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Descriptive study of infection by SARS-COV-2 in adults with Diabetes Mellitus 成人糖尿病患者SARS-COV-2感染的描述性研究
Pub Date : 2021-11-29 DOI: 10.26226/morressier.617c37307c09fc044a975141
maria paula russo, Javier Alberto Pollan, Mariana Andrea Burgos, Maria Florencia Grande Ratti, A. Murujosa
The main objective was to estimate the prevalence of diabetes mellitus (DM) among patients with COVID-19, to explore associ-ated factors;and to describe clinical evolution of hospitalized patients. A cross-sectional study was conducted, which included adults confirmed with COVID-19 between 03/12/2020 and 10/15/2020, at Hospital Italiano de Buenos Aires. From 6009 people with COVID-19, 408 had previous diagnosis of DM, yielding a prevalence of 6% (95%CI 6-7), higher prevalence was associated with age (12% in ≥ 60 years and 3% in < 60 years;p = 0.01). In-hospital mortality was 6% (95%CI 6-7), being 15% in DM and 6% compared in non-diabetics (p < 0.01). Associated factors with DM were cardiovascular variables such as male sex, hypertension, smoking, chronic renal failure, heart failure, previous coronary disease;and clinical variables proxy of frailty such as: age, dementia and previous institutionalization (all with p < 0.01). Only 23% (96/408) of DM had an HbA1c measurement in the last 3 months and 76% in the last year, with an average 8.6%, and 25% in goal (HbA1c ≤ 7%). Management was mostly in-hospital (59%), with an average hospital stay of 12 days, with the following complications during hospitalization: 6% presented a hypoglycemic value (< 70 mg/dl), 42% required oxygen therapy, 19 % went to intensive care unit, 15% required invasive mechanical ventilation (mean 11 days), and 25% (95%CI 20-31) of in-hospital mortality (mean 82 years).
主要目的是估计COVID-19患者中糖尿病(DM)的患病率,探讨相关因素,并描述住院患者的临床演变。在布宜诺斯艾利斯意大利医院进行了一项横断面研究,其中包括2020年12月3日至2020年10月15日期间确诊为COVID-19的成年人。在6009例COVID-19患者中,408例既往诊断为糖尿病,患病率为6% (95%CI 6-7),较高的患病率与年龄相关(≥60岁为12%,< 60岁为3%;p = 0.01)。住院死亡率为6% (95%CI 6-7),糖尿病患者为15%,非糖尿病患者为6% (p < 0.01)。与糖尿病相关的因素有心血管变量,如男性、高血压、吸烟、慢性肾衰竭、心力衰竭、既往冠状动脉疾病;与虚弱相关的临床变量,如年龄、痴呆和既往住院(均p < 0.01)。仅23%(96/408)的糖尿病患者在最近3个月内检测过HbA1c, 76%的糖尿病患者在最近一年内检测过HbA1c,平均为8.6%,目标为25% (HbA1c≤7%)。治疗主要是住院(59%),平均住院时间为12天,住院期间出现以下并发症:6%出现低血糖值(< 70 mg/dl), 42%需要吸氧治疗,19%进入重症监护病房,15%需要有创机械通气(平均11天),25% (95%CI 20-31)住院死亡率(平均82年)。
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