Maman Abdurahman, Kiki Ahmad Rizki, Adi Zufron Pringadi
Around 52.6% of women aged <50 years in Indonesia are diagnosed with breast cancer. One of the chemotherapy regimens with a toxicity effect on reproductive function, especially ovarian follicles, is 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). Anti-Mullerian Hormone (AMH) is a biomarker that can be used to assess the ovarian function. This study aimed to determine the correlation between pre-chemotherapy AMH serum level, menstrual status, and whether the AMH serum level can predict ovarian function recovery in pre-menopausal women receiving FAC chemotherapy. This was an analytical observational study with a prospective cohort design performed in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, during 2021-2022. Data were analyzed using correlation analysis. Subjects were breast cancer patients aged ≤45 years, still of reproductive age, with no prior history of chemotherapy, and were undergoing the FAC chemotherapy. All 32 patients who met the inclusion criteria were included in this study. There was a significant difference (p 0.0001) between pre- and post-6 cycles of chemotherapy AMH levels. Post-6 cycles of chemotherapy showed lower AMH levels. There was a high correlation (p 0.0034) between pre-chemotherapy AMH level and menstrual status six months after six cycles of chemotherapy. The correlation test between post-chemotherapy AMH level and menstrual status showed a non-significant result. Thus, there is a high statistical correlation between pre-chemotherapy anti-Mullerian hormone levels in pre-menopausal women with breast cancer and the menstrual status after FAC chemotherapy which demonstrates that the AMH level could also be used to predict ovarian function recovery.
在印度尼西亚，大约52.6%的50岁妇女被诊断患有乳腺癌。5-氟尿嘧啶-阿霉素-环磷酰胺(FAC)是一种对生殖功能，特别是卵巢卵泡具有毒性作用的化疗方案。抗苗勒管激素(AMH)是一种评价卵巢功能的生物标志物。本研究旨在确定化疗前AMH血清水平与月经状况的相关性，以及AMH血清水平是否可以预测绝经前接受FAC化疗的女性卵巢功能恢复。这是一项前瞻性队列设计的分析性观察研究，于2021-2022年在印度尼西亚万隆的Dr. Hasan Sadikin总医院进行。采用相关分析对数据进行分析。研究对象为年龄≤45岁，仍处于生育年龄，既往无化疗史，正在接受FAC化疗的乳腺癌患者。所有符合纳入标准的32例患者均纳入本研究。化疗前后6个周期的AMH水平有显著差异(p 0.0001)。化疗6个周期后AMH水平降低。化疗前AMH水平与6个周期化疗后6个月的月经状况有高度相关(p 0.0034)。化疗后AMH水平与月经状况的相关性检验结果无统计学意义。因此，绝经前乳腺癌患者化疗前抗苗勒管激素水平与FAC化疗后月经状况具有较高的统计学相关性，表明AMH水平也可用于预测卵巢功能恢复。
{"title":"Correlation Between Pre-Chemotherapy AMH Level, Menstrual Status, and Prediction of Ovarian Function Recovery after FAC Chemotherapy AMH in Breast Cancer Patients","authors":"Maman Abdurahman, Kiki Ahmad Rizki, Adi Zufron Pringadi","doi":"10.15395/mkb.v55n3.3134","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.3134","url":null,"abstract":"Around 52.6% of women aged <50 years in Indonesia are diagnosed with breast cancer. One of the chemotherapy regimens with a toxicity effect on reproductive function, especially ovarian follicles, is 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). Anti-Mullerian Hormone (AMH) is a biomarker that can be used to assess the ovarian function. This study aimed to determine the correlation between pre-chemotherapy AMH serum level, menstrual status, and whether the AMH serum level can predict ovarian function recovery in pre-menopausal women receiving FAC chemotherapy. This was an analytical observational study with a prospective cohort design performed in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, during 2021-2022. Data were analyzed using correlation analysis. Subjects were breast cancer patients aged ≤45 years, still of reproductive age, with no prior history of chemotherapy, and were undergoing the FAC chemotherapy. All 32 patients who met the inclusion criteria were included in this study. There was a significant difference (p 0.0001) between pre- and post-6 cycles of chemotherapy AMH levels. Post-6 cycles of chemotherapy showed lower AMH levels. There was a high correlation (p 0.0034) between pre-chemotherapy AMH level and menstrual status six months after six cycles of chemotherapy. The correlation test between post-chemotherapy AMH level and menstrual status showed a non-significant result. Thus, there is a high statistical correlation between pre-chemotherapy anti-Mullerian hormone levels in pre-menopausal women with breast cancer and the menstrual status after FAC chemotherapy which demonstrates that the AMH level could also be used to predict ovarian function recovery.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in various countries. This study aimed to examine potential effects of dates as a hepatoprotective agent in mice. This study was conducted at the Iratco Group’s eLRosa Laboratory Research Facility, Indonesia, starting from June 2022 to July 2022. Mice from ddY strain were randomly divided into 5 groups (n=5 per group) of positive and negative control groups, and treatment groups 1, 2, and 3. The negative control group as the normal baseline did not receive acetaminophen and date extract. In treatment groups, 30 µL/30 gr BW, 60 µL/30 gr BW, and 100 µL/30 gr BW extract was given per oral to Treatment Group 1, Group 2, and Group 3, respectively for 20 days. On day 21, all treatment groups were induced with 300mg/KgBW acetaminophen for 3 days via the intraperitoneal route. Blood tests were performed on day 24 to measure the serum transaminase level as the parameter of liver damage. The lowest level of transaminase serum was found in group 3 with the highest volume of dates extract, which was 100 µL, followed by group 2 (60 µL), and group 1 (30 µL). There was a significant difference between the positive control group and treatment groups with no significant difference was seen between negative and the treatment groups. This study concludes that dates extract has the potential of being a hepatoprotective agent.
