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Safety Of BBIBP-CorV (Sinopharm) COVID-19 Vaccination In People With Multiple Sclerosis: A Report From Iran BBIBP-CorV(国药)COVID-19疫苗在多发性硬化症患者中的安全性:来自伊朗的报告
Pub Date : 2022-03-22 DOI: 10.14302/issn.2690-4837.ijip-22-4342
S. Nabavi, Mehrnoosh Mehrabani, L. Ghalichi, M. Nahayati, Mehran Ghaffari, F. Ashtari, S. E. Mohammadianinejad, S. Karimi, M. Salari, L. Faghani, S. Yazdanbakhsh, Abbas Najafian, M. Vosough
Introduction: Vaccination against SARS CoV-2 started on March 2020 in Iran and people with multiple sclerosis (pwMS) have a priority to be vaccinated in line of other high-risk population. Up to now, BBIBP-CorV (Sinopharm) is the main vaccine which have been used in Iranian population, and in high risk population such as pwMS. Method: In this survey, the safety and possible side effects of this vaccine after the first or/and second doses in 520 pwMS have been assessed from July to August 2021. MS Patients who have received one or two doses of Sinopharm vaccine were evaluated.Results: Around 44% of pwMS who received Sinopharm reported few minor side effects, whereas its side effect have been reported in 60% of patients who received the second dose. All side effects have begun within the first 24 hours and subsided between 48-96 hours afterward. No serious side effects or mortality have been reported. There was no correlation between the side effects and age, the disability status, and the type of first or second line DMDs (disease modifying drugs). Only some side effects were significantly higher in the progressive form of the disease. Conclusion: MS patients can receive Sinopharm vaccine safely and the minor side effects should not scare them.Keywords: Sinopharm BBIBP-CorV, multiple sclerosis, disease modifying drugs, safety
伊朗于2020年3月开始接种SARS - CoV-2疫苗,多发性硬化症(pwMS)患者与其他高危人群一样,优先接种疫苗。到目前为止,在伊朗人群和高危人群(如pwMS)中使用的主要疫苗是BBIBP-CorV(国药)。方法:本调查于2021年7月至8月对520例pwMS患者进行了第一次或/和第二次接种后的安全性和可能的副作用评估。对接受了一剂或两剂国药疫苗的多发性硬化症患者进行了评估。结果:大约44%的接受国药的pwMS患者报告了轻微的副作用,而接受第二次剂量的患者中有60%报告了其副作用。所有的副作用都是在24小时内开始的,之后48-96小时内消退。没有严重的副作用或死亡的报道。副作用与年龄、残疾状况、一线或二线疾病调节药物(dmd)类型无相关性。只有一些副作用在疾病的进展形式中明显更高。结论:MS患者可以安全接种国药疫苗,轻微的副作用不应使患者感到害怕。关键词:国药BBIBP-CorV;多发性硬化症;减病药物
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引用次数: 0
Cutaneous Myiasis Caused by Tumbu Fly Larvae Infestation in an Infant: A Case Report 坦布蝇幼虫侵染致婴儿皮肤蝇蛆病1例报告
Pub Date : 2022-03-14 DOI: 10.14302/issn.2690-4837.ijip-22-4080
Fa Oyegbemi, B. Otaigbe, O. Amaewhule
Myiasis is a parasitic infestation of the body of a mammal caused by Cordylobia Anthropophaga (Tumbu fly) larvae. The infestation is prevalent in Sub-Saharan Africa, South-East Mexico and Central America. It is usually seen among rural dwellers and has no age or sex predilection. We report a case of Tumbu fly myiasis seen in a 7month-old male living in Port Harcourt, Nigeria who was erroneously thought to have bullous impetigo.
蝇蛆病是一种寄生在哺乳动物体内的疾病,由嗜人虫草蝇(Tumbu蝇)幼虫引起。这种虫害在撒哈拉以南非洲、墨西哥东南部和中美洲普遍存在。它通常见于农村居民,没有年龄或性别偏好。我们报告一个在尼日利亚哈科特港生活的7个月大的男性中发现的通布蝇蛆病,他被错误地认为有大疱性脓疱。
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引用次数: 0
A Theory on the Impact of Copper and Micronutrients Against COVID-19 in Humans 铜和微量营养素对人类COVID-19影响的理论
Pub Date : 2021-11-27 DOI: 10.14302/issn.2690-4837.ijip-21-4015
C. A. C. D. PGDip AMP EHP-C, C. A. C. D. PGDip AMP EHP-C
Copper (Cu) has a strong impact on the function of the immune system through several different pathways. These impacts include helping the function of monocytes, neutrophils, and macrophages, and enhancing Natural Killer cells’ activities. Cu also has a role in antimicrobial properties and inflammatory response. It is also important for IL-2 production and response, which is a component of adaptive immune cells. Additionally, Cu has multiple roles in both proliferation and differentiation of T cells and is involved in the production of antibodies. Cu deficiency can even lead to "increased viral virulence"1. Copper has a long history of use in medicine, and has continued to be used for purification of water, including use in hospitals to prevent legionnaires disease. The CDC pre released information on a study completed in March 2020 on the lifespan of COVID-19 on different surfaces which included its lifespan on copper, where it was completely dead within 4 hours. In addition, "Several reports demonstrated that Cu deficiency weakens the human immune response" 2. Given the multiple avenues of impact, it has been suggested that Cu supplementation, within recommended levels, be given to individuals who are low in Cu to help them fight off COVID-19. It is also possible that Cu supplementation, within recommended levels, may help prevent COVID-19 infection, or help individuals who are not low in Cu to fight off COVID-19 infection. However, dosage would have to be carefully managed, as excess levels of Cu can lead to both neurodegenerative and neurodevelopmental diseases.
