Headache Medicine Connections最新文献

{"title":"Personality Disorder Patients in A Pain Clinic","authors":"Olivia Lee, L. Robbins","doi":"10.52828/hmc.v1i2.2","DOIUrl":"https://doi.org/10.52828/hmc.v1i2.2","url":null,"abstract":"","PeriodicalId":149217,"journal":{"name":"Headache Medicine Connections","volume":"554 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132479806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Refractory Chronic Migraine with Worm Eggs: A Therapy Rooted in Evolution","authors":"L. Robbins, Hanah F. Alley","doi":"10.52828/hmc.v1i2.2021_2","DOIUrl":"https://doi.org/10.52828/hmc.v1i2.2021_2","url":null,"abstract":"Introduction: This was a small open label study designed to determine efficacy of helminth egg therapy in refractory chronic migraine (RCM) patients. It is probable that the immune system is involved in migraine. (1) Helminth worms have populated the GI tract of primates for millions of years. They downregulate the immune response. When the helminths (and other parasites) are removed, the result may be an increase in autoimmune illness. The immune system and inflammation are involved in migraine pathophysiology. Study design: Eleven RCM patients were enrolled. After the run-in period, patients ingested the helminth eggs every 2 weeks for 5 months. These eggs were from the pig whipworm, T. suris . The primary endpoint involved the number of moderate or severe headache days per month. The first (run- in) month was compared to the last 2 months of active therapy. Secondary endpoints included disability, depression, anxiety, and quality of life. Results : 5 of 11 patients met the primary endpoint (a reduction in moderateorsevereheadachedaysbyatleast3permonth).Thenumberofmoderateorsevereheadachedaysdecreasedby14,10,8,7,and3inthesepatients.Thepatientswhomettheprimaryendpointallbeganwithessentiallynoclinicaldepressionatbaseline.Disabilitydeclinedinall5patients,asdidanxiety.Qualityoflife(numberofunhealthydayspermonth)improvedin2ofthe5patientswhomettheprimaryendpoint.4of11patientswhocompletedthestudydidnotmeettheprimaryendpoint.1otherpatientdidnotsupplydata,andanotherdiscontinuedtreatmentduetodiarrhea.Analysisoftheirsecondaryendpointsdidnotresultinanydefinitiveconclusionsastowhytheydidnotimprove. Conclusion: This study indicates that there may possibly be a role for helminth therapy in treating refractory chronic migraineurs. 5 of 11 patients did well. This treatment is rooted in evolution. The presence of helminths results in a downregulation of certain aspects ofour immune system. By re-introducinghelminths into the GI system, we may dampen our immune response. This may possibly help in the treatment of conditions that involve the immune system, such as migraine.","PeriodicalId":149217,"journal":{"name":"Headache Medicine Connections","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128267246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Neurology fortified with Advanced Headache Neurology","authors":"Pravin Thomas","doi":"10.52828/hmc.v1i2.lte","DOIUrl":"https://doi.org/10.52828/hmc.v1i2.lte","url":null,"abstract":"Traditional neurology relies on history and examination to generate a hypothesis of the localisation and aetiology of the disease process. The hypotheses generated in headache medicine is often limited when it is not combined with the syndromic approach that is used in traditional neurology. The diseases which fall within the syndrome are then confirmed by additional history, examination and investigations derived from advances in the field of headache medicine. This fortification will reduce knowledge gap among clinicians. Patient advocacy and empowerment will also benefit by disseminating this enhanced knowledge. Traditional neurology relies heavily on the clinical history with which seasoned clinicians often localize the lesion somewhere in the neuraxis and also postulate the etiopathogenesis. This is followed by a focused clinical examination that often confirms the hypothesis derived from the history, although there may be a few surprises now and then. Investigations are extensions of the clinical examination and may not be fruitful, or even be misguiding if done without a hypothesis, as it may pick up a needle in the haystack instead of the bothersome rat. Traditional neurology relies heavily on the clinical history with which seasoned clinicians often localize the lesion somewhere in the neuraxis and also postulate the etiopathogenesis. This is followed by a focused clinical examination that often confirms the hypothesis derived from the history, although there may be a few surprises now and then. Investigations are extensions of the clinical examination and may not be fruitful, or even be misguiding if done without a hypothesis, as it may pick up a needle in the haystack instead of the bothersome rat. In headache medicine too, this approach has been followed all along. However what has been lacking is a detailed head and neck examination which neurologists often delegate to expert colleagues in the field of ophthalmology, ENT and oral surgery. This is because headachemedicine has been traditionally a subspecialisation of neurology and the 4 step examination of higher mental functions, cranial nerves, motor system and sensory system are the mainstay. By and large this maybe sufficient, and is also reinforced by the general perception that clinical examination contributes very little in headache disorders, unlike, say, neuromuscular disorders. The problem with this approach arises when the patient encounters a headache medicine expert, half of whose armamentarium lieswith other specialists.This void needs to be filled. Fast forward 21st century headache neurology and there is a new breed of headache specialists whose clinical skills are reinforced by training in neuro-ophthalmology, radiology and head and neck surgery. © 2021 Published by World Headache Society. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/)","PeriodicalId":149217,"journal":{"name":"Headache Medicine Connections","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116103614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Anti-CGRP monoclonal antibodies for episodic and chronic migraine on migraine characteristics, disability, impact and quality of life beyond 3 months of treatment: A Systematic review and Meta-analysis","authors":"O. Grosu, N. Yamani, Nathaniel M. Schuster, J. Sreedharan, Joelle Berchan, M. Pradeep, Anis Riahi, Pravin Thomas","doi":"10.52828/hmc.v1i2.1_cgrp","DOIUrl":"https://doi.org/10.52828/hmc.v1i2.1_cgrp","url":null,"abstract":"","PeriodicalId":149217,"journal":{"name":"Headache Medicine Connections","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125913712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dawn of a New Era in Headache Classification","authors":"Pravin Thomas","doi":"10.52828/hmc.v1i1.lte","DOIUrl":"https://doi.org/10.52828/hmc.v1i1.lte","url":null,"abstract":"Among themany things the COVID pandemic taught humanity, a prominent one is thatmedical knowledge is ultra-rapidly changing. Changes are driven by need and the world saw long strides in new knowledge to defeat a common enemy.This was also the time some radically new approaches tomedical publications were made. One eye-catching format was that of living systematic reviews. Evenwith rapid publication, it has been noted that there is a lag bymonths or years in cumulative evidence. Living reviews allowed authors to update previously vetted and peer reviewed literature (1).","PeriodicalId":149217,"journal":{"name":"Headache Medicine Connections","volume":"10 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131957285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of Head, Neck, and Face Pains First Edition (WHS-MCH1): Position paper of the WHS Classification Committee","authors":"Pravin Thomas, Anand Kumar, A. Subir, B. McGeeney, M. Raje, D. Garg, Chaithra D Aroor, A. Elavarasi, Kris Castle","doi":"10.52828/hmc.v1i1.classifications","DOIUrl":"https://doi.org/10.52828/hmc.v1i1.classifications","url":null,"abstract":"","PeriodicalId":149217,"journal":{"name":"Headache Medicine Connections","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128066312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}