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Factors Affecting the Quality of Water 影响水质的因素
Pub Date : 2021-08-30 DOI: 10.9734/bpi/mono/978-93-91882-00-6/ch2
Priya Deivasigamani, Shantakumar Balakrishnan, Tamilanban Thamaraikani
The ground water quality depends on the level of interaction of water and soil, the composition of the recharge water, soil combined with gas and rocks with which the water comes in contact with the unsaturated zone, reactions and the residential time which is taking place inside the aquifer. Henceforth, defined variations could be seen even in the common parts, specifically in the places of rocks of varied compositions and the occurrence of solubility. There are many factors affecting the quality of ground water and surface water. The physical and chemical changes happen to the water which is moving under or over the surface of the land. This type of change is due to either the human activities and/or the natural factors. There are three major factors which are to be considered during the assessment of the quality of water. They are physical factors, chemical factors and biological factors.
地下水的质量取决于水和土壤相互作用的程度、补给水的组成、水与非饱和带接触的土壤与气体和岩石的结合、含水层内发生的反应和停留时间。从此以后,即使在共同的部分,特别是在不同成分的岩石和溶解度发生的地方,也可以看到明显的变化。影响地下水和地表水水质的因素很多。这些物理和化学变化发生在在地表下或地表上流动的水身上。这种类型的变化是由于人类活动和/或自然因素。在评估水质时,有三个主要因素需要考虑。它们是物理因素、化学因素和生物因素。
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引用次数: 0
Pharmaceuticals as Pollutants in the Aquatic Ecosystem – Cardiovascular, Anti-diabetic, Steroids and Related Drugs 水生生态系统中作为污染物的药物——心血管、抗糖尿病、类固醇及相关药物
Pub Date : 2021-08-30 DOI: 10.9734/bpi/mono/978-93-91882-00-6/ch5
M. K. Kathiravan, Senthil M Palaniappan, Narayanan Jayasankar
Drugs like (beta)-blockers (atenolol, propranolol, metoprolol), ACE inhibitors (captopril, enalapril, lisinopril,  ramipril,  fosinopril,  quinapril),  angiotensin  (AT1)  receptor blockers  (losartan, candesartan, valsartan, telmisartan), (alpha)-blockers (prazosin, terazosin, doxazosin, phentolamine, phenoxybenzamine), central sympatholytics (clonidine, methyldopa), cardiac glycosides (digoxin,  digitoxin),  sympathetic  drugs (adrenaline,  dopamine,  isoprenaline),  anticholinergic drugs   (atropine,  scopolamine),  xanthines  (theophylline,  theobromine),  nitrates  (glyceryl trinitrate, isosorbide dinitrate), calcium antagonists (verapamil, diltiazem) and K-channel openers (nicorandil) are used for the treatment of the cardiovascular disorder [1].  Recently a study was conducted on the occurrence  of cardiovascular drugs in surface waters at a global scale. The study had 82 cardiovascular drugs out of which 58 (~71%) were detected at least once in the water bodies. The study also revealed that only 10% of the aquatic pollution was caused by the commonly prescribed antihypertensives (6% by angiotensin receptor-II antagonist and 4% by ACE inhibitors). The maximum contribution as a source  of pollutants were from (beta)-blockers (atenolol, metoprolol, and propranolol) at 38% and 36% to lipid regulating agents (gemfibrozil, bezafibrate and clofibric acid). The ecotoxicity caused by these cardiovascular drugs was further limited to  about  24%.  The  drugs  that are  a  major  risk to  the  aquatic organisms include propranolol, metoprolol, lipid regulating agents,  bezafibrate, and  atorvastatin. The partition coefficient (Log P) value of cardiovascular drugs ranges from  0.6 for  atenolol to  7.7  for telmisartan that results in bioaccumulation in the environmental matrices. Based on the presence of cardiovascular drugs in the aquatic ecosystem, the water pollutants are divided into three major contaminants, municipal water, surface water, and drinking water.
