Objective: To study the pattern and distribution of hematological cancers in Hadhramout sector-Yemen and compare with the findings elsewhere in the country and worldwide. Methods: Descriptive study of patients with Hematological malignancies between January 2011 and December 2015 recorded in National Oncology center- Hadhramout. Cases were sub-grouped according to their lineage into lymphoid types which include Non-Hodgkin’s and Hodgkin’s lymphomas, acute and chronic lymphocytic leukemia and multiple myelomas, and Myeloid types which include acute myeloblastic leukemia and chronic myeloproliferative neoplasms. Patients were classified into four age groups: <18, 18-40, 41-60 and >60 years. Results: 661 cases of Hematological malignancies were registered (22.6% of all cancers registered). 58.7 % males and 41.3% females, (male to female ratio of 1.4:1). Slight female predominance was found in cases of chronic myeloproliferative neoplasms. Hematological malignancies occur at a young age, with an overall median age at diagnosis of 39 years. Non-Hodgkin’s lymphoma was the most common subtype (37.8%), followed by Hodgkin’s lymphoma. The majority of cases were observed among the 18-40 age groups (28%). In children and adolescents <18 years old, acute lymphoblastic leukemia and acute myeloblastic leukemia were more predominant (24%, 11.4%). Multiple myeloma commonly occurred in the 41-61 age groups (57.6%). Chronic lymphocytic leukemia mostly occurred among old patients over 60 years (66.7%). Most cases were from the Hadhramout governorate (n= 507, 76.7%) and Mukalla was the most affected city. Conclusion: The distribution of Hematological malignancies in Hadhramout is more common in adults while decreased in the elder population.
{"title":"Correlation Hematological Malignancies in the Hadhramout Sector Pattern and Distribution","authors":"Daakeek Am, Bahashwan Aa, Bakr Aa, Allam Aa","doi":"10.16966/2471-5026.129","DOIUrl":"https://doi.org/10.16966/2471-5026.129","url":null,"abstract":"Objective: To study the pattern and distribution of hematological cancers in Hadhramout sector-Yemen and compare with the findings elsewhere in the country and worldwide. Methods: Descriptive study of patients with Hematological malignancies between January 2011 and December 2015 recorded in National Oncology center- Hadhramout. Cases were sub-grouped according to their lineage into lymphoid types which include Non-Hodgkin’s and Hodgkin’s lymphomas, acute and chronic lymphocytic leukemia and multiple myelomas, and Myeloid types which include acute myeloblastic leukemia and chronic myeloproliferative neoplasms. Patients were classified into four age groups: <18, 18-40, 41-60 and >60 years. Results: 661 cases of Hematological malignancies were registered (22.6% of all cancers registered). 58.7 % males and 41.3% females, (male to female ratio of 1.4:1). Slight female predominance was found in cases of chronic myeloproliferative neoplasms. Hematological malignancies occur at a young age, with an overall median age at diagnosis of 39 years. Non-Hodgkin’s lymphoma was the most common subtype (37.8%), followed by Hodgkin’s lymphoma. The majority of cases were observed among the 18-40 age groups (28%). In children and adolescents <18 years old, acute lymphoblastic leukemia and acute myeloblastic leukemia were more predominant (24%, 11.4%). Multiple myeloma commonly occurred in the 41-61 age groups (57.6%). Chronic lymphocytic leukemia mostly occurred among old patients over 60 years (66.7%). Most cases were from the Hadhramout governorate (n= 507, 76.7%) and Mukalla was the most affected city. Conclusion: The distribution of Hematological malignancies in Hadhramout is more common in adults while decreased in the elder population.","PeriodicalId":138925,"journal":{"name":"Journal of Blood Disorders and Medicine","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127917540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jain N, T. S, De D, Choudhury A, Sharma J, Sahu M, S. L, A. G, V. K
1Consultant, Transfusion Medicine & Immunohematology, Balco Medical Centre, India 2Consultant, Microbiology, Balco Medical Centre, India 3Consultant, Haemato-oncology, Balco Medical Centre, India 4Consultant, Internal Medicine, Balco Medical Centre, India 5Sr. Consultant, Surgical Oncology, Balco Medical Centre, India 6Blood Transfusion Nurse, Balco Medical Centre, India 7Technical supervisor-Transfusion Medicine, Balco Medical Centre, India 8Chief Operating Officer, Balco Medical Centre, India
{"title":"Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies amongst Health Care Workers: A Tertiary Cancer Centre Study in Chhattisgarh State of Central India","authors":"Jain N, T. S, De D, Choudhury A, Sharma J, Sahu M, S. L, A. G, V. K","doi":"10.16966/2471-5026.126","DOIUrl":"https://doi.org/10.16966/2471-5026.126","url":null,"abstract":"1Consultant, Transfusion Medicine & Immunohematology, Balco Medical Centre, India 2Consultant, Microbiology, Balco Medical Centre, India 3Consultant, Haemato-oncology, Balco Medical Centre, India 4Consultant, Internal Medicine, Balco Medical Centre, India 5Sr. Consultant, Surgical Oncology, Balco Medical Centre, India 6Blood Transfusion Nurse, Balco Medical Centre, India 7Technical supervisor-Transfusion Medicine, Balco Medical Centre, India 8Chief Operating Officer, Balco Medical Centre, India","PeriodicalId":138925,"journal":{"name":"Journal of Blood Disorders and Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133543550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Fo, Bilongo-Bouyou Asw, Gatsongui Bm, Ngolet Lo, O. N., Malanda F, Elira Dockekias A
