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Goat Immunity to Helminthes 山羊对蠕虫免疫
Pub Date : 2020-06-18 DOI: 10.5772/intechopen.91189
M. Ayaz, A. Sheikh, Mubashar Aziz, M. M. Nazir
Goat hematology, especially, shares considerable attention since the last 1980s. Large number of discrepant normal hematologic values is reported. The discrepancies resulted came from the differences in age group, breed, and health standing of goats. This makes it further complex with variances in climate of the region, its environment, and size and methodology applied. With time, many inconsistencies, reasonably standardization in normal caprine kinetic hematologic values, are in place. Both goats and sheep are infested by the same key digestive tract helminthes (DTHs) diseases. Helminthes are exceedingly ubiquitous worm parasites that progressed to adopt with many erudite means to evade host immune system.
自上世纪80年代以来,山羊血液学尤其受到广泛关注。大量的血液学正常值差异被报道。这些差异是由山羊的年龄、品种和健康状况的差异造成的。这使得该地区的气候、环境、规模和方法的差异进一步复杂化。随着时间的推移,许多不一致的地方,合理标准化的正常山羊动力学血液学值,到位。山羊和绵羊都受到相同的消化道蠕虫(DTHs)疾病的侵袭。蠕虫是一种非常普遍的蠕虫寄生虫,它们通过多种手段来逃避宿主的免疫系统。
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引用次数: 2
Pashmina Goat Farming in Cold Arid Desert of Changthang and Its Impact on Economy of Changpa Nomads of This Region 长江干冷荒漠牧羊及其对长滩游牧民族经济的影响
Pub Date : 2019-11-27 DOI: 10.5772/INTECHOPEN.84523
A. Beigh, S. Bashir
In Changthang, there is a trend towards increasing the livestock population, especially a breed of goat ( Capra sibirica ) that produces one of the finest natural fibres: pashmina, which is the mainstay of economy of Changpa nomads. The envi-ronmental condition of this region suits for the development of pashmina, there-fore, these animals are reared in large numbers. Changthangi goats are reared under harsh climatic conditions ( − 40 to +40°C). Best quality pashmina is produced in this region and is economic mainstay of nomadic people of Changthang. Pashmina fibre is very expensive as it is being used for production of world’s finest shawls. The Changthang region alone produces around 35,000 kg of raw pashmina fibre every year from about 0.15 million of Changthangi goats, which form 80% of the total pashmina production of the country. 90% of the population in Changthang area survives on the income from goat and sheep, which is nearly $8.4 million, annually.
在昌昌市,牲畜数量有增加的趋势,特别是一种山羊(Capra sibirica),它生产最优质的天然纤维之一:羊绒,这是昌昌市游牧民族的经济支柱。该地区的环境条件适合羊绒的发展,因此羊绒被大量饲养。昌昌吉山羊在恶劣的气候条件下饲养(- 40至+40°C)。这里出产最优质的羊绒,是昌唐游牧民族的经济支柱。羊绒纤维非常昂贵,因为它被用来生产世界上最好的披肩。仅长唐地区每年就从大约15万只长唐山羊中生产约3.5万公斤原羊绒纤维,占该国羊绒总产量的80%。长唐地区90%的人口靠山羊和绵羊为生,每年的收入近840万美元。
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引用次数: 4
Goat Cheese Quality in North Macedonia 北马其顿山羊奶酪的质量
Pub Date : 2019-10-09 DOI: 10.5772/intechopen.84545
E. Sulejmani
The most significant agricultural industry in North Macedonia is the dairy industry, and white-brined cheese is a popular dairy product with a great history and the most selling cheese in the country. Considering the climatic conditions and the experiences of other countries, the Republic of North Macedonia has capacity for adequate development of goat breeding by creating small-to-medium goat farms and application of intensive or semi-intensive goat farming systems. There are various breeds of goats in the Republic of Macedonia such as the domestic Balkan goat, Saanen, and Alpine and crossbreeds between these breeds. The official restriction of goat breeding in the territory of Macedonia in 1947 had disastrous consequences; however, in 1989, goat breeding was again allowed and has increased. There are three most significant kind of cheeses manufactured in Macedonia, like white-brined, beaten, and kashkaval. White cheese in Macedonia (belo sirenje) is a brine cheese type with salty taste and close texture similar to beyaz peynir (a Turkish white cheese).
