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Efficacy and safety of the combination nifuratel-nystatin and clindamycin-clotrimazole, in the treatment of bacterial vaginosis. Randomized controlled clinical trial 硝呋泰-制霉菌素联合克林霉素-克霉唑治疗细菌性阴道病的疗效及安全性观察。随机对照临床试验
Pub Date : 2021-06-18 DOI: 10.36811/ijrmsh.2021.110010
F. E. L. Hoz
Introduction: Bacterial vaginosis (BV) is the most frequent gynecological infection in women of reproductive age, thus driving the search for effective and safe treatments.Objective: To compare the efficacy and safety of the combination nifuratel-nystatin and clindamycinclotrimazole, in the treatment of bacterial vaginosis.Materials and Methods: Randomized controlled clinical trial in 147 single women (18 to 39 years old), non-pregnant and sexually active, with a diagnosis of BV according to the Amsel clinical criteria and the Nugent score; between 2016 and 2018. In a highly complex private clinic in Armenia, Colombia. Women were randomized into two groups: "A" (73 participants: nifuratel (500 mg) - nystatin (100,000 IU) and "B" (74 participants: clindamycin (100 mg) - clotrimazole (200 mg)); both groups were treated with vaginal ovules, "A" for six days and "B" for three days. All participants were followed-up for clinical and microbiological healing at 7 and 30 days, respectively, after completion of treatment, the STATA® 14.0 program was used.Results: The mean age of women was 28.35±5.79 years. The clinical cure rate with the nifuratelnystatin combination was 93.15%, and that of clindamycin-clotrimazole 97.29%, (p=0.123). The microbiological cure rate with the nifuratel-nystatin combination was 87.67%, and that of clindamycin-clotrimazole 93.24%, (p=0.102). Regarding safety, there were also no significant differences between the two groups (p=0.144); Mild adverse reactions were observed. Recurrence in group "A" was 12.32% compared to 6.75% in group "B" (p>0.05).Conclusions: In this study, the combinations nifuratel (500 mg) -nystatin (100,000 IU) and clindamycin (100 mg)-clotrimazole (200 mg), reported that both are equally effective and safe options in the treatment of BV. It is necessary to evaluate the effect and safety of other combinations in order to implement timely interventions.Keywords: Vaginosis; Bacterial; Efficacy; Safety; Nifuratel; Nystatin; Clindamycin; Clotrimazole.
细菌性阴道病(BV)是育龄妇女中最常见的妇科感染,因此促使人们寻找有效和安全的治疗方法。目的:比较尼夫拉特-制霉菌素与克林霉素联合治疗细菌性阴道病的疗效和安全性。材料与方法:随机对照临床试验147例,年龄18 ~ 39岁,未怀孕,性活跃,根据Amsel临床标准和Nugent评分诊断为BV的单身女性;在2016年到2018年之间。在哥伦比亚亚美尼亚一家非常复杂的私人诊所里。妇女被随机分为两组:“A”组(73名参与者:尼夫拉特(500毫克)-制霉菌素(100,000国际单位)和“B”组(74名参与者:克林霉素(100毫克)-克霉唑(200毫克));两组均接受阴道胚珠治疗,A组治疗6天,B组治疗3天。所有参与者分别在治疗完成后7天和30天随访临床和微生物愈合情况,使用STATA®14.0程序。结果:女性平均年龄28.35±5.79岁。硝伐他汀联合用药的临床治愈率为93.15%,克林霉素-氯曲霉唑联合用药的临床治愈率为97.29%,差异有统计学意义(p=0.123)。硝呋泰联合制霉菌素组微生物治愈率为87.67%,克林霉素联合克霉唑组为93.24%,差异有统计学意义(p=0.102)。在安全性方面,两组间也无显著差异(p=0.144);观察到轻微不良反应。A组复发率为12.32%,B组为6.75% (p < 0.05)。结论:在本研究中,尼夫拉特(500mg)-制霉菌素(100,000 IU)和克林霉素(100mg)-克霉唑(200mg)联合治疗细菌性肠炎是同样有效和安全的选择。为了及时实施干预措施,有必要评估其他联合用药的效果和安全性。关键词:阴道炎;细菌;功效;安全;Nifuratel;制霉菌素;克林霉素;克霉唑。
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引用次数: 1
The Physiological Changes During Pregnancy 怀孕期间的生理变化
Pub Date : 2019-10-09 DOI: 10.36811/ijrmsh.2019.110006
Siniša Franjić
