Stefany Hg, Erika Eb, Alex, W. Er, W. Viraine, Melissa Ll, Michael Jw
Acute pancreatitis in children is associated with abdominal trauma, drug and toxin ingestion, multi-system diseases, viral illness, and structural abnormalities [1]. Pancreatic enzyme levels decline over 3–4 days and often no specific cause is found [1,2]. Mutations in the secretory trypsin inhibitor (SPINK1) gene are associated with both hereditary and chronic pancreatitis (CP). However, its association with acute pancreatitis (AP) [3,4] and acute recurrent pancreatitis (ARP) [5,6] in the literature remains rare, especially in children. We present the case of a child with ARP found to be heterozygous for the N34S mutation of the SPINK1 gene.
{"title":"Acute Recurrent Pancreatitis in a Child Heterozygous for the N34S SPINK1 Gene Mutation","authors":"Stefany Hg, Erika Eb, Alex, W. Er, W. Viraine, Melissa Ll, Michael Jw","doi":"10.4172/rjcp1000114","DOIUrl":"https://doi.org/10.4172/rjcp1000114","url":null,"abstract":"Acute pancreatitis in children is associated with abdominal trauma, drug and toxin ingestion, multi-system diseases, viral illness, and structural abnormalities [1]. Pancreatic enzyme levels decline over 3–4 days and often no specific cause is found [1,2]. Mutations in the secretory trypsin inhibitor (SPINK1) gene are associated with both hereditary and chronic pancreatitis (CP). However, its association with acute pancreatitis (AP) [3,4] and acute recurrent pancreatitis (ARP) [5,6] in the literature remains rare, especially in children. We present the case of a child with ARP found to be heterozygous for the N34S mutation of the SPINK1 gene.","PeriodicalId":22655,"journal":{"name":"The Journal of clinical Pediatrics","volume":"7 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75017084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Zohoun-Guidigbi, G. Sagbo, M. d’Almeida, S. Zohoun
Objective: Describe the epidemiological, clinical and therapeutic features and the outcome of comas among febrile children in the CNHU- Cotonou. Material and methods: This research work was a case-control and descriptive study focused on 97 children aged one (01) month to 15 years admitted to the said unit, from January 1 to December 31, 2014 for fever induced coma. Coma was assessed using Blantyre and Glasgow scores. The study involved all children with coma during more than 24 hours after admission and with temperature higher or equal to a 38°C. Findings: Mean age was 56 months and sex ratio 1.1. In addition to coma, respiratory distress, anemia and convulsions were identified respectively in 24, 16 and 31 cases. 61.9% of isolated pathogens were Plasmodium Falciparum but only case of N meningitidis and one case of Klebsiella P were registered. Bacterial meningitis with unidentified pathogen was found in 10 cases and no etiology was identified in 25 cases. Antimalarial drug was used in 61.9% of cases and probabilistic antibiotic therapy in 36% of cases. After-effects such as aphasia and blindness were observed on discharge of the patient in 14.4% of the cases. Death rate was 6.2%. Coma duration higher than 7 days was associated with occurrence of after-effects (P=0.04). Conclusion: Viral culture should be put in place in Benin in order to extend etiological research. The fight against malaria must be pursued.