铜(Cu)通过几种不同的途径对免疫系统的功能产生强烈的影响。这些影响包括帮助单核细胞、中性粒细胞和巨噬细胞的功能,以及增强自然杀伤细胞的活性。铜还在抗菌特性和炎症反应中发挥作用。它对IL-2的产生和应答也很重要,IL-2是适应性免疫细胞的一个组成部分。此外,Cu在T细胞的增殖和分化中具有多种作用,并参与抗体的产生。缺铜甚至会导致“病毒毒力增加”。铜在医学上有着悠久的使用历史,并继续用于净水,包括在医院使用以预防军团病。疾病预防控制中心提前发布了2020年3月完成的一项研究的信息,该研究是关于COVID-19在不同表面上的寿命,包括它在铜上的寿命,它在铜上的寿命在4小时内完全死亡。此外,“几份报告表明,缺铜会削弱人体的免疫反应”。考虑到影响的多种途径,有人建议在建议水平内向铜含量低的人补充铜,以帮助他们对抗COVID-19。在推荐水平内补充铜也可能有助于预防COVID-19感染,或帮助铜含量不低的个体抵抗COVID-19感染。然而,剂量必须谨慎管理,因为过量的铜会导致神经退行性和神经发育性疾病。
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引用次数: 0
Surgical Site Infection in Cesarean Section Operation: Risk and Management 剖宫产术中手术部位感染:风险与处理
Pub Date : 2019-05-22 DOI: 10.14302/issn.2690-4837.ijip-19-2842
R. Younes, T. F. Farias, Rodrigo A S Sardenberg
Cesarean sections (CS) are one of the most commonly performed surgical procedures worldwide. There is great variability in the percentage of cesarean sections between countries, varying from 3% to 42.9%5. In the US, approximately 32% of deliveries occur through a cesarean section. Overall, a drastic increase in cesarean section rate has been reported reaching its highest level at the present time.In Brazil, considering the types of births by live births from 2006 to 2016, the national percentage of cesarean section was 52.37%. The variability in this percentage can still be perceived within Brazilian territory. The highest cesarean rate occurred in the Southern region, representing 58.33% of births, while the lowest rate occurred in the Northern region, with 41.79%. It is possible to see the steady increase in the percentage of CS over time, from 45.01% in 2006 to 55.39% in 2016.
剖宫产(CS)是世界上最常用的外科手术之一。各国剖宫产率差异很大,从3%到42.9%不等。在美国,大约32%的分娩是通过剖宫产进行的。总体而言,据报道剖宫产率急剧上升,达到目前的最高水平。在巴西,考虑到2006 - 2016年的活产产类型,全国剖宫产率为52.37%。在巴西境内仍然可以看出这一百分比的变化。剖宫产率最高的是南部地区,占新生儿的58.33%,最低的是北部地区,占41.79%。随着时间的推移,CS的比例可能会稳步上升,从2006年的45.01%上升到2016年的55.39%。
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引用次数: 0
Surgical Site Infections: A Still Ongoing Challenge 手术部位感染:一个仍在进行的挑战
Pub Date : 2019-02-03 DOI: 10.14302/ISSN.2690-4837.IJIP-18-2515
Rodrigo Sardenberg, R. Younes
Surgical site infections (SSI) have a high incidence, accounting for 20% of all hospital-acquired in-fections. Surgical site infections are linked to a increased length of stay and the risk of mortality. Although most patients recover from an SSI, 77% of mortality can be attributed to the infection it-self 1, 4. The incidence of SSI is 2% to 5% undergoing inpatient surgery 1. Estimated annual in-cidence varies, but may range from 160,000 to 300,000 in the US 1, 4. These estimates might be understated, given the surveillance failure after discharge
手术部位感染(SSI)发生率高,占所有医院获得性感染的20%。手术部位感染与住院时间延长和死亡风险增加有关。虽然大多数患者从SSI中恢复,但77%的死亡率可归因于感染本身。住院手术的SSI发生率为2% ~ 5% 1。估计每年的发病率各不相同,但在美国可能在16万到30万之间。考虑到排放后的监测失败,这些估计可能被低估了
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引用次数: 0
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International Journal of Infection Prevention
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