枣子(Phoenix dactylifera)被认为是一种众所周知的水果，被许多国家的人们所食用。本研究旨在研究枣作为肝保护剂对小鼠的潜在作用。该研究于2022年6月至2022年7月在Iratco集团位于印度尼西亚的eLRosa实验室研究设施进行。将ddY毒株小鼠随机分为5组(每组n=5)，分别为阳性对照组、阴性对照组和治疗组1、2、3。阴性对照组作为正常基线，不服用对乙酰氨基酚和枣提取物。在治疗组中，治疗组1、组2和组3分别口服30µL/30 gr BW、60µL/30 gr BW和100µL/30 gr BW提取物，持续20 d。第21天，各处理组小鼠腹腔灌胃对乙酰氨基酚300mg/KgBW，连续3 d。第24天进行血液检查，测定血清转氨酶水平，作为肝损害的指标。血清转氨酶水平以3组最低，红枣提取物量最高，为100µL，其次为2组(60µL)， 1组(30µL)。阳性对照组与治疗组比较差异有统计学意义，阴性组与治疗组比较差异无统计学意义。本研究认为枣提取物具有保护肝脏的潜力。
{"title":"Hepatoprotective Potentials of Dates Extract (Phoenix dactylifera) in Acetaminophen-Induced Mice","authors":"Andriyanto Andriyanto, Hamdika Yendri Putra, Sharon Aurelia, Aulia Andi Mustika, Wasmen Manalu, Mawar Subangkit, Elpita Tarigan, Yusa Irarang","doi":"10.15395/mkb.v55n3.3155","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.3155","url":null,"abstract":"Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in various countries. This study aimed to examine potential effects of dates as a hepatoprotective agent in mice. This study was conducted at the Iratco Group’s eLRosa Laboratory Research Facility, Indonesia, starting from June 2022 to July 2022. Mice from ddY strain were randomly divided into 5 groups (n=5 per group) of positive and negative control groups, and treatment groups 1, 2, and 3. The negative control group as the normal baseline did not receive acetaminophen and date extract. In treatment groups, 30 µL/30 gr BW, 60 µL/30 gr BW, and 100 µL/30 gr BW extract was given per oral to Treatment Group 1, Group 2, and Group 3, respectively for 20 days. On day 21, all treatment groups were induced with 300mg/KgBW acetaminophen for 3 days via the intraperitoneal route. Blood tests were performed on day 24 to measure the serum transaminase level as the parameter of liver damage. The lowest level of transaminase serum was found in group 3 with the highest volume of dates extract, which was 100 µL, followed by group 2 (60 µL), and group 1 (30 µL). There was a significant difference between the positive control group and treatment groups with no significant difference was seen between negative and the treatment groups. This study concludes that dates extract has the potential of being a hepatoprotective agent.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sepsis is a severe medical condition characterized by organ dysfunctions resulting from the body's response to an infection. Septic shock is a complication of sepsis that involves circulatory, cellular, and metabolic disturbances. The body's response to infection is typically marked by an increase in neutrophils and a decrease in lymphocytes, leading to increased Neutrophil Lymphocyte Ratio (NLR). This study aimed to investigate the differences in NLR between sepsis and septic shock patients treated at Dr. H. Abdul Moeloek Provincial Hospital, Lampung, Indonesia. This study utilized a comparative analytic study approach with a cross sectional design. A total of 96 sepsis patients who met the inclusion and exclusion criteria treated during the period January 2018 - December 2020 at Dr. H. Abdul Moeloek Provincial Hospital, Lampung, Indonesia, were included in this study. The study found that most of sepsis patients showed an increase in neutrophils (89.58%), a decrease in lymphocytes (94.79%), and elevated NLR values (87.5%). The mean NLR value of septic shock patients (20.10±5.89) was significantly higher than that of sepsis patients (18.01±1.35) (p=0.025). It indicates that the NLR value increases significantly in patients who develop septic shock compared to those with sepsis alone. The findings suggest that NLR could be a potential biomarker for septic shock diagnosis. However, the effectiveness of NLR in predicting the severity of sepsis and determining the risk of mortality in these patients still needs to be examined by conducting studies that involve a larger sample size.