药物如(beta) -阻滞剂(阿替洛尔,普萘洛尔,美托洛尔),ACE抑制剂(卡托普利,依那普利,赖诺普利,雷米普利,福辛普利,喹诺普利),血管紧张素(AT1)受体阻滞剂(氯沙坦,坎地沙坦,缬沙坦,替米沙坦),(alpha) -阻滞剂(普拉唑嗪,特拉唑嗪,多沙唑嗪,酚妥拉明,苯氧苄胺),中枢交感神经抑制剂(氯定,甲基多巴),心脏糖苷(地高辛、地高辛)、交感神经药物(肾上腺素、多巴胺、异丙肾上腺素)、抗胆碱能药物(阿托品、东莨菪碱)、黄嘌呤(茶碱、可可碱)、硝酸盐(三硝酸甘油、硝酸异山梨酯)、钙拮抗剂(维拉帕米、地尔硫卓)和k通道开放剂(尼可地尔)用于治疗心血管疾病bbb。最近对全球范围内地表水中心血管药物的发生情况进行了研究。这项研究有82种心血管药物,其中58种(71种)%) were detected at least once in the water bodies. The study also revealed that only 10% of the aquatic pollution was caused by the commonly prescribed antihypertensives (6% by angiotensin receptor-II antagonist and 4% by ACE inhibitors). The maximum contribution as a source  of pollutants were from (beta)-blockers (atenolol, metoprolol, and propranolol) at 38% and 36% to lipid regulating agents (gemfibrozil, bezafibrate and clofibric acid). The ecotoxicity caused by these cardiovascular drugs was further limited to  about  24%.  The  drugs  that are  a  major  risk to  the  aquatic organisms include propranolol, metoprolol, lipid regulating agents,  bezafibrate, and  atorvastatin. The partition coefficient (Log P) value of cardiovascular drugs ranges from  0.6 for  atenolol to  7.7  for telmisartan that results in bioaccumulation in the environmental matrices. Based on the presence of cardiovascular drugs in the aquatic ecosystem, the water pollutants are divided into three major contaminants, municipal water, surface water, and drinking water.
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引用次数: 2
Pharmaceuticals in Water 水中的药物
Pub Date : 2021-08-30 DOI: 10.9734/bpi/mono/978-93-91882-00-6
M. M. Raja, M. K. Kathiravan
The surface of the earth is covered with about 71% of water. Water constitutes 50 to 70% weight of the entire plants and animals, including humans. The physical and chemical changes of water happen either due to the human activities and/or the natural factors. The increasing usage of prescribed pharmaceuticals estimates that, by end of 2020, the global need would reach 4500 billion doses. The pharmaceuticals after consumption are excreted from the human body in their parent form or as metabolites and conjugate forms. Some of the widely used drugs or active pharmaceutical ingredients (APIs) are detected in various water resources and found to affect the quality of aquatic life species. The impact of the discharge of the pharmaceuticals into aquatic streams in a definite range is unlikely to elicit acute toxicity and their existence also affects the human health as well as agriculture and marine culture. The most relevant approach to decrease the presence of pharmaceuticals in water bodies is to avoid and/or decrease their entry into the water environment. This reduction could be attained through combined preventive measures through specific regulatory bodies which includes enhanced communication to the public on rational drug use and proper disposal of pharmaceuticals.
地球表面覆盖着大约71%的水。水占整个植物和动物(包括人类)重量的50%到70%。水的物理和化学变化是由于人类活动和(或)自然因素而发生的。处方药使用量的增加估计,到2020年底,全球需求将达到4500亿剂。药物服用后以母体形式或代谢物和缀合物形式从人体排出。在各种水资源中检测到一些广泛使用的药物或活性药物成分(api),并发现它们会影响水生生物物种的质量。这些药物在一定范围内排放到水生溪流的影响不大可能引起急性毒性,它们的存在也影响人类健康以及农业和海洋文化。减少水体中药物存在的最相关方法是避免和/或减少它们进入水环境。这种减少可以通过具体管理机构采取联合预防措施来实现,其中包括加强与公众就合理用药和适当处置药品进行沟通。
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引用次数: 2
Pharmaceuticals as Pollutants in the Aquatic Ecosystem – Antibiotics, Anti-inflammatory and Anti-psychotic Drugs 水生生态系统中作为污染物的药物——抗生素、抗炎药和抗精神病药
Pub Date : 2021-08-30 DOI: 10.9734/bpi/mono/978-93-91882-00-6/ch4
Srimathi Radha, Anjana Gopi Valsaladevi, M. Krishnan
Antibiotics came into existence with its discovery in 1929 by Alexander Fleming. With the advancement of science and the progress of drug discovery process led to the introduction of 160 novel antibiotics from synthetic and semi-synthetic origin during the period 1940-1970. The consumption had seen a steady rise of about 42.3 billion daily defined doses (DDD) between the years 2000 and 2015. In spite of antibiotic resistance still antibiotics consumption are found to increase on  a higher scale of about 67% by  2030. Thus,  the largest selling proposition of antibiotics makes  it easily available for detection in sewage,  wastewater  treatment  plants (WWTP), terrestrial, freshwater and marine environments. Globally, 10% of antibiotics usage occurs from hospitals and 80% occurs from community usage.
