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A step-by-step researcher's guide to the use of an AI-based transformer in epidemiology: an exploratory analysis of ChatGPT using the STROBE checklist for observational studies 一步一步的研究人员在流行病学中使用基于人工智能的变压器的指南:使用观察性研究的STROBE检查表对ChatGPT进行探索性分析
Q3 Medicine Pub Date : 2023-02-08 DOI: 10.1101/2023.02.06.23285514
F. Sanmarchi, Andrea Bucci, Andrea Giovanni Nuzzolese, G. Carullo, F. Toscano, N. Nante, D. Golinelli
Objectives. This study aims at investigating how early-stage AI-based transformers can support researchers in designing and conducting an epidemiological study. To accomplish this, we used ChatGPT to reformulate the STROBE recommendations into a list of questions to be answered by the transformer itself. We then qualitatively evaluated the coherence and relevance of the transformers outputs. Study design: Descriptive study. Methods. We first chose a study to be used as a basis for the simulation. We then used ChatGPT to transform each STROBE checklist item into specific prompts. Each answer to the respective prompt was evaluated by independent researchers in terms of coherence and relevance. Results. The mean scores assigned to each prompt were heterogeneous. On average, for the coherence domain, the overall mean score was 3.6 out of 5.0, and for relevance it was 3.3 out of 5.0. The lowest scores were assigned to items belonging to the Methods section of the checklist. Conclusions. ChatGPT can be considered as a valuable support for researchers in conducting an epidemiological study, following internationally recognized guidelines and standards. It is crucial for the users to have knowledge on the subject and a critical mindset when evaluating the outputs. The potential benefits of AI in scientific research and publishing are undeniable, but it is crucial to address the risks, and the ethical and legal consequences associated with its use.
目标。本研究旨在调查早期基于人工智能的变压器如何支持研究人员设计和开展流行病学研究。为了实现这一点,我们使用ChatGPT将STROBE建议重新表述为由转换器本身回答的问题列表。然后我们定性地评估了变压器输出的相干性和相关性。研究设计:描述性研究。方法。我们首先选择了一项研究作为模拟的基础。然后,我们使用ChatGPT将每个STROBE检查表项转换为特定的提示。每个问题的答案都由独立研究人员根据连贯性和相关性进行评估。结果。分配给每个提示的平均分数是不同的。平均而言,在连贯性领域,总体平均得分为3.6分(满分5.0分),而在相关性领域,平均得分为3.3分(满分5.0分)。最低的分数被分配给属于检查表的方法部分的项目。结论。ChatGPT可被视为研究人员根据国际公认的指导方针和标准进行流行病学研究的宝贵支持。用户在评估产出时,掌握有关主题的知识和批判性思维是至关重要的。人工智能在科学研究和出版方面的潜在好处是不可否认的,但解决其风险以及与使用人工智能相关的伦理和法律后果至关重要。
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引用次数: 23
A qualitative analysis of facilitators and barriers to physical activity among patients with moderate mental disorders. 对中度精神障碍患者参加体育锻炼的促进因素和障碍进行定性分析。
Q3 Medicine Pub Date : 2022-06-01 DOI: 10.1007/s10389-022-01720-4
Denise van Rijen, Gill A Ten Hoor

Aim: The current study aims to qualitatively identify determinants, barriers and facilitators of physical activity among a population with mental health disorders.

Subject and methods: Seventeen participants with moderate mental disorders were recruited. Semi-structured interviews were conducted to identify physical activity facilitators and barriers. Data were organized and analysed in ATLAS.ti, mainly based on a generic qualitative research approach.

Results: Most participants found physical activity important and expressed a positive attitude towards it. In general, higher self-efficacy and more social support were beneficial for participants' physical activity levels. Reasons/facilitating factors to be more physically active were: having fun, good weather, progress, routine, self-compassion and a stimulating environment. Barriers were not having fun, being busy, mental complaints, lack of energy, procrastination and physical complaints.