脓毒症是一种严重的疾病，其特征是身体对感染的反应导致器官功能障碍。脓毒性休克是脓毒症的并发症，包括循环、细胞和代谢紊乱。人体对感染的反应通常以中性粒细胞增加和淋巴细胞减少为特征，导致中性粒细胞淋巴细胞比(NLR)增加。本研究旨在调查在印度尼西亚楠蓬省Dr. H. Abdul Moeloek省级医院接受治疗的败血症和感染性休克患者NLR的差异。本研究采用横断面设计的比较分析研究方法。在2018年1月至2020年12月期间，共有96名符合纳入和排除标准的败血症患者在印度尼西亚南榜的Dr. H. Abdul Moeloek省级医院接受了治疗。研究发现，大多数脓毒症患者表现为中性粒细胞升高(89.58%)，淋巴细胞降低(94.79%)，NLR值升高(87.5%)。脓毒症休克患者NLR平均值(20.10±5.89)显著高于脓毒症患者(18.01±1.35)(p=0.025)。结果表明，脓毒性休克患者的NLR值明显高于单纯脓毒症患者。研究结果表明NLR可能是脓毒性休克诊断的潜在生物标志物。然而，NLR在预测脓毒症严重程度和确定这些患者死亡风险方面的有效性仍需要进行更大样本量的研究来检验。
{"title":"Differences in Neutrophil Lymphocyte Ratio (NLR) between Sepsis and Septic Shock Patients in a Tertiary Hospital in Indonesia","authors":"Intanri Kurniati, Ferdian Syukri Arisqan, Utari Gita Mutiara","doi":"10.15395/mkb.v55n3.3149","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.3149","url":null,"abstract":"Sepsis is a severe medical condition characterized by organ dysfunctions resulting from the body's response to an infection. Septic shock is a complication of sepsis that involves circulatory, cellular, and metabolic disturbances. The body's response to infection is typically marked by an increase in neutrophils and a decrease in lymphocytes, leading to increased Neutrophil Lymphocyte Ratio (NLR). This study aimed to investigate the differences in NLR between sepsis and septic shock patients treated at Dr. H. Abdul Moeloek Provincial Hospital, Lampung, Indonesia. This study utilized a comparative analytic study approach with a cross sectional design. A total of 96 sepsis patients who met the inclusion and exclusion criteria treated during the period January 2018 - December 2020 at Dr. H. Abdul Moeloek Provincial Hospital, Lampung, Indonesia, were included in this study. The study found that most of sepsis patients showed an increase in neutrophils (89.58%), a decrease in lymphocytes (94.79%), and elevated NLR values (87.5%). The mean NLR value of septic shock patients (20.10±5.89) was significantly higher than that of sepsis patients (18.01±1.35) (p=0.025). It indicates that the NLR value increases significantly in patients who develop septic shock compared to those with sepsis alone. The findings suggest that NLR could be a potential biomarker for septic shock diagnosis. However, the effectiveness of NLR in predicting the severity of sepsis and determining the risk of mortality in these patients still needs to be examined by conducting studies that involve a larger sample size.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hepatitis B virus infection in pregnancy has become a major concern in many developing countries,. The relationship between hepatitis B virus infection and pregnancy is complex and puzzling. This study aimed to investigate the relationship between hepatitis B virus infection and pregnancy outcomes with the insights into the AST to Platelet Ratio Index (APRI) and Fib-4 score. This was a cross-sectional study on pregnant women with hepatitis B virus infections who underwent labor at dr. Zainal Abidin Hospital General Hospital, Aceh, Indonesia. Data were collected from the obstetric ward patient medical records from 2017 to 2019 and 77 pregnant women was identified to be infected with hepatitis B virus, of which 44 had complete medical record data and were included in the analysis. The median APRI in this study was 0.30 (0.1-1.2) while the median FIB-4 score was 0.74 (0.3-1.9). Delivery with live births was identified in 42 (95.5%) women. Term pregnancy and vaginal delivery were observed in 39 (88.6%) and 10 (22.7%) women, respectively, Complicated pregnancy was seen in 14 (31.8%) of pregnancies that included complications such as oligohydramnios, HELLP, severe preeclampsia, placenta previa, and premature rupture of membranes. APRI was higher in the stillbirth group (0.5 [0.2-0.8] p = 0.682) and preterm birth group (0.4 [0.2-0.6], p = 0.502). FIB-4 scores were higher in the stillbirth group (1.2 [0.5-1.8], p = 0.517) and preterm birth group (0.9 [0.4-1.9], p = 0.529). Hence, pregnancy does not always worsen liver function and is not related to the natural course of hepatitis B infection. Pregnancy with hepatitis B without fibrosis is not associated with poor pregnancy outcomes. Routine liver function examination is needed in pregnant mothers with hepatitis B virus infections.
