W. Lina, Zhan Ying, Ji Fuhai, C. Jun, Yu-kun Zhang, Liu Li, Wang Yang
Objective To study the changes of intramucosal pH(pHi) and serum protein levels after early enteral nutrition in patients with severe craniocerebral injury.Methods According to the vital signs and intestinal sounds,enteral nutrition(EN) and parenteral nutrition(PN) were respectively given to the patients 12 to 72 h after operation.The value of pHi was monitored continuously in the following 5 days.Results The value of pHi and serum protein levels increased in both groups on the 5th day after operation(P0.05).Moreover,the value of pHi and serum protein levels of EN group increased more than that of PN group(P0.05).The restoration of anal exhaust time of EN group shortened significantly than that of PN group(P0.05).Conclusion The use of early enteral nutrition can improve the blood perfusion and oxygenation of gastrointestinal mucosae as well as the nutritional status in severe craniocerebral injury patients.
{"title":"Effect of early enteral nutrition on intramucosal pH and serum protein in patients with severe head injury.","authors":"W. Lina, Zhan Ying, Ji Fuhai, C. Jun, Yu-kun Zhang, Liu Li, Wang Yang","doi":"10.1084/JEM20610OIA21","DOIUrl":"https://doi.org/10.1084/JEM20610OIA21","url":null,"abstract":"Objective To study the changes of intramucosal pH(pHi) and serum protein levels after early enteral nutrition in patients with severe craniocerebral injury.Methods According to the vital signs and intestinal sounds,enteral nutrition(EN) and parenteral nutrition(PN) were respectively given to the patients 12 to 72 h after operation.The value of pHi was monitored continuously in the following 5 days.Results The value of pHi and serum protein levels increased in both groups on the 5th day after operation(P0.05).Moreover,the value of pHi and serum protein levels of EN group increased more than that of PN group(P0.05).The restoration of anal exhaust time of EN group shortened significantly than that of PN group(P0.05).Conclusion The use of early enteral nutrition can improve the blood perfusion and oxygenation of gastrointestinal mucosae as well as the nutritional status in severe craniocerebral injury patients.","PeriodicalId":21737,"journal":{"name":"Shandong Medical Journal","volume":"49 1","pages":"21-22"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60796201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To research the method and effect of nonmyeloablative allogeneic peripheral blood stem cell transplantation (NAST) in the treatment of severe aplastic anemia(SAA). Twenty patients with SAA received improved NAST.They were conditioned with small dosage of immunosuppressive agents of cyclophosphamide (CTX) and anti- lymphoid cell globulin or anti- thymus gland cell globulins; cyclophosphamidemycophenolate mofeti and anti-CD25 were used to prevent the graft-versus-host disease (GVHD). The engrafted donor cell were identified by STR-PCR. Ten patients who received allogene peripheral blood stem cell transplantation acquired fast reconstruction and eight patients who received cord blood stem cell transplantation were not implanted but recovered hematopoiesis. One developed acute GVHD, Two of them developed chronic GVHD, Three patients who developed respectively severe septic shock, interstitial pneumonia and ichorrhemia were all cured. One patient died of acute heart failure,and two patients died of hematopoiesis reconstruction failture and infection. Improved NAST is a effective project for SAA because of its positive curative effect, high rate of embedding, few complication and rapid recovering hematopiesis.
{"title":"Effect of improved nonmyeloablative allogeneic peripheral blood stem cell transplantation for severe aplastic anemia","authors":"Zhe Yu, Lin-fu Ge, N. Huang, Xi-min Liu, Fang Zhou, Lin-na Xie","doi":"10.3760/CMA.J.ISSN.1009-9921.2009.08.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1009-9921.2009.08.012","url":null,"abstract":"To research the method and effect of nonmyeloablative allogeneic peripheral blood stem cell transplantation (NAST) in the treatment of severe aplastic anemia(SAA). Twenty patients with SAA received improved NAST.They were conditioned with small dosage of immunosuppressive agents of cyclophosphamide (CTX) and anti- lymphoid cell globulin or anti- thymus gland cell globulins; cyclophosphamidemycophenolate mofeti and anti-CD25 were used to prevent the graft-versus-host disease (GVHD). The engrafted donor cell were identified by STR-PCR. Ten patients who received allogene peripheral blood stem cell transplantation acquired fast reconstruction and eight patients who received cord blood stem cell transplantation were not implanted but recovered hematopoiesis. One developed acute GVHD, Two of them developed chronic GVHD, Three patients who developed respectively severe septic shock, interstitial pneumonia and ichorrhemia were all cured. One patient died of acute heart failure,and two patients died of hematopoiesis reconstruction failture and infection. Improved NAST is a effective project for SAA because of its positive curative effect, high rate of embedding, few complication and rapid recovering hematopiesis.","PeriodicalId":21737,"journal":{"name":"Shandong Medical Journal","volume":"140 1","pages":"476-477"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69837264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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