Conclusion: Future interventions could promote physical activity among people with moderate mental disorders to help them identify and overcome barriers. The newly identified determinant 'self-compassion' could be an interesting target for promoting physical activity in this group of people with moderate mental disorders.

目的:本研究旨在从定性角度确定精神疾病患者参加体育锻炼的决定因素、障碍和促进因素:招募了 17 名患有中度精神障碍的参与者。我们进行了半结构式访谈,以确定体育锻炼的促进因素和障碍。数据在 ATLAS.ti 中进行了整理和分析,主要基于通用的定性研究方法:结果:大多数参与者认为体育锻炼很重要,并对体育锻炼持积极态度。一般来说,较高的自我效能感和更多的社会支持有利于提高参与者的体育锻炼水平。加强体育锻炼的原因/促进因素包括:有乐趣、天气好、有进步、有规律、自我同情和有激励的环境。阻碍因素包括:没有乐趣、忙碌、精神抱怨、缺乏活力、拖延和身体抱怨:结论:未来的干预措施可以促进中度精神障碍患者的体育锻炼,帮助他们识别并克服障碍。新发现的决定因素 "自我同情 "可能是促进中度精神障碍患者体育锻炼的一个有趣的目标。
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引用次数: 0
Influences on the uptake of a population health approach to sexual health programs in Ontario public health units: a qualitative descriptive study. 安大略省公共卫生单位采用人口健康方法开展性健康计划的影响因素:定性描述研究。
Q3 Medicine Pub Date : 2022-05-17 DOI: 10.1007/s10389-022-01715-1
Linda Frost, Ruta Valaitis, Michelle Butt, Susan M Jack, Noori Akhtar-Danesh

Aim: Population-level prevention initiatives are the cornerstone of public health practice. However, despite this normative practice, sexual health programming within public health has not utilized this approach to the same extent as other public health programs. Understanding requirements to put a population-level approach into practice is needed. The objective of this study was to explore the barriers and facilitators experienced by sexual health programs and services within public health when implementing a population health approach.

Subject design and methods: The principles of qualitative description guided all sampling, data collection and analysis decisions. Data collection involved in-depth semi-structured interviews with 12 sexual health managers and/or supervisors from ten Ontario public health units. Directed content analysis was used to code and synthesize the data. Data collection and analysis was guided using constructs from the Consolidated Framework for Implementation Research.

Results: Factors that served as either barriers and facilitators to implementing a population health approach, were mainly in the inner and outer setting domains of the Consolidated Framework for Implementation Research. Participants identified the presence of community partnerships, adequate staff training on population health, and access to data on population health served as facilitators. In comparison, barriers to implementation included a lack of resources (human, financial) and clinicians' value of and preferences for delivering services at the individual clinic level.

Conclusion: Some clear barriers and facilitators influenced if staff in sexual health programs and services could implement a population health approach. Results indicate where public health resources need to be enhanced to move toward a population health approach and provide insight into what worked and should be considered by public health organizations.