{"title":"Febrile Coma in the Pediatric Unit of the National University Teaching Hospital (CNHU) of Cotonou: Etiologic and Therapeutic Features and Outcome","authors":"L. Zohoun-Guidigbi, G. Sagbo, M. d’Almeida, S. Zohoun","doi":"10.4172/RJCP1000111","DOIUrl":"https://doi.org/10.4172/RJCP1000111","url":null,"abstract":"Objective: Describe the epidemiological, clinical and therapeutic features and the outcome of comas among febrile children in the CNHU- Cotonou. \u0000Material and methods: This research work was a case-control and descriptive study focused on 97 children aged one (01) month to 15 years admitted to the said unit, from January 1 to December 31, 2014 for fever induced coma. Coma was assessed using Blantyre and Glasgow scores. The study involved all children with coma during more than 24 hours after admission and with temperature higher or equal to a 38°C. \u0000Findings: Mean age was 56 months and sex ratio 1.1. In addition to coma, respiratory distress, anemia and convulsions were identified respectively in 24, 16 and 31 cases. 61.9% of isolated pathogens were Plasmodium Falciparum but only case of N meningitidis and one case of Klebsiella P were registered. Bacterial meningitis with unidentified pathogen was found in 10 cases and no etiology was identified in 25 cases. Antimalarial drug was used in 61.9% of cases and probabilistic antibiotic therapy in 36% of cases. After-effects such as aphasia and blindness were observed on discharge of the patient in 14.4% of the cases. Death rate was 6.2%. Coma duration higher than 7 days was associated with occurrence of after-effects (P=0.04). \u0000Conclusion: Viral culture should be put in place in Benin in order to extend etiological research. The fight against malaria must be pursued.","PeriodicalId":22655,"journal":{"name":"The Journal of clinical Pediatrics","volume":"48 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86190533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adedemy Jd, A. Noudamadjo, J. Agossou, L. Zohoun, Cakpo Eg, Sayi Ad, M. d’Almeida
Introduction: The oral - dental pathologies as tooth decay raise a serious public health problem in the world. They remain a reason of morbidity related to the access to treatment and socio-economic problems. Objective: The aim of this research was to study the prevalence and the factors associated to the tooth decay in scholar environment in Parakou in 2014. Methods: It was across sectional descriptive and analytic survey which has taken place from May to June 2014. School children aged five to fourteen years old in public primary schools of Parakou were included. The sampling was probabilistic and multi-stages (three degrees). The school children and their mothers answered a questionnaire completed with an oral-dental examination. Results: Our survey was based upon 536 school children and their mothers. The mean age of the school children was 9.61 years ± 1.82 year and the sex - ratio was 1.22. The tooth brush was the most used brushing instrument used (60.82%). In 60.82% of the cases, the school children consumed sweets at least once a day. The average DMFT index was of 1.23. The prevalence of tooth decay was 38.62%. Factors associated with the tooth decay were the consumption of sweets (p=0.032), the control of teeth cleanness by parent after brushing (p=0,007), the dental pains (p=0,000), the education level (p=0,000) and the living environment (p=0,000). Conclusion: These results confirm the existence of the tooth decay among scholars. It is necessary to implement preventive measures among them.
{"title":"Prevalence of Tooth Decay and Associated Factors in North-Benin Schools in 2014","authors":"Adedemy Jd, A. Noudamadjo, J. Agossou, L. Zohoun, Cakpo Eg, Sayi Ad, M. d’Almeida","doi":"10.4172/RJCP.1000105","DOIUrl":"https://doi.org/10.4172/RJCP.1000105","url":null,"abstract":"Introduction: The oral - dental pathologies as tooth decay raise a serious public health problem in the world. They remain a reason of morbidity related to the access to treatment and socio-economic problems. Objective: The aim of this research was to study the prevalence and the factors associated to the tooth decay in scholar environment in Parakou in 2014. Methods: It was across sectional descriptive and analytic survey which has taken place from May to June 2014. School children aged five to fourteen years old in public primary schools of Parakou were included. The sampling was probabilistic and multi-stages (three degrees). The school children and their mothers answered a questionnaire completed with an oral-dental examination. Results: Our survey was based upon 536 school children and their mothers. The mean age of the school children was 9.61 years ± 1.82 year and the sex - ratio was 1.22. The tooth brush was the most used brushing instrument used (60.82%). In 60.82% of the cases, the school children consumed sweets at least once a day. The average DMFT index was of 1.23. The prevalence of tooth decay was 38.62%. Factors associated with the tooth decay were the consumption of sweets (p=0.032), the control of teeth cleanness by parent after brushing (p=0,007), the dental pains (p=0,000), the education level (p=0,000) and the living environment (p=0,000). Conclusion: These results confirm the existence of the tooth decay among scholars. It is necessary to implement preventive measures among them.","PeriodicalId":22655,"journal":{"name":"The Journal of clinical Pediatrics","volume":"12 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88821877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pulmonary hypertension can be diagnosed at all ages and characterized by increased vascular resistance in the lungs. Pulmonary hypertension in the pediatric population is less studied than in adults with much of the therapy extrapolated from adult data. Suboptimal survival rate of patients with pulmonary hypertension and the economic impact this disease has on the healthcare system warrant the need for new therapeutic options, such as citrulline. Citrulline is a non-essential amino acid involved in the urea cycle, which ultimately converts to nitric oxide to help dilate the pulmonary vasculature. Based on the available animal and few human studies, citrulline can potentially be a preventive remedy for pediatric patients at high risk of developing pulmonary hypertension after undergoing congenital cardiac surgery. However, new clinical trials are needed before using citrulline as a standard treatment option and incorporating it into practice guidelines.