北马其顿最重要的农业产业是乳制品业,白卤奶酪是一种受欢迎的乳制品,有着悠久的历史,也是该国最畅销的奶酪。考虑到气候条件和其他国家的经验,北马其顿共和国有能力通过建立中小型山羊养殖场和应用集约化或半集约化山羊养殖系统来充分发展山羊养殖。马其顿共和国有各种山羊品种,如国内的巴尔干山羊、萨宁山羊和阿尔卑斯山羊以及这些品种之间的杂交品种。1947年马其顿境内对山羊繁殖的官方限制造成了灾难性的后果;然而,在1989年,山羊的繁殖再次被允许并且有所增加。马其顿生产的奶酪有三种最重要的奶酪,白盐水奶酪、打制奶酪和卡什卡瓦尔奶酪。马其顿的白奶酪(belo sirenje)是一种卤水奶酪,味道咸,质地类似于beyaz peynir(土耳其白奶酪)。
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引用次数: 0
Local Goat Breeds in the United States 美国当地山羊品种
Pub Date : 2019-10-04 DOI: 10.5772/intechopen.89213
D. Sponenberg
Goat production in the United States has largely relied upon breed resources imported less than a century ago. In addition to these imported breeds that are commonly used for production are a few local breeds that have been developed over centuries in the USA and other developed more recently. These include Spanish and Myotonic goats for meat production, Lamancha goats for dairy production, and an archaic type of Navajo Angora goat that still finds a role in mohair production. Additional genetic resources reside in a few populations of feral goats, although these now persist in domestication after having been eliminated from their feral ranges. The local breeds are increasingly the target of investigations into their genetics and levels of production. Results of those investigations are finding these local breeds to be productive and valuable additions to agricultural systems.
美国的山羊生产在很大程度上依赖于不到一个世纪前进口的品种资源。除了这些通常用于生产的进口品种外,还有一些在美国发展了几个世纪的当地品种,以及最近发展起来的其他品种。其中包括用于肉类生产的西班牙山羊和肌强直山羊,用于乳制品生产的拉曼查山羊,以及一种古老的纳瓦霍安哥拉山羊,它仍然在马海毛生产中发挥着作用。额外的遗传资源存在于少数野生山羊种群中,尽管这些野生山羊在从其野生范围内被消灭后,现在仍在驯化中。当地品种日益成为调查其遗传和生产水平的目标。这些调查的结果发现,这些地方品种具有生产力,是农业系统的宝贵补充。
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引用次数: 1
Breeds and Breeding System of Indigenous and Crossbred Goats in Nepal 尼泊尔本地山羊和杂交山羊的品种和繁殖系统
Pub Date : 2019-08-13 DOI: 10.5772/INTECHOPEN.82821
N. Bhattarai, N. Gorkhali, M. Kolakshyapati, S. Sapkota
Goats are the indispensable component of rural economy in Nepal where 10.98 million goats accounting for 45.3% of total ruminants contribute to 20.3% of the total meat production and 49.2 million US dollar in the national economy. Being popular as “poor man’s cow” and “living cheque,” they significantly contribute to food, nutritional, and economic security of the marginalized farmers creating employment opportunities in the country. This chapter has tried to review the existing breeds, their breeding systems, challenges and way forward to enhance production and productivity of goats. Findings revealed that Nepal is endowed with four major indigenous genetic resources of goats and their crosses with Boer, Jamnapari, Barbari, Sirohi, etc. Occasionally, native goat breeds of Nepal were crossed with Kiko and Damascus as well. Breeding of goats in Nepal is mainly based on selection, pure breeding within indigenous flock, and crossbreeding to the available exotic breeds. There have been some biotechnological approaches applied in goat breeding and evaluation of native breeds. Estrus synchronization followed by artificial insemination is currently being practiced. Goats, being the most popular and easy source of household income and family nutrition in Nepal, could be the important source of national revenue provided with improved breeding and other husbandry practices. Chyangra in the haplogroup B2 in their genetic four mtDNA haplogroups of domestic goats. no between the geographic regions of and relationships among goat These sequences were compared with published data of other domestic goats from neighboring countries India, Pakistan, and China) to determine the relationship of Nepalese goats among goat resources of the region. The study revealed certain level of gene flow among the neighboring goat populations. The complex mtDNA diversity and structure identified among indigenous Nepalese goats can be explained by the gene flow through ancient trading and current “free” movement of goats from/to the geographic vicinities in India and China.
