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Testosterone and resistance training improved physical performance and reduced fatigue in frail older men: 1 year follow-up of a randomized clinical trial. 睾酮和阻力训练可改善体弱老年男性的体能表现并减轻疲劳:随机临床试验的一年随访。
Pub Date : 2024-09-17 DOI: 10.1080/13685538.2024.2403519
Rune Skovgaard Rasmussen,Mette Midttun,Bo Zerahn,Maria Pedersen,Anahita Rashid,Peter Busch Østergren,Tine Kolenda Paulin,Thea Winther Pødenphanth,Linda Katharina Karlsson,Eva Rosendahl,Anne-Mette Ragle,Anders Vinther,Karsten Overgaard
OBJECTIVETo improve health conditions among hypogonadal men ≥70 years of age using testosterone undecanoate (TU) injections, progressive strength training, and oral supplements of vitamin D, calcium, and protein.METHODSThis study is a 1-year follow-up of a double-blind RCT lasting 20 weeks, including 148 older men ≥70 years old with low testosterone levels and mobility problems. During 52 weeks, 4 groups received either testosterone therapy (TU) or progressive resistance training (Training), both (Combo), or no intervention (Controls). Physiotherapists supported the training groups until week 20, while these participants continued trained on their own during weeks 21 to 52. The main outcome measure was the 30-s chair stand test.RESULTSThe following numbers of participants completed the trial: 20 (Combo), 20 (Controls), 24 (TU), and 14 (Training). When examining 30-s chair stand test performance within each group at baseline, and at weeks 4, 20 and 52, only the Combo group improved (p = 0.001, Friedman Test). Compared to controls, only the Combo group experienced reduced fatigue and tiredness (p < 0.05).CONCLUSIONSFifty-two weeks of testosterone supplementation combined with progressive resistance training may enhance physical performance, alleviate fatigue, and had no notable detrimental impacts among males aged ≥70 suffering from mobility issues and testosterone insufficiency.Trial registration - Clinical Trials NCT02873559.
目的:通过注射十一酸睾酮 (TU)、渐进式力量训练以及口服维生素 D、钙和蛋白质补充剂,改善年龄≥70 岁的性腺功能低下男性的健康状况。方法:本研究是一项为期 20 周的双盲 RCT 的 1 年随访,其中包括 148 名年龄≥70 岁、睾酮水平低且行动不便的老年男性。在为期 52 周的时间里,4 个小组分别接受了睾酮疗法(TU)或渐进阻力训练(训练)、两种疗法(组合)或无干预措施(对照组)。物理治疗师为训练组提供支持直至第 20 周,而这些参与者在第 21 至 52 周期间继续自行训练。结果完成试验的参与者人数如下:20 人(组合组)、20 人(对照组)、24 人(训练组)和 14 人(训练组)。在基线、第 4 周、第 20 周和第 52 周时,如果对各组的 30 秒椅子站立测试成绩进行检查,只有组合组的成绩有所提高(P = 0.001,弗里德曼测试)。结论52周的睾酮补充与渐进阻力训练相结合,可提高身体机能,缓解疲劳,并且对≥70岁患有行动不便和睾酮不足的男性没有明显的不利影响。
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引用次数: 0
Associations between organic erectile dysfunction and the risk of herpes zoster and postherpetic neuralgia in men 男性器质性勃起功能障碍与带状疱疹和带状疱疹后遗神经痛风险之间的关系
Pub Date : 2024-04-29 DOI: 10.1080/13685538.2024.2346310
Kuan-Hsun Wang, Wen-Che Hsieh, Heng-Jun Lin, Fuu-Jen Tsai, Chao-Yu Hsu
Whether erectile dysfunction (ED) leads to considerable stress for affected men remains unclear? In this study, we investigated whether organic ED (OED) is associated with increased risks of herpes...
勃起功能障碍(ED)是否会给受影响的男性带来巨大压力,目前仍不清楚?在这项研究中,我们调查了器质性勃起功能障碍(OED)是否与疱疹风险的增加有关。
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引用次数: 0
Red blood cell folate and benign prostatic hyperplasia: results from the NHANES 2001-2008 红细胞叶酸与良性前列腺增生:2001-2008 年 NHANES 调查结果
Pub Date : 2024-04-22 DOI: 10.1080/13685538.2024.2336625
TingTing Chen, YuanPeng Huang
Benign prostatic hyperplasia (BPH) affects 30% of men worldwide, folate is essential for life. However, few studies have investigated the relationship between folate levels and BPH. The present stu...
