those dollars are those of citizen tax payers, should be subject to at least occasional scrutiny and stock-taking (Joyner, Paneth, and Ioannidis 2016). This Special Issue of Perspectives in Biology and Medicine is an attempt to do just that: to ask whether the massive investment of money, equipment and human scientific talent that has been poured into studying the human genome under the assumption that this enormous scientific endeavor will advance human health has been worth it thus far, and whether it is likely to bear fruit in the future The expression that best encapsulates the goal of using genomic information to alter trajectories of disease has varied from time to time in the 15 years since the completion of the Human Genome Project (HGP) in 2003. “Personalized medicine” held sway for the first few years, but that term has now been eclipsed by “precision medicine.” Whichever term is used, the underlying principle is much the same, namely, that what modern medicine most lacks is the incorpo-
这些钱是公民纳税人的钱，至少应该偶尔接受审查和盘点(Joyner, Paneth, and Ioannidis 2016)。本期《生物学和医学视角》特刊就是这样一种尝试:人们认为这项巨大的科学努力将促进人类健康，因此投入大量资金、设备和人类科学人才来研究人类基因组，到目前为止是否值得，自2003年人类基因组计划(HGP)完成以来的15年里，最能概括利用基因组信息改变疾病轨迹这一目标的表达方式不时发生变化。“个性化医疗”在最初几年占据主导地位，但现在这个词已经被“精准医疗”所取代。无论使用哪种术语，其基本原理都是相同的，即现代医学最缺乏的是融合
{"title":"Introduction: Introduction to the Special Issue","authors":"W. Penuel, Michael Cole, D. K. O'Neill","doi":"10.4324/9780203703106-1","DOIUrl":"https://doi.org/10.4324/9780203703106-1","url":null,"abstract":"those dollars are those of citizen tax payers, should be subject to at least occasional scrutiny and stock-taking (Joyner, Paneth, and Ioannidis 2016). This Special Issue of Perspectives in Biology and Medicine is an attempt to do just that: to ask whether the massive investment of money, equipment and human scientific talent that has been poured into studying the human genome under the assumption that this enormous scientific endeavor will advance human health has been worth it thus far, and whether it is likely to bear fruit in the future The expression that best encapsulates the goal of using genomic information to alter trajectories of disease has varied from time to time in the 15 years since the completion of the Human Genome Project (HGP) in 2003. “Personalized medicine” held sway for the first few years, but that term has now been eclipsed by “precision medicine.” Whichever term is used, the underlying principle is much the same, namely, that what modern medicine most lacks is the incorpo-","PeriodicalId":211016,"journal":{"name":"Cultural-Historical Activity Theory Approaches to Design-Based Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127585841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary: Cultural-Historical Activity Theory/Design-Based Research in Pasteur’s Quadrant","authors":"J. Greeno","doi":"10.4324/9780203703106-7","DOIUrl":"https://doi.org/10.4324/9780203703106-7","url":null,"abstract":"","PeriodicalId":211016,"journal":{"name":"Cultural-Historical Activity Theory Approaches to Design-Based Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129282603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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