山羊是尼泊尔农村经济不可缺少的组成部分。尼泊尔有1098万只山羊,占反刍动物总数的45.3%,占肉类总产量的20.3%,为国民经济贡献了4920万美元。它们被称为“穷人的牛”和“生活支票”,为边缘农民的粮食、营养和经济安全做出了重大贡献,并在该国创造了就业机会。本章试图审查现有的品种,它们的育种系统,挑战和前进的道路,以提高山羊的产量和生产力。调查结果显示,尼泊尔拥有4种主要的本土山羊遗传资源,以及它们与Boer、Jamnapari、Barbari、Sirohi等的杂交。偶尔,尼泊尔的本地山羊品种也与Kiko和大马士革杂交。尼泊尔山羊的育种主要基于选择、本地羊群的纯育种以及与现有外来品种的杂交。一些生物技术方法已应用于山羊的育种和乡土品种的评价。目前正在实行的是同步发情,然后人工授精。山羊是尼泊尔最受欢迎和最容易获得的家庭收入和家庭营养来源,通过改进饲养和其他饲养方法,山羊可以成为国家收入的重要来源。在家山羊遗传的4个mtDNA单倍群中,Chyangra属于B2单倍群。将这些序列与邻近国家(印度、巴基斯坦和中国)的其他国内山羊的已发表数据进行比较,以确定尼泊尔山羊与该地区山羊资源之间的关系。该研究揭示了邻近山羊种群之间一定程度的基因流动。在尼泊尔本土山羊中发现的复杂mtDNA多样性和结构可以通过古代贸易和目前山羊在印度和中国地理附近的“自由”流动的基因流动来解释。
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引用次数: 8
Unique Pharmacokinetic and Pharmacodynamic Parameters of Antimicrobials in Goats 抗微生物药物在山羊体内独特的药动学和药效学参数
Pub Date : 2019-05-03 DOI: 10.5772/INTECHOPEN.84551
S. Saganuwan
Pharmacokinetics, the process that involves drug absorption, distribution, metabolism and excretion (ADME) of antimicrobials, determines pharmacodynamic response, that is, what drugs do to the body. Therefore, of all the pharmacokinetic parameters, elimination half-life (T 1 / 2 β ), volume of distribution (Vd), maximum plasma concentration (Cmax) and maximum time reached (Tmax) are the most important parameters. Hence, the parameters are unique in determining pharmacokinetic and pharmacodynamic response of antimicrobials. However, it is elimination half-life and minimum inhibitory concentration (MIC) that determine the dosing interval of antimicrobials. The dose range of 2.5 mg/kg for gentamicin passing through 4 mg/kg (ciprofloxacin), 4.2 mg/kg (ampicillin L/A), 5 mg/kg (kanamycin, enrofloxacin, gatifloxacin and norfloxacin), 7 mg/kg (mequindox), 10 mg/kg (amikacin, enrofloxacin, lincomycin, pefloxacin, cefpirome, erythromycin and isoniazid), 20 mg/kg (oxytetracycline) and 30 mg/kg (metronidazole) have elimination half-life of 1.2 – 67.2 h, Cmax of 0.12 – 54.4 μ g/ml, Tmax of 0.2 – 24 h, bioavailability of 16 – 99.8% and plasma protein binding of 0 – >80% when administered intramuscularly, intravenously and orally. Human equivalent dose formula could be used to extrapolate human-goat therapeutic doses of antimicrobials. How-ever, some antimicrobials such as sulfadimidine, tulathromycin, oxytetracycline and azithromycin may have high residues in the milk, kidneys, liver, intestines, brain and skeletal muscles and may portend high risk of antimicrobial resistance, hypersensitivity reaction, epidermal necrolysis, Stevens-Johnson syndrome and other adverse drug reactions.
