Hui-ru An, X. Bai, Jian-qin Liang, Tao Wang, Zhong-Yuan Wang, Y. Xue, Yinping Liu, Lan Wang, Xueling Wu
The aim of the present study is to investigate the clinical value and characteristics of peripheral blood lymphocyte subsets in patients with pulmonary tuberculosis (PTB) using flow cytometry.
本研究的目的是利用流式细胞术探讨肺结核患者外周血淋巴细胞亚群的临床价值和特点。
{"title":"The relationship between absolute counts of lymphocyte subsets and clinical features in patients with pulmonary tuberculosis","authors":"Hui-ru An, X. Bai, Jian-qin Liang, Tao Wang, Zhong-Yuan Wang, Y. Xue, Yinping Liu, Lan Wang, Xueling Wu","doi":"10.1111/crj.13490","DOIUrl":"https://doi.org/10.1111/crj.13490","url":null,"abstract":"The aim of the present study is to investigate the clinical value and characteristics of peripheral blood lymphocyte subsets in patients with pulmonary tuberculosis (PTB) using flow cytometry.","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"118010232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Mikami, T. Jo, H. Matsuzaki, Taro Ishimori, Minako Saito, Y. Sakamoto, Y. Yamauchi, D. Takai, Y. Yatomi, T. Nagase
Obstructive lung disease (OLD) is a risk factor for postoperative pulmonary complications (PPC) and is incidentally discovered during preoperative evaluation. The key treatments for OLD are inhaled long‐acting bronchodilators (LAB). However, the advantage of preoperative bronchodilator treatment for patients with OLD remains unclear. The aim of this study is to elucidate the effect of preoperative LAB treatment in patients with untreated OLD on postoperative outcomes.
{"title":"Preoperative intervention with long‐acting bronchodilators for the reduction of postoperative pulmonary complications in untreated patients with obstructive lung disease","authors":"Yu Mikami, T. Jo, H. Matsuzaki, Taro Ishimori, Minako Saito, Y. Sakamoto, Y. Yamauchi, D. Takai, Y. Yatomi, T. Nagase","doi":"10.1111/crj.13105","DOIUrl":"https://doi.org/10.1111/crj.13105","url":null,"abstract":"Obstructive lung disease (OLD) is a risk factor for postoperative pulmonary complications (PPC) and is incidentally discovered during preoperative evaluation. The key treatments for OLD are inhaled long‐acting bronchodilators (LAB). However, the advantage of preoperative bronchodilator treatment for patients with OLD remains unclear. The aim of this study is to elucidate the effect of preoperative LAB treatment in patients with untreated OLD on postoperative outcomes.","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"17 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117562029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahsa Dastranj, A. Farahani, Abdolrazagh Hashemi Shahraki, S. Atashi, P. Mohajeri
Infections by non‐tuberculous mycobacteria (NTM) has rapidly increased in recent years, due to high infection rates related to the populations at risk like immunocompromised individuals, patients predisposed by prior pulmonary. The aim of this study was to investigate the presence of NTM in clinical samples and genetic diversity using 16S rRNA and rpoB sequence analysis.
