is not a solution if rice farming efficiency cannot be sustained for the next hundred years. The study analysed the efficiency of rice farmers in Oyo State. A multistage sampling procedure was employed to select 128 rice farmers for the study. Primary data were obtained with the aid of well-structured questionnaire and interview schedule. Descriptive statistics and stochastic frontier model were employed in the analysis of the data. Majority (78.1%) of the rice farmers had one form of education or the other while the age of rice farmers ranges from 25 to 78 years and mean age of 47 years. The stochastic frontier results (Maximum Likelihood Estimates) revealed that farm output increases with farm size, hired labour, and fertilizer but decreases with herbicides. Also, technical efficiency of the farmers increases with formal education, farming experience, household size, extension contact and distance of farm to market. The mean technical efficiency, allocative efficiency and economic efficiency of 88.5 percent, 66.9 percent and 58.3 percent respectively showed that there is room for improvement in technical efficiency by 11.5 percent, allocative efficiency by 33.1 percent and economic efficiency by 41.7 percent with the present technology. Policy option requires the rice farmers to reduce the use of agro chemical. Farmers should expand their farm land to ensure efficient utilization of resources. Above all, formal education and adult literacy education should be strengthened among the rice farmers.
{"title":"ANALYSIS OF EFFICIENCY AMONG RICE FARMERS IN OYO STATE, NIGERIA","authors":"W. O. Adeshina, O. A. C. Ologbon, A. Idowu","doi":"10.46881/ajsn.v6i0.142","DOIUrl":"https://doi.org/10.46881/ajsn.v6i0.142","url":null,"abstract":"Increased rice productivity for years is not a solution if rice farming efficiency cannot be sustained for the next hundred years. The study analysed the efficiency of rice farmers in Oyo State. A multistage sampling procedure was employed to select 128 rice farmers for the study. Primary data were obtained with the aid of well-structured questionnaire and interview schedule. Descriptive statistics and stochastic frontier model were employed in the analysis of the data. Majority (78.1%) of the rice farmers had one form of education or the other while the age of rice farmers ranges from 25 to 78 years and mean age of 47 years. The stochastic frontier results (Maximum Likelihood Estimates) revealed that farm output increases with farm size, hired labour, and fertilizer but decreases with herbicides. Also, technical efficiency of the farmers increases with formal education, farming experience, household size, extension contact and distance of farm to market. The mean technical efficiency, allocative efficiency and economic efficiency of 88.5 percent, 66.9 percent and 58.3 percent respectively showed that there is room for improvement in technical efficiency by 11.5 percent, allocative efficiency by 33.1 percent and economic efficiency by 41.7 percent with the present technology. Policy option requires the rice farmers to reduce the use of agro chemical. Farmers should expand their farm land to ensure efficient utilization of resources. Above all, formal education and adult literacy education should be strengthened among the rice farmers.","PeriodicalId":120574,"journal":{"name":"African Journal of Science and Nature","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117315968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Oyesiku, O. O. Akinyemi, S. Giwa, N. Lawal, B. O. Adetifa
The challenges of carrying agricultural loads and forestry products were rightly identified as essentially the rural dwellers burden. Little efforts have been made to have an adaptive mobility frame (attached to bicycle and motorcycle) to carry goods and products from the point of harvest to the point of sales (the markets), a situation that leads to systematic rot of agriculture products on the farms, leading to low revenue and productivity of the rural people. Therefore, the goal of this research is to develop an improved carriage (trailer) to bicycle and motorcycle for goods mobility in rural areas of Nigeria. The design criteria for these trailers include: lightness in weight; ease of usage; flexibility; adaptability with various bicycle and motorcycle types; low cost of engineering materials, durability and availability of materials; and it is required that the trailer carries 200 kg load on smooth road (tarred and untarred). Factors considered for this design include; weight of the rider, weight of bicycle and motorcycle, type of road, type of load and factor of safety. Three different trailer designs were developed for the bicycle namely fixed plate design (FPD), convertible plate design (CPD) and wire mesh design (WMD), while the motorcycle trailers developed are the fixed plate design (FPD) and the convertible plate design (CPD). The hitch system used for the WMD bicycle trailer was a conventional universal joint and collar attached to the trailer front frame and the hitch system for the bicycle and motorcycle FPD and CPD comprises an annular of heavy duty cylindrical cone housing and a bolt. These designs are due in part to their simplicity, availability and ease of replacement for rural dwellers. Preliminary evaluations have shown satisfactory performance based on the load carrying capacity; stability of the trailer, bicycle and motorcycle turning ability; comfort of the operator and ease of disassembling the hitch system. A proper usage of the trailers presented in this study will boost the health and wealth of farmers and other rural dweller users.
