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Treatment of Latent Tuberculosis Infection: New U.S. Guidelines 治疗潜伏性结核感染:新的美国指南
Pub Date : 2001-02-01 DOI: 10.1097/00019048-200102000-00005
C. Hirsch, John L. Johnson
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引用次数: 0
Skin, Hair and Nail Fungal Infections * 皮肤、头发和指甲真菌感染*
Pub Date : 2001-02-01 DOI: 10.1097/00019048-200102000-00009
R. Aly
Fungal infections of the skin, hair and nails are among the most common skin diseases. The increased incidence of these infections in recent years has been attributed to the large number of immunocompromised patients, life-style changes (greater attendance at gymnasiums, public baths, etc.), the use of chemotherapeutic agents, and the greater presence of elderly people in the general population. Superficial fungal infections were also the most frequent and troublesome dermatological condition occurring among US forces during the war in Vietnam.
皮肤、头发和指甲的真菌感染是最常见的皮肤病。近年来,这些感染的发病率增加是由于大量免疫功能低下的患者、生活方式的改变(更多地去健身房、公共浴室等)、化疗药物的使用以及一般人群中老年人的增加。在越南战争期间,表面真菌感染也是美军中最常见和最麻烦的皮肤病。
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引用次数: 5
Antimicrobial Resistance Among Escherichia coli Urinary Tract Isolates in the United States: A Current View Provided by Electronic Surveillance 美国大肠杆菌尿路分离株的抗菌素耐药性:电子监测提供的当前观点
Pub Date : 2001-02-01 DOI: 10.1097/00019048-200102000-00004
J. Karlowsky, C. Thornsberry, D. Peterson, D. C. Mayfield, D. Sahm
Given the numbers of urinary tract infections treated by family physicians and the rapid rise in resistance to traditional first-line therapies, there is a need to monitor antimicrobial resistance regionally and among various patient groups, and to use this information to predict effective empiric therapy. To determine current rates of resistance among Escherichia coli to three commonly prescribed antimicrobials, susceptibility testing results and patient demographic information were gathered via Internet-based electronic surveillance. Among 133,941 urinary tract isolates of E. coli, overall resistance rates were 38.5% for ampicillin, 18.0% for trimethoprim-sulfamethoxazole (TMP-SMX), and 2.2% for ciprofloxacin. Resistance to ampicillin and TMP-SMX was highest among patients aged 18–65 years, whereas resistance to ciprofloxacin was low for all age groups but highest among patients aged >65 years. TMP-SMX resistance was >10% in every region of the United States, ranging from 12.9 to 23.2%. Ciprofloxacin demonstrated the lowest resistance overall (2.2%), as well as low levels of cross-resistance (<2%) with ampicillin and TMP-SMX. Current levels of resistance among E. coli to TMP-SMX suggest that its effectiveness for empiric therapy may be limited in some areas.
鉴于家庭医生治疗的尿路感染人数和对传统一线治疗的耐药性迅速上升,有必要监测区域和不同患者群体的抗菌素耐药性,并利用这一信息预测有效的经验性治疗。为了确定目前大肠杆菌对三种常用抗菌素的耐药率,通过基于互联网的电子监测收集了药敏试验结果和患者人口统计信息。在尿路分离的133941株大肠杆菌中,氨苄西林耐药率为38.5%,磺胺甲恶唑(TMP-SMX)耐药率为18.0%,环丙沙星耐药率为2.2%。对氨苄西林和TMP-SMX的耐药性在18-65岁的患者中最高,而对环丙沙星的耐药性在所有年龄组中都很低,但在bb0 - 65岁的患者中最高。在美国各地区,对TMP-SMX的耐药性为10%左右,范围从12.9%到23.2%不等。环丙沙星总体耐药性最低(2.2%),与氨苄西林和TMP-SMX的交叉耐药水平也较低(<2%)。目前大肠杆菌对TMP-SMX的耐药水平表明,在某些地区,其经验性治疗的有效性可能有限。
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引用次数: 10
The Effect of a Multivitamin on the Immunologic Response to the Influenza Vaccine in the Elderly 多种维生素对老年人流感疫苗免疫反应的影响
Pub Date : 2001-02-01 DOI: 10.1097/00019048-200102000-00003
P. Ender, Peter K. DeRussy, M. Caldwell, S. Taylor, S. Trevino, D. Ybarra
The immunologic response to the influenza vaccine is suboptimal in the elderly. This poor response may be caused by vitamin deficiencies, which are common in the elderly. Seventy-nine subjects were randomized to receive multivitamin or placebo 100 days before influenza vaccination. Serologic analysis was done at the time of vaccination and 1 month later, using the influenza antigens used in the influenza vaccine in 1998–1999. The placebo group had a higher percentage of twofold (78% versus 56%, p = .048) and fourfold increases in titer (56% versus 35%, p = .072). The placebo group also had higher postvaccination geometric mean titers and increases in the geometric mean titer (GMT). This was statistically significant for the A/Beijing/262/95 (H1N1) antigen GMT (p = .0061) and the increase in the A/Beijing/262/95 (H1N1) antigen GMT (p = .0031). In the elderly, multivitamin use does not improve, and may decrease, the serologic response rate to the influenza vaccine.
老年人对流感疫苗的免疫反应并不理想。这种不良反应可能是由维生素缺乏引起的,这在老年人中很常见。79名受试者在流感疫苗接种前100天随机接受复合维生素或安慰剂。使用1998-1999年流感疫苗中使用的流感抗原,在接种疫苗时和1个月后进行血清学分析。安慰剂组的两倍(78%对56%,p = 0.048)和四倍滴度增加的百分比更高(56%对35%,p = 0.072)。安慰剂组也有较高的接种后几何平均滴度和几何平均滴度(GMT)的增加。A/Beijing/262/95 (H1N1)抗原GMT升高(p = 0.0061)和A/Beijing/262/95 (H1N1)抗原GMT升高(p = 0.0031)具有统计学意义。在老年人中,复合维生素的使用并不能提高流感疫苗的血清学应答率,甚至可能降低。
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引用次数: 2
Recurrent Group B Streptococcus Bacteremia Associated with Menstruation 复发性B型链球菌菌血症与月经有关
Pub Date : 2001-02-01 DOI: 10.1097/00019048-200102000-00007
M. Kanno, G. Poré, D. Levine
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引用次数: 1
Tropical Viral Infections * 热带病毒感染*
Pub Date : 1998-10-01 DOI: 10.1097/00019048-200102000-00008
Theodare F. Tsai, S. Halstead
This section should be of particular interest to the travel medicine physician as it reports many new manifestations of exotic viral infections, both in terms of new clinical expression or extension to new geographical territory. Included are descriptions of improved diagnostic methodologies for arboviral diseases, a discussion of safety issues involving a licensed travel medicine vaccine and a randomized placebocontrolled trial of a drug widely prescribed to reduce vascular permeability in dengue hemorrhagic fever.
这一节应该是旅行医学医生特别感兴趣的,因为它报告了许多外来病毒感染的新表现,无论是在新的临床表现还是扩展到新的地理领域。书中描述了虫媒病毒性疾病的改进诊断方法,讨论了涉及一种获得许可的旅行用药疫苗的安全问题,并对一种广泛用于降低登革热出血热患者血管渗透性的药物进行了随机安慰剂对照试验。
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引用次数: 4
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Infectious Disease in Clinical Practice
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