{"title":"Molecular identification and distribution of non‐tuberculous mycobacteria isolated from clinical specimens by PCR‐sequencing method in West of Iran","authors":"Mahsa Dastranj, A. Farahani, Abdolrazagh Hashemi Shahraki, S. Atashi, P. Mohajeri","doi":"10.1111/crj.12617","DOIUrl":"https://doi.org/10.1111/crj.12617","url":null,"abstract":"Infections by non‐tuberculous mycobacteria (NTM) has rapidly increased in recent years, due to high infection rates related to the populations at risk like immunocompromised individuals, patients predisposed by prior pulmonary. The aim of this study was to investigate the presence of NTM in clinical samples and genetic diversity using 16S rRNA and rpoB sequence analysis.","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120506281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In pulmonary hypertension (PH), unopposed increases in pulmonary vascular resistance will trigger right ventricular (RV) structural and functional remodeling changes that could result in RV failure, the main cause of death in patients with PH. While transthoracic echocardiography (TTE) is a widely recognized noninvasive imaging tool in the evaluation of RV abnormalities in PH; the electrocardiogram (ECG) though still obtained as part of initial PH workup suffers from limitations in sensitivity (55%) and specificity (70%). However, recent cardiac magnetic resonance data suggests that ECGs might still be useful to detect changes in RV load. Consequently, we queried our database and found a heterogeneous group of 85 patients with PH who had both ECG and TTE to determine whether any of the common ECG abnormalities known to occur in PH such as resting tachycardia, changes in the amplitude of R and S waves in precordial lead V1, and frontal axis deviation 110 degrees was useful in identifying any significant RV structural or functional abnormalities by echocardiography. The University of Cincinnati IRB approved this study. All TTE examinations were performed according to published guidelines and measurements were compared using two-tailed unpaired t-test assuming unequal variances. ECGs were read by two independent readers (Inter-rater agreement: Kappa static5 0.86 and 95% confidence interval) blinded to TTE results. P-values of less than .05 were considered to be statistically significant. All statistics were calculated in MedCalc Software bvba Version 14.12.0 (Belgium). In the population studied, patients with sinus tachycardia had significantly higher pulmonary artery systolic pressures. In the case of right axis deviation, not only patients were younger but also had higher pulmonary artery systolic pressures with worse RV systolic function. Finally, no RV echocardiographic abnormalities were abnormal with an rsR’ pattern in lead V1. The results of this small comparative study once again fail to show any significant correlation between ECG and RV abnormalities when assessed by TTE. However, before we completely discredit the utility of ECGs to assess PH patients it is important to highlight data from recent studies in both rats and humans showing that even a mild increase in RV pressure load is associated with substantial changes in myocardial electrical properties, detectable in a standard ECG recording when three-dimensional echocardiography or cardiac magnetic resonance imaging are used. Furthermore, some ECG abnormalities are known to occur more commonly in specific subgroups of PH patients. More specifically, right bundle branch block is an independent predictor of mortality in patients with systemic sclerosis while conduction abnormalities not only are common in patients with chronic obstructive pulmonary disease, but also these ECG abnormalities increase with disease severity. In conclusion, the jury is still regarding the potential value for
在肺动脉高压(PH)中，肺血管阻力的无对抗性增加会引发右心室(RV)结构和功能重构的改变，从而导致右心室衰竭，这是PH患者死亡的主要原因。而经胸超声心动图(TTE)是一种广泛认可的评估PH下右心室异常的无创成像工具;心电图(ECG)虽然仍然是初始PH检查的一部分，但在敏感性(55%)和特异性(70%)方面存在局限性。然而，最近的心脏磁共振数据表明，心电图可能仍然有助于检测右心室负荷的变化。因此，我们查询了我们的数据库，并找到了85名同时有ECG和TTE的PH患者，以确定是否有任何已知的PH中常见的ECG异常，如静息性心动过速，心前导联V1 R和S波振幅的变化，额轴偏差110度，这些都有助于通过超声心动图识别任何显著的RV结构或功能异常。辛辛那提大学伦理委员会批准了这项研究。所有TTE检查均按照已发表的指南进行，测量结果采用假设方差不等的双尾非配对t检验进行比较。心电图由两个独立的阅读者(评分间一致:Kappa静态值为0.86,95%置信区间)对TTE结果盲读。p值小于0.05被认为具有统计学意义。所有统计数据均在MedCalc Software bvba Version 14.12.0(比利时)中计算。在研究的人群中，窦性心动过速患者的肺动脉收缩压明显较高。右轴偏位患者不仅年龄小，而且肺动脉收缩压高，右心室收缩功能差。最后，没有右心室超声心动图异常与V1导联rsR模式异常。这项小型比较研究的结果再次没有显示ECG和RV异常在TTE评估时有任何显著的相关性。然而，在我们完全否定心电图评估PH患者的实用性之前，重要的是要强调最近在大鼠和人身上的研究数据，这些研究表明，即使右心室压力负荷的轻微增加也与心肌电特性的实质性变化有关，当使用三维超声心动图或心脏磁共振成像时，在标准心电图记录中可以检测到这一点。此外，已知某些ECG异常在PH患者的特定亚组中更常见。更具体地说，右束支传导阻滞是系统性硬化症患者死亡率的独立预测指标，而传导异常不仅在慢性阻塞性肺疾病患者中很常见，而且随着疾病严重程度的增加，这些心电图异常也会增加。总之，陪审团仍然对ECG在PH中的潜在价值，特别是在解剖和功能性RV异常方面的潜在价值持怀疑态度。因此，在我们放弃ECG在评估PH患者时的潜在效用之前，对使用更先进成像工具的正在进行的研究结果继续保持警惕是至关重要的。