目的:人群层面的预防措施是公共卫生实践的基石。然而,尽管有这种规范性做法,公共卫生领域的性健康计划却没有像其他公共卫生计划那样在同等程度上采用这种方法。我们需要了解将人口层面方法付诸实践的要求。本研究旨在探讨公共卫生领域的性健康计划和服务在实施人群健康方法时遇到的障碍和促进因素:定性描述的原则指导了所有的取样、数据收集和分析决策。数据收集包括对安大略省 10 个公共卫生单位的 12 名性健康管理人员和/或主管进行深入的半结构化访谈。采用指导性内容分析法对数据进行编码和综合。数据收集和分析以实施研究综合框架中的构建为指导:作为实施人口健康方法的障碍和促进因素,主要集中在实施研究综合框架的内部和外部环境领域。参与者认为,社区伙伴关系的存在、对员工进行人口健康方面的充分培训以及获取人口健康数据都是促进因素。相比之下,实施的障碍包括缺乏资源(人力、财力)以及临床医生对在单个诊所层面提供服务的重视和偏好:结论:一些明显的障碍和促进因素影响着性健康计划和服务人员能否实施人群健康方法。研究结果表明,公共卫生资源在哪些方面需要得到加强,以便向全民健康方法转变,并提供了公共卫生组织在哪些方面行之有效并应加以考虑的见解。
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引用次数: 0
Factors associated with the implementation of health-promoting telework from the perspective of company decision makers after the first COVID-19 lockdown 从公司决策者的角度看,在第一次COVID-19封锁后,实施促进健康的远程办公的相关因素
Q3 Medicine Pub Date : 2022-05-04 DOI: 10.1007/s10389-022-01717-z
G. Lang, K. Hofer-Fischanger
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引用次数: 5
How useful is the Making Every Contact Count Healthy Conversation Skills approach for supporting people with musculoskeletal conditions? “让每一次接触都算数”的健康谈话技巧方法对患有肌肉骨骼疾病的人有多大帮助?
Q3 Medicine Pub Date : 2022-05-04 DOI: 10.1007/s10389-022-01718-y
A. Parchment, W. Lawrence, E. Rahman, N. Townsend, E. Wainwright, D. Wainwright
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引用次数: 2
Has the COVID-19 pandemic lockdown worsened eating disorders symptoms among patients with eating disorders? A systematic review COVID-19大流行的封锁是否加剧了饮食失调患者的饮食失调症状?系统回顾
Q3 Medicine Pub Date : 2022-03-29 DOI: 10.1007/s10389-022-01704-4
Yu-lin Gao, N. Bagheri, L. Furuya-Kanamori
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引用次数: 27
Physical activity, mental and physical health during the Covid-19 outbreak: longitudinal predictors of suicide ideation in Germany. Covid-19 爆发期间的体育活动、身心健康:德国自杀意念的纵向预测因素。
Q3 Medicine Pub Date : 2022-03-25 DOI: 10.1007/s10389-022-01708-0
Julia Brailovskaia, Inga Truskauskaite-Kuneviciene, Evaldas Kazlauskas, Odeta Gelezelyte, Tobias Teismann, Jürgen Margraf

Aim: Suicide ideation has increased since the outbreak of Covid-19 in many countries. The present longitudinal study investigated potential predictors of suicide ideation.

Subject and methods: Data of 406 participants from Germany (age M = 27.69, SD = 6.88) were assessed via online surveys in spring 2020 (baseline, BL) and in spring 2021 (follow-up, FU).

Results: The current results reveal a significant increase in symptoms of depression, anxiety, and stress between 2020 and 2021. Positive mental health (PMH), sense of control, and physical health significantly decreased. Depression symptoms (BL), PMH (BL), and consciously enhanced physical activity since the pandemic outbreak (FU) significantly predicted 12-month suicide ideation (FU). In a moderated mediation analysis, the positive relationship between depression and suicide ideation was significantly mediated by PMH. Consciously enhanced physical activity significantly moderated the negative association between PMH and suicide ideation.

Conclusion: The context of Covid-19 could negatively impact mental health and physical health. This might increase the risk for suicide ideation. However, PMH and physical activity might serve as protective factors. The protective effect of physical activity could be especially important in people with high depression symptoms and low PMH, such as clinical patients. Potential ways of how PMH and physical activity could be enhanced in the Covid-19 context to prevent suicide ideation are discussed.

