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Formulation and Evaluation of Colon Targeted Ciprofloxacin Microspheres 结肠靶向环丙沙星微球的研制与评价
Pub Date : 2023-09-30 DOI: 10.46610/tpnt.2023.v05i02.004
Ch. Srilatha, T Giriraj kulkarni
In the present study, Colon-targeted Ciprofloxacin hydrochloride microspheres were formulated and their in vitro properties were assessed to determine whether or not the antibiotic could be delivered to the colon. By utilizing span-80 as an emulsifying agent, ciprofloxacin hydrochloride microspheres for colon targeting were prepared using the emulsion-solvent evaporation method. According to the preliminary trial findings, the ratio of drug to polymer had an impact on the microspheres' properties. The Ciprofloxacin: Eudragit S-100+HPMC 6cps ratio of 1:1, 1:2, 1:3, 1:4, 1:5, and 1:6 were used to make the colon targeting microspheres, in which the ratio of Eudragit S-100 to HPMC was always 1:1. The combination of Eudragit S-100 and HPMC demonstrated increased release lag time and regulated release rate, which improved protection of the drug-containing core. For the majority of the formulations examined, zero-order release followed a time delay caused by the hydrogel's swelling/retarding behaviour before the medication started to come out of the microspheres. The colon-targeting microspheres were also tested for micrometrics, particle size and surface properties, percentage drug content, encapsulation effectiveness, and in vitro drug release study in the three different pH environments (0.1 N HCL, Phosphate buffer pH 6.8 and Phosphate buffer pH 7.4) for 12 hours. The kinetics of drug release in vitro and the drug release mechanism of the microspheres were further investigated. With a particle size of 58.9 m, an almost spherical shape, and free-flowing characteristics, the best formulation batch had the highest drug entrapment efficiency of 86.81%. It was followed by a zero-order rate release with a non-fiction-diffusion mechanism, which had an 82.77% drug release rate.
在本研究中,配制了结肠靶向盐酸环丙沙星微球,并评估了其体外特性,以确定抗生素是否可以给药到结肠。以span-80为乳化剂,采用乳剂-溶剂蒸发法制备结肠靶向用环丙沙星微球。根据初步试验结果,药物与聚合物的比例对微球的性能有影响。采用环丙沙星:尤德拉吉S-100+HPMC 6cps的比例分别为1:1、1:2、1:3、1:4、1:5、1:6制备结肠靶向微球,尤德拉吉S-100与HPMC的比例始终为1:1。Eudragit S-100与HPMC联用后释放滞后时间增加,释放速率调节,增强了对含药核心的保护作用。对于大多数被检查的配方,在药物开始从微球中流出之前,由于水凝胶的肿胀/延迟行为导致的时间延迟导致零级释放。在三种不同的pH环境(0.1 N HCL,磷酸缓冲液pH 6.8和磷酸缓冲液pH 7.4)下,对结肠靶向微球进行了12小时的显微测量、粒度和表面性质、药物含量百分比、包封效果和体外释药研究。进一步研究了微球的体外释药动力学和释药机制。最佳配方批粒径58.9 m,粒径近似球形,具有自由流动的特点,包封效率最高,为86.81%。其次为零级释放,具有非虚构扩散机制,释药率为82.77%。
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引用次数: 0
3D-Printed Composites: Multiple Applications, Recent Advances, and Emerging Prospects 3d打印复合材料:多种应用,最新进展和新兴前景
Pub Date : 2023-09-30 DOI: 10.46610/tpnt.2023.v05i02.003
Vivek Kahale, Madhukar Shende
3D printing technology (3DPT) is presently extensively employed in several areas of R&D. Unfortunately; the practical potential of this potentially revolutionary technology is now constrained by the narrow spectrum of physicochemical properties available in 3D-printed materials. High-performance composites made from many materials, each with its unique features, are becoming more popular as a means to improve and vary the characteristics of standard printing materials. In the past, 3D-printed composites have been employed for a wide range of purposes, including the creation of biological, mechanical, electrical, thermal, and optical enhancements. Rapid prototyping has increased the popularity of 3DP composites because of their ability to create complex geometries at a cheap cost. This study reveals that traditional 3DP materials may be upgraded to produce composites with enhanced biometric, electrical, mechanical, optical, thermal, and other characteristics by using nanoparticles, fibres, other polymers, or a chemical reaction.
