Pub Date : 2020-01-01DOI: 10.1093/med/9780198794585.003.0023
A. Holland
This chapter describes the concept of behavioural phenotypes with examples of genetically-determined neurodevelopmental syndromes which are associated with particular developmental trajectories and specific comorbid risks for challenging behaviour or mental ill-health. Potential neural and other mechanisms that might explain the observed genotype/phenotype associations are explored as are treatment modalities including a focus on novel syndrome specific treatments. The chapter is primarily aimed at trainees, clinicians, and clinical researchers and, for this reason, is about those aspects of the behavioural phenotypes that impinge negatively on a person’s health, well-being, and quality of life.
{"title":"Behavioural Phenotypes","authors":"A. Holland","doi":"10.1093/med/9780198794585.003.0023","DOIUrl":"https://doi.org/10.1093/med/9780198794585.003.0023","url":null,"abstract":"This chapter describes the concept of behavioural phenotypes with examples of genetically-determined neurodevelopmental syndromes which are associated with particular developmental trajectories and specific comorbid risks for challenging behaviour or mental ill-health. Potential neural and other mechanisms that might explain the observed genotype/phenotype associations are explored as are treatment modalities including a focus on novel syndrome specific treatments. The chapter is primarily aimed at trainees, clinicians, and clinical researchers and, for this reason, is about those aspects of the behavioural phenotypes that impinge negatively on a person’s health, well-being, and quality of life.","PeriodicalId":322174,"journal":{"name":"Oxford Textbook of the Psychiatry of Intellectual Disability","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133808087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1093/med/9780198794585.003.0022
R. Shankar, M. Walker
It is well recognized that both Intellectual Disability (ID) and epilepsy individually have higher rates of premature mortality. Thus, the two conditions in combination will be more likely to lead to premature mortality than either individually. People with ID and epilepsy have a higher likelihood of communication, psychiatric, behavioural, and drug sensitivity problems that makes their treatment difficult. This is not a homogenous group. At one end of the spectrum are patients with mild ID, 10–12% of who have epilepsy and treatment is mainly focused on areas like compliance and risky behaviours. At the other end are patients with severe ID, up to 50% of who have epilepsy and treatment is more focused on factors such as the co-morbidity, impact of medications, recognition of side effects, treatment resistance, and informed consent. This chapter looks to collate and provide an overview of epilepsy diagnosis and management and the current good practice on its applicability to people with ID.
{"title":"Epilepsy in People with Intellectual Disability","authors":"R. Shankar, M. Walker","doi":"10.1093/med/9780198794585.003.0022","DOIUrl":"https://doi.org/10.1093/med/9780198794585.003.0022","url":null,"abstract":"It is well recognized that both Intellectual Disability (ID) and epilepsy individually have higher rates of premature mortality. Thus, the two conditions in combination will be more likely to lead to premature mortality than either individually. People with ID and epilepsy have a higher likelihood of communication, psychiatric, behavioural, and drug sensitivity problems that makes their treatment difficult. This is not a homogenous group. At one end of the spectrum are patients with mild ID, 10–12% of who have epilepsy and treatment is mainly focused on areas like compliance and risky behaviours. At the other end are patients with severe ID, up to 50% of who have epilepsy and treatment is more focused on factors such as the co-morbidity, impact of medications, recognition of side effects, treatment resistance, and informed consent. This chapter looks to collate and provide an overview of epilepsy diagnosis and management and the current good practice on its applicability to people with ID.","PeriodicalId":322174,"journal":{"name":"Oxford Textbook of the Psychiatry of Intellectual Disability","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126640970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1093/med/9780198794585.003.0020
U. Chauhan, Ken Courtenay, Matthew Hoghton
The aim of this chapter is to outline the importance of good physical health for a person with intellectual disability (ID) on their mental health and wellbeing; the impact of the choice of psychotropic therapy on their physical health; the presentations of mental disorders in people with ID with health problems; what to include in assessment—good history taking, physical examination, and investigations. Other aspects covered are the management of health problems including health prevention and what to monitor; the role of guidelines; and importance of liaison with GPs and the Primary Care Team.
{"title":"Physical Health in People with Intellectual Disabilities","authors":"U. Chauhan, Ken Courtenay, Matthew Hoghton","doi":"10.1093/med/9780198794585.003.0020","DOIUrl":"https://doi.org/10.1093/med/9780198794585.003.0020","url":null,"abstract":"The aim of this chapter is to outline the importance of good physical health for a person with intellectual disability (ID) on their mental health and wellbeing; the impact of the choice of psychotropic therapy on their physical health; the presentations of mental disorders in people with ID with health problems; what to include in assessment—good history taking, physical examination, and investigations. Other aspects covered are the management of health problems including health prevention and what to monitor; the role of guidelines; and importance of liaison with GPs and the Primary Care Team.","PeriodicalId":322174,"journal":{"name":"Oxford Textbook of the Psychiatry of Intellectual Disability","volume":"254 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117322472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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