Obesity induced by a single intracerebral injection with the carcinogett, 4-nitroquinoline 1-oxide (NQO), was studied physiologically and histopathologically incomparison with that indtuced by intraperitoneal injection with goldthioglucose (GTG).NQO- and GTG-obese mice showed a more remarkable inc?-ease in body weight thanuntreated cou?tro1s, having exhibited an elevated intake of food and water, as well as anincreased oxygen consumption. The levels of blood glucose ;tncl serum cholesterol weresignificantly higher in fat animals than in controls. There was n?o significant differencein any of these metabolic parautteters between NQO- and GTG-obese animals. It wasevident, however, tltat cerebral lesions were mostly localized in the limbic system (septvxm, psalterium, corpus callosum and hippocampus) in the NQO-obese animals and in tltemiddle regioua of tlte hypothalamus in the GTG-obese animals.
{"title":"4-ニトロキノリン1-オキサイドによってマウスに発生した肥満と脳損傷","authors":"T. Mizutani","doi":"10.1292/JVMS1939.38.117","DOIUrl":"https://doi.org/10.1292/JVMS1939.38.117","url":null,"abstract":"Obesity induced by a single intracerebral injection with the carcinogett, 4-nitroquinoline 1-oxide (NQO), was studied physiologically and histopathologically incomparison with that indtuced by intraperitoneal injection with goldthioglucose (GTG).NQO- and GTG-obese mice showed a more remarkable inc?-ease in body weight thanuntreated cou?tro1s, having exhibited an elevated intake of food and water, as well as anincreased oxygen consumption. The levels of blood glucose ;tncl serum cholesterol weresignificantly higher in fat animals than in controls. There was n?o significant differencein any of these metabolic parautteters between NQO- and GTG-obese animals. It wasevident, however, tltat cerebral lesions were mostly localized in the limbic system (septvxm, psalterium, corpus callosum and hippocampus) in the NQO-obese animals and in tltemiddle regioua of tlte hypothalamus in the GTG-obese animals.","PeriodicalId":22586,"journal":{"name":"The Japanese journal of veterinary science","volume":"126 1","pages":"117-125"},"PeriodicalIF":0.0,"publicationDate":"1976-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87711693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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