{"title":"AST to Platelet Ratio Index (APRI), Fib-4 Score, and Pregnancy Outcome of Pregnant Women with Hepatitis B","authors":"Desi Maghfirah, Fauzi Yusuf, Azzaki Abubakar, Dewi Karlina Rusly, Darnifayanti Darnifayanti","doi":"10.15395/mkb.v55n3.3066","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.3066","url":null,"abstract":"Hepatitis B virus infection in pregnancy has become a major concern in many developing countries,. The relationship between hepatitis B virus infection and pregnancy is complex and puzzling. This study aimed to investigate the relationship between hepatitis B virus infection and pregnancy outcomes with the insights into the AST to Platelet Ratio Index (APRI) and Fib-4 score. This was a cross-sectional study on pregnant women with hepatitis B virus infections who underwent labor at dr. Zainal Abidin Hospital General Hospital, Aceh, Indonesia. Data were collected from the obstetric ward patient medical records from 2017 to 2019 and 77 pregnant women was identified to be infected with hepatitis B virus, of which 44 had complete medical record data and were included in the analysis. The median APRI in this study was 0.30 (0.1-1.2) while the median FIB-4 score was 0.74 (0.3-1.9). Delivery with live births was identified in 42 (95.5%) women. Term pregnancy and vaginal delivery were observed in 39 (88.6%) and 10 (22.7%) women, respectively, Complicated pregnancy was seen in 14 (31.8%) of pregnancies that included complications such as oligohydramnios, HELLP, severe preeclampsia, placenta previa, and premature rupture of membranes. APRI was higher in the stillbirth group (0.5 [0.2-0.8] p = 0.682) and preterm birth group (0.4 [0.2-0.6], p = 0.502). FIB-4 scores were higher in the stillbirth group (1.2 [0.5-1.8], p = 0.517) and preterm birth group (0.9 [0.4-1.9], p = 0.529). Hence, pregnancy does not always worsen liver function and is not related to the natural course of hepatitis B infection. Pregnancy with hepatitis B without fibrosis is not associated with poor pregnancy outcomes. Routine liver function examination is needed in pregnant mothers with hepatitis B virus infections.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the causes of cerebral venous sinus thrombosis (CVST) is platelet hyperactivity. Adhesion and secretion are the beginning of platelet activation, which is indicated by a change in the Platelet-selectin (P-selectin) level. The end result of platelet activation is platelet aggregation. However, it is unknown whether the beginning of platelet activation ends with platelet aggregation. This study aimed to discover the correlation between P-selectin level and platelet aggregation in CVST. This study used a cross-sectional escriptive observational correlative approach. Subjects were the CVST outpatients visiting the Neurology Department of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from July to September 2021. A total of 49 subjects met the inclusion and exclusion criteria. This study used citrate plasma samples for platelet aggregation and serum for P-selectin assessment. Platelet aggregation were assessed using the light transmission platelet aggregation method while P-selectin was assessed using Enzyme-linked immunosorbent assay (ELISA). Platelet aggregation median was 10.6% (range 0.2–82.4%), which reflected normoaggregation. Platelet hyperaggregation were seen in 9 samples (8.4%). Median of P-selectin was 2.4 ng/mL (range 0.1–10.1 ng/mL) which were normal. High P-selectin level was observed in 16 (32.7%) with 4/16 (25%) experiencing platelet hyperaggregation. Statistical analysis showed a weak negative correlation between P-selectin and platelet aggregation (r=-0.012; p=0.467). In conclusion, no correlation is seen between P-selectin and platelet aggregation, which may be due to the fact that platelets are influenced by many factors that are not examined in this study.