目的:自 Covid-19 在许多国家爆发以来,自杀意念有所增加。本纵向研究调查了自杀意念的潜在预测因素:2020 年春季(基线,BL)和 2021 年春季(随访,FU),通过在线调查对 406 名德国参与者(年龄 M = 27.69,SD = 6.88)的数据进行了评估:目前的结果显示,在 2020 年和 2021 年之间,抑郁、焦虑和压力症状明显增加。积极心理健康(PMH)、控制感和身体健康明显下降。抑郁症状(BL)、积极心理健康(PMH)(BL)以及自大流行病爆发以来有意识地加强体育锻炼(FU)可显著预测 12 个月的自杀意念(FU)。在调节中介分析中,抑郁与自杀意念之间的正相关关系在很大程度上受 PMH 的调节。有意识地加强体育锻炼能明显缓和PMH与自杀意念之间的负相关:结论:Covid-19 的环境会对心理健康和身体健康产生负面影响。结论:Covid-19 的背景可能会对心理健康和身体健康产生负面影响,这可能会增加萌生自杀念头的风险。然而,PMH 和体育锻炼可作为保护因素。体育锻炼的保护作用对于抑郁症状较重而 PMH 较低的人群(如临床患者)尤为重要。本文讨论了如何在 Covid-19 的背景下加强 PMH 和体育锻炼以预防自杀意念的潜在方法。
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引用次数: 0
Trust in Healthcare during COVID-19 in Europe: vulnerable groups trust the least. 欧洲 COVID-19 期间对医疗保健的信任度:弱势群体信任度最低。
Q3 Medicine Pub Date : 2022-03-24 DOI: 10.1007/s10389-022-01705-3
Johannes Beller, Jürgen Schäfers, Jörg Haier, Siegfried Geyer, Jelena Epping

Aim: We examined predictors of trust in the healthcare system during the COVID-19 pandemic in 27 European countries.

Subjects and methods: We used population-based data drawn from the Living, working and COVID-19 survey (N = 21,884, 52% female, ages 18 to 92 years) covering 27 European countries dated June and July 2020. Multilevel linear regression, linear regression, and regression-tree analyses were conducted.

Results: We found that most participants tended to trust the healthcare system, although a substantial part could still be classified as distrusting (approx. 21%). Multiple variables, including being middle-aged or of older age, being female, lower levels of education, unemployment, worse general health status, having income difficulties, having unmet needs for healthcare, no healthcare contact during the COVID-19 pandemic, higher mental distress, and loneliness, were significantly associated with lower levels of trust. Among these variables mental distress, income difficulties, and unmet needs for healthcare emerged as especially important and, across European regions and countries, consistent predictors for lower trust in the healthcare system during the COVID-19 pandemic.

Conclusions: Medically vulnerable subgroups, such as individuals with unmet healthcare needs, higher levels of mental distress, and older age, as well as people living in socially and economically vulnerable situations, such as higher levels of loneliness and financial difficulties, were the least trusting of the healthcare system during the COVID-19 pandemic. As these vulnerable subgroups are also at highest risk for contracting COVID-19 and experiencing negative COVID-19-related outcomes, more targeted prevention and intervention efforts should be implemented in these groups.

Supplementary information: The online version contains supplementary material available at 10.1007/s10389-022-01705-3.

目的:我们研究了欧洲 27 个国家在 COVID-19 大流行期间对医疗系统信任度的预测因素:我们使用了 2020 年 6 月和 7 月在 27 个欧洲国家进行的 "生活、工作和 COVID-19 调查"(N = 21,884 人,52% 为女性,年龄在 18 岁至 92 岁之间)中获得的人口数据。我们进行了多层次线性回归、线性回归和回归树分析:我们发现,大多数参与者倾向于信任医疗系统,但仍有相当一部分人(约 21%)不信任医疗系统。中年或老年、女性、教育程度较低、失业、总体健康状况较差、收入困难、医疗保健需求未得到满足、在 COVID-19 大流行期间未接触过医疗保健、精神压力较大以及孤独等多个变量与信任度较低有显著关联。在这些变量中,精神痛苦、收入困难和未满足的医疗保健需求尤其重要,而且在欧洲地区和国家中,它们是 COVID-19 大流行期间医疗保健系统信任度较低的一致预测因素:结论:在 COVID-19 大流行期间,在医疗方面处于弱势的亚群体(如医疗需求未得到满足、精神压力较大和年龄较大的个人)以及在社会和经济方面处于弱势的人群(如孤独和经济困难程度较高的人群)最不信任医疗系统。由于这些弱势群体也是感染COVID-19和经历COVID-19相关负面结果的高危人群,因此应在这些群体中开展更有针对性的预防和干预工作:在线版本包含补充材料,可查阅 10.1007/s10389-022-01705-3。
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引用次数: 0
Efficacy of approved vaccines to prevent COVID-19: a systematic review and network meta-analysis of reconstructed individual patient data from randomized trials. 获批疫苗对预防 COVID-19 的功效:对随机试验中重建的患者个体数据进行系统回顾和网络荟萃分析。
Q3 Medicine Pub Date : 2022-03-23 DOI: 10.1007/s10389-022-01707-1
Alhassane Diallo, Miguel Carlos-Bolumbu, Mamadou Hassimiou Diallo, Alain Makinson, Florence Galtier

