Pub Date : 1900-01-01DOI: 10.1016/b978-0-08-102680-9.20001-2
{"title":"Index","authors":"","doi":"10.1016/b978-0-08-102680-9.20001-2","DOIUrl":"https://doi.org/10.1016/b978-0-08-102680-9.20001-2","url":null,"abstract":"","PeriodicalId":313975,"journal":{"name":"Biointegration of Medical Implant Materials","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122961992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1533/9781845699802.2.204
W. Paul, C. Sharma
Abstract Inorganic nanoparticles are nontoxic, hydrophilic, biocompatible, and highly stable compared with organic materials. It poses unique physicochemical properties such as high surface area per unit volume and unique optical and magnetic properties and can be functionalized with various specific ligands to enhance their affinity toward target cells or molecules. Apart from their ability of controlled drug release profile, inorganic nanoparticles protect the drug from degradation and can reduce the frequency of administration and dose of the drug, thereby a significant reduction in the toxicity of drugs, particularly of cancer drugs. Drug delivery systems designed for enhanced drug efficacy and reduced adverse effects have evolved accompanied by the development of novel materials. Biomedical applications of nanotechnology are mainly suited for diagnostic techniques, nanodrugs and delivery systems, and biomedical implants. Nanoenabled drug delivery has been projected as the single largest market opportunity. Recent advancement in nanotechnology has led to the introduction of various inorganic nanoparticles other than calcium phosphates as excellent drug delivery matrices. Nanoparticles are now having highly advanced chemical properties, and many inorganic nanoparticles have been used as drug carriers. Extensive studies have been done on the use of inorganic nanoparticles toward cancer detection and therapy, and its applications go on increasing. This chapter reviews some of the recent developments and applications of calcium phosphate nanoparticles, gold nanoparticles, and iron oxide nanoparticles in drug delivery and tissue engineering.
{"title":"Inorganic nanoparticles for targeted drug delivery","authors":"W. Paul, C. Sharma","doi":"10.1533/9781845699802.2.204","DOIUrl":"https://doi.org/10.1533/9781845699802.2.204","url":null,"abstract":"Abstract Inorganic nanoparticles are nontoxic, hydrophilic, biocompatible, and highly stable compared with organic materials. It poses unique physicochemical properties such as high surface area per unit volume and unique optical and magnetic properties and can be functionalized with various specific ligands to enhance their affinity toward target cells or molecules. Apart from their ability of controlled drug release profile, inorganic nanoparticles protect the drug from degradation and can reduce the frequency of administration and dose of the drug, thereby a significant reduction in the toxicity of drugs, particularly of cancer drugs. Drug delivery systems designed for enhanced drug efficacy and reduced adverse effects have evolved accompanied by the development of novel materials. Biomedical applications of nanotechnology are mainly suited for diagnostic techniques, nanodrugs and delivery systems, and biomedical implants. Nanoenabled drug delivery has been projected as the single largest market opportunity. Recent advancement in nanotechnology has led to the introduction of various inorganic nanoparticles other than calcium phosphates as excellent drug delivery matrices. Nanoparticles are now having highly advanced chemical properties, and many inorganic nanoparticles have been used as drug carriers. Extensive studies have been done on the use of inorganic nanoparticles toward cancer detection and therapy, and its applications go on increasing. This chapter reviews some of the recent developments and applications of calcium phosphate nanoparticles, gold nanoparticles, and iron oxide nanoparticles in drug delivery and tissue engineering.","PeriodicalId":313975,"journal":{"name":"Biointegration of Medical Implant Materials","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117033706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1533/9781845699802.3.301
T. Chandy
Abstract All materials intended for application in humans as biomaterials, medical devices, or prostheses undergo tissue responses when implanted into living tissue. Similarly, when blood contacts a biomaterial surface, a variety of blood components interfere with the surface leading to thrombosis or complement activation. This chapter first describes fundamental aspects of tissue/blood responses to materials, which are commonly described as the tissue/blood response continuum. These actions involve fundamental aspects of tissue responses including injury, inflammatory and wound healing responses, foreign body reactions, and fibrous encapsulation of the biomaterial, medical device, or prosthesis. The second part of this chapter describes the biocompatibility of materials being used in medical device and prostheses to suit their applications. The review includes an emphasis on the biocompatibility of biomaterials being used in drug delivery and micro- and nanospheres for cancer drug delivery and tissue engineering applications. This also summarizes the use of scaffolds in the dual role of structural support for cell growth and vehicle for controlled release of tissue inductive factors or DNA encoding for these factors. The confluence of molecular and cell biology, materials science, and engineering provides the tools to create controllable microenvironments that mimic natural developmental processes and direct tissue formation for experimental and therapeutic applications and for improving the biointegration of implants. This ends with the recent approaches toward combination therapy devices such as stent modifications with surface engineering and site-specific drug delivery.
