{"title":"Front Matter: Volume 10895","authors":"","doi":"10.1117/12.2531309","DOIUrl":"https://doi.org/10.1117/12.2531309","url":null,"abstract":"","PeriodicalId":221157,"journal":{"name":"Frontiers in Biological Detection: From Nanosensors to Systems XI","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121941295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A multiplexed platform for point of care diagnostics based on optical waveguide technology (Conference Presentation)","authors":"C. Myatt","doi":"10.1117/12.2513799","DOIUrl":"https://doi.org/10.1117/12.2513799","url":null,"abstract":"","PeriodicalId":221157,"journal":{"name":"Frontiers in Biological Detection: From Nanosensors to Systems XI","volume":"134 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130962786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of silicon nitride photonic microring resonator arrays as a biosensing platform for multiplex detection of biologically relevant protein targets (Conference Presentation)","authors":"Michael R. Bryan, B. Miller","doi":"10.1117/12.2510453","DOIUrl":"https://doi.org/10.1117/12.2510453","url":null,"abstract":"","PeriodicalId":221157,"journal":{"name":"Frontiers in Biological Detection: From Nanosensors to Systems XI","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127393974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Anker, M. Arifuzzaman, Paul W. Millhouse, Apeksha Rajamathrilage, S. Beladi-Behbahani, Nathan T. Carrington, J. DesJardins, Jeremy Tzeng, T. Pace, K. Jeray, Caleb J. Behrend
{"title":"X-ray readout for implanted medical sensors (Conference Presentation)","authors":"J. Anker, M. Arifuzzaman, Paul W. Millhouse, Apeksha Rajamathrilage, S. Beladi-Behbahani, Nathan T. Carrington, J. DesJardins, Jeremy Tzeng, T. Pace, K. Jeray, Caleb J. Behrend","doi":"10.1117/12.2513811","DOIUrl":"https://doi.org/10.1117/12.2513811","url":null,"abstract":"","PeriodicalId":221157,"journal":{"name":"Frontiers in Biological Detection: From Nanosensors to Systems XI","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128566345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cost-effective optical biosensing using integrated photonics (Conference Presentation)","authors":"Daniel J. Steiner, Michael R. Bryan, B. Miller","doi":"10.1117/12.2509924","DOIUrl":"https://doi.org/10.1117/12.2509924","url":null,"abstract":"","PeriodicalId":221157,"journal":{"name":"Frontiers in Biological Detection: From Nanosensors to Systems XI","volume":"10 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133076087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenneth J. Squire, Paul Leduff, G. Rorrer, Alan X. Wang
Optical biosensing has achieved remarkable levels of sensitivity and has enabled early detection of various toxins and biomarkers. Fluorescence spectroscopy is among the most common and powerful optical detection techniques, capable of single molecule detection. This is done by exciting the sample using a light source, collecting the fluorescence light inherent in the sample or on a reporter molecule, and measuring the fluorescence spectrum using a spectrometer. This modality is effective for multiplex sensing as full spectral data is acquired. However, fluorescence spectroscopy requires multiple measurements at multiple points to achieve a representative sampling of a sensor. Fluorescence imaging is a detection modality similar to fluorescence spectroscopy, but replaces the spectrometer with an imager such as a camera thus reducing cost and complexity. Imaging allows data acquisition at multiple points in a large area of your sensor in a single measurement making it a more efficient sensing method but does not acquire spectral data. Both fluorescence sensing modalities have been shown to be very powerful in pristine laboratory settings but when the equipment or measurement area are not ideal, additional enhancement is needed. This can be achieved by implementing a sensing substrate capable of enhancing fluorescence signals to practical detection levels. Diatoms are unicellular marine organisms that grow a biosilica shell called a frustule. These frustules are porous with nanostructured patterns and represent naturally occurring photonic crystals which are known to enhance excitation and emission of fluorophores. In addition to the optical enhancements of diatoms, the large surface area allows for large numbers of analytes to aggregate making fluorescence signals stronger. In this work, we employ naturally occurring photonic crystal diatoms to create a sensor capable of enhancing the fluorescence of a standard sandwich immunoassay. Using this sensor, we achieved detection down to 10-16 M using fluorescence spectroscopy and 10-15 M for fluorescence imaging. These represent a 100× and 10× enhancement for the two respective detection modalities over equivalent, non-diatom sensors. This highlights the capability of our sensor to enhance fluorescence optical signals and its potential to be used in point-of-care biosensing applications.