Aim: To optimize vaccination strategy, evidence on vaccine efficacy against COVID-19 is needed.

Method: The present network meta-analysis uses reconstructed individual patient data from phase III trials on vaccine efficacy (VE), identified through MEDLINE, EMBASE, and Cochrane library (CENTRAL) peer-reviewed and published in English before August 31, 2021. The primary outcome was the VE against confirmed COVID-19 at any time after the first dose as defined in each study. VE was re-estimated using the two-stage approach. Poisson regression models were applied to each trial at the first stage, and the incidence risk ratio (IRR) and their 95% CI were aggregated to allow random-effects network meta-analysis (NMA) at the second stage. VE was expressed as: (1-IRR) × 100. The study protocol is registered in PROSPERO (CRD42020200012).

Results: A total of eight studies, evaluating nine different vaccines were identified and analyzed. Between April 23, 2020 and January 05, 2021, 210,418 participants were recruited in 354 sites worldwide. During a median (IQR) follow-up duration of 69.8 (69.7-70.3) days, 2131 confirmed COVID-19 cases occurred (604; 26.0 per 1000 person-years in vaccine recipients and 1527; 85.9 per 1000 person-years in the control group). The mRNA-1273 vaccine was the most effective (P-score 0.99); at any time after dose 1, incidence reduction for mRNA-1273 ranged from 78% to 98% compared to the other vaccines.

Conclusion: Our results provide evidence for the short-term superiority of mRNA vaccines, especially the mRNA-1273 vaccine in prevention of COVID-19 in different populations.

Supplementary information: The online version contains supplementary material available at 10.1007/s10389-022-01707-1.

目的:为优化疫苗接种策略,需要有关 COVID-19 疫苗疗效的证据:本网络荟萃分析使用的是经 MEDLINE、EMBASE 和 Cochrane 图书馆 (CENTRAL) 同行评审并在 2021 年 8 月 31 日之前以英文发表的有关疫苗疗效 (VE) 的 III 期试验中重建的患者个体数据。主要结果是每项研究中定义的在首次用药后的任何时间针对确诊的 COVID-19 的 VE。VE采用两阶段法重新估计。第一阶段对每项试验采用泊松回归模型,第二阶段汇总发病风险比 (IRR) 及其 95% CI,以进行随机效应网络荟萃分析 (NMA)。VE 表示为(1-IRR) ×100。研究方案已在 PROSPERO(CRD42020200012)上注册:结果:共确定并分析了 8 项研究,评估了 9 种不同的疫苗。在 2020 年 4 月 23 日至 2021 年 1 月 5 日期间,全球 354 个地点共招募了 210,418 名参与者。在中位数(IQR)为69.8(69.7-70.3)天的随访期间,共发生了2131例COVID-19确诊病例(疫苗接种者为604例;每1000人年26.0例;对照组为1527例;每1000人年85.9例)。mRNA-1273疫苗最有效(P-score 0.99);与其他疫苗相比,mRNA-1273疫苗在第1剂后的任何时间都能降低78%到98%的发病率:我们的研究结果为mRNA疫苗,尤其是mRNA-1273疫苗在不同人群中预防COVID-19的短期优势提供了证据:在线版本包含补充材料,可在 10.1007/s10389-022-01707-1。
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引用次数: 0
Analysis of HIV pre-exposure prophylaxis (PrEP) needs and PrEP use in Germany among men who have sex with men. 德国男男性行为者的艾滋病暴露前预防(PrEP)需求和 PrEP 使用情况分析。
Q3 Medicine Pub Date : 2022-03-04 DOI: 10.1007/s10389-022-01699-y
Ulrich Marcus, Daniel Schmidt, Susanne B Schink, Uwe Koppe