Every adult woman is responsible for their body, and the decisions they make have an impact on their life and their health. However, there are times in life, pregnancy, when a person is deeply responsible for a new life in development. Safe signs of pregnancy are the presence of a fetus seen by ultrasound, listening to heart tones, touching parts of the fetal body and the presence of pregnancy hormones in the urine. After fertilization, measurable concentrations of hCG begin to emerge in the body after 7-10 days, which can be evidenced from the urine or blood of the woman. The immunological tests used today are mostly based on the use of latex particles. The presence of Human chorionic gonadotropin, the polypeptide beta subunit of which is used to prove pregnancy (abbreviated b-hCG) at a concentration of 25 mIU in the urine of a woman, equivalent to a period between the fourth and fifth weeks of pregnancy, can be demonstrated. A planned pregnancy presupposes a series of procedures that will contribute to the proper and complete development of the embryo. Each stage of pregnancy brings certain biological changes in the body of the woman. Pregnancy should last a minimum of 37 weeks, but it can take up to 42 weeks.
每个成年妇女都对自己的身体负责,她们所做的决定对她们的生活和健康有影响。然而,在人生的某些阶段,比如怀孕,一个人对新生命的发育负有重大责任。怀孕的安全标志是通过超声波看到胎儿,听心音,触摸胎儿身体的某些部位以及尿液中存在妊娠激素。受精后7-10天后,体内开始出现可测量的hCG浓度,这可以从女性的尿液或血液中得到证明。目前使用的免疫测试主要基于乳胶颗粒的使用。人绒毛膜促性腺激素的存在,其多肽β亚基被用来证明怀孕(简称b-hCG),浓度为25 mIU的妇女的尿液,相当于怀孕的第4和第5周之间,可以证明。有计划的怀孕以一系列的程序为前提,这些程序将有助于胚胎的适当和完整的发育。怀孕的每个阶段都会给女性的身体带来一定的生理变化。怀孕应该至少持续37周,但也可能长达42周。
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引用次数: 6
Efficacy Evaluation of Standardized Fenugreek seeds extract as Furostanolic Saponins & Myo-Inositol (Nutricyst-M) in Management of Insulin Resistance (IR) & Ovary Volume in PCOS Subjects 标准化胡芦巴籽提取物糠甾醇皂苷和肌醇(Nutricyst-M)对PCOS患者胰岛素抵抗(IR)和卵巢体积的疗效评价
Pub Date : 2019-07-01 DOI: 10.36811/ijrmsh.2019.110004
A. Jaipuriar, A. Malik, G. Lamgora
Polycystic ovarian syndrome (PCOS) currently affects nearly 6-10% of women of reproductive age. A frequent feature of women with PCOS is insulin resistance accompanied by compensatory hyperinsulinemia, and increasing evidence suggests that hyperinsulinemia plays an important role in the pathogenesis of PCOS, pointing the way to new and novel therapy for PCOS. The study was planned with one natural alternative remedy Standardized Fenugreek seeds extract as FurostanolicSaponins and Myo-Inositol.Standardized Fenugreek seeds extract as Furostanolic saponins which contains bioactive components Saponins extracted from Fenugreek seeds improves insulin sensitivity and, in turn, may regulate circulating androgen levels. It improves insulin-mediated glucosedisposal in women with PCOS [1,2]. It also decreased theLuteinizing HormoneLH/FSH (Follicle- Stimulating Hormone) ratio as observed in my last study [2-4]. Myo-inositol not only improves fertility by lowering male sex hormones in both, women with and without PCOS but it could also improve ovulation in women with PCOS. In addition, Myo-inositol also reduces insulin resistance and increases estrogen levels. Myo-inositol reduced testosterone, LH, and insulin levels. The present observation study is to establish efficacy and safety in management of IR and ovarian volume.
