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Biophotonics in Africa Powered by Light Technology Applied to Medical Work 非洲生物光子学在医疗工作中的应用
Pub Date : 2020-04-09 DOI: 10.5772/intechopen.90779
Klaudia Freire
Biophotonics technologies can be designed to provide unique, dynamic information about tissue structure and biochemical composition. Their impact spans from medical diagnostic and therapeutic devices to consumer-based wearable sensors. With advances in device miniaturization and high-performance biophotonics com-ponents, the line between conventional medical instruments and consumer devices is becoming increasingly blurred. Health care economic pressures are further accelerating this ambiguity by shifting clinical attention from expensive disease treatments to strategies for cost-effective disease management and prevention. This clinical research collaboration introduces emerging biophotonics technologies that are capable of characterizing brain tissue structure and biochemical composition spanning from micro to macroscopic regimes.
生物光子学技术可以提供关于组织结构和生化组成的独特的动态信息。它们的影响范围从医疗诊断和治疗设备到基于消费者的可穿戴传感器。随着设备小型化和高性能生物光子学组件的进步,传统医疗器械和消费设备之间的界限变得越来越模糊。医疗保健的经济压力使临床注意力从昂贵的疾病治疗转向具有成本效益的疾病管理和预防战略,从而进一步加速了这种模糊性。这项临床研究合作引入了新兴的生物光子学技术,这些技术能够表征从微观到宏观的脑组织结构和生化成分。
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引用次数: 0
Nanolithography by Scanning Probes for Biorecognition 扫描探针纳米光刻技术用于生物识别
Pub Date : 2019-12-18 DOI: 10.5772/intechopen.90535
J. Martı́nez
With the invention of the scanning tunneling microscope (STM) and subsequently with the atomic force microscope (AFM), the human being was able to enter in the nanoscale world. At first, these devices were only used for imaging samples, but with a small modification of its electronics, they can be used for a precise and controlled manipulation of the scanning probe, creating different types of nanolithographed motifs. The development of this type of lithography has allowed the manufacture of nanometric-scale structures that have led spectacular advances in the field of nanotechnology. In this book chapter, we present the most innovative and reliable probe nanolithography techniques. All of them are based on the spatial confinement of a chemical reaction within a nanometric size region of the sample surface. In that way, 2D or even 3D nanostructures can be fabricated. The full potential of probe nanolithography techniques is demonstrated by showing a range of applications such as the controlled deposition of molecules with high precision or nanotransistors that can be used as sensors for biorecognition processes.
随着扫描隧道显微镜(STM)和原子力显微镜(AFM)的发明,人类得以进入纳米世界。起初,这些设备仅用于成像样品,但通过对其电子设备进行少量修改,它们可以用于精确和受控的扫描探针操作,从而创建不同类型的纳米光刻图案。这种光刻技术的发展使得纳米级结构的制造成为可能,从而在纳米技术领域取得了惊人的进步。在这本书的章节中,我们提出了最创新和可靠的探针纳米光刻技术。所有这些都是基于化学反应在样品表面纳米尺寸区域的空间限制。通过这种方式,可以制造2D甚至3D纳米结构。探针纳米光刻技术的全部潜力是通过展示一系列应用来证明的,例如高精度分子的控制沉积或纳米晶体管,可以用作生物识别过程的传感器。
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引用次数: 0
Electrostatic Discharge, Electrical Overstress, and Latchup in VLSI Microelectronics 超大规模集成电路微电子中的静电放电、电过应力和闭锁
Pub Date : 2019-11-27 DOI: 10.5772/INTECHOPEN.89855
S. Voldman
Electrostatic discharge (ESD), electrical overstress (EOS), and latchup have been an issue in devices, circuit and systems for VLSI microelectronics for many decades and continue to be an issue till today. In this chapter, the issue of ESD, EOS and latchup will be discussed. This chapter will address some of the fundamental reasons decisions that are made for choice of circuits and layout. Many publications do not explain why certain choices are made, and we will address these in this chapter. Physical models, failure mechanisms and design solutions will be highlighted. The chapter will close with discussion on how to provide both EOS and ESD robust devices, circuits, and systems, design practices and procedures. EOS sources also occur from design characteristics of devices, circuits, and systems.
