Emerging evidence suggests that classical psychedelics possess immunomodulatory and anti-inflammatory properties; however, these effects are yet to be well-established. This systematic review aims to provide a timely and comprehensive overview of the immunomodulatory effects of classical psychedelics in preclinical studies. A systematic search was conducted on six databases, including CINAHL, EMBASE, MEDLINE, PsychINFO, Scopus, and Web of Science. Eligible studies targeting classical psychedelics for evaluation of their effects on inflammatory markers and immunomodulation have been included for analysis. Data was extracted from 40 out of 2822 eligible articles, and their risk of bias was assessed using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool and Quality Assessment Tool for In Vitro Studies (QUIN). Studies examined 2,5-dimethoxy-4-iodoamphetamine (DOI; n = 18); psilocybin (4-PO-DMT; n = 9); N,N-dimethyltryptamine (DMT; n = 8); lysergic acid diethylamide (LSD; n = 6); 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; n = 3); psilocin (4-HO-DMT; n = 3); and mescaline (n = 2). In 36 studies where inflammatory cytokine levels were measured following psychedelic administration, a decrease in at least one inflammatory cytokine was observed in 29 studies. Immune cell activity was assessed in 10 studies and findings were mixed, with an equal number of studies (n = 5 out of 10) reporting either an increase or decrease in immune cell activity. Classical psychedelics were found to alleviate pre-existing inflammation but promote inflammation when administered under normal physiological conditions. This information is anticipated to inform future clinical trials, exploring classical psychedelics' potential to alleviate inflammation in various pathologies.
{"title":"The immunomodulatory effects of classical psychedelics: A systematic review of preclinical studies.","authors":"Zhen Xuen Brandon Low,Wei Shen Ng,Eugene Sheng Yao Lim,Bey Hing Goh,Yatinesh Kumari","doi":"10.1016/j.pnpbp.2024.111139","DOIUrl":"https://doi.org/10.1016/j.pnpbp.2024.111139","url":null,"abstract":"Emerging evidence suggests that classical psychedelics possess immunomodulatory and anti-inflammatory properties; however, these effects are yet to be well-established. This systematic review aims to provide a timely and comprehensive overview of the immunomodulatory effects of classical psychedelics in preclinical studies. A systematic search was conducted on six databases, including CINAHL, EMBASE, MEDLINE, PsychINFO, Scopus, and Web of Science. Eligible studies targeting classical psychedelics for evaluation of their effects on inflammatory markers and immunomodulation have been included for analysis. Data was extracted from 40 out of 2822 eligible articles, and their risk of bias was assessed using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool and Quality Assessment Tool for In Vitro Studies (QUIN). Studies examined 2,5-dimethoxy-4-iodoamphetamine (DOI; n = 18); psilocybin (4-PO-DMT; n = 9); N,N-dimethyltryptamine (DMT; n = 8); lysergic acid diethylamide (LSD; n = 6); 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; n = 3); psilocin (4-HO-DMT; n = 3); and mescaline (n = 2). In 36 studies where inflammatory cytokine levels were measured following psychedelic administration, a decrease in at least one inflammatory cytokine was observed in 29 studies. Immune cell activity was assessed in 10 studies and findings were mixed, with an equal number of studies (n = 5 out of 10) reporting either an increase or decrease in immune cell activity. Classical psychedelics were found to alleviate pre-existing inflammation but promote inflammation when administered under normal physiological conditions. This information is anticipated to inform future clinical trials, exploring classical psychedelics' potential to alleviate inflammation in various pathologies.","PeriodicalId":20824,"journal":{"name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-14DOI: 10.1016/j.pnpbp.2024.111027
Xinghao Wang, Qian Chen, Yan Huang, Han Lv, Pengfei Zhao, Zhenghan Yang, Zhenchang Wang
{"title":"Mendelian randomization analyses support causal relationships between tinnitus of different stages and severity and structural characteristics of specific brain regions","authors":"Xinghao Wang, Qian Chen, Yan Huang, Han Lv, Pengfei Zhao, Zhenghan Yang, Zhenchang Wang","doi":"10.1016/j.pnpbp.2024.111027","DOIUrl":"https://doi.org/10.1016/j.pnpbp.2024.111027","url":null,"abstract":"","PeriodicalId":20824,"journal":{"name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1016/j.pnpbp.2024.111031
A. Holck, P. Movahed, Åsa Westrin, Owen M Wolkowitz, Daniel Lindqvist, Marie Asp
{"title":"Peripheral serotonin levels as a predictor of antidepressant treatment response: A systematic review","authors":"A. Holck, P. Movahed, Åsa Westrin, Owen M Wolkowitz, Daniel Lindqvist, Marie Asp","doi":"10.1016/j.pnpbp.2024.111031","DOIUrl":"https://doi.org/10.1016/j.pnpbp.2024.111031","url":null,"abstract":"","PeriodicalId":20824,"journal":{"name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141054262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-17DOI: 10.1016/j.pnpbp.2024.110973
J. Kreutzmann, Evelyn Kahl, M. Fendt
{"title":"Sex-specific modulation of safety learning in Shank2-deficient mice","authors":"J. Kreutzmann, Evelyn Kahl, M. Fendt","doi":"10.1016/j.pnpbp.2024.110973","DOIUrl":"https://doi.org/10.1016/j.pnpbp.2024.110973","url":null,"abstract":"","PeriodicalId":20824,"journal":{"name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-17DOI: 10.1016/j.pnpbp.2024.110981
