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TRANSFORMATION OF THE TOURIST AND RECREATION SPHERE OF THE RUSSIAN-BELARUSIAN BORDER REGION AND THE PANDEMIC CONSEQUENCES 俄白边境地区旅游和娱乐领域的转变和流行病的后果
Anastasia K. Nizhnikova
The COVID-19 pandemic has become a serious challenge for the whole world. All sectors of the economy suffered damage to a certain degree, taking all possible measures to prevent the aggravation of the epidemiological situation. The tourism and recreation sector found itself among the most affected industries. This article is devoted to the urgent problems of transformation in the tourist and recreational sphere of the Russian-Belarusian border areas, in the context of changes in the volume and structure of the flow of tourists, the reasons for their appearance and possible development prospects in the context of the geopolitical and economic crisis. The purpose of the article is to characterize and analyze the state of the tourism and recreation industry in the period from 2019 to 2021. To achieve this goal, the paper presents and analyzes the statistical data of tourist activities in Russia, Belarus and the regions of the Russian-Belarusian border within the specified period. The main criteria for the transformation were selected indicators of the tourist flow in general by country, as well as separately by border regions. The author proposes a typology of border regions in terms of their potential for adaptation to crisis conditions and prospects for increasing this potential through the development of natural and nature-oriented tourism.
新冠肺炎疫情已成为全球面临的严峻挑战。所有经济部门都受到了一定程度的损害,采取了一切可能的措施防止疫情的恶化。旅游和娱乐部门发现自己是受影响最大的行业之一。本文致力于俄罗斯-白俄罗斯边境地区旅游和娱乐领域转型的紧迫问题,在游客流量和结构变化的背景下,其出现的原因以及在地缘政治和经济危机的背景下可能的发展前景。本文的目的是表征和分析旅游和娱乐行业的状态在2019年至2021年期间。为了实现这一目标,本文提出并分析了俄罗斯、白俄罗斯以及俄白边境地区在特定时期内的旅游活动统计数据。转换的主要标准是按国家和边境地区分别选择旅游流量的总体指标。作者提出了一种边境地区的类型学,根据其适应危机条件的潜力和通过发展自然和以自然为导向的旅游来增加这种潜力的前景。
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引用次数: 0
DETERMINATION OF THE OPTIMAL APPROACH TO MEASURING THE SPLEEN SIZES BY SONOGRAPHY 超声测量脾脏大小最佳方法的确定
Sergey V Morozov, V. Izranov
There is a large number of ways to measure the size of the spleen by ultrasonography. Methodically correct examination is the key to the accurate determination of splenomegaly. The article describes well-known methods for determining its size and volume, which are used in sonography, computed tomography and magnetic resonance imaging. The aim of the study is to identify the most accurate way to measure the volume of the spleen during ultrasound examination. Therefore, the authors performed the ultrasound examination of the spleen of 40 patients, the measurement was carried out in three positions of the patient’s body, in each of the positions three methods of measuring and calculating the volume of the organ were used. During the processing of the results, it was revealed that optimal visualization was provided in the patient’s supine position, the orientation of the ultrasound transducer along the long axis of the spleen. One patient obtained different volume values — the average difference was 40—70 ml, and in some cases reached 150 ml. This indicates the influence of additional factors on visualization — these include the somatic type of the patient, the variability of the shape of the spleen when changing the position of the body, the shape of the spleen.