{"title":"The Use of Citrulline for Pediatric Pulmonary Hypertension","authors":"S. Yang, So Ty","doi":"10.4172/RJCP1000101","DOIUrl":"https://doi.org/10.4172/RJCP1000101","url":null,"abstract":"Pulmonary hypertension can be diagnosed at all ages and characterized by increased vascular resistance in the lungs. Pulmonary hypertension in the pediatric population is less studied than in adults with much of the therapy extrapolated from adult data. Suboptimal survival rate of patients with pulmonary hypertension and the economic impact this disease has on the healthcare system warrant the need for new therapeutic options, such as citrulline. Citrulline is a non-essential amino acid involved in the urea cycle, which ultimately converts to nitric oxide to help dilate the pulmonary vasculature. Based on the available animal and few human studies, citrulline can potentially be a preventive remedy for pediatric patients at high risk of developing pulmonary hypertension after undergoing congenital cardiac surgery. However, new clinical trials are needed before using citrulline as a standard treatment option and incorporating it into practice guidelines.","PeriodicalId":22655,"journal":{"name":"The Journal of clinical Pediatrics","volume":"75 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86305768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Donaire Ae, S. Sethuram, E. Kitsos, P. Ankola, R. Benamanahali
Congenital dislocation of the knee (CDK), is commonly referred with a variety of names, mainly genum recurvatum of knee, backward bending of the knee, hyperextension of the knee, dislocation of the knee, and recently as developmental dysplasia and dislocation of the knees [1]. Whichever name is used, the typical clinical features in an infant is an abnormal anterior hyperextensive position of either one or both knees noted at birth [1,2].
{"title":"Congenital Bilateral Knee Hyperextension in a Well-Newborn Infant","authors":"Donaire Ae, S. Sethuram, E. Kitsos, P. Ankola, R. Benamanahali","doi":"10.4172/RJCP1000103","DOIUrl":"https://doi.org/10.4172/RJCP1000103","url":null,"abstract":"Congenital dislocation of the knee (CDK), is commonly referred with a variety of names, mainly genum recurvatum of knee, backward bending of the knee, hyperextension of the knee, dislocation of the knee, and recently as developmental dysplasia and dislocation of the knees [1]. Whichever name is used, the typical clinical features in an infant is an abnormal anterior hyperextensive position of either one or both knees noted at birth [1,2].","PeriodicalId":22655,"journal":{"name":"The Journal of clinical Pediatrics","volume":"3 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79533881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1965-02-01DOI: 10.11411/JSPD1963.22.4_889
辰野 克子
{"title":"Cornelia de Lange症候群の1例","authors":"辰野 克子","doi":"10.11411/JSPD1963.22.4_889","DOIUrl":"https://doi.org/10.11411/JSPD1963.22.4_889","url":null,"abstract":"","PeriodicalId":22655,"journal":{"name":"The Journal of clinical Pediatrics","volume":"157 1","pages":"889-897"},"PeriodicalIF":0.0,"publicationDate":"1965-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77057070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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