K. Gbyl, Vytautas Labanaukas, Christoffer C Lundsgaard, André Mathiassen, Adam Ryszczuk, H. Siebner, Egill Rostrup, Kristoffer Madsen, Poul Videbech
{"title":"Electroconvulsive therapy disrupts functional connectivity between hippocampus and posterior default mode network","authors":"K. Gbyl, Vytautas Labanaukas, Christoffer C Lundsgaard, André Mathiassen, Adam Ryszczuk, H. Siebner, Egill Rostrup, Kristoffer Madsen, Poul Videbech","doi":"10.1016/j.pnpbp.2024.110981","DOIUrl":"https://doi.org/10.1016/j.pnpbp.2024.110981","url":null,"abstract":"","PeriodicalId":20824,"journal":{"name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139773797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-16DOI: 10.1016/j.pnpbp.2024.110969
Akihiro Koreki, K. Ogyu, Takahiro Miyazaki, Kazumasa Takenouchi, K. Matsushita, S. Honda, T. Koizumi, M. Onaya, Hiroyuki Uchida, Masaru Mimura, S. Nakajima, Yoshihiro Noda
{"title":"Aberrant heartbeat-evoked potential in schizophrenia","authors":"Akihiro Koreki, K. Ogyu, Takahiro Miyazaki, Kazumasa Takenouchi, K. Matsushita, S. Honda, T. Koizumi, M. Onaya, Hiroyuki Uchida, Masaru Mimura, S. Nakajima, Yoshihiro Noda","doi":"10.1016/j.pnpbp.2024.110969","DOIUrl":"https://doi.org/10.1016/j.pnpbp.2024.110969","url":null,"abstract":"","PeriodicalId":20824,"journal":{"name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139773862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.pnpbp.2024.110972
C. Fabbri, C. Lewis, A. Serretti
{"title":"Polygenic risk scores for mood and related disorders and environmental factors: Interaction effects on wellbeing in the UK biobank","authors":"C. Fabbri, C. Lewis, A. Serretti","doi":"10.1016/j.pnpbp.2024.110972","DOIUrl":"https://doi.org/10.1016/j.pnpbp.2024.110972","url":null,"abstract":"","PeriodicalId":20824,"journal":{"name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139824475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-25DOI: 10.1101/2020.04.23.054734
S. Jesuthasan, Seetha Krishnan, R. Cheng, A. Mathuru
Background Detection of predator cues changes the brain state in prey species and helps them avoid danger. Dysfunctionality in changing the central state appropriately in stressful situations is proposed to be an underlying cause of multiple psychiatric disorders in humans. Methods Here, we investigate the dynamics of neural circuits mediating response to a threat, to characterize these states and to identify potential control networks. We use resonant scanning 2-photon microscopy for in vivo brain-wide imaging and custom designed behavioral assays for the study. Results We first show that 5-7 day old zebrafish larvae react to an alarm pheromone (Schreckstoff) with reduced mobility. They subsequently display heightened vigilance, as evidenced by increased dark avoidance. Calcium imaging indicates that exposure to Schreckstoff elicits stimulus-locked activity in olfactory sensory neurons innervating a lateral glomerulus and in telencephalic regions including the putative medial amygdala and entopeduncular nucleus. Sustained activity outlasting the stimulus delivery was detected in regions regulating neuromodulator release, including the lateral habenula, posterior tuberculum, superior raphe, and locus coeruleus. Conclusion We propose that these latter regions contribute to the network that defines the “threatened” state, while neurons with transient activity serve as the trigger. Our study highlights the utility of the zebrafish larval alarm response system to examine neural circuits during stress dependent brain state transitions and to discover potential therapeutic agents when such transitions are disrupted.
{"title":"Neural correlates of state transitions elicited by a chemosensory danger cue","authors":"S. Jesuthasan, Seetha Krishnan, R. Cheng, A. Mathuru","doi":"10.1101/2020.04.23.054734","DOIUrl":"https://doi.org/10.1101/2020.04.23.054734","url":null,"abstract":"Background Detection of predator cues changes the brain state in prey species and helps them avoid danger. Dysfunctionality in changing the central state appropriately in stressful situations is proposed to be an underlying cause of multiple psychiatric disorders in humans. Methods Here, we investigate the dynamics of neural circuits mediating response to a threat, to characterize these states and to identify potential control networks. We use resonant scanning 2-photon microscopy for in vivo brain-wide imaging and custom designed behavioral assays for the study. Results We first show that 5-7 day old zebrafish larvae react to an alarm pheromone (Schreckstoff) with reduced mobility. They subsequently display heightened vigilance, as evidenced by increased dark avoidance. Calcium imaging indicates that exposure to Schreckstoff elicits stimulus-locked activity in olfactory sensory neurons innervating a lateral glomerulus and in telencephalic regions including the putative medial amygdala and entopeduncular nucleus. Sustained activity outlasting the stimulus delivery was detected in regions regulating neuromodulator release, including the lateral habenula, posterior tuberculum, superior raphe, and locus coeruleus. Conclusion We propose that these latter regions contribute to the network that defines the “threatened” state, while neurons with transient activity serve as the trigger. Our study highlights the utility of the zebrafish larval alarm response system to examine neural circuits during stress dependent brain state transitions and to discover potential therapeutic agents when such transitions are disrupted.","PeriodicalId":20824,"journal":{"name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78981476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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