Pub Date : 2023-12-22DOI: 10.1016/j.niox.2023.12.003
Sajad Abolfazli, Parham Mortazavi, Ali Kheirandish, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
The continuously rising prevalence of cardiovascular disease (CVD) globally substantially impacts the economic growth of developing countries. Indeed, one of the leading causes of death worldwide is unfavorable cardiovascular events. Reduced nitric oxide (NO) generation is the pathogenic foundation of endothelial dysfunction, which is regarded as the first stage in the development of a number of CVDs. Nitric oxide exerts an array of biological effects, including vasodilation, the suppression of vascular smooth muscle cell proliferation and the functional control of cardiac cells. Numerous treatment strategies aim to increase NO synthesis or upregulate downstream NO signaling pathways. The major component of Curcuma longa, curcumin, has long been utilized in traditional medicine to treat various illnesses, especially CVDs. Curcumin improves CV function as well as having important pleiotropic effects, such as anti-inflammatory and antioxidant, through its ability to increase the bioavailability of NO and to positively impact NO-related signaling pathways. In this review, we discuss the scientific literature relating to curcumin's positive effects on NO signaling and vascular endothelial function.
全球心血管疾病（CVD）发病率的持续上升严重影响了发展中国家的经济增长。事实上，不利的心血管事件是导致全球死亡的主要原因之一。一氧化氮（NO）生成减少是内皮功能障碍的致病基础，而内皮功能障碍被认为是多种心血管疾病发展的第一阶段。一氧化氮具有一系列生物效应，包括扩张血管、抑制血管平滑肌细胞增殖和对心脏细胞进行功能控制。许多治疗策略都旨在增加一氧化氮的合成或上调下游一氧化氮信号通路。莪术的主要成分姜黄素在传统医学中一直被用来治疗各种疾病，尤其是心血管疾病。姜黄素能提高 NO 的生物利用率，并对 NO 相关信号通路产生积极影响，从而改善心血管功能，并具有抗炎和抗氧化等重要的多效应。在这篇综述中，我们将讨论有关姜黄素对 NO 信号传导和血管内皮功能的积极影响的科学文献。
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