Pub Date : 1900-01-01DOI: 10.4018/978-1-7998-4760-1.CH009
M. V. Dias-Souza, C. G. Dias
In the field of bioinorganic chemistry, porosity has been explored for the development of metal-organic frameworks (MOFs), innovative polymers, or networks composed of metal centers that stabilize organic molecules with high contact surface and well-defined crystalline structures. MOFs have also been investigated for drug therapies due to their high loading capacity, thermal stability, low electrical conductivity, biodegradability, biocompatibility, easy functionalization, and size considered adequate to control drug release in vivo. MOFs can be sensitive to variations in pH, magnetism, temperature, pressure, light, and humidity, making them desirable for vectorizing extended release systems. Among the most investigated pharmacological groups for association with MOFs are anti-inflammatory and antineoplasic drugs. Here the authors explore the recent advances of MOFs-based drug delivery systems, their current limitations, and discuss the evidences towards their potential clinical use.
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Pub Date : 1900-01-01DOI: 10.4018/978-1-7998-4760-1.CH006
Mintu Maan Dutta, Paran J. Borpatra
Clean and safe drinking water is one of the most important and essential components on earth for human survival. However, due to the various anthropogenic activities, the surface and groundwater have been contaminated with heavy metals and radionuclides, and it has become a serious problem of concern globally. These non-biodegradable heavy metal ions from water tends to accumulate in the soil and living organisms and causes serious health hazards in humans. Thus, the finding of recyclable, water-stable MOFs, and multi-functional MOFs (hybrid MOFs) with superior adsorption capability have emerged as a novel material for the removal of heavy metal species (such as Cr(III)/Cr(VI), Cu(II), Hg(II), Cd(II), As(III)/As(V), Pb(II), radionuclides U(VI), Se(IV)/(VI), Cs(I) from aqueous solution. This chapter deals with the recent development of MOFs and their application in heavy metal removal from water.
清洁和安全的饮用水是地球上人类生存最重要和最基本的组成部分之一。然而，由于各种人为活动，地表水和地下水受到重金属和放射性核素的污染，已成为全球关注的严重问题。这些来自水中的不可生物降解的重金属离子往往在土壤和生物体内积累，对人类健康造成严重危害。因此，具有优异吸附能力的可循环、水稳定的多功能MOFs(杂化MOFs)已成为一种去除水溶液中重金属(如Cr(III)/Cr(VI)、Cu(II)、Hg(II)、Cd(II)、as (III)/ as (V)、Pb(II)、放射性核素U(VI)、Se(IV)/(VI)、Cs(I))的新材料。本章介绍了MOFs的最新发展及其在水中重金属去除中的应用。
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