多囊卵巢综合征(PCOS)目前影响了近6-10%的育龄妇女。胰岛素抵抗伴代偿性高胰岛素血症是PCOS女性的常见特征,越来越多的证据表明高胰岛素血症在PCOS的发病机制中起重要作用,为PCOS的新治疗指明了方向。该研究计划采用一种天然替代药物标准胡芦巴籽提取物作为糠甾醇皂苷和肌醇。胡芦巴籽提取物含有生物活性成分糠甾醇皂苷,从胡芦巴籽中提取的皂苷可改善胰岛素敏感性,进而调节循环雄激素水平。它可以改善多囊卵巢综合征女性胰岛素介导的葡萄糖处理[1,2]。它还降低了促黄体生成素elh /FSH(促卵泡激素)的比例,这是我在上一项研究中观察到的[2-4]。肌醇不仅通过降低多囊卵巢综合征女性和非多囊卵巢综合征女性的雄性激素来提高生育能力,而且还可以改善多囊卵巢综合征女性的排卵。此外,肌醇还能降低胰岛素抵抗,提高雌激素水平。肌醇降低睾酮、黄体生成素和胰岛素水平。本观察研究的目的是建立治疗IR和卵巢体积的有效性和安全性。
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引用次数: 0
Female Sexual Dysfunction 女性性功能障碍
Pub Date : 2019-04-25 DOI: 10.36811/IJRMSH.2019.110003
Siniša Franjić
If a woman finds that she has a problem in sex life, if they are interfering with these relationships, it is definitely a moment to visit a doctor. Initial problems can in most cases be successfully monitored; By advancing the problem they will only accumulate, and inter-party relations will irreversibly be disrupted. It would be ideal to apply an interdisciplinary approach to treatment, meaning to include specialists of various specialties, such as gynecologists, psychiatrists, psychologists, general practitioners and others. Of course, treatment, or therapeutic approach, will be adjusted to the root cause. In treatment should be considered estrogenic creams, modification of basic therapy, psychotherapy and medicaments according to the recommendation of a psychiatrist, physical exercise etc.
如果一个女人发现她在性生活中有问题,如果他们干扰了这些关系,那绝对是去看医生的时候了。在大多数情况下,可以成功地监测到最初的问题;通过推进问题,他们只会积累,而党际关系将不可逆转地受到破坏。理想的做法是采用跨学科的方法进行治疗,这意味着包括各种专业的专家,如妇科医生、精神科医生、心理学家、全科医生等。当然,治疗,或治疗方法,将调整到根本原因。在治疗中应考虑使用雌激素乳膏、修改基础疗法、根据精神科医生的建议进行心理治疗和药物治疗、体育锻炼等。
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引用次数: 0
Is induced abortion becoming a family planning method in Ghana?: A situational analysis of induce abortion and contraception uptake in two urban cities of Ghana 在加纳,人工流产是否成为一种计划生育方法?:加纳两个城市的人工流产和避孕情况分析
Pub Date : 2019-03-29 DOI: 10.36811/IJRMSH.2019.110002
F. Y. Gbagbo, Josephine Akosua Gbagbo
Background: Following amendment of Ghanaian abortion law in 1985, abortion services became more available as permitted by law. Services data however remain scares due to provider and facility stigmatization.Objective: To explore the use of abortion as a family planning option using provider reports, trends of contraception and induced abortion service uptake in facilities within two urban cities in Ghana.Methods: Cross-sectional, descriptive design, using facility data from 50 private (42) and Non-Governmental Organizations (8). Ten in-depth interviews were also held with midwife providers (6) and medical officers (4) between January 2010 and December 2017 in Accra and Kumasi Metropolises.Results: Facility patronage of abortion services in Accra and Kumasi Metropolises increase steadily each year with contraception uptake. Abortion services in NGO facilities were however reported as target driven and providers’ performances/bonuses were tied to meeting set targets thereby encouraging abortion on demand. Whereas NGO facilities provide both abortion and full contraception method mix, majority (38 out of 42) of private facilities provide only abortion services. Those providing contraception focus mainly on short term methods (pills and injections) due to lack of interest and/or trained providers. There are more midwife lead abortion providing facilities in Accra (40) than in Kumasi (10). Where midwives provided abortion services, contraceptives were readily available and clients encouraged to take a method following abortion. This practice was very common in NGO facilities as post abortion contraception was reported to be a mandatory package.Conclusions: The Ghanaian abortion law allows conditional abortion and not on demand. However, increasing numbers of abortions in the study area coupled with reported target setting for abortion services suggest abortion on demand and its being used as a family planning option. A nationwide facility based assessment of abortion and contraception service delivery is recommended to inform policy.