{"title":"Is the electrocardiogram still useful in detecting right ventricular abnormalities in patients with pulmonary hypertension when compared to echocardiography?","authors":"Alfredo Lamela Domenech, A. López-Candales","doi":"10.1111/crj.12607","DOIUrl":"https://doi.org/10.1111/crj.12607","url":null,"abstract":"In pulmonary hypertension (PH), unopposed increases in pulmonary vascular resistance will trigger right ventricular (RV) structural and functional remodeling changes that could result in RV failure, the main cause of death in patients with PH. While transthoracic echocardiography (TTE) is a widely recognized noninvasive imaging tool in the evaluation of RV abnormalities in PH; the electrocardiogram (ECG) though still obtained as part of initial PH workup suffers from limitations in sensitivity (55%) and specificity (70%). However, recent cardiac magnetic resonance data suggests that ECGs might still be useful to detect changes in RV load. Consequently, we queried our database and found a heterogeneous group of 85 patients with PH who had both ECG and TTE to determine whether any of the common ECG abnormalities known to occur in PH such as resting tachycardia, changes in the amplitude of R and S waves in precordial lead V1, and frontal axis deviation 110 degrees was useful in identifying any significant RV structural or functional abnormalities by echocardiography. The University of Cincinnati IRB approved this study. All TTE examinations were performed according to published guidelines and measurements were compared using two-tailed unpaired t-test assuming unequal variances. ECGs were read by two independent readers (Inter-rater agreement: Kappa static5 0.86 and 95% confidence interval) blinded to TTE results. P-values of less than .05 were considered to be statistically significant. All statistics were calculated in MedCalc Software bvba Version 14.12.0 (Belgium). In the population studied, patients with sinus tachycardia had significantly higher pulmonary artery systolic pressures. In the case of right axis deviation, not only patients were younger but also had higher pulmonary artery systolic pressures with worse RV systolic function. Finally, no RV echocardiographic abnormalities were abnormal with an rsR’ pattern in lead V1. The results of this small comparative study once again fail to show any significant correlation between ECG and RV abnormalities when assessed by TTE. However, before we completely discredit the utility of ECGs to assess PH patients it is important to highlight data from recent studies in both rats and humans showing that even a mild increase in RV pressure load is associated with substantial changes in myocardial electrical properties, detectable in a standard ECG recording when three-dimensional echocardiography or cardiac magnetic resonance imaging are used. Furthermore, some ECG abnormalities are known to occur more commonly in specific subgroups of PH patients. More specifically, right bundle branch block is an independent predictor of mortality in patients with systemic sclerosis while conduction abnormalities not only are common in patients with chronic obstructive pulmonary disease, but also these ECG abnormalities increase with disease severity. In conclusion, the jury is still regarding the potential value for","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"118805043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mlika, Meriem Triki, H. Kwas, E. Braham, H. Ghédira, F. Mezni
A 30-year-old non-smoker woman without a particular past medical history consulted for dyspnoea and non-productive cough. Chest CT scan revealed mediastinal and hilar adenopathies associated with bilateral ground glass opacities with thickened interlobular septa. Bronchoalveolar lavage was performed (Fig. 1). The fluid was opaque with a milky turbid gross appearance. On microscopic examination, finely granular amorphous material was apparent in the background along with numerous lymphocytes and fragmented macrophages. Zhiel stain was performed but was negative. The diagnosis of pulmonary alveolar proteinosis (PAP) was suspected but the association of mediastinal adenomegalies was not concordant with the diagnosis. Surgical biopsy of the lung and the mediastinal lymph nodes was performed. Histological examination revealed granulomatous inflammation with caseous necrosis in the lymph nodes and an amorphous PAS positif lipoprotein material filling the alveolar spaces in the lung (Fig. 2). The final diagnosis of associated PAP with tuberculosis infection was established. The patient was put on anti-tuberculosis drugs and presented an improvement of her general state.