{"title":"Fluorescence imaging immuno-assay biosensors on biological photonic crystals (Conference Presentation)","authors":"Kenneth J. Squire, Paul Leduff, G. Rorrer, Alan X. Wang","doi":"10.1117/12.2512116","DOIUrl":"https://doi.org/10.1117/12.2512116","url":null,"abstract":"Optical biosensing has achieved remarkable levels of sensitivity and has enabled early detection of various toxins and biomarkers. Fluorescence spectroscopy is among the most common and powerful optical detection techniques, capable of single molecule detection. This is done by exciting the sample using a light source, collecting the fluorescence light inherent in the sample or on a reporter molecule, and measuring the fluorescence spectrum using a spectrometer. This modality is effective for multiplex sensing as full spectral data is acquired. However, fluorescence spectroscopy requires multiple measurements at multiple points to achieve a representative sampling of a sensor. Fluorescence imaging is a detection modality similar to fluorescence spectroscopy, but replaces the spectrometer with an imager such as a camera thus reducing cost and complexity. Imaging allows data acquisition at multiple points in a large area of your sensor in a single measurement making it a more efficient sensing method but does not acquire spectral data. Both fluorescence sensing modalities have been shown to be very powerful in pristine laboratory settings but when the equipment or measurement area are not ideal, additional enhancement is needed. This can be achieved by implementing a sensing substrate capable of enhancing fluorescence signals to practical detection levels. Diatoms are unicellular marine organisms that grow a biosilica shell called a frustule. These frustules are porous with nanostructured patterns and represent naturally occurring photonic crystals which are known to enhance excitation and emission of fluorophores. In addition to the optical enhancements of diatoms, the large surface area allows for large numbers of analytes to aggregate making fluorescence signals stronger. In this work, we employ naturally occurring photonic crystal diatoms to create a sensor capable of enhancing the fluorescence of a standard sandwich immunoassay. Using this sensor, we achieved detection down to 10-16 M using fluorescence spectroscopy and 10-15 M for fluorescence imaging. These represent a 100× and 10× enhancement for the two respective detection modalities over equivalent, non-diatom sensors. This highlights the capability of our sensor to enhance fluorescence optical signals and its potential to be used in point-of-care biosensing applications.","PeriodicalId":221157,"journal":{"name":"Frontiers in Biological Detection: From Nanosensors to Systems XI","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133441354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naseem Abbas, Xun Lu, M. A. Badshah, W. Heo, S. Seo, Seok-min Kim
{"title":"Identification of body fluids using metal enhanced fluorescence substrate with glancing angle deposited Ag nanorods (Conference Presentation)","authors":"Naseem Abbas, Xun Lu, M. A. Badshah, W. Heo, S. Seo, Seok-min Kim","doi":"10.1117/12.2511045","DOIUrl":"https://doi.org/10.1117/12.2511045","url":null,"abstract":"","PeriodicalId":221157,"journal":{"name":"Frontiers in Biological Detection: From Nanosensors to Systems XI","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133066576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ching-Wen Chang, Xiaochuan Xu, S. Chakravarty, Hui-Chun Huang, Q. Y. Chen, L. Tu, Ray T. Chen