{"title":"Correlation Between P-Selectin Level and Platelet Aggregation in Cerebral Venous Sinus Thrombosis Patients","authors":"Rahmawati Nurmin, Leni Lismayanti, Tiene Rostini, Agnes Rengga Indrati, Lisda Amalia","doi":"10.15395/mkb.v55n3.2777","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.2777","url":null,"abstract":"One of the causes of cerebral venous sinus thrombosis (CVST) is platelet hyperactivity. Adhesion and secretion are the beginning of platelet activation, which is indicated by a change in the Platelet-selectin (P-selectin) level. The end result of platelet activation is platelet aggregation. However, it is unknown whether the beginning of platelet activation ends with platelet aggregation. This study aimed to discover the correlation between P-selectin level and platelet aggregation in CVST. This study used a cross-sectional escriptive observational correlative approach. Subjects were the CVST outpatients visiting the Neurology Department of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from July to September 2021. A total of 49 subjects met the inclusion and exclusion criteria. This study used citrate plasma samples for platelet aggregation and serum for P-selectin assessment. Platelet aggregation were assessed using the light transmission platelet aggregation method while P-selectin was assessed using Enzyme-linked immunosorbent assay (ELISA). Platelet aggregation median was 10.6% (range 0.2–82.4%), which reflected normoaggregation. Platelet hyperaggregation were seen in 9 samples (8.4%). Median of P-selectin was 2.4 ng/mL (range 0.1–10.1 ng/mL) which were normal. High P-selectin level was observed in 16 (32.7%) with 4/16 (25%) experiencing platelet hyperaggregation. Statistical analysis showed a weak negative correlation between P-selectin and platelet aggregation (r=-0.012; p=0.467). In conclusion, no correlation is seen between P-selectin and platelet aggregation, which may be due to the fact that platelets are influenced by many factors that are not examined in this study.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Both tall and short parents are concerned about their children's short stature. This study aimed to explore the knowledge about short stature (SS) and attitude towards its treatment among the general public of Saudi Arabia. This was a cross-sectional study that utilized an online-administered questionnaire distributed between August 2021 and March 2022. Binary logistic regression was conducted to identify factors that affect participants’ knowledge. This study included a total of 6,852 individuals. The vast majority of the participants (77.5%) expressed satisfaction with their height. A total of 40.4% of participants stated that they were aware of a treatment option for their low height. With a mean score of 13.0 (SD:5.8) out of 25, the participants demonstrated a moderate level of knowledge of short stature (52.0%). The majority of participants (78.0%) stated that if they have a problem with short stature or want to enhance their own or their children's height, they are willing to consult a doctor about it. Participants living in the northern and eastern areas, those with bachelor degree, and those working in the healthcare field were more likely to be knowledgeable about short stature compared to others (p≤0.01). Saudi Arabians have a moderate understanding of SS, which needs to be improved. Campaigns to increase the general public's and parents' knowledge about SS, which is ultimately connected to earlier diagnosis and better management outcomes, are needed. Additional research is required to examine the most effective strategies for raising public knowledge of SS.
{"title":"Knowledge and Attitude of Short Stature and Its Treatment in Saudi Arabia","authors":"Majdi Hashem, Reem Abdulrahman AlMohaini","doi":"10.15395/mkb.v55n3.3328","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.3328","url":null,"abstract":"Both tall and short parents are concerned about their children's short stature. This study aimed to explore the knowledge about short stature (SS) and attitude towards its treatment among the general public of Saudi Arabia. This was a cross-sectional study that utilized an online-administered questionnaire distributed between August 2021 and March 2022. Binary logistic regression was conducted to identify factors that affect participants’ knowledge. This study included a total of 6,852 individuals. The vast majority of the participants (77.5%) expressed satisfaction with their height. A total of 40.4% of participants stated that they were aware of a treatment option for their low height. With a mean score of 13.0 (SD:5.8) out of 25, the participants demonstrated a moderate level of knowledge of short stature (52.0%). The majority of participants (78.0%) stated that if they have a problem with short stature or want to enhance their own or their children's height, they are willing to consult a doctor about it. Participants living in the northern and eastern areas, those with bachelor degree, and those working in the healthcare field were more likely to be knowledgeable about short stature compared to others (p≤0.01). Saudi Arabians have a moderate understanding of SS, which needs to be improved. Campaigns to increase the general public's and parents' knowledge about SS, which is ultimately connected to earlier diagnosis and better management outcomes, are needed. Additional research is required to examine the most effective strategies for raising public knowledge of SS.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Ainul Mahfuz, Muhammad Sopiyudin Dahlan, Juliani Ibrahim, Ayu Sastinawati
As a country with a high proportion of rural areas, Indonesia continues to struggle with a rapid and accurate diagnosis of COVID-19, necessitating the development of a diagnostic tool or parameter that is less expensive, easier to obtain, and produces rapid results. This retrospective study aimed to explore the diagnostic accuracy of oxygen saturation in detecting COVID-19 in rural areas of Indonesia. Data were collected consecutively from medical records of adult patient (30 – 90 years old) suspected of having COVID-19 based on the WHO criteria and underwent RT-PCR swab test in three (3) hospitals in one of the regions of Indonesia during the timeframe of May 1, 2020 to September 31, 2021. Analysis was conducted using the cross-table analysis with sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) as the variables with their respective confidence interval. Results indicated that 548 of 700 patients included in the analysis were confirmed positive for COVID-19 based on the RT-PCR test results. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) value of oxygen saturation for detecting COVID-19 were 33% (CI 95% 29 – 37%), 78% (CI 95% 72 – 85) %), 84% (CI 95% 80 – 89%), 24% (CI 95% 21 – 28%), and 56% (CI 95% 51– 61%), respectively. Thus, the oxygen saturation level alone does not have adequate diagnostic accuracy for the diagnosis of COVID-19 and, therefore, is not recommended to be used for diagnosing COVID-19.
