Alile Carmo, A. C. Mariz, Leandro Brito Santos, M. Torres, R. Santos, R. Monteiro
Osteomas are benign mesenchymal tumors, characterized by proliferation of compact or modularly bone. They are small, slow-growing lesions, usuallyasymptomatic and detected in young adults. This tumors can affect the paranasal sinuses and are often diagnosed with incidental findings through imaging tests. Osteomas are typically restricted to the craniofacial skeleton and rarely foundin other bones. Osteoma of the gnathic bones may be peripheral or endosteal.The osteomas’ etiology is controversial and still unknown. It is more frequent in the frontal sinuses, corresponding to 57% of the paranasal sinuses osteomas, followed by the ethmoidal and maxillary sinuses. Computed Tomography (CT) is the gold standard to assess the location, extent, and aspects of the injury. The objective of this paper is to present a case report of osteoma diagnosed by computed tomography (CT) scan, indicating the importance of the technology of imaging in the medicine diagnostic.
{"title":"Osteoma: A Case Report Based on Image Technology","authors":"Alile Carmo, A. C. Mariz, Leandro Brito Santos, M. Torres, R. Santos, R. Monteiro","doi":"10.34178/jbth.v2i2.60","DOIUrl":"https://doi.org/10.34178/jbth.v2i2.60","url":null,"abstract":"Osteomas are benign mesenchymal tumors, characterized by proliferation of compact or modularly bone. They are small, slow-growing lesions, usuallyasymptomatic and detected in young adults. This tumors can affect the paranasal sinuses and are often diagnosed with incidental findings through imaging tests. Osteomas are typically restricted to the craniofacial skeleton and rarely foundin other bones. Osteoma of the gnathic bones may be peripheral or endosteal.The osteomas’ etiology is controversial and still unknown. It is more frequent in the frontal sinuses, corresponding to 57% of the paranasal sinuses osteomas, followed by the ethmoidal and maxillary sinuses. Computed Tomography (CT) is the gold standard to assess the location, extent, and aspects of the injury. The objective of this paper is to present a case report of osteoma diagnosed by computed tomography (CT) scan, indicating the importance of the technology of imaging in the medicine diagnostic.","PeriodicalId":277735,"journal":{"name":"JOURNAL OF BIOENGINEERING OF AND TECCHNOLOGY applied to Health","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133932247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We reviewed the use of liposomes for cancer therapy using computational biostatistics. We used virtual libraries, such as PubMed, LILACS, National Health Institute (NHI) and the Food Drug Administration (FDA) to conduct the review. Cluster analysis and correlation were developed using the Tanimoto coefficient (TC) of 0.7 using the modeling tool ChemMine Tools from databases (PubChem, DailyMed, DrugBank, Drug @ FDA). The results pointed fifteen molecules in the pharmaceutical form of liposome for the oncological clinic. Of these, 13 are classified by size into small-molecules and were analyzed by computational statistical modeling. Of these, only 4 were approved for use by the FDA, and 9 are in phases of research by the pharmaceutical industry as liposomal formulations. Essential differences in physical-chemical properties and molecules structure were observed, indicating original proposal in the development of liposomal as an anticancer drugs.
我们用计算生物统计学回顾了脂质体在癌症治疗中的应用。我们使用了PubMed、LILACS、National Health Institute (NHI)和Food Drug Administration (FDA)等虚拟图书馆来进行审查。使用数据库(PubChem, DailyMed, DrugBank, Drug @ FDA)中的建模工具ChemMine Tools，采用0.7的谷本系数(TC)进行聚类分析和相关性分析。研究结果为肿瘤临床提供了15种药物形式的脂质体。其中，13种按大小分为小分子，并通过计算统计模型进行分析。其中，只有4种被FDA批准使用，9种正处于制药行业作为脂质体制剂的研究阶段。在物理化学性质和分子结构上观察到本质上的差异，提示了作为抗癌药物的脂质体开发的最初设想。
{"title":"Liposome Drug Delivery in Cancer Chemotherapy: Review and Multifactorial Analysis","authors":"T. Regis, L. Knop, B. Machado, V. Senna","doi":"10.34178/jbth.v2i2.58","DOIUrl":"https://doi.org/10.34178/jbth.v2i2.58","url":null,"abstract":"We reviewed the use of liposomes for cancer therapy using computational biostatistics. We used virtual libraries, such as PubMed, LILACS, National Health Institute (NHI) and the Food Drug Administration (FDA) to conduct the review. Cluster analysis and correlation were developed using the Tanimoto coefficient (TC) of 0.7 using the modeling tool ChemMine Tools from databases (PubChem, DailyMed, DrugBank, Drug @ FDA). The results pointed