{"title":"When the bronchoalveolar lavage makes the diagnosis of interstitial pneumonia","authors":"M. Mlika, Meriem Triki, H. Kwas, E. Braham, H. Ghédira, F. Mezni","doi":"10.1111/crj.12464","DOIUrl":"https://doi.org/10.1111/crj.12464","url":null,"abstract":"A 30-year-old non-smoker woman without a particular past medical history consulted for dyspnoea and non-productive cough. Chest CT scan revealed mediastinal and hilar adenopathies associated with bilateral ground glass opacities with thickened interlobular septa. Bronchoalveolar lavage was performed (Fig. 1). The fluid was opaque with a milky turbid gross appearance. On microscopic examination, finely granular amorphous material was apparent in the background along with numerous lymphocytes and fragmented macrophages. Zhiel stain was performed but was negative. The diagnosis of pulmonary alveolar proteinosis (PAP) was suspected but the association of mediastinal adenomegalies was not concordant with the diagnosis. Surgical biopsy of the lung and the mediastinal lymph nodes was performed. Histological examination revealed granulomatous inflammation with caseous necrosis in the lymph nodes and an amorphous PAS positif lipoprotein material filling the alveolar spaces in the lung (Fig. 2). The final diagnosis of associated PAP with tuberculosis infection was established. The patient was put on anti-tuberculosis drugs and presented an improvement of her general state.","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"30 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120164418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lingli Liu, Jian Xu, Yuhai Zhang, Liying Fang, Yaqin Chai, Meng-jie Niu, Shengqing Li
Pulmonary sarcoidosis is often complicated by pulmonary hypertension, a complication that is associated with increased disability and mortality. To this point, however, little progress has been made in the treatment of sarcoidosis associated with pulmonary hypertension (SAPH).
{"title":"Interventional therapy in sarcoidosis‐associated pulmonary arterial stenosis and pulmonary hypertension","authors":"Lingli Liu, Jian Xu, Yuhai Zhang, Liying Fang, Yaqin Chai, Meng-jie Niu, Shengqing Li","doi":"10.1111/crj.12435","DOIUrl":"https://doi.org/10.1111/crj.12435","url":null,"abstract":"Pulmonary sarcoidosis is often complicated by pulmonary hypertension, a complication that is associated with increased disability and mortality. To this point, however, little progress has been made in the treatment of sarcoidosis associated with pulmonary hypertension (SAPH).","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"119715532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Odler, Á. Cseh, T. Constantin, G. Fekete, G. Losonczy, L. Tamási, K. Benke, B. Szilveszter, V. Müller
Fabry disease is an X‐linked lysosomal storage disorder, causing accumulation of globotriaosylceramid in different organs. Glycolipids are activators of different immune cell subsets the resulting inflammation is responsible for organ damage. Pulmonary involvement leads to airway inflammation; however, data on severity, as well as the effect of enzyme replacement therapy on lung function parameters and changes in peripheral immune cell subsets on lung involvement are sparse.