3D打印技术(3DPT)目前广泛应用于多个研发领域。不幸的是,这种潜在的革命性技术的实际潜力现在受到3d打印材料中可用的物理化学性质的狭窄范围的限制。由多种材料制成的高性能复合材料,每种材料都有其独特的特性,作为改进和改变标准印刷材料特性的一种手段,正变得越来越流行。在过去,3d打印复合材料已被用于广泛的目的,包括创建生物,机械,电气,热和光学增强。快速成型增加了3d打印复合材料的普及,因为它们能够以低廉的成本创建复杂的几何形状。这项研究表明,通过使用纳米颗粒、纤维、其他聚合物或化学反应,传统的3d打印材料可以升级为具有增强生物特征、电学、机械、光学、热学和其他特性的复合材料。
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引用次数: 0
Global Contributions on Nanotechnology of Regulatory Aspects of Drugs 纳米技术在药物监管方面的全球贡献
Pub Date : 2023-08-24 DOI: 10.46610/tpnt.2023.v05i02.002
Sai Grandhi Meena, Koushik Yetukuri
Background and Objective: The food, pharmaceutical, and agricultural industries can contribute to, develop, and benefit from the use of nanotechnology, which is a major advanced technology. The manufacture of healthier, safer, and high-quality functional foods that are perishable or semi-perishable could be led qualitatively and quantitatively by nonmaterial. Nanotechnology has become one of the most significant frontline areas in many traditional study areas of science and technology. Methods: It contains several international regulations that have helped spread awareness of the value of nanotechnology in pharmaceuticals. The article on pharmaceuticals and food was framed following the regulatory authorities of each country's criteria. Results: Nanotechnology's uses in emerging nations' products, including medicine, and other goods. Conclusion: The potential for nanotechnology to advance food research across a wide range of disciplines is considerable. These nanomaterial devices have numerous uses in the food industry, including food processing, preservation, and packaging. Different nanomaterials have been used for a variety of biomedical applications, including drug delivery systems, optical imaging, and bioimaging, depending on the physical and chemical properties of their surfaces. For the benefit of all people, it justifies paying attention to the incredibly promising topic of nanotechnology.
背景与目的:纳米技术是一项重要的先进技术,食品、制药和农业工业可以为纳米技术的使用做出贡献、发展并从中受益。制造更健康、更安全、高质量的易腐烂或半易腐烂的功能性食品可以通过非材料来进行定性和定量。纳米技术已成为许多传统科学技术研究领域最重要的前沿领域之一。方法:它包含了一些国际法规,这些法规有助于传播纳米技术在药物中的价值。关于药品和食品的文章是根据每个国家的监管当局的标准制定的。结果:纳米技术在新兴国家产品中的应用,包括药品和其他产品。结论:纳米技术在广泛的学科领域推进食品研究的潜力是巨大的。这些纳米材料装置在食品工业中有许多用途,包括食品加工、保存和包装。不同的纳米材料已被用于各种生物医学应用,包括药物输送系统、光学成像和生物成像,这取决于其表面的物理和化学性质。为了所有人的利益,它证明了关注纳米技术这个令人难以置信的有前途的话题是合理的。
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引用次数: 0
High Sensitive and Selective Cu-doped ZnO Thin film for No2 Sensing with Chemical Root Method 化学根法高敏选择性cu掺杂ZnO薄膜No2传感
Pub Date : 2023-02-21 DOI: 10.46610/tpnt.2023.v05i01.003
S. J.
Copper Doped Zinc Oxide-Thin films are prepared by the Sol-Gel method and annealing at 400°C, For sol preparation, we prepare 2- different types of solution, one is zinc nitrate hexahydrate and the second is copper nitrate, that are deeply discussed in this paper. The thin size was varied by XRD, the detected (h k l) peaks are confirmed with 2θ values and the morphology was also studied by field emission scanning electron microscopy (FESEM), the Nano-bubbles and nano-balls was observed. Electrical properties and VI- Characteristics were also done, and getting highly sensitive Performing results, finally, the gas sensing characteristic was taken by chemiresistive process. And the Gas Sensing performance was done with closed chamber methods and the High sensitive and selective performance result have been shown. The sensing parameters such as electrical properties, and VI- characteristics, for gases, are also observed we shown the response time and recovery time, The S=Rg/Ra formula is used for calculate the response of the films. The best of lower gas detection limits, towards NO2 gas, and also finalize the selectivity and sensitivity performance of the thin film. The final result shown that ZnO thinfilm can act as NO2 sensor and breath analyzer, for diabetes.
