Pub Date : 2023-01-01DOI: 10.21146/2413-9084-2023-28-1-79-90
Natalia V. Popkova
The prospects for the analysis of technology with the help of the philosophy of dialogue are considered. A person’s desire to get rid of external restrictions is realized with the help of material and non-material technology. From the very beginning of the philosophical analysis of technology, there has been a dispute: whether technology increases the freedom and creative potential of a person or reduces it. The philosophy of dialogue explores the opposite of a technical relationship to the world. It is shown that technology is the opposite of dialogue: a monologue of a person who, according to his own will, transforms nature and other people (who transform him). Technical is the relation of a person to the world, based on the desire to remake it in order to adapt to one’s desires: this attitude is the opposite of the readiness to remake oneself to adapt to the world, which is characteristic of traditional societies and biological species in general. Both attitudes to the world – technological and personal, monologue and dialogue – are justified by necessity and must take their place in life, but today the technological attitude is replacing the personal one. Technology increases the creative potential of a person as an active agent in a passive environment, so it does not increase his freedom: technology is the freedom of a monologue.
{"title":"Philosophical analysis of technology and philosophy of dialogue","authors":"Natalia V. Popkova","doi":"10.21146/2413-9084-2023-28-1-79-90","DOIUrl":"https://doi.org/10.21146/2413-9084-2023-28-1-79-90","url":null,"abstract":"The prospects for the analysis of technology with the help of the philosophy of dialogue are considered. A person’s desire to get rid of external restrictions is realized with the help of material and non-material technology. From the very beginning of the philosophical analysis of technology, there has been a dispute: whether technology increases the freedom and creative potential of a person or reduces it. The philosophy of dialogue explores the opposite of a technical relationship to the world. It is shown that technology is the opposite of dialogue: a monologue of a person who, according to his own will, transforms nature and other people (who transform him). Technical is the relation of a person to the world, based on the desire to remake it in order to adapt to one’s desires: this attitude is the opposite of the readiness to remake oneself to adapt to the world, which is characteristic of traditional societies and biological species in general. Both attitudes to the world – technological and personal, monologue and dialogue – are justified by necessity and must take their place in life, but today the technological attitude is replacing the personal one. Technology increases the creative potential of a person as an active agent in a passive environment, so it does not increase his freedom: technology is the freedom of a monologue.","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masoumeh Rajabi Ozudi, Masoumeh Bagheri-Nesami, J. Setareh, M. Moosazadeh, Valiollah Habib, K. Saatchi
{"title":"The effect of head and facial massage on sleep condition after coronary artery bypass graft surgery","authors":"Masoumeh Rajabi Ozudi, Masoumeh Bagheri-Nesami, J. Setareh, M. Moosazadeh, Valiollah Habib, K. Saatchi","doi":"10.53388/tmr20220117002","DOIUrl":"https://doi.org/10.53388/tmr20220117002","url":null,"abstract":"","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70822316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Han Li, Hui Zhang, Baochao Pan, Yuan-song Wang, Xiu-hai Su, Shu-fang Zhang, Shuquan Lyu, Zhai-Yi Zhang
{"title":"Mechanism of Baihu Renshen decoction on T2DM rats based on mitochondrial autophagy mediated by PINK1/Parkin","authors":"Han Li, Hui Zhang, Baochao Pan, Yuan-song Wang, Xiu-hai Su, Shu-fang Zhang, Shuquan Lyu, Zhai-Yi Zhang","doi":"10.53388/tmr20220921005","DOIUrl":"https://doi.org/10.53388/tmr20220921005","url":null,"abstract":"","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Di Liang, Wei-Mei Zhang, Xu Liang, Hong Tian, Xuemei Zhang, Xia Li, Wenhai Gao
{"title":"A review on the extraction and separation of andrographolide from Andrographis paniculata: extraction selectivity, current challenges and strategies","authors":"Di Liang, Wei-Mei Zhang, Xu Liang, Hong Tian, Xuemei Zhang, Xia Li, Wenhai Gao","doi":"10.53388/tmr20230107001","DOIUrl":"https://doi.org/10.53388/tmr20230107001","url":null,"abstract":"","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70825716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Qin, Min Feng, Chi Zhang, X. Bu, W. Gong, Yuemei Chen, Yan Tang, Hui Li, Kun Liu, Guo-Zhong Chen, Xianping Tang
Background: The Qingjiehuagong decoction (QJHGD), which has been used in clinical trials to treat acute pancreatitis (AP), has demonstrated encouraging results. Methods: In this particular investigation, we used both metabolomics and network pharmacology to investigate the fundamental processes and targets that QJHGFD employs to cure AP. Results: Using a cerulein-induced rat model of AP, we showed that QJHGD effectively improved pancreatic tissue damage and reduced serum levels of AMY, LPS, IL-1β, IL-6, IL-8 and TNF-α. In total, 28 blood entry compounds derived from QJHGD were identified by ultra-performance liquid chromatography-high resolution mass spectrometry technology. The intersecting target genes of 108 genes associated with identified compounds in QJHGD and AP disease genes were identified using a network pharmacology approach. The protein interaction network revealed AKT1, TNF-α, IL-6, VEGFA, and TP53 as important targets. Gene ontology analysis showed that response to