{"title":"Long time enzyme replacement therapy stabilizes obstructive lung disease and alters peripheral immune cell subsets in Fabry patients","authors":"B. Odler, Á. Cseh, T. Constantin, G. Fekete, G. Losonczy, L. Tamási, K. Benke, B. Szilveszter, V. Müller","doi":"10.1111/crj.12446","DOIUrl":"https://doi.org/10.1111/crj.12446","url":null,"abstract":"Fabry disease is an X‐linked lysosomal storage disorder, causing accumulation of globotriaosylceramid in different organs. Glycolipids are activators of different immune cell subsets the resulting inflammation is responsible for organ damage. Pulmonary involvement leads to airway inflammation; however, data on severity, as well as the effect of enzyme replacement therapy on lung function parameters and changes in peripheral immune cell subsets on lung involvement are sparse.","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"119361214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the relationship of pathogen DNA copies with clinic and laboratory features among children with Mycoplasma pneumoniae (MP) pneumonia.
目的探讨肺炎支原体肺炎患儿病原体DNA拷贝数与临床及实验室特征的关系。
{"title":"Atopy: a risk factor of refractory mycoplasma pneumoniae pneumonia?","authors":"Y. Bao, Jing Li, Ye Tian, Q. Liu, Jun Bao","doi":"10.1111/crj.12439","DOIUrl":"https://doi.org/10.1111/crj.12439","url":null,"abstract":"To investigate the relationship of pathogen DNA copies with clinic and laboratory features among children with Mycoplasma pneumoniae (MP) pneumonia.","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"118219130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Calik-Kutukcu, H. Arikan, M. Sağlam, N. Vardar-Yagli, C. Oksuz, D. Inal-Ince, S. Savcı, T. Duger, L. Coplu
Arm strength training may improve functional performance for patients with chronic obstructive pulmonary disease (COPD). This trial investigated the effects of arm strength training on arm exercise capacity, activities of daily living (ADL) and occupational performance in patients with COPD.
{"title":"Arm strength training improves activities of daily living and occupational performance in patients with COPD","authors":"E. Calik-Kutukcu, H. Arikan, M. Sağlam, N. Vardar-Yagli, C. Oksuz, D. Inal-Ince, S. Savcı, T. Duger, L. Coplu","doi":"10.1111/crj.12422","DOIUrl":"https://doi.org/10.1111/crj.12422","url":null,"abstract":"Arm strength training may improve functional performance for patients with chronic obstructive pulmonary disease (COPD). This trial investigated the effects of arm strength training on arm exercise capacity, activities of daily living (ADL) and occupational performance in patients with COPD.","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"119351625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. López‐Sánchez, M. Muñoz-Esquerre, Daniel Huertas, A. Montes, M. Molina-Molina, F. Manresa, J. Dorca, S. Santos
Left ventricular diastolic dysfunction (LVDD) is a frequent condition in chronic obstructive pulmonary disease (COPD). Tenascin‐C (Tn‐C) and matrix metalloproteinase‐9 (MMP‐9) are extracellular matrix proteins associated with myocardial fibrosis and wall remodeling because of inflammation.
{"title":"Inflammatory markers and circulating extracellular matrix proteins in patients with chronic obstructive pulmonary disease and left ventricular diastolic dysfunction","authors":"M. López‐Sánchez, M. Muñoz-Esquerre, Daniel Huertas, A. Montes, M. Molina-Molina, F. Manresa, J. Dorca, S. Santos","doi":"10.1111/crj.12428","DOIUrl":"https://doi.org/10.1111/crj.12428","url":null,"abstract":"Left ventricular diastolic dysfunction (LVDD) is a frequent condition in chronic obstructive pulmonary disease (COPD). Tenascin‐C (Tn‐C) and matrix metalloproteinase‐9 (MMP‐9) are extracellular matrix proteins associated with myocardial fibrosis and wall remodeling because of inflammation.","PeriodicalId":187910,"journal":{"name":"The Clinical Respiratory Journal","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"119068399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：