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Disease-Modifying Therapy in Dementia最新文献

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Cognitive stimulation, training, and rehabilitation 认知刺激、训练和康复
Pub Date : 2019-03-01 DOI: 10.31887/dcns.2019.21.1/akurz
A. Kurz
Cognition-focused interventions for people with cognitive impairment including mild-to-moderate dementia may be classified into three categories: cognitive stimulation, training, and rehabilitation. Cognitive stimulation, consisting of nonspecific cognition-enhancing activities often in group format, produces small improvements on some aspects of cognitive ability which can be accompanied by gains in quality of life, everyday functioning, and social interaction. Cognitive training which involves repeated practice of tasks that target specific cognitive functions, often using computers, provides improvements on trained tasks that usually do not translate to nontrained tasks and have little impact on real life. Cognitive rehabilitation represents an individual approach that focuses on disability rather than cognition per se and is helpful in terms of reaching personally relevant goals and improving day-to-day performance. Data are largely lacking to support commercial claims regarding the efficacy of video games or virtual reality and augmented reality devices. There is insufficient evidence from randomized controlled trials whether cognition-focused interventions can delay or prevent cognitive decline. However, data from prospective cohort studies strongly suggest that late-life cognitive activity is associated with a reduced risk of dementia.
针对包括轻度至中度痴呆在内的认知障碍患者的以认知为重点的干预措施可分为三类:认知刺激、训练和康复。认知刺激由非特异性的认知增强活动组成,通常以群体形式进行,对认知能力的某些方面产生微小的改善,这可能伴随着生活质量、日常功能和社会互动的提高。认知训练涉及到针对特定认知功能的任务的反复练习,通常使用计算机,提供训练任务的改进,这些任务通常不能转化为非训练任务,对现实生活影响不大。认知康复是一种专注于残疾而不是认知本身的个人方法,在实现个人相关目标和提高日常表现方面很有帮助。关于视频游戏或虚拟现实和增强现实设备功效的商业声明在很大程度上缺乏数据支持。以认知为重点的干预是否能延缓或预防认知能力下降,尚无随机对照试验的充分证据。然而,来自前瞻性队列研究的数据强烈表明,晚年认知活动与痴呆症风险降低有关。
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Disease-Modifying Therapy in Dementia
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