stimulus, molecular function regulator and organelle part were the main functions, and Kyoto Encyclopedia of Genes and Genomes analysis showed that 20 pathways such as AGE-RAGE signaling pathway in diabetic complications and the IL-17 signaling pathway were the main pathways involved in the anti-AP effects of QJHGD. Thirty-two potential metabolic markers and 13 possible metabolic pathways were identified by metabolomics analysis. Combined network pharmacological analysis revealed that QJHGD affects four metabolic pathways (tryptophan metabolism; glycolysis and gluconeogenesis metabolism; valine, leucine and isoleucine degradation metabolism; the urea cycle and metabolism of arginine, proline, glutamate, aspartate and asparagine), five metabolites (indole-3-acetate, pyruvate, methylmalonate, L-citrulline, N-acetyl-l-glutamate) and four related targets (AKT1, ALDH2, NOS2, NOS3) to combat inflammation. The strong affinity of QJHGD’s interactions with its primary targets was established by molecular docking and molecular dynamics simulations. Conclusion: This research investigate the critical targets and mechanisms of QJHGFD for treating AP. The results of this investigation provide novel tactics and complementary techniques for the clinical treatment of AP.
{"title":"Integrating serum pharmacochemistry, network pharmacology and metabolomics analysis to explore the possible mechanism of Qingjiehuagong decoction in the treatment of acute pancreatitis","authors":"B. Qin, Min Feng, Chi Zhang, X. Bu, W. Gong, Yuemei Chen, Yan Tang, Hui Li, Kun Liu, Guo-Zhong Chen, Xianping Tang","doi":"10.53388/tmr20230330002","DOIUrl":"https://doi.org/10.53388/tmr20230330002","url":null,"abstract":"Background: The Qingjiehuagong decoction (QJHGD), which has been used in clinical trials to treat acute pancreatitis (AP), has demonstrated encouraging results. Methods: In this particular investigation, we used both metabolomics and network pharmacology to investigate the fundamental processes and targets that QJHGFD employs to cure AP. Results: Using a cerulein-induced rat model of AP, we showed that QJHGD effectively improved pancreatic tissue damage and reduced serum levels of AMY, LPS, IL-1β, IL-6, IL-8 and TNF-α. In total, 28 blood entry compounds derived from QJHGD were identified by ultra-performance liquid chromatography-high resolution mass spectrometry technology. The intersecting target genes of 108 genes associated with identified compounds in QJHGD and AP disease genes were identified using a network pharmacology approach. The protein interaction network revealed AKT1, TNF-α, IL-6, VEGFA, and TP53 as important targets. Gene ontology analysis showed that response to stimulus, molecular function regulator and organelle part were the main functions, and Kyoto Encyclopedia of Genes and Genomes analysis showed that 20 pathways such as AGE-RAGE signaling pathway in diabetic complications and the IL-17 signaling pathway were the main pathways involved in the anti-AP effects of QJHGD. Thirty-two potential metabolic markers and 13 possible metabolic pathways were identified by metabolomics analysis. Combined network pharmacological analysis revealed that QJHGD affects four metabolic pathways (tryptophan metabolism; glycolysis and gluconeogenesis metabolism; valine, leucine and isoleucine degradation metabolism; the urea cycle and metabolism of arginine, proline, glutamate, aspartate and asparagine), five metabolites (indole-3-acetate, pyruvate, methylmalonate, L-citrulline, N-acetyl-l-glutamate) and four related targets (AKT1, ALDH2, NOS2, NOS3) to combat inflammation. The strong affinity of QJHGD’s interactions with its primary targets was established by molecular docking and molecular dynamics simulations. Conclusion: This research investigate the critical targets and mechanisms of QJHGFD for treating AP. The results of this investigation provide novel tactics and complementary techniques for the clinical treatment of AP.","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70826203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Subhransu Sekhar Dash, Neha Bajwa, Abinash Choudhury, P. Singh
Traditional remedies have gained recognition for their effectiveness in treating various conditions such as diabetes, arthritic pain, liver disease, cough and cold, memory enhancement, and immunological stimulation. Their perceived safety has led to the increasing use of herbs by people without prescriptions. These therapies remain significant in areas with limited access to modern drugs or cultural preferences for traditional treatments. With a long history of use, traditional medicines have been the primary method of pain management. This review article explores natural and herb-based analgesics, their origins, and potential benefits, along with the growing scientific evidence supporting their effectiveness. Studies have examined their efficacy in treating musculoskeletal pain, neuropathic pain, and migraines. Rather than being seen as separate therapies, traditional medicines should be considered supplementary or alternative options that can be integrated into comprehensive pain management regimens. However, some studies have reported adverse drug reactions associated with herbal formulations and plants. Therefore, there is a need for pharmacovigilance in traditional medicine to ensure patient safety and promote evidence-based practices. Although pharmacovigilance in this field is still developing, it faces challenges due to the wide availability of herbal medicines without on-site medical supervision. This paper discusses the complex challenges of herbal pharmacovigilance, provides insights on recent advancements, and offers recommendations for improving the safety monitoring of traditional medications in the future.