有很多方法可以通过超声来测量脾脏的大小。系统正确的检查是准确判断脾肿大的关键。本文介绍了超声、计算机断层扫描和磁共振成像中常用的确定其大小和体积的方法。本研究的目的是确定在超声检查中测量脾脏体积的最准确方法。因此,作者对40例患者的脾脏进行了超声检查,在患者身体的三个体位进行测量,在每个体位使用三种测量和计算器官体积的方法。结果显示,在处理过程中,患者仰卧位,超声换能器沿脾脏长轴方向的方向显示效果最佳。一名患者获得了不同的容积值——平均差异为40-70毫升,在某些情况下达到150毫升。这表明了其他因素对可视化的影响,这些因素包括患者的身体类型,改变身体位置时脾脏形状的可变性,脾脏形状。
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引用次数: 0
DEVELOPMENT AND TERRITORIAL DIFFERENCES OF AGRICULTURE IN THE KALININGRAD REGION 加里宁格勒地区农业的发展与地域差异
G. Fedorov
The patterns of development and distribution of production, including agricultural production, common to the country, are also characteristic of the exclave Kaliningrad region. However, spatial isolation from other Russian regions causes, firstly, a greater dependence on external geoeconomic and geopolitical factors and, secondly, a clearer manifestation of the patterns of spatial differentiation in the economy. Research methods are based on the spatio-temporal analysis of statistical data, using methods of comparative geographic diagnostics. The article shows a deeper decline in agricultural production in the region during the crisis years of the 1990s and increased rates of development in more favorable decades of the 21st century, as well as an acute manifestation of the polarization concepts and location of agricultural production within a separate territory compared to the country’s interior regions. The study which relied on the level of agricultural development and specialization of the territory of the region, the degree of use of land and labor resources in crop production, animal husbandry, hunting and the provision of services in these areas, substantiated to distinguish four types of municipalities according to the factors of agricultural development. Given each type, the author noted the need for a special socio-economic policy.
发展模式和生产分布,包括农业生产,是全国共有的,也是飞地加里宁格勒地区的特点。然而,与俄罗斯其他地区在空间上的隔绝,首先造成了对外部地缘经济和地缘政治因素的更大依赖,其次造成了经济空间分化格局的更清晰表现。研究方法以统计数据的时空分析为基础,采用比较地理诊断学的方法。文章显示了该地区在20世纪90年代危机时期农业生产的深度下降,以及在21世纪较有利的几十年中发展速度的提高,以及与该国内陆地区相比,在一个单独的领土内进行农业生产的两极分化概念和位置的尖锐表现。该研究基于该地区的农业发展水平和专业化程度,以及这些地区在作物生产、畜牧业、狩猎和服务提供方面对土地和劳动力资源的利用程度,证实了根据农业发展因素区分出四种类型的城市。鉴于每一种类型,发件人指出需要一项特殊的社会经济政策。
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引用次数: 0
CYTOKINE-INDUCED REGULATION OF MATURATION, DIFFERENTIATION, AND APOPTOTIC DEATH OF IMMUNE MEMORY T-LYMPHOCYTES 细胞因子诱导的免疫记忆t淋巴细胞成熟、分化和凋亡的调控
K. Yurova, D. D. Ligatyuk, D. A. Semenova, L. Litvinova
To maintain the normal state of the immune system, the processes of cell proliferation must be strictly regulated and balanced by the processes of apoptotic death to prevent the development of autoimmune and neoplastic reactions. T-lymphocytes of immune memory are under strict control from the immune system. The role of γc-cytokines (IL-2, IL-7, and IL-15) in the regulation of maturation, differentiation, and apoptotic death of memory T-lymphocytes under in vitro cultivation conditions was evaluated. The study revealed the ability of γc-cytokines to increase the content of CD3+HLA-DR+CD95+ T cells in the effector populations of immune memory cytotoxic lymphocytes, which may indicate the processes of cell differentiation and maturation under the influence of γc-cytokines. The authors also showed that in CD3+CD4+CD45RO+ T-lymphocytes have a relative resistance to the action of γc-cytokines, in comparison with cytotoxic CD45RO+ T-cells. Thus, maintaining homeostatic concentrations of γc-cytokines plays an important role in maintaining the normal functioning of the immune system by maintaining the balance of homeostatic proliferation and apoptotic death. We also noted that cytokine imbalance contributes to an increase in the surface expression of late activation molecules (HLA-DR) and apoptosis (CD95), which is necessary to control excessive proliferation of lymphocytes, and, ultimately, prevents the breakdown of immune tolerance mechanisms and the development of hyperproliferative pathologies of the immune system.