{"title":"DEVELOPMENT OF BICYCLE AND MOTORCYCLE CARRIAGE FOR GOODS MOBILITY IN RURAL AREAS OF NIGERIA","authors":"O. Oyesiku, O. O. Akinyemi, S. Giwa, N. Lawal, B. O. Adetifa","doi":"10.46881/ajsn.v6i0.149","DOIUrl":"https://doi.org/10.46881/ajsn.v6i0.149","url":null,"abstract":"The challenges of carrying agricultural loads and forestry products were rightly identified as essentially the rural dwellers burden. Little efforts have been made to have an adaptive mobility frame (attached to bicycle and motorcycle) to carry goods and products from the point of harvest to the point of sales (the markets), a situation that leads to systematic rot of agriculture products on the farms, leading to low revenue and productivity of the rural people. Therefore, the goal of this research is to develop an improved carriage (trailer) to bicycle and motorcycle for goods mobility in rural areas of Nigeria. The design criteria for these trailers include: lightness in weight; ease of usage; flexibility; adaptability with various bicycle and motorcycle types; low cost of engineering materials, durability and availability of materials; and it is required that the trailer carries 200 kg load on smooth road (tarred and untarred). Factors considered for this design include; weight of the rider, weight of bicycle and motorcycle, type of road, type of load and factor of safety. Three different trailer designs were developed for the bicycle namely fixed plate design (FPD), convertible plate design (CPD) and wire mesh design (WMD), while the motorcycle trailers developed are the fixed plate design (FPD) and the convertible plate design (CPD). The hitch system used for the WMD bicycle trailer was a conventional universal joint and collar attached to the trailer front frame and the hitch system for the bicycle and motorcycle FPD and CPD comprises an annular of heavy duty cylindrical cone housing and a bolt. These designs are due in part to their simplicity, availability and ease of replacement for rural dwellers. Preliminary evaluations have shown satisfactory performance based on the load carrying capacity; stability of the trailer, bicycle and motorcycle turning ability; comfort of the operator and ease of disassembling the hitch system. A proper usage of the trailers presented in this study will boost the health and wealth of farmers and other rural dweller users.","PeriodicalId":120574,"journal":{"name":"African Journal of Science and Nature","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117225948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EN Ezima, A. Ademakinwa, Temitope Fasanya, A. A. Adelegan, A. E. Ojo
Cyanide is produced throughout a plant's life cycle, its production increases during certain developmental stages such as seed germination, seedling elongation, fruit ripening and senescence. Beta-cyanoalanine synthase is the most important cyanide metabolizing enzyme found in plants. This work is aimed at studying the tissue distribution, partial purification and some physicochemical properties of β-cyanoalanine synthase from bean seeds (Phaseolus vulgaris). β-cyanolalanine synthase was isolated and partially purified using a combination of ammonium sulphate precipitation, desalting on Sephadex G-10 and gel filtration chromatography on Sephacryl S-200 column. The biochemical characteristics of the enzyme were investigated. Results obtained from this work showed that β-cyanolalanine synthase is more concentrated in the seeds (20.53 nmol/HS/mg) when compared 2 to the cotyledons (10.08 nmol/HS/mg) and the seed coats (5.82 nmol/HS/mg). The partially purified 2 2 enzyme showed a specific activity of 26.77 nmol/HS/mg and an apparent molecular weight of about 2 60,000Da, K values for cyanide and L-cysteine of 0.741 mM and 1.724 mM respectively. The V max m value obtained for cyanide was 25.00 nmol/H S/ml/minwhile that of L-cysteine was 2 o666.67nmol/H S/ml/min. The enzyme showed an optimum temperature of 40C and optimum pH of 2 10.0.Studies on the effect of chloride salt indicated that NaCl and MnCl had strong inhibitory effect 2 on the enzyme; NHCl had slight negative effect while KCl and ZnCl activated the enzyme dose 4 2 dependently.This study showed the presence of β-cyanoalanine synthase in bean seeds which is believed to function in the detoxification of cyanide produced in its tissues especially during germination.