{"title":"Why pharmacovigilance of traditional medicines used as analgesics is important?","authors":"Subhransu Sekhar Dash, Neha Bajwa, Abinash Choudhury, P. Singh","doi":"10.53388/tmr20230531001","DOIUrl":"https://doi.org/10.53388/tmr20230531001","url":null,"abstract":"Traditional remedies have gained recognition for their effectiveness in treating various conditions such as diabetes, arthritic pain, liver disease, cough and cold, memory enhancement, and immunological stimulation. Their perceived safety has led to the increasing use of herbs by people without prescriptions. These therapies remain significant in areas with limited access to modern drugs or cultural preferences for traditional treatments. With a long history of use, traditional medicines have been the primary method of pain management. This review article explores natural and herb-based analgesics, their origins, and potential benefits, along with the growing scientific evidence supporting their effectiveness. Studies have examined their efficacy in treating musculoskeletal pain, neuropathic pain, and migraines. Rather than being seen as separate therapies, traditional medicines should be considered supplementary or alternative options that can be integrated into comprehensive pain management regimens. However, some studies have reported adverse drug reactions associated with herbal formulations and plants. Therefore, there is a need for pharmacovigilance in traditional medicine to ensure patient safety and promote evidence-based practices. Although pharmacovigilance in this field is still developing, it faces challenges due to the wide availability of herbal medicines without on-site medical supervision. This paper discusses the complex challenges of herbal pharmacovigilance, provides insights on recent advancements, and offers recommendations for improving the safety monitoring of traditional medications in the future.","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70826938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiang-Hua Xiao, Junmin Guo, Xin Zheng, Wen Sun, Qiu-Xiang Ning, Li Tang, Jianfeng Xiao, Liang Li, Ping Yang
Background: Bupleuri Radix is a common Chinese medicinal material in traditional Chinese medicine. Currently, the therapeutic effect of treating schizophrenia is relatively well understood. However, there are fewer studies examining the underlying mechanisms of its treatment. The objective of the study was to investigate the primary mechanisms of Bupleuri Radix in treating schizophrenia through network pharmacology and clinical validation. Method: Network pharmacology revealed possible molecular mechanisms, followed by clinical verification. Sixty-seven schizophrenia patients undergoing treatment at the Hunan Brain Hospital between October and November 2022 were recruited and randomly divided into the olanzapine group and the olanzapine + Bupleuri Radix group. Additionally, 32 healthy people undergoing physical examinations during the same period were included as the control group. The patient’s positive and negative symptom scale scores were compared. qPCR was used to detect the mRNA expression levels of ESR1, mTOR, EIF4E, and SMAD4 in peripheral blood. Results: Through network pharmacological analysis, it was concluded in this study that Bupleuri Radix might regulate the mTOR, PI3K-Akt, and HIF-1 signaling pathways. Clinical experiments indicated that compared with before treatment, the positive and negative symptom scale scores and total scores of the two treatment groups were significantly decreased after treatment ( P < 0.01). In addition, the positive and negative symptom scale scores and total scores in the olanzapine + Bupleuri Radix group were significantly decreased ( P < 0.01) compared to the olanzapine group after treatment. Before treatment, ESR1 mRNA expression levels in peripheral blood were significantly higher in the two treatment groups than in the control group, whereas the mRNA expression levels of mTOR, EIF4E, and SMAD4 in peripheral blood were significantly lower ( P < 0.01). The mRNA expression levels of mTOR, EIF4E, and SMAD4 in peripheral blood were significantly higher after therapy than before treatment, whereas the mRNA expression levels of ESR1 in peripheral blood were significantly lower ( P < 0.01). After therapy, the olanzapine + Bupleuri Radix group’s mRNA expression levels of mTOR, EIF4E, and SMAD4 were significantly higher than those of the olanzapine group, whereas the mRNA expression levels of ESR1 were significantly lower ( P < 0.01). Conclusion: The mechanism of Bupleuri Radix ’s therapeutic efficacy in schizophrenia may involve the up-regulation of mTOR, EIF4E, and SMAD4 mRNA expression and the down-regulation of ESR1 mRNA expression in peripheral blood.