fifteen molecules in the pharmaceutical form of liposome for the oncological clinic. Of these, 13 are classified by size into small-molecules and were analyzed by computational statistical modeling. Of these, only 4 were approved for use by the FDA, and 9 are in phases of research by the pharmaceutical industry as liposomal formulations. Essential differences in physical-chemical properties and molecules structure were observed, indicating original proposal in the development of liposomal as an anticancer drugs.","PeriodicalId":277735,"journal":{"name":"JOURNAL OF BIOENGINEERING OF AND TECCHNOLOGY applied to Health","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128744678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alile Carmo, A. C. Mariz, Leandro Brito Santos, M. Torres, Raí Santos, Roberto L. S. Monteiro
There are several methods used in the identification process of human remains. The most of them are based on comparing of antemortem and postmortem data available. Although the technique of fingerprinting is considered more accurate in many cases, it cannot be used when the bodies are mutilated, decomposed, burned, or fragmented. This article aims to compare the metric values obtained by Galvão (1994) and Saliba (2001) to differentiate male and female through dry skulls, using the measurement of the Radiocef Studio 2 Program. It was used 16 teleradiographs (11 females and 5 males). The linear measurements used in this article were: 1. The bodies stature of the mandible; and 2. Distance Nasium-Front Nasal Spine. Several radiological techniques are used to aid the human identification process for determining sex, ethnic group, and age. The analyses of X-rays and Computer Tomography (CT) scans, antemortem and postmortem, have been an important tool for human identification in forensic dentistry, especially with the refinement of techniques acquired with the advancement of radiology and CT scans. We concluded that the knowledge of the best method by forensic dentists with a careful application of the technique and report’s interpretation is essential to fulfilling the necessary characteristics for a successful identification of sex using skull measures.
在人类遗骸的鉴定过程中有几种方法。其中大多数是基于对死前和死后可用数据的比较。虽然指纹技术被认为在许多情况下更准确，但当尸体被肢解、腐烂、燃烧或破碎时，它就不能使用了。本文旨在比较galv(1994)和Saliba(2001)获得的公制值，利用Radiocef Studio 2程序的测量，通过干颅骨来区分男性和女性。共使用16台远摄机(女11台，男5台)。本文采用的线性测量方法为:1。下颌骨的身体高度;和2。鼻前棘距离。几种放射学技术被用来帮助确定性别、种族和年龄的人类识别过程。特别是随着放射学和CT扫描技术的进步，x射线和计算机断层扫描(CT)扫描的分析，死前和死后，已经成为法医牙科鉴定人类的重要工具。我们得出的结论是，法医牙医通过仔细应用该技术和报告的解释来了解最佳方法，对于实现使用颅骨测量成功识别性别的必要特征至关重要。
{"title":"Identification of Sex Using Linear Skull Measures: The Importance of Imaging in Biotechnology","authors":"Alile Carmo, A. C. Mariz, Leandro Brito Santos, M. Torres, Raí Santos, Roberto L. S. Monteiro","doi":"10.34178/jbth.v2i2.57","DOIUrl":"https://doi.org/10.34178/jbth.v2i2.57","url":null,"abstract":"There are several methods used in the identification process of human remains. The most of them are based on comparing of antemortem and postmortem data available. Although the technique of fingerprinting is considered more accurate in many cases, it cannot be used when the bodies are mutilated, decomposed, burned, or fragmented. This article aims to compare the metric values obtained by Galvão (1994) and Saliba (2001) to differentiate male and female through dry skulls, using the measurement of the Radiocef Studio 2 Program. It was used 16 teleradiographs (11 females and 5 males). The linear measurements used in this article were: 1. The bodies stature of the mandible; and 2. Distance Nasium-Front Nasal Spine. Several radiological techniques are used to aid the human identification process for determining sex, ethnic group, and age. The analyses of X-rays and Computer Tomography (CT) scans, antemortem and postmortem, have been an important tool for human identification in forensic dentistry, especially with the refinement of techniques acquired with the advancement of radiology and CT scans. We concluded that the knowledge of the best method by forensic dentists with a careful application of the technique and report’s interpretation is essential to fulfilling the necessary characteristics for a successful identification of sex using skull measures.","PeriodicalId":277735,"journal":{"name":"JOURNAL OF BIOENGINEERING OF AND TECCHNOLOGY applied to Health","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128273751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：