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The changes and significances of platelet GMP - 140 and GMP - 140 in plasma in patients with acute cerebral infarction 急性脑梗死患者血浆血小板GMP - 140和血浆GMP - 140的变化及意义
Pub Date : 2001-05-15 DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.05.010
Zhanc Zhong-hui
Objective To explore the changes and significances of platelet Granule membrane protein - 140(GMP - 140)and GMP - 140 in patients with acute cerebral infarction. Method The platelet GMP - 140 was measured with enzyme-linked immunosorbent assay(ELISA) competitive method and GMP - 140 in plasma by ELISA double antibody method in blood collecting in 3d and 2 week after onset in large (n= 22)and small (n = 25)size cerebral infarcyion groups. Result The platelet GMP - 140 and GMP - 140 in plasma in large cerebral infarction group in 3d after onset were much higher than control group(P 0. 001 ), and small group were higher(P 0. 05 )than control but lower than large group. The platelet GMP - 140 andGMP - 140 in plasma in 2 groups in 2 week after onest had been clearly lower but higher than control group(P 0. 05 ). Conclusion The platelet GMP - 140 and GMP - 140 in plasma in acute cerebral infarction patients were much higher and was related with states of the illness, The changes of platelet GMP - 140 is correlated with GMP - 140 in plasma.
目的探讨急性脑梗死患者血小板颗粒膜蛋白- 140(GMP - 140)和GMP - 140的变化及其意义。方法采用酶联免疫吸附试验(ELISA)竞争法检测大(22例)和小(25例)脑梗死组发病后3d和2周采血时血小板GMP - 140, ELISA双抗体法检测血浆GMP - 140。结果大脑梗死组发病后3d血小板GMP - 140、血浆GMP - 140明显高于对照组(P < 0.05)。0.001),小组较高(P < 0.05)。0.05)低于对照组,但低于大组。两组患者术后2周血小板GMP - 140和血浆GMP - 140均明显低于对照组,但高于对照组(P < 0.05)。05 ). 结论急性脑梗死患者血浆血小板GMP - 140和GMP - 140水平明显升高,且与病情有关,血小板GMP - 140的变化与血浆GMP - 140的变化有一定的相关性。
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Modern Rehabilitation
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