{"title":"Active components of Bupleuri Radix in the treatment of schizophrenia analyzed by network pharmacology and clinical verification","authors":"Jiang-Hua Xiao, Junmin Guo, Xin Zheng, Wen Sun, Qiu-Xiang Ning, Li Tang, Jianfeng Xiao, Liang Li, Ping Yang","doi":"10.53388/tmr20230520001","DOIUrl":"https://doi.org/10.53388/tmr20230520001","url":null,"abstract":"Background: Bupleuri Radix is a common Chinese medicinal material in traditional Chinese medicine. Currently, the therapeutic effect of treating schizophrenia is relatively well understood. However, there are fewer studies examining the underlying mechanisms of its treatment. The objective of the study was to investigate the primary mechanisms of Bupleuri Radix in treating schizophrenia through network pharmacology and clinical validation. Method: Network pharmacology revealed possible molecular mechanisms, followed by clinical verification. Sixty-seven schizophrenia patients undergoing treatment at the Hunan Brain Hospital between October and November 2022 were recruited and randomly divided into the olanzapine group and the olanzapine + Bupleuri Radix group. Additionally, 32 healthy people undergoing physical examinations during the same period were included as the control group. The patient’s positive and negative symptom scale scores were compared. qPCR was used to detect the mRNA expression levels of ESR1, mTOR, EIF4E, and SMAD4 in peripheral blood. Results: Through network pharmacological analysis, it was concluded in this study that Bupleuri Radix might regulate the mTOR, PI3K-Akt, and HIF-1 signaling pathways. Clinical experiments indicated that compared with before treatment, the positive and negative symptom scale scores and total scores of the two treatment groups were significantly decreased after treatment ( P < 0.01). In addition, the positive and negative symptom scale scores and total scores in the olanzapine + Bupleuri Radix group were significantly decreased ( P < 0.01) compared to the olanzapine group after treatment. Before treatment, ESR1 mRNA expression levels in peripheral blood were significantly higher in the two treatment groups than in the control group, whereas the mRNA expression levels of mTOR, EIF4E, and SMAD4 in peripheral blood were significantly lower ( P < 0.01). The mRNA expression levels of mTOR, EIF4E, and SMAD4 in peripheral blood were significantly higher after therapy than before treatment, whereas the mRNA expression levels of ESR1 in peripheral blood were significantly lower ( P < 0.01). After therapy, the olanzapine + Bupleuri Radix group’s mRNA expression levels of mTOR, EIF4E, and SMAD4 were significantly higher than those of the olanzapine group, whereas the mRNA expression levels of ESR1 were significantly lower ( P < 0.01). Conclusion: The mechanism of Bupleuri Radix ’s therapeutic efficacy in schizophrenia may involve the up-regulation of mTOR, EIF4E, and SMAD4 mRNA expression and the down-regulation of ESR1 mRNA expression in peripheral blood.","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70827135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Alembagheri, H. Hajimehdipoor, R. Choopani, S. Esmaeili
{"title":"The role of selected medicinal plants from Iranian traditional medicine for the treatment of fatigue in metabolic syndrome","authors":"A. Alembagheri, H. Hajimehdipoor, R. Choopani, S. Esmaeili","doi":"10.53388/tmr20220706001","DOIUrl":"https://doi.org/10.53388/tmr20220706001","url":null,"abstract":"","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the compatibility theory of traditional Chinese medicine formulae: the disassembled prescriptions study","authors":"Xue Yang, Xinyu Luan","doi":"10.53388/tmr20221015001","DOIUrl":"https://doi.org/10.53388/tmr20221015001","url":null,"abstract":"","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70825022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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