{"title":"Biocompatibility of materials and its relevance to drug delivery and tissue engineering","authors":"T. Chandy","doi":"10.1533/9781845699802.3.301","DOIUrl":"https://doi.org/10.1533/9781845699802.3.301","url":null,"abstract":"Abstract All materials intended for application in humans as biomaterials, medical devices, or prostheses undergo tissue responses when implanted into living tissue. Similarly, when blood contacts a biomaterial surface, a variety of blood components interfere with the surface leading to thrombosis or complement activation. This chapter first describes fundamental aspects of tissue/blood responses to materials, which are commonly described as the tissue/blood response continuum. These actions involve fundamental aspects of tissue responses including injury, inflammatory and wound healing responses, foreign body reactions, and fibrous encapsulation of the biomaterial, medical device, or prosthesis. The second part of this chapter describes the biocompatibility of materials being used in medical device and prostheses to suit their applications. The review includes an emphasis on the biocompatibility of biomaterials being used in drug delivery and micro- and nanospheres for cancer drug delivery and tissue engineering applications. This also summarizes the use of scaffolds in the dual role of structural support for cell growth and vehicle for controlled release of tissue inductive factors or DNA encoding for these factors. The confluence of molecular and cell biology, materials science, and engineering provides the tools to create controllable microenvironments that mimic natural developmental processes and direct tissue formation for experimental and therapeutic applications and for improving the biointegration of implants. This ends with the recent approaches toward combination therapy devices such as stent modifications with surface engineering and site-specific drug delivery.","PeriodicalId":313975,"journal":{"name":"Biointegration of Medical Implant Materials","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124852053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-08-102680-9.00001-9
S. P. Victor, C. Pillai, C. P. Sharma
{"title":"Biointegration","authors":"S. P. Victor, C. Pillai, C. P. Sharma","doi":"10.1016/b978-0-08-102680-9.00001-9","DOIUrl":"https://doi.org/10.1016/b978-0-08-102680-9.00001-9","url":null,"abstract":"","PeriodicalId":313975,"journal":{"name":"Biointegration of Medical Implant Materials","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127758795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-08-102680-9.12001-3
{"title":"Copyright","authors":"","doi":"10.1016/b978-0-08-102680-9.12001-3","DOIUrl":"https://doi.org/10.1016/b978-0-08-102680-9.12001-3","url":null,"abstract":"","PeriodicalId":313975,"journal":{"name":"Biointegration of Medical Implant Materials","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132736154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1533/9781845699802.1.51
E. Wentrup-Byrne, L. Grøndahl, A. Chandler-Temple
The challenges faced by any tissue repair and regeneration process resulting from either trauma or disease are many and complex. Although it is of course impossible to identify any one anatomical region as being the most demanding in this respect, the craniofacial region surely qualifies. The judicious choice of available, well-defined and tested repair materials to be used in the reconstruction process by the multi-disciplinary team of reconstructive surgeons is critical. This chapter addresses one aspect of facial reconstruction that has been less well addressed in the literature; namely the materials used to repair and regenerate soft tissue both in terms of fillers and in terms of materials used at the hard-soft tissue interface.
{"title":"Replacement materials for facial reconstruction at the soft tissue–bone interface","authors":"E. Wentrup-Byrne, L. Grøndahl, A. Chandler-Temple","doi":"10.1533/9781845699802.1.51","DOIUrl":"https://doi.org/10.1533/9781845699802.1.51","url":null,"abstract":"The challenges faced by any tissue repair and regeneration process resulting from either trauma or disease are many and complex. Although it is of course impossible to identify any one anatomical region as being the most demanding in this respect, the craniofacial region surely qualifies. The judicious choice of available, well-defined and tested repair materials to be used in the reconstruction process by the multi-disciplinary team of reconstructive surgeons is critical. This chapter addresses one aspect of facial reconstruction that has been less well addressed in the literature; namely the materials used to repair and regenerate soft tissue both in terms of fillers and in terms of materials used at the hard-soft tissue interface.","PeriodicalId":313975,"journal":{"name":"Biointegration of Medical Implant Materials","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133519864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-08-102680-9.00008-1
Jeffery D. St. Jeor, Donnie Pfeifer, Krishna S. Vyas
{"title":"Tendon Regeneration","authors":"Jeffery D. St. Jeor, Donnie Pfeifer, Krishna S. Vyas","doi":"10.1016/b978-0-08-102680-9.00008-1","DOIUrl":"https://doi.org/10.1016/b978-0-08-102680-9.00008-1","url":null,"abstract":"","PeriodicalId":313975,"journal":{"name":"Biointegration of Medical Implant Materials","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124785946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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