{"title":"Oxygen Saturation Diagnostic Accuracy Against COVID-19 in Rural Areas of Indonesia","authors":"Muhammad Ainul Mahfuz, Muhammad Sopiyudin Dahlan, Juliani Ibrahim, Ayu Sastinawati","doi":"10.15395/mkb.v55n3.2990","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.2990","url":null,"abstract":"As a country with a high proportion of rural areas, Indonesia continues to struggle with a rapid and accurate diagnosis of COVID-19, necessitating the development of a diagnostic tool or parameter that is less expensive, easier to obtain, and produces rapid results. This retrospective study aimed to explore the diagnostic accuracy of oxygen saturation in detecting COVID-19 in rural areas of Indonesia. Data were collected consecutively from medical records of adult patient (30 – 90 years old) suspected of having COVID-19 based on the WHO criteria and underwent RT-PCR swab test in three (3) hospitals in one of the regions of Indonesia during the timeframe of May 1, 2020 to September 31, 2021. Analysis was conducted using the cross-table analysis with sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) as the variables with their respective confidence interval. Results indicated that 548 of 700 patients included in the analysis were confirmed positive for COVID-19 based on the RT-PCR test results. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) value of oxygen saturation for detecting COVID-19 were 33% (CI 95% 29 – 37%), 78% (CI 95% 72 – 85) %), 84% (CI 95% 80 – 89%), 24% (CI 95% 21 – 28%), and 56% (CI 95% 51– 61%), respectively. Thus, the oxygen saturation level alone does not have adequate diagnostic accuracy for the diagnosis of COVID-19 and, therefore, is not recommended to be used for diagnosing COVID-19.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mario Nataputra, Dewi Yulianti Bisri, Dhany Budipratama
Post anesthesia shivering (PAS) is a repetitive involuntary movement of one or more muscle groups as a result of a decrease in core body temperature. Pharmacological therapy in preventing PAS may include meperidine and paracetamol. This study compared the effectiveness of paracetamol to meperidine in reducing the incidence of post-anesthesia shivering. This study used an experimental randomized double-blind comparative analytic design on patients underwent exploratory laparotomy surgery under general anesthesia at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from September 2021 to August 2022. Patients with 50 ASA 1-2 physical status were included and divided into two groups. One group received 15 mg/kg group paracetamol and the other received 0.35 mg/kg meperidine. Data on tympanic membrane temperature and hemodynamics before and after induction and after extubating were collected. Furthermore, data on the results of the assessment of the incidence and grade of shivering in each treatment group were also collected. The results of this study showed that there was a decrease in the frequency of PAS in patients receiving intravenous 15 mg/kg paracetamol (p<0.05), as well as less side effects in the form of nausea and vomiting (p < 0.05). The incidence and degree of shivering after general anesthesia using intravenous 15 mg/kg paracetamol was lower compared to the use of 0.35 mg/kg meperidine. In the meperidine group, the decrease in body temperature was lower than in the paracetamol group, while the incidence of nausea and vomiting in the paracetamol group was lower than in the meperidine group. In conclusion, paracetamol reduces the incidence of post-anesthesia shivering better than meperidine.