采用溶胶-凝胶法制备了铜掺杂氧化锌薄膜,并在400℃下进行了退火,制备了两种不同类型的溶液,一种是六水硝酸锌,另一种是硝酸铜,本文对此进行了深入的讨论。利用x射线衍射(XRD)测定了样品的薄层尺寸,用2θ值确定了检测峰(h k l),并用场发射扫描电镜(FESEM)研究了样品的形貌,观察到了纳米气泡和纳米球的形貌。并对其电学性能和VI-特性进行了测试,得到了高灵敏度的性能结果,最后采用化学电阻法测定了其气敏特性。采用闭室法进行了气敏性能测试,显示出高灵敏度和选择性的性能结果。测量了薄膜的电学特性和VI-特性等传感参数,并给出了响应时间和恢复时间,采用S=Rg/Ra公式计算薄膜的响应。对NO2气体的最佳检测限较低,同时也确定了薄膜的选择性和灵敏度性能。结果表明,ZnO薄膜可以作为糖尿病患者的NO2传感器和呼吸分析仪。
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引用次数: 0
A Comprehensive Review on Synthesis and Application of Zinc Oxide Nanoparticles 氧化锌纳米颗粒的合成及应用综述
Pub Date : 2023-01-31 DOI: 10.46610/tpnt.2023.v05i01.002
A. Jamal, Kashina Aslam, Amara Anwar, S. Rafiq, H. Shaheen
ZnO which are used as nanoparticles have been used in many varieties of paint, beautifiers, elastics, and covering. Just because of its biocompatibility, low toxicity as well as economic viability which are known as its exceptional cases, it has been the most used nanoparticle of metal oxides in many applications for the last twenty years. It can release particles of zinc, ability to induce cell death as well as the ability for producing oxygen species in excessive amounts. Due to its vast application in technology, it is also used in applications of biomedicines such as anticancer as well as antibacterial. Zinc also play important role in maintaining insulin credibility. Nanoparticles of zinc have been widely used for diabetes treatment. Additionally, it has been exceptionally dazzling applications that have leading them to be a candidate for use in bio imaging. Here, we are going to summarize the synthesis as well as continuing developments of nanoparticles of ZnO in the sector of biomedical, which may useful for fostering more advancement in the field of medicine and focusing on the areas of biomedical.
氧化锌作为纳米粒子被广泛应用于各种涂料、美容剂、弹性材料和覆盖物中。正是由于其独特的生物相容性、低毒性和经济可行性,在过去的二十年中,它一直是金属氧化物中应用最多的纳米颗粒。它能释放出锌颗粒,有诱导细胞死亡的能力,并能产生过量的氧气。由于其在技术上的广泛应用,它也被用于生物医学的应用,如抗癌和抗菌。锌在维持胰岛素的可信度方面也起着重要作用。锌纳米颗粒已广泛应用于糖尿病的治疗。此外,它还具有非常令人眼花缭乱的应用,使其成为生物成像的候选应用。本文将对纳米氧化锌在生物医学领域的合成和发展进行综述,以期对促进医学领域的进一步发展和对生物医学领域的关注有所帮助。
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引用次数: 0
Bio-Inspired Synthesis of Zinc and Zinc Oxide Nanoparticles and Their Administration in Biomedical Sphere: An Overview 锌和氧化锌纳米颗粒的仿生合成及其在生物医学领域的应用综述
Pub Date : 2022-11-14 DOI: 10.46610/tpnt.2022.v04i02.005
Apoorva Bangroo, Akshay Malhotra, A. Kaur
As of late, an organic methodology of combining nanomaterials through ecological green-based procedures including regular materials, for example, plants, microscopic organisms, parasites, ocean growth, polysaccharides, biodegradable polymers, e-waste, plant-mediated things, and green methodology has persisted to be utilized as an elective technique for the combination of zinc and zinc oxide nanoparticles. Besides expanding energy for proficient green science, biosynthetic procedures intended for creating nanoparticles have stimulated many intrigues since they are ecologically amicable, no intermediate addition of stabilizing agent, less costly, and clean innovation. They neither include perilous synthetic concoctions nor have impurities and consequences. Of these bio-elements, plant concentrates have extraordinary consideration because of their capacity to decrease and balance out metal nanoparticles in a solitary advanced combination utilizing their regular qualities. This owes to their multitudinous and convoluted compositions, natural organic Phyto- ingredients biomolecules being in- factory separates (alkaloids, flavonoids, polyphenols, terpenoids, and tannins) as reducing as well as stabilizing instrumentalities. Primarily, this paper gives revived check of zinc oxide nanoparticles and the changes, headlines, and current employments of verdant ways exercising natural coffers. Farther, this review aims to analogize colourful hiatuses and terminations of conflation and characterization styles. Also, this review has covered biomedical operations with emphasis on cancer treatment, anti-microbial exertion, and medicine quittance fields.
