Pub Date : 2018-05-09DOI: 10.7208/chicago/9780226611235.003.0010
R. Pulk, J. Graham, F. Lichtenberg, D. Maeng, Marc S. Williams, E. Wright
{"title":"The Value of Cytochrome P450 2C19 Pharmacogenomic Information for Patients Receiving Clopidogrel Therapy following a Major Cardiovascular Event","authors":"R. Pulk, J. Graham, F. Lichtenberg, D. Maeng, Marc S. Williams, E. Wright","doi":"10.7208/chicago/9780226611235.003.0010","DOIUrl":"https://doi.org/10.7208/chicago/9780226611235.003.0010","url":null,"abstract":"","PeriodicalId":320470,"journal":{"name":"Economic Dimensions of Personalized and Precision Medicine","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126732081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-16DOI: 10.7208/chicago/9780226611235.003.0007
Kristopher J. Hult
{"title":"Measuring the Potential Health Impact of Personalized Medicine","authors":"Kristopher J. Hult","doi":"10.7208/chicago/9780226611235.003.0007","DOIUrl":"https://doi.org/10.7208/chicago/9780226611235.003.0007","url":null,"abstract":"","PeriodicalId":320470,"journal":{"name":"Economic Dimensions of Personalized and Precision Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132338414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-02DOI: 10.7208/chicago/9780226611235.003.0001
T. Philipson
{"title":"The Economic Value and Pricing of Personalized Medicine","authors":"T. Philipson","doi":"10.7208/chicago/9780226611235.003.0001","DOIUrl":"https://doi.org/10.7208/chicago/9780226611235.003.0001","url":null,"abstract":"","PeriodicalId":320470,"journal":{"name":"Economic Dimensions of Personalized and Precision Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128781502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-02DOI: 10.7208/chicago/9780226611235.003.0008
David H. Howard, J. Hockenberry, G. David
{"title":"Physicians’ Financial Incentives to Personalize Medicine","authors":"David H. Howard, J. Hockenberry, G. David","doi":"10.7208/chicago/9780226611235.003.0008","DOIUrl":"https://doi.org/10.7208/chicago/9780226611235.003.0008","url":null,"abstract":"","PeriodicalId":320470,"journal":{"name":"Economic Dimensions of Personalized and Precision Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114717082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.7208/chicago/9780226611235.003.0009
{"title":"Economic Dimensions of Personalized and Precision Medicine in Asia","authors":"","doi":"10.7208/chicago/9780226611235.003.0009","DOIUrl":"https://doi.org/10.7208/chicago/9780226611235.003.0009","url":null,"abstract":"","PeriodicalId":320470,"journal":{"name":"Economic Dimensions of Personalized and Precision Medicine","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126697730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.7208/chicago/9780226611235.003.0011
Orphan Drug (OD) legislation has been implemented with regulatory and financial incentives to encourage the drug innovation to treat rare diseases. This study aims to test whether OD Designations (ODD) granted by the Food and Drug Administration (FDA) to pharmaceuticals and biotechnology start-up companies may be considered as relevant signals in, attracting entrepreneurial finance and increasing the amount invested at the time of the Initial Public Offering (IPO) in the US stock markets. Furthermore, ODD before going public may also influence the access to other relevant resources for start-ups companies as for instance venture capital investments, collaborative revenues and employees prior to IPO. We found that the signaling power of ODD is positively and statistically significant for IPO investors in stock markets: an ODD prior to an IPO increase the IPO proceeds by about 37,5%. Regression results also suggest that ODD are stronger than p tents applications to attract IPO investors and other valuable resources before that the company goes public. Scholar and policy implications are discussed in the light of the signaling theory and drug development policies
{"title":"Orphan Drug Designations as Valuable Intangible Assets for IPO Investors in Pharma-Biotech Companies","authors":"","doi":"10.7208/chicago/9780226611235.003.0011","DOIUrl":"https://doi.org/10.7208/chicago/9780226611235.003.0011","url":null,"abstract":"Orphan Drug (OD) legislation has been implemented with regulatory and financial incentives to encourage the drug innovation to treat rare diseases. This study aims to test whether OD Designations (ODD) granted by the Food and Drug Administration (FDA) to pharmaceuticals and biotechnology start-up companies may be considered as relevant signals in, attracting entrepreneurial finance and increasing the amount invested at the time of the Initial Public Offering (IPO) in the US stock markets. Furthermore, ODD before going public may also influence the access to other relevant resources for start-ups companies as for instance venture capital investments, collaborative revenues and employees prior to IPO. We found that the signaling power of ODD is positively and statistically significant for IPO investors in stock markets: an ODD prior to an IPO increase the IPO proceeds by about 37,5%. Regression results also suggest that ODD are stronger than p tents applications to attract IPO investors and other valuable resources before that the company goes public. Scholar and policy implications are discussed in the light of the signaling theory and drug development policies","PeriodicalId":320470,"journal":{"name":"Economic Dimensions of Personalized and Precision Medicine","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130558463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.7208/chicago/9780226611235.003.0002
{"title":"Therapeutic Translation of Genomic Science","authors":"","doi":"10.7208/chicago/9780226611235.003.0002","DOIUrl":"https://doi.org/10.7208/chicago/9780226611235.003.0002","url":null,"abstract":"","PeriodicalId":320470,"journal":{"name":"Economic Dimensions of Personalized and Precision Medicine","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116169539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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