麻醉后颤抖(PAS)是由于核心体温下降而引起的一个或多个肌肉群的不自主重复运动。预防PAS的药物治疗包括哌替啶和扑热息痛。本研究比较了扑热息痛和哌替啶在减少麻醉后寒战发生率方面的有效性。本研究采用实验性随机双盲比较分析设计，研究对象为2021年9月至2022年8月在印度尼西亚万隆哈桑·萨迪金总医院(Dr. Hasan Sadikin general Hospital)接受全麻下剖腹探查手术的患者。纳入ASA 1-2身体状态为50的患者，分为两组。一组给予15 mg/kg扑热息痛组，另一组给予0.35 mg/kg哌替啶组。收集诱导前后和拔管后的鼓膜温度和血流动力学数据。此外，还收集了每个治疗组中寒战发生率和等级评估结果的数据。本研究结果显示静脉注射15mg /kg扑热息痛的患者出现PAS的频率降低(p<0.05)，恶心和呕吐的副作用也减少(p<0.05)。0.05)。静脉注射15 mg/kg扑热息痛的患者全身麻醉后发抖的发生率和程度低于静脉注射0.35 mg/kg哌啶的患者。扑热息痛组体温下降低于扑热息痛组，恶心呕吐发生率低于扑热息痛组。综上所述，扑热息痛比哌啶更能降低麻醉后寒战的发生率。
{"title":"Comparison of Preemptive Post-Intubation 15 Mg/KgBW Paracetamol to 0.35 Mg/KgBW Meperidine in Incidence of Post-Anesthetic Shivering","authors":"Mario Nataputra, Dewi Yulianti Bisri, Dhany Budipratama","doi":"10.15395/mkb.v55n3.3047","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.3047","url":null,"abstract":"Post anesthesia shivering (PAS) is a repetitive involuntary movement of one or more muscle groups as a result of a decrease in core body temperature. Pharmacological therapy in preventing PAS may include meperidine and paracetamol. This study compared the effectiveness of paracetamol to meperidine in reducing the incidence of post-anesthesia shivering. This study used an experimental randomized double-blind comparative analytic design on patients underwent exploratory laparotomy surgery under general anesthesia at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from September 2021 to August 2022. Patients with 50 ASA 1-2 physical status were included and divided into two groups. One group received 15 mg/kg group paracetamol and the other received 0.35 mg/kg meperidine. Data on tympanic membrane temperature and hemodynamics before and after induction and after extubating were collected. Furthermore, data on the results of the assessment of the incidence and grade of shivering in each treatment group were also collected. The results of this study showed that there was a decrease in the frequency of PAS in patients receiving intravenous 15 mg/kg paracetamol (p<0.05), as well as less side effects in the form of nausea and vomiting (p < 0.05). The incidence and degree of shivering after general anesthesia using intravenous 15 mg/kg paracetamol was lower compared to the use of 0.35 mg/kg meperidine. In the meperidine group, the decrease in body temperature was lower than in the paracetamol group, while the incidence of nausea and vomiting in the paracetamol group was lower than in the meperidine group. In conclusion, paracetamol reduces the incidence of post-anesthesia shivering better than meperidine.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agus Limanto, Elma Eka Fitra Husain, Anna Maria Dewajanti
Over the last decade, the global prevalence of hypertension rate has increased by 5.2% and, in Indonesia, the prevalence rate has increased significantly from 25.8% in 2013 to 34.1% in 2018. Hypertension treatments using blood pressure-lowering drugs, such as angiotensin-converting enzyme (ACE) inhibitors, often cause unpleasant side effects. These side effects increase the interest in using potentially effective natural remedies, such as garlic. This study aimed to determine which organosulfur compounds in garlic can act as an ACE inhibitor to reduce blood pressure in hypertension using a cheminformatics approach. Eighteen organosulfur compounds of Allium sativum L. were screened based on Lipinski’s rules and ADMET evaluation. Seven compounds passed the screening and were subjected to QSAR analysis, molecular docking analysis, and molecular dynamics simulations to assess the stability of the protein. The seven compounds then underwent molecular docking and QSAR analysis. Ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) and S-allylmercaptocysteine (SAMC) were two compounds with better docking values compared to the positive control compound. The QSAR analysis also showed that SAMC had an activity as an ACE inhibitor. The ADMET evaluation showed that Ajoene and SAMC had good absorption and could not penetrate the blood-brain barrier. Molecular dynamics simulation of ACE complexes Ajoene, SAMC, and Captopril ranged from 0.05 to 5.61 Å but exhibited a pattern of synonymous fluctuations for most residues. Based on the simulation data, the organosulfur compounds from garlic, Ajoene, and SAMC are proven to have a mechanism of action as ACE inhibitors to reduce blood pressure in hypertension.