{"title":"TISSUE DISTRIBUTION AND BIOCHEMICAL CHARACTERIZATION OF BETA-CYANOALANINE SYNTHASE FROM COMMON BEAN SEEDS (PHASEOLUS VULGARIS)","authors":"EN Ezima, A. Ademakinwa, Temitope Fasanya, A. A. Adelegan, A. E. Ojo","doi":"10.46881/ajsn.v6i0.146","DOIUrl":"https://doi.org/10.46881/ajsn.v6i0.146","url":null,"abstract":"Cyanide is produced throughout a plant's life cycle, its production increases during certain developmental stages such as seed germination, seedling elongation, fruit ripening and senescence. Beta-cyanoalanine synthase is the most important cyanide metabolizing enzyme found in plants. This work is aimed at studying the tissue distribution, partial purification and some physicochemical properties of β-cyanoalanine synthase from bean seeds (Phaseolus vulgaris). β-cyanolalanine synthase was isolated and partially purified using a combination of ammonium sulphate precipitation, desalting on Sephadex G-10 and gel filtration chromatography on Sephacryl S-200 column. The biochemical characteristics of the enzyme were investigated. Results obtained from this work showed that β-cyanolalanine synthase is more concentrated in the seeds (20.53 nmol/HS/mg) when compared 2 to the cotyledons (10.08 nmol/HS/mg) and the seed coats (5.82 nmol/HS/mg). The partially purified 2 2 enzyme showed a specific activity of 26.77 nmol/HS/mg and an apparent molecular weight of about 2 60,000Da, K values for cyanide and L-cysteine of 0.741 mM and 1.724 mM respectively. The V max m value obtained for cyanide was 25.00 nmol/H S/ml/minwhile that of L-cysteine was 2 o666.67nmol/H S/ml/min. The enzyme showed an optimum temperature of 40C and optimum pH of 2 10.0.Studies on the effect of chloride salt indicated that NaCl and MnCl had strong inhibitory effect 2 on the enzyme; NHCl had slight negative effect while KCl and ZnCl activated the enzyme dose 4 2 dependently.This study showed the presence of β-cyanoalanine synthase in bean seeds which is believed to function in the detoxification of cyanide produced in its tissues especially during germination.","PeriodicalId":120574,"journal":{"name":"African Journal of Science and Nature","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130328120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Field trials were conducted at University Organic–Agriculture farm, Federal University of Agriculture Abeokuta in 2011 to determine the response of different mulching materials on growth and yield of okra. It was a 3x3 factorial laid out in Randomized Complete Block Design (RCBD) with the main factor as the plant material Chromolaena odorata (CO) Glycine max (GM) and Panicum maximum ( PM) while rate ( 0, 5 and 10t/ha) of mulching materials were applied once before the first cropping was the sub-factor and all were replicated three times. Data were collected on growth parameters and yield attributes of okra (NHAE- 47-4) at first and second planting. The parameters assessed were significantly influenced (P <0.05) by the mulching material and rate of application. Higher values for plant height ( 56.3cm and 60.7cm ) , number of leaves ( 22 and 22) and stem girth (1.5cm and 2.1cm) at 16 weeks after planting (WAP) were obtained during the first and second planting from CO application of 10t/ha. Although, the higher number of flowers ( 14 and 21), number of pods ( 29 and 21) and weight of pods/plant (0.51kg and 0.44kg) were derived from PM when 10t/ha was used at 16 WAP during both plantings. Thus, optimum okra yield were obtained with application of 10t/ha of plant residues, therefore, mulching with PM residues at 10t/ha is recommended for high fruit yield of okra in the region of investigation.