背景:1985年加纳修改堕胎法后,在法律允许的情况下,堕胎服务变得更加容易获得。然而,由于供应商和设施的污名化,服务数据仍然令人恐惧。目的:利用提供者报告、避孕和人工流产服务在加纳两个城市内设施的发展趋势,探讨堕胎作为一种计划生育选择的使用。方法:采用横断面描述性设计,使用来自50家私营(42家)和非政府组织(8家)的设施数据。2010年1月至2017年12月期间,还对阿克拉和库马西大都市的助产士(6家)和医务人员(4家)进行了10次深度访谈。结果:阿克拉和库马西两大城市堕胎服务设施的使用率随着避孕措施的采用逐年稳步上升。然而,据报道,非政府组织设施中的堕胎服务是目标驱动的,提供者的业绩/奖金与达到既定目标挂钩,从而鼓励按需堕胎。非政府机构提供堕胎和全面避孕方法,而大多数(42个机构中有38个)私人机构只提供堕胎服务。由于缺乏兴趣和/或训练有素的提供者,提供避孕措施的机构主要侧重于短期方法(药丸和注射)。阿克拉(40名)比库马西(10名)有更多的助产士提供堕胎服务。在助产士提供堕胎服务的地方,可以随时获得避孕药具,并鼓励客户在堕胎后采取避孕措施。这种做法在非政府组织的设施中非常普遍,因为据报道堕胎后避孕是一项强制性措施。结论:加纳堕胎法允许有条件堕胎,而不是按要求堕胎。然而,研究地区的堕胎数量不断增加,加上报告的堕胎服务目标设定,表明按需堕胎并将其作为计划生育选择。建议在全国范围内对堕胎和避孕服务提供情况进行评估,以便为政策提供信息。
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引用次数: 0
Robson’s class and caesarean scar defects 罗布森类和剖宫产疤痕缺陷
Pub Date : 2019-03-08 DOI: 10.36811/IJRMSH.2019.110001
C. Alovisi, R. Amadori, C. Alovisi, D. Surico
Caesarean scar defect (CSD) may lead to the occurrence of gynecologic symptoms such as abnormal uterine bleeding secondary to intermittent passage of retained menstrual blood within the CSD pelvic pain, and infertility. This prospective cohort study was conducted at the Department of Obstetrics at Maria Vittoria Hospital in Turin (Italy), from January 2013 to December 2013 to analyze the effects of two different suturing techniques (single layer and double layer closure of the hysterotomy) and Robson's class impact on the incidence of CSD. All procedures were performed using a modified Stark technique by the same single senior surgeon. The way of closure of the uterine incision was alternated every three months, in order to have two groups of partecipants: one with a single layer and the other with a double layer closure technique. Single layer was carried out as one continuous locking stitch; double layer was performed with a first closure identical to the single layer and an additional suture with a continuous unlocked stitch used to imbricate the first layer. Both ways of closure of the uterine incision were performed using monofilament synthetic absorbable polydioxanone suture. Twelve months after their caesarean section, the women had an ultrasound examination of the uterine scar performed by a single experienced operator blinded to suture technique and the Robson class. The trial recruited 85 cases. 21 patients (24.8%) belonged to Robson's class 1, 5(6%) to class 2, 1(1.3%) to class 4, 35(41%) to class 5, 13(15.4%) to class 6, 6(7%) to class 7, 4(4.5%) to class 8. During the ultrasound follow up we found 10 CSD (11,8%): 8/10 CSD (80%) were found in Robson's class 5, 1 in class 1 and 1 in class 6 (p 0.008), with no correlation with single- or double-layer suture (p 0.141). To our knowledge, no previous studies evaluated the correlation with Robson classification and CSD.