药代动力学是涉及抗菌剂的药物吸收、分布、代谢和排泄(ADME)的过程,它决定了药效学反应,即药物对身体的作用。因此,在所有药代动力学参数中,消除半衰期(t1 / 2 β)、分布体积(Vd)、最大血药浓度(Cmax)和最大到达时间(Tmax)是最重要的参数。因此,这些参数在确定抗菌素的药代动力学和药效学反应方面是独一无二的。然而,它是消除半衰期和最低抑制浓度(MIC)决定给药间隔的抗菌素。庆大霉素在2.5 mg/kg的剂量范围内通过4 mg/kg(环丙沙星)、4.2 mg/kg(氨苄西林L/A)、5 mg/kg(卡那霉素、恩诺沙星、加替沙星、诺氟沙星)、7 mg/kg(甲喹诺多)、10 mg/kg(阿米卡星、恩诺沙星、林可霉素、培氟沙星、头孢匹罗、红霉素、异烟肼)、20 mg/kg(土霉素)、30 mg/kg(甲硝唑),消除半衰期为1.2 ~ 67.2 h, Cmax为0.12 ~ 54.4 μ g/ml, Tmax为0.2 ~ 24 h。肌肉、静脉和口服给药时生物利用度为16 - 99.8%,血浆蛋白结合率为0 - >80%。人等效剂量公式可用于推断人-羊抗微生物药物的治疗剂量。然而,磺胺嘧啶、土拉霉素、土霉素、阿奇霉素等抗菌素在乳汁、肾脏、肝脏、肠道、大脑和骨骼肌中的残留量可能很高,可能是抗菌素耐药、过敏反应、表皮坏死松解、史蒂文斯-约翰逊综合征等药物不良反应的高风险。
{"title":"Unique Pharmacokinetic and Pharmacodynamic Parameters of Antimicrobials in Goats","authors":"S. Saganuwan","doi":"10.5772/INTECHOPEN.84551","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.84551","url":null,"abstract":"Pharmacokinetics, the process that involves drug absorption, distribution, metabolism and excretion (ADME) of antimicrobials, determines pharmacodynamic response, that is, what drugs do to the body. Therefore, of all the pharmacokinetic parameters, elimination half-life (T 1 / 2 β ), volume of distribution (Vd), maximum plasma concentration (Cmax) and maximum time reached (Tmax) are the most important parameters. Hence, the parameters are unique in determining pharmacokinetic and pharmacodynamic response of antimicrobials. However, it is elimination half-life and minimum inhibitory concentration (MIC) that determine the dosing interval of antimicrobials. The dose range of 2.5 mg/kg for gentamicin passing through 4 mg/kg (ciprofloxacin), 4.2 mg/kg (ampicillin L/A), 5 mg/kg (kanamycin, enrofloxacin, gatifloxacin and norfloxacin), 7 mg/kg (mequindox), 10 mg/kg (amikacin, enrofloxacin, lincomycin, pefloxacin, cefpirome, erythromycin and isoniazid), 20 mg/kg (oxytetracycline) and 30 mg/kg (metronidazole) have elimination half-life of 1.2 – 67.2 h, Cmax of 0.12 – 54.4 μ g/ml, Tmax of 0.2 – 24 h, bioavailability of 16 – 99.8% and plasma protein binding of 0 – >80% when administered intramuscularly, intravenously and orally. Human equivalent dose formula could be used to extrapolate human-goat therapeutic doses of antimicrobials. How-ever, some antimicrobials such as sulfadimidine, tulathromycin, oxytetracycline and azithromycin may have high residues in the milk, kidneys, liver, intestines, brain and skeletal muscles and may portend high risk of antimicrobial resistance, hypersensitivity reaction, epidermal necrolysis, Stevens-Johnson syndrome and other adverse drug reactions.","PeriodicalId":299858,"journal":{"name":"Goats (Capra) - From Ancient to Modern","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130460001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The Goat Sector in Spain: Situation, Local Breeds, and Production Systems 西班牙山羊部门:形势、地方品种和生产系统