Introduction: Aseptic Osteonecrosis of the Femoral Head (AOFH) is a degenerative complication of sickle cell disease. In the absence of care, it is a source of disability through painful lameness and functional impotence that it causes over time. Its data in african children are scarce. This work aimed at determining its prevalence and describing its characteristics. Methodology: It was about a descriptive study conducted over a4 years- period at the CNRDr on children suffering from homozygous sickle cell disease and presenting with ONFH. The studied variables were epidemiological, clinical and paraclinical, collected from medical records. The Postel Merle-d’Aubigné functional score was used to assess the functional status of the hips and the Arlet and Ficat classification for radiological staging. Results: The study involved 31 children (18 boys and 13 girls). The prevalence of AOFH was 2.15%. The average age was 11.51 ± 2.17 years old. Almost half were under 11 (45.16%). At diagnosis, the damage was bilateral in 10/31 cases, bringing the number of pathological hips to 41/62. Hip pain was constant and associated with lameness in 83.87% of cases. Hip function was good, fair, and poor respectively in 41.94%, 54.84% and 3.22% of cases. One child presented with two stiff hips. Radiologically, stages I and II on one hand and III and IV on the other hand of Arlet and Ficat were respectively found in 45.16% and 54.84% of cases. Conclusion: We report one of the most important series of black Africa. AOFH affects young children. The diagnosis is frequently late, made at the stage of functional impotence with joint destruction. The search for predictive factors is important to improve the prognosis of these young patients.
{"title":"Aseptic Osteonecrosis of the Femoral Head in Children Living with Sickle Cell Disease at the National Reference Center for Sickle Cell Disease of Brazzaville, Congo","authors":"G. Fo, Bilongo-Bouyou Asw, Gatsongui Bm, Ngolet Lo, O. N., Malanda F, Elira Dockekias A","doi":"10.16966/2471-5026.131","DOIUrl":"https://doi.org/10.16966/2471-5026.131","url":null,"abstract":"Introduction: Aseptic Osteonecrosis of the Femoral Head (AOFH) is a degenerative complication of sickle cell disease. In the absence of care, it is a source of disability through painful lameness and functional impotence that it causes over time. Its data in african children are scarce. This work aimed at determining its prevalence and describing its characteristics. Methodology: It was about a descriptive study conducted over a4 years- period at the CNRDr on children suffering from homozygous sickle cell disease and presenting with ONFH. The studied variables were epidemiological, clinical and paraclinical, collected from medical records. The Postel Merle-d’Aubigné functional score was used to assess the functional status of the hips and the Arlet and Ficat classification for radiological staging. Results: The study involved 31 children (18 boys and 13 girls). The prevalence of AOFH was 2.15%. The average age was 11.51 ± 2.17 years old. Almost half were under 11 (45.16%). At diagnosis, the damage was bilateral in 10/31 cases, bringing the number of pathological hips to 41/62. Hip pain was constant and associated with lameness in 83.87% of cases. Hip function was good, fair, and poor respectively in 41.94%, 54.84% and 3.22% of cases. One child presented with two stiff hips. Radiologically, stages I and II on one hand and III and IV on the other hand of Arlet and Ficat were respectively found in 45.16% and 54.84% of cases. Conclusion: We report one of the most important series of black Africa. AOFH affects young children. The diagnosis is frequently late, made at the stage of functional impotence with joint destruction. The search for predictive factors is important to improve the prognosis of these young patients.","PeriodicalId":138925,"journal":{"name":"Journal of Blood Disorders and Medicine","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130968241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Okamba Fr, Ocko Lt, Tsaty Ad, Nzoussi B, Etoka-Beka Mk, Nguimbi E, Ahombo G
Introduction: E-selectin and ICAM-1 are cellular adhesion molecules that play important roles in the pathogenesis of Sickle Cell Disease (SCD), especially in the vaso-occlusion process. Numerous studies reported that single nucleotide polymorphisms in E-selectin and ICAM-1 genes may be associated with the clinical expression of several diseases. However, no evidence exists regarding the association with SCD. Objectives: Investigate the association of E-selectins (S128R and S149R) and ICAM-1K469E polymorphisms with SCD in Congolese patients. Methodology: This case-control study included 110 SCD patients in vaso-occlusive pain crisis and 120 controls (healthy non-sickle cell subjects). Polymorphisms were genotyped by PCR-RFLP method. The differences in genotype and allele frequencies between both groups were analyzed with the Fisher’s exact test. A P level of <0.05 was considered significant. Results: The frequency of the ICAM-1-K469E EE genotype was significantly higher in SCD patients compared to controls (8.2% vs 0.8%; P=0.008). The odd ratio value (OR=11.89; 95% CI = 1.48-96.53; P=0.01) indicated a high association with SCD. Furthermore, the E allele was also significantly associated with SCD (OR=1.72; 95% CI=1.10-2.68; P=0.008). By contrast, no statistically significant differences were found between SCD patients and controls regarding the allele and genotype frequencies of E- selectin S128R and S149R polymorphisms. Conclusion: Our findings suggest that the ICAM-1-K469E polymorphism may be associated with SCD among Congolese patients, possibly with the vaso-occlusive crisis. The EE genotype and the E allele may be genetic risk factors. However, because of the small sample size, this report should be considered as exploratory and further studies are required to confirm these genetic associations with SCD.