最近,通过生态绿色程序结合纳米材料的有机方法,包括常规材料,例如植物、微生物、寄生虫、海洋生长、多糖、可生物降解聚合物、电子废物、植物介导的东西,以及绿色方法,一直被用作锌和氧化锌纳米颗粒结合的选择性技术。除了为熟练的绿色科学扩展能源之外,用于制造纳米粒子的生物合成程序已经激发了许多兴趣,因为它们对生态友好,不需要添加中间稳定剂,成本更低,而且是清洁的创新。它们既不含危险的合成混合物,也没有杂质和后果。在这些生物元素中,植物浓缩物受到了特别的关注,因为它们能够利用金属纳米粒子的常规特性,在一个单独的高级组合中减少和平衡金属纳米粒子。这要归功于它们众多而复杂的成分,天然有机植物成分生物分子在工厂中分离(生物碱、类黄酮、多酚、萜类和单宁),作为还原和稳定的工具。首先,本文重新审视了氧化锌纳米粒子的变化,头条新闻,以及目前使用的绿色方式行使天然金库。此外,本综述旨在类比彩色中断和终止的合并和表征风格。此外,本综述还涵盖了生物医学操作,重点是癌症治疗,抗微生物作用和药物退出领域。
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引用次数: 0
Review on Synthesis of Electro Chemical Cell by Nano Materials and its uses for Drug Delivery Systems 纳米材料合成电化学电池及其在药物传递系统中的应用研究进展
Pub Date : 2022-08-30 DOI: 10.46610/tpnt.2022.v04i02.002
A. Jamal, Afia Abdul Wahid, Naffisa Naveed, Hafiz Qamar ul Ghofoor, Tanveer Ahmad
Cancer is very lethal to health and lives around the world chemists are always trying to formulate the advance anticancer drugs with better efficacy for treatment. Side by side, these drugs have adverse effects for monitoring that drugs the electrochemistry helps to device electrochemical cells. The cells can monitor the drugs in the body. Nanomaterials are helpful full in this regard. They improve the drug efficacy and drug delivery systems to protect the body from the adverse effects. In this review paper we described the applications of nanomaterials in sense that they have intensive surface area as compared to macro materials so this have enhanced catalytic properties that enable for great sensing applications.
癌症对人类的健康和生命是致命的,世界各地的化学家们一直在努力研制出更有效的抗癌药物来治疗癌症。同时,这些药物对监测有不利影响,药物的电化学有助于装置电化学电池。这些细胞可以监测体内的药物。纳米材料在这方面很有帮助。它们改善了药物功效和药物输送系统,以保护身体免受不良反应的影响。在这篇综述文章中,我们从某种意义上描述了纳米材料的应用,与宏观材料相比,纳米材料具有更大的表面积,因此纳米材料具有增强的催化性能,能够实现巨大的传感应用。
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引用次数: 0
A Comprehensive review on Photocatalytic activity of CdO Nanoparticles 纳米CdO光催化活性研究综述
Pub Date : 2022-07-15 DOI: 10.46610/tpnt.2022.v04i02.001
A. Jamal, H. Shaheen, S. Rafiq, J. Saif, Kashina Aslam
Photocatalytic activity is a commonly used the function of semiconductor nanoparticles of CdO. CdO nanocomposites were analyzed by X-pillar diffraction (XRD), energy dispersive X-bar (EDX), high objective transmission electron microscopy (HR-TEM), Raman spectroscopy (RS), brilliant clear spectroscopy (UV–Vis.) and photo-luminescence (PL) spectroscopy techniques. Photocatalytic activity of the arranged models has been investigated under UV light. The decrease in the power of surge tops exhibits that the photo generated charge carriers have been moved from CdO NPs sheets, which causes to build the thickness of O2−and •OH progressives in the shading arrangement. The normal molecule sizes of CdO nanoparticles were found to be 14 nm. The blended CdO nanoparticles were utilized as photo catalyst some dyes are RhB, MY, MB, ARS etc. The photo degradation of methylene blue was advanced under different response conditions, for example impetus stacking, color focus, temperature, and pH. The upgraded photocatalytic activity can be attributed to synergistic impact of CdO.
光催化活性是半导体纳米CdO常用的功能。采用x柱衍射(XRD)、能量色散x棒(EDX)、高物镜透射电子显微镜(HR-TEM)、拉曼光谱(RS)、紫外-可见光谱学(UV-Vis)和光致发光(PL)等技术对CdO纳米复合材料进行了分析。在紫外光下研究了排列模型的光催化活性。浪涌顶功率的下降表明,光产生的载流子已经从CdO NPs片上移出,这导致在遮光排列中O2−和•OH的厚度逐渐增加。发现CdO纳米颗粒的正常分子尺寸为14 nm。采用复合纳米CdO作为光催化剂,制备了RhB、MY、MB、ARS等染料。在动力叠加、色焦、温度和ph等不同响应条件下,亚甲基蓝的光催化活性得到了提升,这可归因于CdO的协同作用。
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引用次数: 0
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Trends in Pharmaceuticals and Nanotechnology
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