{"title":"EFFECT OF DIFFERENT MULCHING MATERIALS AND RATE OF APPLICATION ON GROWTH AND YIELD OF OKRA (Abelmoschus esculentus L. )","authors":"S. Azeez, C. Adejuyigbe, W. B. Bello, T. Fawole","doi":"10.46881/ajsn.v6i0.145","DOIUrl":"https://doi.org/10.46881/ajsn.v6i0.145","url":null,"abstract":"Field trials were conducted at University Organic–Agriculture farm, Federal University of Agriculture Abeokuta in 2011 to determine the response of different mulching materials on growth and yield of okra. It was a 3x3 factorial laid out in Randomized Complete Block Design (RCBD) with the main factor as the plant material Chromolaena odorata (CO) Glycine max (GM) and Panicum maximum ( PM) while rate ( 0, 5 and 10t/ha) of mulching materials were applied once before the first cropping was the sub-factor and all were replicated three times. Data were collected on growth parameters and yield attributes of okra (NHAE- 47-4) at first and second planting. The parameters assessed were significantly influenced (P <0.05) by the mulching material and rate of application. Higher values for plant height ( 56.3cm and 60.7cm ) , number of leaves ( 22 and 22) and stem girth (1.5cm and 2.1cm) at 16 weeks after planting (WAP) were obtained during the first and second planting from CO application of 10t/ha. Although, the higher number of flowers ( 14 and 21), number of pods ( 29 and 21) and weight of pods/plant (0.51kg and 0.44kg) were derived from PM when 10t/ha was used at 16 WAP during both plantings. Thus, optimum okra yield were obtained with application of 10t/ha of plant residues, therefore, mulching with PM residues at 10t/ha is recommended for high fruit yield of okra in the region of investigation.","PeriodicalId":120574,"journal":{"name":"African Journal of Science and Nature","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124722104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
International Diabetes Foundation puts Nigeria's national diabetes prevalence rate at 3.9% in year 2013. Number of drugs per patient is the main factor associated with adverse reactions among elderly patients. Objective was to evaluate prescription pattern for elderly diabetic patients. This was descriptive prospective study of 150 case files of older patients diagnosed with type 2 diabetes and receiving treatment in the endocrinology clinic of Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State. Data collected included socio-demographic characteristics and pattern of prescribed medications. Data were analyzed with SPSS version 16. P 0.05 was considered significant. Mean age of the group was 65.8±10.0 years. Metformin was the most frequently prescribed (81.3%) and in combination of other antidiabetics, the highest being that with Metformin+Pioglitazone+ Glimepiride (18%). The most commonly prescribed anti hypertensives was lisinopril/Ramipril (50.0%). Mean number of drugs per prescription was 6.0. Patients mostly encountered a range of 5-7 drugs per prescription (63.3%). Drugs prescribed in generics and from essential drug list were significantly lower than the recommended WHO values (p >0.05). The findings indicate that the prescribing pattern could be said to be in compliant with our treatment guidelines although not in line with WHO's recommendations.
国际糖尿病基金会(International Diabetes Foundation)估计，2013年尼日利亚全国糖尿病患病率为3.9%。患者人均用药数量是影响老年患者不良反应的主要因素。目的探讨老年糖尿病患者的处方模式。这是一项描述性前瞻性研究，研究对象是在奥贡州Sagamu的奥拉比西奥纳班乔大学教学医院内分泌科门诊诊断为2型糖尿病并接受治疗的150例老年患者。收集的数据包括社会人口学特征和处方药物的模式。数据采用SPSS version 16进行分析。P < 0.05认为差异有统计学意义。患者平均年龄65.8±10.0岁。二甲双胍是最常见的处方(81.3%)，并与其他抗糖尿病药物联合使用，最高的是二甲双胍+吡格列酮+格列美脲(18%)。最常用的抗高血压药物是赖诺普利/雷米普利(50.0%)。每张处方的平均药物数为6.0种。患者在每张处方中最多遇到5-7种药物(63.3%)。非专利药和基本药物目录中使用的药物显著低于WHO推荐值(p >0.05)。调查结果表明，处方模式可以说符合我们的治疗指南，尽管不符合世卫组织的建议。
{"title":"RATIONAL USE OF MEDICINES AMONGST ELDERLY DIABETIC PATIENTS IN A TERTIARY HOSPITAL IN SOUTHERN NIGERIA","authors":"W. Ojieabu, P. Erah","doi":"10.46881/ajsn.v6i0.150","DOIUrl":"https://doi.org/10.46881/ajsn.v6i0.150","url":null,"abstract":"International Diabetes Foundation puts Nigeria's national diabetes prevalence rate at 3.9% in year 2013. Number of drugs per patient is the main factor associated with adverse reactions among elderly patients. Objective was to evaluate prescription pattern for elderly diabetic patients. This was descriptive prospective study of 150 case files of older patients diagnosed with type 2 diabetes and receiving treatment in the endocrinology clinic of Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State. Data collected included socio-demographic characteristics and pattern of prescribed medications. Data were analyzed with SPSS version 16. P 0.05 was considered significant. Mean age of the group was 65.8±10.0 years. Metformin was the most frequently prescribed (81.3%) and in combination of other antidiabetics, the highest being that with Metformin+Pioglitazone+ Glimepiride (18%). The most commonly prescribed anti hypertensives was lisinopril/Ramipril (50.0%). Mean number of drugs per prescription was 6.0. Patients mostly encountered a range of 5-7 drugs per prescription (63.3%). Drugs prescribed in generics and from essential drug list were significantly lower than the recommended WHO values (p >0.05). The findings indicate that the prescribing pattern could be said to be in compliant with our treatment guidelines although not in line with WHO's recommendations.","PeriodicalId":120574,"journal":{"name":"African Journal of Science and Nature","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131482618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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