Silicon photonics has been studied intensively for biosensing applications due to the potential of leveraging the matured fabrication process to integrate thousands of sensors on a single chip and massively produce sensing chips at an affordable cost. However, the high index contrast of silicon does not only enable ultra-compact sensors, but also limits the interaction between optical field and analytes. To enhance the sensitivity, silicon subwavelength grating metamaterial (SGM) microring resonator was proposed to improve the interaction between photons and analytes and has demonstrated significant sensitivity improvement. Due to the asymmetric index profile along the vertical direction, further increasing the sensitivity becomes challenging. To reduce the asymmetricity, in this paper, we propose pedestaled SGM which allows further increasing the interaction between optical field and analytes. We analyzed and demonstrated enhanced bulk sensitivity and limit of detection (LOD) in SGM microring resonators with pedestal structure. To compare the bulk sensitivity and LOD of regular SGM microring resonator (Sample A) and pedestal SGM microring resonators, the devices with same structure design as Sample A were soaked in buffered oxide etch (BOE) for 30 seconds (Sample B) and 50 seconds (Sample C) to make pedestal shape. Real time monitoring of the resonance shift measurement shows the detection of streptavidin at a low concentration of 0.1 ng/mL for Sample C and a similar response for 1 ng/mL, 10 ng/mL, 100 ng/mL, 1 μg/mL, 10 μg/mL, and 100 μg/mL. Our results suggest that such pedestaled SGM microring resonators have great potential for specific biomarkers diagnosis.
{"title":"Pedestaled subwavelength grating metamaterial waveguide for sensitivity enhancement (Conference Presentation)","authors":"Ching-Wen Chang, Xiaochuan Xu, S. Chakravarty, Hui-Chun Huang, Q. Y. Chen, L. Tu, Ray T. Chen","doi":"10.1117/12.2510648","DOIUrl":"https://doi.org/10.1117/12.2510648","url":null,"abstract":"Silicon photonics has been studied intensively for biosensing applications due to the potential of leveraging the matured fabrication process to integrate thousands of sensors on a single chip and massively produce sensing chips at an affordable cost. However, the high index contrast of silicon does not only enable ultra-compact sensors, but also limits the interaction between optical field and analytes. To enhance the sensitivity, silicon subwavelength grating metamaterial (SGM) microring resonator was proposed to improve the interaction between photons and analytes and has demonstrated significant sensitivity improvement. Due to the asymmetric index profile along the vertical direction, further increasing the sensitivity becomes challenging. To reduce the asymmetricity, in this paper, we propose pedestaled SGM which allows further increasing the interaction between optical field and analytes. We analyzed and demonstrated enhanced bulk sensitivity and limit of detection (LOD) in SGM microring resonators with pedestal structure. To compare the bulk sensitivity and LOD of regular SGM microring resonator (Sample A) and pedestal SGM microring resonators, the devices with same structure design as Sample A were soaked in buffered oxide etch (BOE) for 30 seconds (Sample B) and 50 seconds (Sample C) to make pedestal shape. Real time monitoring of the resonance shift measurement shows the detection of streptavidin at a low concentration of 0.1 ng/mL for Sample C and a similar response for 1 ng/mL, 10 ng/mL, 100 ng/mL, 1 μg/mL, 10 μg/mL, and 100 μg/mL. Our results suggest that such pedestaled SGM microring resonators have great potential for specific biomarkers diagnosis.","PeriodicalId":221157,"journal":{"name":"Frontiers in Biological Detection: From Nanosensors to Systems XI","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132039243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheng Li, M. Teimourpour, Phuong-Diem Nguyen, Lei Chen, E. Mcleod, Judith Su
{"title":"Dark mode plasmonic cavity biosensor (Conference Presentation)","authors":"Cheng Li, M. Teimourpour, Phuong-Diem Nguyen, Lei Chen, E. Mcleod, Judith Su","doi":"10.1117/12.2509157","DOIUrl":"https://doi.org/10.1117/12.2509157","url":null,"abstract":"","PeriodicalId":221157,"journal":{"name":"Frontiers in Biological Detection: From Nanosensors to Systems XI","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132964706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：