Pub Date : 1900-01-01DOI: 10.21775/9781913652555.02
Tina M. Cairns, S. Connolly
{"title":"Entry of Alphaherpesviruses","authors":"Tina M. Cairns, S. Connolly","doi":"10.21775/9781913652555.02","DOIUrl":"https://doi.org/10.21775/9781913652555.02","url":null,"abstract":"","PeriodicalId":186962,"journal":{"name":"Alphaherpesviruses: Molecular Biology, Host Interactions and Control","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117253594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21775/9781913652555.05
Orkide O. Koyuncu, L. Enquist, E. Engel
{"title":"Invasion of the Nervous System","authors":"Orkide O. Koyuncu, L. Enquist, E. Engel","doi":"10.21775/9781913652555.05","DOIUrl":"https://doi.org/10.21775/9781913652555.05","url":null,"abstract":"","PeriodicalId":186962,"journal":{"name":"Alphaherpesviruses: Molecular Biology, Host Interactions and Control","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117147614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21775/9781913652555.03
Gregory A. Smith
{"title":"Navigating the Cytoplasm: Delivery of the Alphaherpesvirus Genome to the Nucleus","authors":"Gregory A. Smith","doi":"10.21775/9781913652555.03","DOIUrl":"https://doi.org/10.21775/9781913652555.03","url":null,"abstract":"","PeriodicalId":186962,"journal":{"name":"Alphaherpesviruses: Molecular Biology, Host Interactions and Control","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114929372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21775/9781913652555.06
N. Sawtell, R. Thompson
{"title":"Alpha Herpesvirus Latency and Reactivation With a Focus on Herpes Simplex Virus","authors":"N. Sawtell, R. Thompson","doi":"10.21775/9781913652555.06","DOIUrl":"https://doi.org/10.21775/9781913652555.06","url":null,"abstract":"","PeriodicalId":186962,"journal":{"name":"Alphaherpesviruses: Molecular Biology, Host Interactions and Control","volume":" 17","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120933972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21775/9781913652555.08
Elizabeth B. Draganova, Michael K. Thorsen, E. Heldwein
During viral replication, herpesviruses utilize a unique strategy, termed nuclear egress, to translocate capsids from the nucleus into the cytoplasm. This initial budding step transfers a newly formed capsid from within the nucleus, too large to fit through nuclear pores, through the inner nuclear membrane to the perinuclear space. The perinuclear enveloped virion must then fuse with the outer nuclear membrane to be released into the cytoplasm for further maturation, undergoing budding once again at the trans-Golgi network or early endosomes, and ultimately exit the cell non-lytically to spread infection. This first budding process is mediated by two conserved viral proteins, UL31 and UL34, that form a heterodimer called the nuclear egress complex (NEC). This chapter focuses on what we know about how the NEC mediates capsid transport to the perinuclear space, including steps prior to and after this budding event. Additionally, we discuss the involvement of other viral proteins in this process and how NEC-mediated budding may be regulated during infection.
{"title":"Nuclear Egress","authors":"Elizabeth B. Draganova, Michael K. Thorsen, E. Heldwein","doi":"10.21775/9781913652555.08","DOIUrl":"https://doi.org/10.21775/9781913652555.08","url":null,"abstract":"During viral replication, herpesviruses utilize a unique strategy, termed nuclear egress, to translocate capsids from the nucleus into the cytoplasm. This initial budding step transfers a newly formed capsid from within the nucleus, too large to fit through nuclear pores, through the inner nuclear membrane to the perinuclear space. The perinuclear enveloped virion must then fuse with the outer nuclear membrane to be released into the cytoplasm for further maturation, undergoing budding once again at the trans-Golgi network or early endosomes, and ultimately exit the cell non-lytically to spread infection. This first budding process is mediated by two conserved viral proteins, UL31 and UL34, that form a heterodimer called the nuclear egress complex (NEC). This chapter focuses on what we know about how the NEC mediates capsid transport to the perinuclear space, including steps prior to and after this budding event. Additionally, we discuss the involvement of other viral proteins in this process and how NEC-mediated budding may be regulated during infection.","PeriodicalId":186962,"journal":{"name":"Alphaherpesviruses: Molecular Biology, Host Interactions and Control","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125210611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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