为了维持免疫系统的正常状态,细胞增殖过程必须受到凋亡死亡过程的严格调控和平衡,以防止自身免疫和肿瘤反应的发生。免疫记忆的t淋巴细胞受到免疫系统的严格控制。研究了γ -c细胞因子(IL-2、IL-7和IL-15)在体外培养条件下对记忆t淋巴细胞成熟、分化和凋亡的调控作用。本研究揭示了γ -c细胞因子能够增加免疫记忆细胞毒淋巴细胞效应群体中CD3+HLA-DR+CD95+ T细胞的含量,这可能提示了γ -c细胞因子影响下细胞分化和成熟的过程。作者还表明,与细胞毒性CD45RO+ t细胞相比,CD3+CD4+CD45RO+ t淋巴细胞对γ -c细胞因子的作用具有相对抗性。因此,维持γ -c细胞因子的稳态浓度,通过维持稳态增殖和凋亡死亡的平衡,对维持免疫系统的正常功能起着重要作用。我们还注意到,细胞因子失衡导致晚期活化分子(HLA-DR)和细胞凋亡(CD95)的表面表达增加,这是控制淋巴细胞过度增殖所必需的,并最终防止免疫耐受机制的破坏和免疫系统超增殖病理的发展。
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引用次数: 0
COGNITIVE FEATURES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PATIENTS WITH ALCOHOL ADDICTION 慢性阻塞性肺疾病酒精成瘾患者的认知特征
M. Ivanova, A. A. Punin, S. Vaulin
Chronic obstructive pulmonary disease (COPD) is a significant public health problem due to its widespread prevalence. It becomes a medical and social burden for both society and the patient. To what extent comorbid alcoholism is able to influence the features of the clinical course of COPD remains an open issue. The study aimed to reveal the impact of alcoholism on the level of COPD subjective symptoms in patients with different compliance. Materials and methods. 147 men with COPD in the age of 40―88 years were examined. The study relied on spirometry criteria, mMRC, CAT, domestic questionnaire of adherence to therapy, 6-minutes walking tests. It also established the stage of alcohol disease. The inhalation therapy was clarified during the interview, the episodic and systemic omissions fixed. Results and discussion. We observed the trend to subjective COPD symptoms underestimation in patients with the II, III stages of alcohol disease. Alcohol disease did not affect subjective symptoms in patients with stages III, IV of COPD. The compliance level and subjective symptoms severity showed no interrelation in patients suffering from alcoholism. This emphasized the absent association between the high level of compliance and critical self-state perception in patients with concomitant diseases. Regardless of the concomitant dependence, systemic omissions were rarely observed in patients receiving inhalers with a lower dosage frequency. Conclusion. The poor informativity of mMRC dyspnea scale and CAT-test was demonstrated in patients with mild and moderate COPD and severe alcoholism. The high level of compliance showed no impact on this tendency. Using single dose per day regimen was associated with a better compliance to recommendations, regardless of alcohol adherence.
慢性阻塞性肺疾病(COPD)因其广泛流行而成为一个重大的公共卫生问题。它成为社会和患者的医疗和社会负担。共病性酒精中毒在多大程度上能够影响慢性阻塞性肺病临床病程的特征仍然是一个悬而未决的问题。本研究旨在揭示酒精中毒对不同依从性患者COPD主观症状水平的影响。材料和方法。对147名年龄在40-88岁之间的男性COPD患者进行了检查。研究依据肺活量测定标准、mMRC、CAT、国内治疗依从性问卷、6分钟步行测试。它还确立了酒精疾病的分期。在访谈中明确了吸入疗法,固定了发作性和全身性遗漏。结果和讨论。我们观察到II、III期酒精性疾病患者主观COPD症状低估的趋势。酒精疾病对慢性阻塞性肺病III、IV期患者的主观症状没有影响。酒精中毒患者依从性水平与主观症状严重程度无相关性。这强调了伴随疾病患者的高依从性与临界自我状态感知之间缺乏关联。不管伴随的依赖,在接受较低剂量频率吸入器的患者中很少观察到全身性遗漏。结论。在轻中度COPD合并重度酒精中毒患者中,mMRC呼吸困难量表和cat测试的信息性较差。高依从性对这种趋势没有影响。使用每日单剂量方案与更好的依从性相关,无论酒精依从性如何。
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引用次数: 0
SECTORAL COMPOSITION OF THE ECONOMY AS A TYPOLOGICAL ATTRIBUTE 经济的部门构成作为一种类型属性
Anna G. Volkova
Structuring information is critical to learning the difference between the countries of the world. The typology is one of the scientific methods of systematizing information. Selecting a typological attribute becomes a major challenge of methodology for creating a typology due to the richness of information. This article provides an example of the typology of the countries based on their types of sectoral composition of the economy. The research attempts at assessing the degree of the information richness of sectoral composition of the economy as typological attribute for economy typology. The article concern definitions «typology», «GDP», «sectoral composition of the economy», «servicization» and «tertiarization». The author offers some methodology to determine the types of sectoral composition of the economy and the thresholds for GDP. The article also analyzes relation between type of sectoral composition of the economy and income of the population expressed in GDP per capita. The economic types proposed the article form homogeneous areas, which include several countries. Types of sectoral structure of the world’s economies are located on the world map with certain patterns.