抗生素是由亚历山大·弗莱明于1929年发现的。随着科学的进步和药物发现过程的进展,在1940-1970年期间,从合成和半合成来源引入了160种新型抗生素。2000年至2015年期间,消费量稳步增长,约为423亿每日限定剂量(DDD)。尽管存在抗生素耐药性,但到2030年,抗生素消费量仍将以更高的规模增长约67%。因此,抗生素的最大卖点是在污水、废水处理厂(WWTP)、陆地、淡水和海洋环境中容易检测到抗生素。在全球范围内,10%的抗生素使用来自医院,80%来自社区。
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引用次数: 0
Effect of Pharmaceuticals in Environment and Human Health 药物对环境和人体健康的影响
Pub Date : 2021-08-30 DOI: 10.9734/bpi/mono/978-93-91882-00-6/ch6
M. M. Raja, Agilandeswari Devarajan
The  water sources  contaminated with the  pharmaceutical pollutants flows into agricultural farmland, surface water, groundwater and drinking water. These  waters are directed towards cultivation and  it impacts the  quality of the  soil  and  the  crops  cultivated through  this contaminated water (Tables 1 and 2). Pharmaceutical pollutants are considered as external factors from the environment that affect the quality of the crops . The ingestion of pharmaceuticals as pollutants into the plants is either through soil or air. The pathway that the pollutants enter the plant is from the soil, through their roots and transported to the stem. The other route through which the plants take up the pollutants is through air in which, the leaves are capable of absorbing the atmospheric pollutants . The  pharmaceutical  pollutants  such  as  (beta)-lactams, aminoglycosides,  macrolides,  tetracyclines,  sulfa  drugs,  herbicides  including  sulfonylurea, triazines, imidazolinone, phenylurea and bisphenol (BPA) are found to cause toxicity in plants. Polychlorinated biphenyls (PCBs) affect the plant growth, reproduction and crop productivity.
被药物污染物污染的水源流入农田、地表水、地下水和饮用水。这些水直接用于种植,它影响土壤质量和通过这些污染的水种植的作物(表1和2)。药物污染物被认为是影响作物质量的外部环境因素。作为污染物的药物通过土壤或空气进入植物。污染物进入植物的途径是从土壤,通过它们的根输送到茎。植物吸收污染物的另一种途径是通过空气,其中叶子能够吸收大气中的污染物。药物污染物如(beta) -内酰胺类、氨基糖苷类、大环内酯类、四环素类、磺胺类药物、除草剂(包括磺脲类、三嗪类、咪唑啉酮类、苯脲类和双酚类)对植物造成毒性。多氯联苯(PCBs)影响植物生长、繁殖和作物生产力。
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引用次数: 0
Pharmaceuticals in Water System 水系统中的药物
Pub Date : 2021-08-30 DOI: 10.9734/bpi/mono/978-93-91882-00-6/ch3
Sundarrajan Thirugnanasambandam, Thirumal Margesan, Velmurugan Vadivel
Pharmaceutical synthetic drugs are predominant sources of therapeutic treatment around the globe and modern practice of medicine, medical treatment without these drugs is unimaginable. The increasing usage of prescribed pharmaceuticals estimates that, by end of 2020, the global need would reach 4500 billion doses. Some of the widely used drugs or active pharmaceutical ingredients (APIs) are detected in various water resources and found to affect the quality of aquatic life species. These include the presence of antibiotics, anti-inflammatory, psychotropic including antidepressants, antiepileptic drugs, anxiolytic agents, cardiovascular drugs, antidiabetic agents, steroids, and their byproducts and metabolites.  The presence of these pharmaceuticals is highly elicited in the aquatic environment due to its unchanged form of the drug being discharged, about 10% of carbamazepine (an antidepressant) is been detected in wastewater treatment plant. The physicochemical properties such as lower log Po/w could be one of the reasons for its bioaccumulation in the aquatic environment.  The other factors that increase the pharmaceuticals as pollutants in the environment are its higher rate of consumption due to its wider availability and usage of over-the-counter drugs (antibiotics, anti-inflammatory etc.). The marine species affected due to these pharmaceuticals include cyanobacteria and blue- green algae by antibiotics ; plants, invertebrates, and fish affected with residues of diclofenac, ibuprofen (NSAIDs); green algae and zebra mussels affected with selective serotonin reuptake inhibitors (SSRIs)  used  as antidepressants.  