Pub Date : 2019-02-14 DOI: 10.5772/INTECHOPEN.82539
A. Guerrero, J. Abecia, C. Sañudo
Goats throughout history have been adapted to the different orographic and climatological conditions of diverse continents and regions, in which they have been widely spread. Consequently, this species has developed different aptitudes and specialties (meat, milk, hair, etc.) depending on the specific necessities that are covered. This specialization and its geographical conditions have created a great variety of breeds that have been adapted to different production systems. This chapter compiles the evolution and present situation of the goat sector in Spain and the perspectives for its future, describing the most important production systems currently used for different aptitudes in the country (dairy and meat) and compil-ing the characteristics of the main national autochthonous breeds.
纵观历史,山羊已经适应了不同大陆和地区的不同地形和气候条件,它们在这些地区广泛传播。因此,这个物种发展出了不同的能力和特长(肉、奶、毛等),这取决于它们所覆盖的特定必需品。这种专业化及其地理条件造就了适应不同生产系统的品种繁多。本章汇编了西班牙山羊部门的演变和现状及其未来的前景,描述了该国目前用于不同用途的最重要的生产系统(乳制品和肉类),并汇编了主要民族本土品种的特征。
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引用次数: 2
Goats in the Ancient Near East and Their Relationship with the Mythology, Fairytale and Folklore of These Cultures 古代近东的山羊及其与这些文化的神话、童话和民间传说的关系
Pub Date : 2018-12-18 DOI: 10.5772/INTECHOPEN.82531
M. Roets
This study investigates the role of goats in the myths and folklore of various Ancient Near Eastern (ANE) cultures. Images in artefacts, and metaphors or direct reference to goats in texts (the primary sources in this study) from the geographic area of Mesopotamia, Sumer, Akkad, Anatolia and Ancient Iran (Elam) were stud-ied. Secondary sources provided the context within which the sources occurred. Where images and references to goats occurred, their meaning and relationship to belief systems or their underlying ‘motifs’ within the ANE cultures are identified, categorised and discussed. This study shows that aside from the important utilitarian function of goats in the ANE, their use in rituals and symbolism has provided us with several motifs related to goats that are still in use today. These include the motifs of fertility, intelligence and craftiness.
本研究探讨了山羊在各种古代近东(ANE)文化的神话和民间传说中的作用。研究了来自美索不达米亚、苏美尔、阿卡德、安纳托利亚和古伊朗(埃兰)地理区域的人工制品中的图像,以及文本中对山羊的隐喻或直接参考(本研究的主要来源)。次要来源提供了来源发生的上下文。在出现山羊图像和引用的地方,它们的意义和与信仰系统的关系或它们在ANE文化中的潜在“主题”被识别、分类和讨论。这项研究表明,除了山羊在ANE中重要的实用功能外,它们在仪式和象征意义上的使用为我们提供了一些与山羊有关的主题,这些主题至今仍在使用。这些主题包括生育、智慧和狡猾。
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引用次数: 1
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Goats (Capra) - From Ancient to Modern
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