构建信息对于了解世界各国之间的差异至关重要。类型学是将信息系统化的科学方法之一。由于信息的丰富性,选择类型学属性成为创建类型学方法的主要挑战。本文提供了一个基于经济部门构成类型的国家类型学的例子。本研究试图评估经济部门构成的信息丰富程度,作为经济类型学的类型属性。这篇文章涉及定义“类型学”、“GDP”、“经济的部门构成”、“服务化”和“第三化”。作者提供了一些方法来确定经济部门构成的类型和GDP的阈值。文章还分析了经济部门构成类型与以人均GDP表示的人口收入之间的关系。文章提出的经济类型形成同质区域,其中包括几个国家。世界经济部门结构的类型在世界地图上有一定的格局。
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引用次数: 1
FEATURES OF THE CURRENT ALLOCATION PATTERNS OF AGRICULTURAL PRODUCTS IN THE RUSSIAN NON-BLACK SOIL ZONE 俄罗斯非黑土区农产品配置模式的现状特征
A. Kostyaev, G. Nikonova
The macro-region Nonblack Soil Zone plays an important role in the development of the Russian economy, ensuring its food security. With the transition of the country to market relations, the distribution of agricultural production in all its regions has been transformed. These changes for the Nonblack Soil Zone have not been properly studied. This study focuses on the patterns of change in the location of agricultural production in the Nonblack Soil Zone. Research methodology relies on a combination of statistical analysis methods with heuristic methods (taking into account zonal and azonal factors) based on the use of fundamental works on agricultural zoning. The study has established trends towards a decrease in the role of the Nonblack Soil Zone in the all-Russian production of crop products and towards its growth for livestock products. An excessive concentration of production in pig and poultry farming has been revealed. On the basis of zonal factors, the northern, central, and southern groups of regions are identified. Taking into account the azonal factors, the central regions are divided into two subgroups: the main agricultural regions and those with suburban agriculture. The research has established Tendencies in changing the location of agricultural production. The authors have concluded that the main zone of commercial production of grain (except rye) and industrial crops (except fiber flax) is the group of southern regions, and the commercial production of winter rye, oats, fiber flax is the agrarian regions of the central zone. For the southern regions, there is a trend of high growth rates of corn for grain, sugar beet, sunflower. The group of central regions is the main producer of livestock goods. Given the trends, the role of the southern regions in the production of beef cattle and poultry products will increase in the future. In regions with suburban farming, the dairy specialization of cattle breeding is on the rise and the production of eggs and all types of livestock for slaughter is decreasing. Meanwhile, in the group of northern regions, the development of dairy and meat cattle breeding, the production of potatoes and vegetables is likely to improve.