Approximately 90% of marine vertebrates  and invertebrates are  detected  with propranolol, cardiovascular agent;  fish, crustaceans,  snails, mussels, rotifers, aquatic plant, hydrae and algae contaminated with metformin, an antidiabetic agent and species of fish such as zebrafish, pipefish, seawater fish, sand gobies are detected with the presence of steroidal drugs. The concentration of pharmaceuticals in marine species ranges from a few ng/L to several (mu)g/L.
药物合成药物是全球治疗和现代医学实践的主要来源,没有这些药物的医疗是不可想象的。处方药使用量的增加估计,到2020年底,全球需求将达到4500亿剂。在各种水资源中检测到一些广泛使用的药物或活性药物成分(api),并发现它们会影响水生生物物种的质量。这些因素包括抗生素、抗炎药、精神药物(包括抗抑郁药)、抗癫痫药、抗焦虑药、心血管药物、抗糖尿病药物、类固醇及其副产物和代谢物。这些药物的存在在水生环境中是高度诱导的,因为其排出的药物形式不变,约10% of carbamazepine (an antidepressant) is been detected in wastewater treatment plant. The physicochemical properties such as lower log Po/w could be one of the reasons for its bioaccumulation in the aquatic environment.  The other factors that increase the pharmaceuticals as pollutants in the environment are its higher rate of consumption due to its wider availability and usage of over-the-counter drugs (antibiotics, anti-inflammatory etc.). The marine species affected due to these pharmaceuticals include cyanobacteria and blue- green algae by antibiotics ; plants, invertebrates, and fish affected with residues of diclofenac, ibuprofen (NSAIDs); green algae and zebra mussels affected with selective serotonin reuptake inhibitors (SSRIs)  used  as antidepressants.  Approximately 90% of marine vertebrates  and invertebrates are  detected  with propranolol, cardiovascular agent;  fish, crustaceans,  snails, mussels, rotifers, aquatic plant, hydrae and algae contaminated with metformin, an antidiabetic agent and species of fish such as zebrafish, pipefish, seawater fish, sand gobies are detected with the presence of steroidal drugs. The concentration of pharmaceuticals in marine species ranges from a few ng/L to several (mu)g/L.
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引用次数: 0
Hydrology: The Basics 水文学:基础
Pub Date : 2021-08-30 DOI: 10.9734/bpi/mono/978-93-91882-00-6/ch1
Agilandeswari Devarajan
The word "water" is derived from the older English word “waeter”, or proto-German “water” or German “Wasser”. All these words derived from various languages mean "wet." The word water basically refers the liquid state of the compound. Water exists in various forms. Water is termed as “ice” when it is in solid form, as “steam” when it is in the gas form. Super-critical fluid is formed by water under definite conditions. Hydrology can be defined as the studies related to the movement and the further distribution of the quantities of water above and/or below the surface of the earth. Water cycle or hydrologic cycle is the process of the form of water which continually changes and circulates between the oceans, atmosphere and land. The water of the earth circulates in three media like hydrosphere, atmosphere and the upper part of lithosphere. Water circulates from ocean to the atmosphere, then to lithosphere and finally from lithosphere to the ocean through a complex and interdependent processes which includes evaporation, transpiration, run off, ground water flow, precipitation etc. To have a simple understanding, water rises above the sea level reaching the surface of the earth in the form of vapour. Then clouds are formed from the water vapor which further falls on the earth’s ground as rain.  Some amount of rain water gets penetrated into the ground while some other parts of rain water are joined to the moving water systems like streams and rivers.