{"title":"In-silico study of the Effectiveness of Allium sativum L. extract as an Angiotensin-Converting Enzyme (ACE) Inhibitor in Hypertension","authors":"Agus Limanto, Elma Eka Fitra Husain, Anna Maria Dewajanti","doi":"10.15395/mkb.v55n3.3287","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.3287","url":null,"abstract":"Over the last decade, the global prevalence of hypertension rate has increased by 5.2% and, in Indonesia, the prevalence rate has increased significantly from 25.8% in 2013 to 34.1% in 2018. Hypertension treatments using blood pressure-lowering drugs, such as angiotensin-converting enzyme (ACE) inhibitors, often cause unpleasant side effects. These side effects increase the interest in using potentially effective natural remedies, such as garlic. This study aimed to determine which organosulfur compounds in garlic can act as an ACE inhibitor to reduce blood pressure in hypertension using a cheminformatics approach. Eighteen organosulfur compounds of Allium sativum L. were screened based on Lipinski’s rules and ADMET evaluation. Seven compounds passed the screening and were subjected to QSAR analysis, molecular docking analysis, and molecular dynamics simulations to assess the stability of the protein. The seven compounds then underwent molecular docking and QSAR analysis. Ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) and S-allylmercaptocysteine (SAMC) were two compounds with better docking values compared to the positive control compound. The QSAR analysis also showed that SAMC had an activity as an ACE inhibitor. The ADMET evaluation showed that Ajoene and SAMC had good absorption and could not penetrate the blood-brain barrier. Molecular dynamics simulation of ACE complexes Ajoene, SAMC, and Captopril ranged from 0.05 to 5.61 Å but exhibited a pattern of synonymous fluctuations for most residues. Based on the simulation data, the organosulfur compounds from garlic, Ajoene, and SAMC are proven to have a mechanism of action as ACE inhibitors to reduce blood pressure in hypertension.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Alamsyah Aziz, Chandra Garnida Syahbana, Jusuf Sulaeman Effendi, Benny Hasan Purwara, Tita Husnitawati Madjid, Hadi Susiarno
Premature rupture of membranes (PROM) is still a health problem with a reasonably high incidence among pregnant women in Indonesia. The PROM is defined as the rupture of membranes before signs of labor are observed. Better knowledge on the causes, signs, symptoms, and complications of PROM is believed to help in reducing maternal and infant mortality caused by PROM. This was a cross-sectional, analytic observational study conducted in Cipacing Village, Sumedang, West Java, Indonesia during the period of June-July 2022. . Community education was held to give better knowledge about PROM for women with an obstetric and gynecology specialist and fetomaternal consultant as the resource person. Total sampling was obtained from 62 women. Data were collection using pre-test and post-tests before and after the education session. The mean pre-test score was 6.48, while the mean post-test score was 7.96. A dependent T-test was used to determine the relationship between scores before and after the community education with a p-value of 0.0001. There was a significant increase in knowledge about PROM after the education session compared to before the session. This means community education is effective and impactful to increase the level of knowledge about PROM among women.
{"title":"Effect of Community Education on Community Knowledge of Premature Rupture of Membranes","authors":"Muhammad Alamsyah Aziz, Chandra Garnida Syahbana, Jusuf Sulaeman Effendi, Benny Hasan Purwara, Tita Husnitawati Madjid, Hadi Susiarno","doi":"10.15395/mkb.v55n3.3070","DOIUrl":"https://doi.org/10.15395/mkb.v55n3.3070","url":null,"abstract":"Premature rupture of membranes (PROM) is still a health problem with a reasonably high incidence among pregnant women in Indonesia. The PROM is defined as the rupture of membranes before signs of labor are observed. Better knowledge on the causes, signs, symptoms, and complications of PROM is believed to help in reducing maternal and infant mortality caused by PROM. This was a cross-sectional, analytic observational study conducted in Cipacing Village, Sumedang, West Java, Indonesia during the period of June-July 2022. . Community education was held to give better knowledge about PROM for women with an obstetric and gynecology specialist and fetomaternal consultant as the resource person. Total sampling was obtained from 62 women. Data were collection using pre-test and post-tests before and after the education session. The mean pre-test score was 6.48, while the mean post-test score was 7.96. A dependent T-test was used to determine the relationship between scores before and after the community education with a p-value of 0.0001. There was a significant increase in knowledge about PROM after the education session compared to before the session. This means community education is effective and impactful to increase the level of knowledge about PROM among women.","PeriodicalId":18171,"journal":{"name":"Majalah Kedokteran Bandung","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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