剖宫产瘢痕缺损(Caesarean scar缺损,CSD)可导致子宫异常出血继发于CSD内经血潴留间歇性通过盆腔疼痛、不孕症等妇科症状。本前瞻性队列研究于2013年1月至2013年12月在意大利都灵Maria Vittoria医院产科进行,分析两种不同缝合技术(单层和双层子宫切开术)对CSD发生率的影响以及Robson分级对CSD发生率的影响。所有手术均由同一位资深外科医生使用改良的Stark技术进行。子宫切口的闭合方式每三个月交替进行一次,以便有两组参与者:一组采用单层闭合技术,另一组采用双层闭合技术。单层作为一个连续的锁针进行;进行双层缝合,第一次缝合与单层缝合相同,并使用连续无锁缝线进行额外缝合,用于覆盖第一层。两路子宫切口均采用单丝合成可吸收聚二恶酮缝合。剖宫产12个月后,由一名经验丰富的操作员对子宫疤痕进行超声检查,该操作员对缝合技术和Robson类别一无所知。该试验招募了85例患者。21例(24.8%)患者属于Robson分类1级,5例(6%)至2级,1例(1.3%)至4级,35例(41%)至5级,13例(15.4%)至6级,6例(7%)至7级,4例(4.5%)至8级。超声随访发现10例CSD(11.8%): 8/10例CSD(80%)为Robson's 5级,1级1例,6级1例(p 0.008),与单层缝合或双层缝合无关(p 0.141)。据我们所知,以前没有研究评估与Robson分类和CSD的相关性。
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引用次数: 0
Fertility regulation 生育调节
Pub Date : 2019-01-01 DOI: 10.36811/ijrmsh.2019.110005
Siniša Franjić
Ovarian cells or the number of incompetent ovarian cells that may lead to pregnancy is reduced. At a certain age, for example, after 40 years of age, naturally reduces the possibility of conception also the possibilities of spontaneous abortion and anomalies. Fertility of men and women also depends on life habits, the presence of certain illnesses, the enjoyment of various opiates, etc. Unhealthy lifestyle, poor nutrition and obesity are also factors that reduce fertility in men and women. An average, healthy couple it is necessary six to Fertility of men and women depends primarily on their age. In women, for example, the number of twelve months of active endeavours to conceive of pregnancy. If pregnancy does not occur during this period, it is necessary to seek medical help.
卵巢细胞或可能导致怀孕的无能卵巢细胞数量减少。在一定的年龄,例如,40岁以后,自然地减少了受孕的可能性,也减少了自然流产和异常的可能性。男性和女性的生育能力也取决于生活习惯、某些疾病的存在、各种鸦片剂的使用等。不健康的生活方式、营养不良和肥胖也是降低男女生育能力的因素。平均来说,一对健康的夫妇必须有6个生育能力,男女的生育能力主要取决于他们的年龄。例如,在妇女中,为怀孕而积极努力的12个月的数目。如果在此期间没有怀孕,有必要寻求医疗帮助。
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引用次数: 0
期刊
International Journal of Reproductive Medicine and Sexual Health
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