几十年来,静电放电(ESD)、电过应力(EOS)和闭锁一直是VLSI微电子器件、电路和系统中的一个问题,直到今天仍然是一个问题。在本章中,将讨论ESD、EOS和锁紧的问题。本章将讨论电路和布局选择的一些基本原因。许多出版物没有解释为什么做出某些选择,我们将在本章中解决这些问题。将重点介绍物理模型、失效机制和设计解决方案。本章最后将讨论如何提供EOS和ESD健壮的设备、电路和系统、设计实践和程序。EOS的来源也来自于设备、电路和系统的设计特性。
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引用次数: 0
Development and Characterization of Poly Ethylene-Co-Vinyl Acetate (PEVA) Hybrid Nanocomposite Encapsulates for Solar PV 聚乙烯醇-醋酸乙烯酯(PEVA)杂化纳米复合材料太阳能光伏封装材料的研制与表征
Pub Date : 2019-09-26 DOI: 10.5772/intechopen.88794
R. Aradhya, Madhu Bilugali Mahadevaswamy, Poornima
In the solar photo voltaic (PV) module, encapsulant material provides the environmental protection, insulation, optical absorption, besides serving as a good adhesive between solar cell and components of PV module for improving the efficiency. It is desired to develop an improved encapsulating material by incorporating the light absorbing inorganic nanofillers in thermoplastic polymers. One such matrix material is poly ethylene-co-vinyl acetate (PEVA), finding its importance in solar materials, such as PV modules and agricultural greenhouse polymer sheets. Inorganic nanofillers have the potential to transmit necessary radiance in the UV spectra, which can improve the PV panel efficiency. In this study, the optimum effect of inorganic fillers such as organically modified montmorillonite clay (OMMT) and titanium dioxide (TiO 2 ) anatase in PEVA matrix is observed. The fabricated nanocomposite films were etched from the glass mold. The morphology and miscibility of fabricated nanocomposite films were analyzed and investigated by scanning electron microscopy (SEM), X-ray diffraction technique (XRD), UV-Vis absorption (UV-Vis), and Fourier-Transform Infrared Spectroscopy (FTIR). The dielectric properties of the fabricated hybrid nanocomposite films were analyzed for its insulation behavior. The thermal behavior was studied using Thermo-gravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC). The hybrid nanocomposite with 5.0 weight percentage (wt.%) OMMT and 5.0 weight percentage (wt.%) of TiO 2 indicates lowest dielectric constant of 2.4 and marginal increase in dissipation factor with respect to frequency. Increased thermal stability, glass transition temperature, high transmittance and optimum UV-shielding efficiency were found with the same wt.% in the proposed work.
在太阳能光伏组件中,封装材料具有环保、绝缘、光吸收等作用,同时作为太阳能电池与光伏组件之间良好的粘结剂,提高效率。希望通过在热塑性聚合物中掺入吸收光的无机纳米填料来开发一种改进的封装材料。其中一种基质材料是聚乙烯-醋酸乙烯酯(PEVA),在太阳能材料中发挥着重要作用,如光伏组件和农业温室聚合物片材。无机纳米填料有可能在紫外光谱中传输必要的辐射,这可以提高光伏电池板的效率。本研究考察了有机改性蒙脱土(OMMT)和二氧化钛(tio2)锐钛矿等无机填料在PEVA基体中的最佳效果。制备的纳米复合薄膜是在玻璃模具上蚀刻的。采用扫描电镜(SEM)、x射线衍射技术(XRD)、紫外-可见吸收(UV-Vis)和傅里叶变换红外光谱(FTIR)对制备的纳米复合膜的形貌和混相性进行了分析和研究。对制备的杂化纳米复合薄膜的绝缘性能进行了分析。采用热重分析(TGA)和差示扫描量热法(DSC)研究了其热行为。当OMMT质量百分比(wt.%)为5.0,tio2质量百分比(wt.%)为5.0时,混合纳米复合材料的介电常数最低,为2.4,耗散系数相对于频率有边际增加。在相同wt %的条件下,提高了热稳定性、玻璃化转变温度、高透光率和最佳的紫外线屏蔽效率。
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引用次数: 1
A Novel Sensing Method for VOCs Using Nanoparticle-Coated Nanoporous Silicon 纳米颗粒包覆纳米多孔硅的VOCs传感新方法
Pub Date : 2019-07-19 DOI: 10.5772/INTECHOPEN.86105
Selvakumar Varadarajan Subramani, S. Selvakumar, S. Lakshminarayanan
Structural aspects, such as grain size, pore size, and crack-free film morphology, of porous silicon (PS), etc., play a vital role in the sensing of volatile organic compounds (VOCs). This chapter discusses a novel method for sensing of VOCs using porous silicon coated with a layer of ZnO (PS-ZnO). It was noted that the sensing ability of the PS sensor has increased due to the transconductance mechanism, as a result of the coating of ZnO over PS. Initially, porous silicon is formed by electrochemical wet etching of silicon and by electrophoretic deposition (EPD), ZnO is coated over porous silicon. An increase in the selectivity is due to the increase in surface-to-volume ratio and uniformity in the pore structures. The thickness of ZnO layer can be tuned up to 25 nm by applying a DC voltage between the copper electrode and the conductive silicon substrate immersed in a suspension of ZnO quantum dots. The influence of quantum dot concentration on the final layer thickness was studied by X-ray diffraction (XRD). The change in resistance for ethanol was found to be 12.8–16 MΩ and 8–16 MΩ for methanol.
