Aim: This review aims to summarize current evidence on Krukenberg Tumors (KT), addressing the main prognostic determinants and its’ management. Background: Krukenberg Tumors are rare metastatic tumors of the ovary. They were initially described by Friederich Ernst Krukenberg in 1896. They arise from extra-ovarian primary signet-ring cell carcinomas, being the gastrointestinal tract the most common site of origin. The most common clinical presentation of KT is an abdominal mass or discomfort in a premenopausal 40 to the 50-year-old woman. The prognosis is extremely poor compared to primary ovarian cancer. Results: Overall survival may vary significantly according to the choice and timing of treatment. The effective treatment strategies for KT are still controversial. However, therapeutic options include surgical resection as the mainstay of treatment when possible and the application of different Chemotherapy (CT) regimens. Conclusions: Several factors negatively affect prognosis: an incomplete metastasectomy, extensive disease at diagnosis and the origin of the tumor are the main factors that most authors agree incur in a worse prognosis. KT’s optimal therapeutic strategies are still a matter of debate, raising the need for more studies to achieve consensus.
目的:本综述旨在总结目前关于Krukenberg肿瘤(KT)的证据，讨论主要的预后决定因素及其治疗。背景:Krukenberg肿瘤是一种罕见的卵巢转移性肿瘤。它们最初是由Friederich Ernst Krukenberg在1896年描述的。它们起源于卵巢外原发性印戒细胞癌，胃肠道是最常见的起源部位。最常见的临床表现是腹部肿块或不适在绝经前40至50岁的妇女。与原发性卵巢癌相比，预后极差。结果:根据治疗的选择和时机，总生存期可能会有显著差异。对于KT的有效治疗策略仍存在争议。然而，治疗选择包括手术切除作为可能的主要治疗方法，以及应用不同的化疗(CT)方案。结论:影响预后的主要因素有转移性切除不完全、诊断时病变范围广、肿瘤的起源等，多数作者认为这是导致预后较差的主要因素。KT的最佳治疗策略仍然是一个有争议的问题，需要更多的研究来达成共识。
{"title":"Krukenberg Tumor: A Review of Prognostic Factors and Management","authors":"A. Zolezzi","doi":"10.52916/OTR204003","DOIUrl":"https://doi.org/10.52916/OTR204003","url":null,"abstract":"Aim: This review aims to summarize current evidence on Krukenberg Tumors (KT), addressing the main prognostic determinants and its’ management. Background: Krukenberg Tumors are rare metastatic tumors of the ovary. They were initially described by Friederich Ernst Krukenberg in 1896. They arise from extra-ovarian primary signet-ring cell carcinomas, being the gastrointestinal tract the most common site of origin. The most common clinical presentation of KT is an abdominal mass or discomfort in a premenopausal 40 to the 50-year-old woman. The prognosis is extremely poor compared to primary ovarian cancer. Results: Overall survival may vary significantly according to the choice and timing of treatment. The effective treatment strategies for KT are still controversial. However, therapeutic options include surgical resection as the mainstay of treatment when possible and the application of different Chemotherapy (CT) regimens. Conclusions: Several factors negatively affect prognosis: an incomplete metastasectomy, extensive disease at diagnosis and the origin of the tumor are the main factors that most authors agree incur in a worse prognosis. KT’s optimal therapeutic strategies are still a matter of debate, raising the need for more studies to achieve consensus.","PeriodicalId":133240,"journal":{"name":"Oncology: Tumor & Research","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124678003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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