宏观区域非黑土区在俄罗斯经济发展中发挥着重要作用,保障了俄罗斯的粮食安全。随着国家向市场关系的转变,全国各地的农业生产分布都发生了变化。非黑土带的这些变化尚未得到适当的研究。本文主要研究非黑土区农业生产区位的变化规律。研究方法是在借鉴农业区划基础著作的基础上,结合统计分析方法和启发式方法(考虑地带性和地带性因素)。该研究确定了非黑土区在全俄罗斯作物产品生产中的作用下降和牲畜产品增长的趋势。生产过度集中于养猪和家禽养殖业的现象已被揭露。在地带性因素的基础上,划分出北部、中部和南部三个区域群。考虑地带性因素,将中部地区划分为两个亚群:主要农业区和郊区农业区。研究确定了农业生产区位转移的趋势。得出粮食(黑麦除外)和经济作物(纤维亚麻除外)的商业生产以南部地区为主,冬黑麦、燕麦、纤维亚麻的商业生产以中部地区的农业区为主。在南方地区,粮食用玉米、甜菜、向日葵有高增长趋势。中部地区是畜产品的主要产地。鉴于这种趋势,南方地区在肉牛和家禽产品生产中的作用将在未来增加。在有郊区农业的地区,奶牛养殖的专业化程度正在上升,而用于屠宰的蛋类和各类牲畜的产量正在下降。同时,在北方地区,发展奶牛和肉牛养殖,土豆和蔬菜的生产有可能提高。
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引用次数: 2
PECULIARITIES OF OBTAINING FODDER AMINO ACIDS WHEN CULTURING CORYNEBACTERIUM ON SOYBEAN MOLASSE 在大豆糖蜜上培养棒状杆菌获得饲料氨基酸的特点
M. Zimina, S. Noskova, E. Ulrikh, K. S. Afanasyeva, Natalia S. Fedotovskikh, O. Krieger
Currently, soybeans and soybean derivatives are widely used for food and animal feed. A significant content of carbohydrates in soy molasses makes it possible to use it as a component of a nutrient medium for cultivating microorganisms that produce feed amino acids. The aim of this work was to study the process of biosynthesis of feed amino acids on a soy molasses medium using bacterial strains of the genus Corynebacterium glutamicum. The following research methods were used: microscopy, spectrometry, refractometry, pH-metry and high-performance liquid chromatography. It has been established that when cultivating on soy molasses, the strains C. glutamicum B-1002 and C. glutamicum B-1722 have the greatest ability to assimilate the components of the medium. The addition of such growth components as nicotinic acid and NaCl had no significant effect on the accumulation of C. glutamicum B-1002 and C. glutamicum B-1722 biomass. It has been proven that the best medium for cultivation of C. glutamicum is molasse that has gone through the entire technological process and contains the maximum amount of components necessary for the cultivation of C. glutamicum and the production of feed amino acids. The production of feed amino acids by C. glutamicum is influenced by such factors as dry matter content and active acidity of the medium. It was found that the best producers of feed acids are C. glutamicum B-1002 and C. glutamicum B-1722 strains cultivated on media composed of soy molasses and distilled water at a dilution of 1 : 9.
目前,大豆及其衍生物被广泛用于食品和动物饲料。大豆糖蜜中碳水化合物的显著含量使得可以将其用作培养产生饲料氨基酸的微生物的营养培养基的组成部分。本研究的目的是利用谷氨酸棒状杆菌在大豆糖蜜培养基上生物合成饲料氨基酸的过程。研究方法:显微法、光谱法、折射法、ph法、高效液相色谱法。在大豆糖蜜上培养时,菌株C. glutamicum B-1002和C. glutamicum B-1722对培养基成分的同化能力最强。添加烟酸和NaCl等生长成分对谷氨酰胺B-1002和谷氨酰胺B-1722生物量积累无显著影响。实验证明,培养谷氨酰胺的最佳培养基是糖蜜,糖蜜经过了整个工艺过程,含有谷氨酰胺培养和饲料氨基酸生产所必需的最大量的成分。培养基干物质含量和活性酸度等因素对谷氨酰胺生产饲料氨基酸的影响较大。结果表明,在大豆糖蜜和蒸馏水的比例为1:9的培养基上培养的C. glutamum B-1002和C. glutamum B-1722菌株产生饲料酸的效果最好。
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引用次数: 0
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Vestnik of Immanuel Kant Baltic Federal University. Series: Natural and Medical Sciences
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