“水”这个词来源于古英语单词“water”,或原德语单词“water”或德语单词“Wasser”。所有这些来自不同语言的单词都有“潮湿”的意思。水这个词基本上是指化合物的液态。水以各种形式存在。水以固体形式被称为“冰”,以气体形式被称为“蒸汽”。超临界流体是水在一定条件下形成的流体。水文学可以定义为研究地球表面上下水量的运动和进一步分布的学科。水循环或水文循环是水的形态在海洋、大气和陆地之间不断变化和循环的过程。地球上的水在水圈、大气和岩石圈上部三种介质中循环。水循环从海洋到大气,然后到岩石圈,最后从岩石圈到海洋,经过一个复杂而相互依存的过程,包括蒸发、蒸腾、径流、地下水流动、降水等。简单地说,水以水蒸气的形式上升到海平面以上到达地球表面。水蒸气进一步以雨的形式落在地面上,然后形成云。一些雨水渗透到地下,而另一些雨水加入了流动的水系统,如溪流和河流。
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引用次数: 0
Control Measures and Risk Management 控制措施和风险管理
Pub Date : 2021-08-30 DOI: 10.9734/bpi/mono/978-93-91882-00-6/ch7
Ravi Manne, Agilandeswari Devarajan
The major pharmaceuticals concentrations present in the water system can be decreased through natural processes like biological degradation, solar photo degradation, adsorption drinking water or even during the wastewater treatment processes. In spite of their exclusive pharmacological properties, pharmaceuticals respond to treatment in a different way from other organic chemicals, with removal rates depending on their physicochemical properties and the respective treatment technology being used. Conventional water treatment processes like chlorination, can remove about 50% of these compounds,  while more advanced  treatment processes, namely ozonation, activated carbon, advanced oxidation, reverse  osmosis and nanofiltration, are  able to achieve higher removal rates. For  example, reverse  osmosis process  has the ability to remove  more than 99% of large pharmaceutical molecules. The most relevant approach to decrease the presence of pharmaceuticals in drinking-water and reduce human exposure is to avoid and/or decrease their entry into the water environment. This reduction could be attained through combined preventive measures which includes enhanced communication to the public on rational drug use and proper disposal of pharmaceuticals (for example, to avoid flushing of unused drugs down to the toilet), education for prescribers and systematic drug take-back programmes (awareness programmes).  In line with the water safety plan, the principle aim is to control contaminants at the source. It would be appropriate to investigate the improvement in wastewater treatment for the removal of the pharmaceutical substance and other harmful contaminants of concern from their major path of entry into the water bodies.
存在于水系统中的主要药物浓度可以通过生物降解、太阳能光降解、吸附饮用水甚至废水处理过程等自然过程来降低。尽管药物具有独特的药理学性质,但它们对治疗的反应与其他有机化学品不同,去除率取决于它们的物理化学性质和所使用的各自的治疗技术。传统的水处理工艺,如氯化,可以去除约50%的这些化合物,而更高级的处理工艺,即臭氧化,活性炭,高级氧化,反渗透和纳滤,能够达到更高的去除率。例如,反渗透过程具有去除99%以上的大药物分子的能力。减少饮用水中药物的存在和减少人类接触的最相关方法是避免和/或减少它们进入水环境。这种减少可以通过综合预防措施来实现,其中包括加强与公众就合理使用药物和适当处置药物(例如,避免将未使用的药物冲入厕所)的沟通,对开处方者进行教育和有系统的药物回收方案(提高认识方案)。根据水安全计划,主要目标是在源头控制污染物。研究如何改进废水处理,从进入水体的主要途径中去除药物物质和其他有害污染物是适当的。
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引用次数: 1
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Pharmaceuticals in Water
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