全世界有 30% 的男性患有良性前列腺增生症(BPH),叶酸是生命的必需品。然而,很少有研究调查叶酸水平与良性前列腺增生之间的关系。本研究...
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引用次数: 0
Metabolic dysfunction, rather than obesity, is a risk factor for chronic kidney disease in Chinese population 代谢功能障碍而非肥胖是中国人患慢性肾病的风险因素
Pub Date : 2024-04-10 DOI: 10.1080/13685538.2024.2335158
Shan Yang, Jiaxiu Ling, Siliang Zhang, Yang Li, Gangyi Yang
Metabolic dysfunction and obesity are closely related to chronic kidney disease (CKD). However, studies on the relationship between various metabolic syndrome-body mass index (MetS-BMI) phenotypes ...
代谢功能障碍和肥胖与慢性肾脏病(CKD)密切相关。然而,关于各种代谢综合征-体重指数(MetS-BMI)表型之间关系的研究...
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引用次数: 0
Comment on “Risk analysis of metformin use in prostate cancer: a national population-based study” 关于 "前列腺癌患者服用二甲双胍的风险分析:一项基于全国人口的研究 "的评论
Pub Date : 2024-04-08 DOI: 10.1080/13685538.2024.2340087
Shih-Wei Lai, Bing-Fang Hwang, Chiu-Shong Liu, Kuan-Fu Liao
Published in The Aging Male (Vol. 27, No. 1, 2024)
发表于《老年男性》(第 27 卷第 1 期,2024 年)
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引用次数: 0
A novel strategy to induce penile erection during penile doppler ultrasound: oral sildenafil administration plus alprostadil injection 阴茎多普勒超声检查中诱导阴茎勃起的新策略:口服西地那非加注射阿洛前列地尔
Pub Date : 2024-04-08 DOI: 10.1080/13685538.2024.2339352
Yuyang Zhang, Xu Wu, Xingliang Feng, Guodong Liu, Hui Jiang, Xiansheng Zhang
To evaluate the efficacy of a novel approach to achieve the optimal penile erection during the penile doppler ultrasound (PDU) examination, which was oral sildenafil combined alprostadil injection....
评估在阴茎多普勒超声(PDU)检查中实现最佳阴茎勃起的新方法(口服西地那非联合阿洛司他地注射液....)的疗效
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引用次数: 0
Sexual function and pelvic floor function in men with systemic sclerosis compared to healthy controls: a cross-sectional study 与健康对照组相比,系统性硬化症男性患者的性功能和盆底功能:一项横断面研究
Pub Date : 2024-04-07 DOI: 10.1080/13685538.2024.2336630
Barbora Heřmánková, Sabína Oreská, Maja Špiritović, Hana Štorkánová, Martin Komarc, Karel Pavelka, Ladislav Šenolt, Jiří Vencovský, Radim Bečvář, Michal Tomčík
This cross-sectional study aimed to compare the sexual function (SF) and pelvic floor function of men with systemic sclerosis (SSc) with age-matched healthy controls (HC) and to identify the implic...
这项横断面研究旨在比较系统性硬化症(SSc)男性患者与年龄匹配的健康对照组(HC)的性功能(SF)和盆底功能,并确定两者之间的关系。
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引用次数: 0
Penile erection and cardiovascular function: effects and pathophysiology 阴茎勃起和心血管功能:影响和病理生理学
Pub Date : 2024-04-03 DOI: 10.1080/13685538.2024.2336627
B. A. Akorede, S. A. Hassan, R. E. Akhigbe
Penile erection (PE) is a hemodynamic event that results from a neuroendocrine process, and it is influenced by the cardiovascular status of the patient. However, it may also modulate an individual...
阴茎勃起(PE)是由神经内分泌过程导致的血液动力学事件,受患者心血管状态的影响。然而,它也可能调节个体...
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引用次数: 0
Navigating the unregulated terrain of testosterone boosters: a growing concern in men’s health 驾驭不受监管的睾酮促进剂:男性健康中日益严重的问题
Pub Date : 2024-02-02 DOI: 10.1080/13685538.2024.2312176
Dr Nisanth Puliyath, Dr Venugopalan AV
Published in The Aging Male (Vol. 27, No. 1, 2024)
发表于《老年男性》(第 27 卷第 1 期,2024 年)
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引用次数: 0
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