Aims: We aim to estimate the number of HIV pre-exposure prophylaxis (PrEP) users among men having sex with men (MSM) in Germany from 2017 through 2020, and analyse if PrEP needs expressed in 2017 might have been met by the expansion of PrEP until 2020.

Subject and methods: We estimated the number of PrEP users by using drug prescription data and information on on-demand/intermittent PrEP use from online surveys to determine the proportion of on-demand/intermittent and daily PrEP use as well as the average number of PrEP pills used.The number of MSM in need of PrEP in 2017 was estimated based on four groups defined among respondents to a large online survey, combining respondents with PrEP use intention and respondents indicating substantial sexual risks. The size of each group was estimated based on self-selection biases. MSM with PrEP need in 2017 were compared with the estimated number of persons taking PrEP by June 2020.

Results: We estimated a total of 15,600 to 21,600 PrEP users in Germany by the end of June 2020, corresponding to 40-55% of men with PrEP use intention in 2017. A correlation between the regional distribution of PrEP use intention in 11/2017 and actual PrEP use by 06/2020 suggested an unequal regional distribution of unsatisfied needs. The number of men with unmet PrEP needs ranged between 27,500 and 93,000 in 06/2020.

Conclusion: PrEP use in Germany has increased considerably between 10/2017 and 06/2020, but large regional inequalities persist. PrEP is not yet readily accessible, and there is a need to expand services and encourage uptake.

Supplementary information: The online version contains supplementary material available at 10.1007/s10389-022-01699-y.

目的:我们旨在估算2017年至2020年德国男男性行为者(MSM)中艾滋病暴露前预防(PrEP)使用者的数量,并分析在2020年之前扩大PrEP的使用范围是否能够满足2017年所表达的PrEP需求:我们通过药物处方数据和在线调查中按需/间歇性使用 PrEP 的信息来估算 PrEP 使用者的数量,从而确定按需/间歇性和每日使用 PrEP 的比例以及平均使用的 PrEP 药片数量。我们根据大型在线调查受访者中定义的四组人群来估算 2017 年需要 PrEP 的 MSM 人数,这四组人群包括有 PrEP 使用意向的受访者和表示存在重大性风险的受访者。每个群体的规模是根据自我选择偏差估算的。将 2017 年有 PrEP 需求的 MSM 与 2020 年 6 月前服用 PrEP 的估计人数进行了比较:我们估计,到 2020 年 6 月底,德国将有 15600 到 21600 名 PrEP 使用者,相当于 2017 年有 PrEP 使用意向的男性的 40-55%。2017 年 11 月 PrEP 使用意向的地区分布与 2020 年 6 月 PrEP 实际使用情况之间的相关性表明,未满足需求的地区分布不均。到2020年6月,未满足PrEP需求的男性人数在2.75万到9.3万之间:结论:在 2017 年 10 月至 2020 年 6 月期间,德国 PrEP 的使用率大幅提高,但地区间仍存在巨大的不平等。PrEP尚未普及,有必要扩大服务范围并鼓励使用:在线版本包含补充材料,可查阅 10.1007/s10389-022-01699-y。
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引用次数: 0
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