导读:e -选择素和ICAM-1是细胞粘附分子，在镰状细胞病(SCD)的发病机制中起重要作用，特别是在血管闭塞过程中。大量研究报道，e -选择素和ICAM-1基因的单核苷酸多态性可能与多种疾病的临床表达有关。然而，没有证据表明它与SCD有关。目的:研究e选择(S128R和S149R)和ICAM-1K469E多态性与刚果患者SCD的关系。方法:本病例对照研究包括110例血管闭塞性疼痛危像SCD患者和120例对照组(健康非镰状细胞受试者)。采用PCR-RFLP方法对多态性进行基因分型。用Fisher精确检验分析两组间基因型和等位基因频率的差异。P <0.05为显著性差异。结果:ICAM-1-K469E EE基因型在SCD患者中的频率显著高于对照组(8.2% vs 0.8%;P = 0.008)。奇比值(OR=11.89;95% ci = 1.48 ~ 96.53;P=0.01)表明与SCD高度相关。此外，E等位基因也与SCD显著相关(OR=1.72;95%可信区间= 1.10 - -2.68;P = 0.008)。相比之下，SCD患者与对照组之间E-选择素S128R和S149R多态性的等位基因和基因型频率无统计学差异。结论:我们的研究结果表明，ICAM-1-K469E多态性可能与刚果患者的SCD有关，可能与血管闭塞危象有关。EE基因型和E等位基因可能是遗传危险因素。然而，由于样本量小，该报告应被视为探索性的，需要进一步的研究来证实这些与SCD的遗传关联。
{"title":"Polymorphism and Association of the E-selectin and ICAM-1-K469E Genes with Sickle Cell Disease in Congo","authors":"Okamba Fr, Ocko Lt, Tsaty Ad, Nzoussi B, Etoka-Beka Mk, Nguimbi E, Ahombo G","doi":"10.16966/2471-5026.130","DOIUrl":"https://doi.org/10.16966/2471-5026.130","url":null,"abstract":"Introduction: E-selectin and ICAM-1 are cellular adhesion molecules that play important roles in the pathogenesis of Sickle Cell Disease (SCD), especially in the vaso-occlusion process. Numerous studies reported that single nucleotide polymorphisms in E-selectin and ICAM-1 genes may be associated with the clinical expression of several diseases. However, no evidence exists regarding the association with SCD. Objectives: Investigate the association of E-selectins (S128R and S149R) and ICAM-1K469E polymorphisms with SCD in Congolese patients. Methodology: This case-control study included 110 SCD patients in vaso-occlusive pain crisis and 120 controls (healthy non-sickle cell subjects). Polymorphisms were genotyped by PCR-RFLP method. The differences in genotype and allele frequencies between both groups were analyzed with the Fisher’s exact test. A P level of <0.05 was considered significant. Results: The frequency of the ICAM-1-K469E EE genotype was significantly higher in SCD patients compared to controls (8.2% vs 0.8%; P=0.008). The odd ratio value (OR=11.89; 95% CI = 1.48-96.53; P=0.01) indicated a high association with SCD. Furthermore, the E allele was also significantly associated with SCD (OR=1.72; 95% CI=1.10-2.68; P=0.008). By contrast, no statistically significant differences were found between SCD patients and controls regarding the allele and genotype frequencies of E- selectin S128R and S149R polymorphisms. Conclusion: Our findings suggest that the ICAM-1-K469E polymorphism may be associated with SCD among Congolese patients, possibly with the vaso-occlusive crisis. The EE genotype and the E allele may be genetic risk factors. However, because of the small sample size, this report should be considered as exploratory and further studies are required to confirm these genetic associations with SCD.","PeriodicalId":138925,"journal":{"name":"Journal of Blood Disorders and Medicine","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125924221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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