多孔硅(PS)的晶粒尺寸、孔径和无裂纹膜形态等结构方面在挥发性有机化合物(VOCs)的检测中起着至关重要的作用。本章讨论了一种利用多孔硅包覆一层ZnO (PS-ZnO)来检测VOCs的新方法。由于在PS表面涂覆ZnO, PS传感器的传感能力由于跨导机制而提高。最初,多孔硅是通过硅的电化学湿蚀刻形成的,然后通过电泳沉积(EPD)将ZnO涂覆在多孔硅上。选择性的增加是由于表面体积比的增加和孔隙结构的均匀性。通过在铜电极和浸入ZnO量子点悬浮液中的导电硅衬底之间施加直流电压,可以将ZnO层的厚度调整到25 nm。利用x射线衍射(XRD)研究了量子点浓度对最终层厚度的影响。对乙醇的抗性变化为12.8-16 MΩ,对甲醇的抗性变化为8-16 MΩ。
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引用次数: 0
Optical Tweezers in Biotechnology 生物技术中的光学镊子
Pub Date : 2019-04-28 DOI: 10.5772/INTECHOPEN.86031
Z. Gong, Yuchao Li
Three-dimensional optical manipulation of microparticles, cells, and biomolecules in a noncontact and noninvasive manner is crucial for biophotonic, nanophotonic, and biomedical fields. Optical tweezers, as a standard optical manipulation technique, have some limitations in precise manipulation of micro-objects in microfluidics and in vivo because of their bulky lens system and limited penetration depth. Moreover, when applied for trapping nanoscale objects, especially with sizes smaller than 100 nm, the strength of optical tweezers becomes significantly weak due to the diffraction limit of light. The emerging near-field methods, such as plasmon tweezers and photonic crystal resonators, have enabled surpassing of the diffraction limit. However, these methods msay lead to local heating effects that will damage the biological specimens and reduce the trapping stability. Furthermore, the available near-field techniques rely on complex nanostructures fixed on substrates, which are usually used for 2D manipulation. The optical tweezers are of great potential for the applications including nanostructure assembly, cancer cell sorting, targeted drug delivery, single-molecule studies, and biosensing.
以非接触和非侵入方式对微粒子、细胞和生物分子进行三维光学操作对于生物光子、纳米光子和生物医学领域至关重要。光学镊子作为一种标准的光学操作技术,由于其透镜系统体积大,穿透深度有限,在微流体和体内的微物体精确操作方面存在一定的局限性。此外,当用于捕获纳米尺度的物体,特别是小于100 nm的物体时,由于光的衍射极限,光镊的强度会变得明显变弱。等离激子镊子和光子晶体谐振器等新出现的近场方法,使超衍射极限成为可能。然而,这些方法可能会导致局部加热效应,从而破坏生物标本并降低捕获稳定性。此外,现有的近场技术依赖于固定在衬底上的复杂纳米结构,通常用于二维操作。光镊在纳米结构组装、癌细胞分选、靶向药物递送、单分子研究和生物传感等方面具有巨大的应用潜力。
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引用次数: 1
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