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Cerebral Palsy - Clinical and Therapeutic Aspects最新文献

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Baclofen Pump Implantation for Cerebral Palsy 巴氯芬泵植入治疗脑瘫
Pub Date : 2018-12-19 DOI: 10.5772/INTECHOPEN.79619
Moneer K. Faraj
Programmable baclofen pump implantation is used to provide the patient with minimal intrathecal dose of baclofen to provide relaxation when the oral permitted doses are no longer withstand able by the patient. We discussed the efficiency of programmable baclofen pump implantation in treating spasticity by reviewing several international papers. Satisfactory relaxation was noticed in most of the patients. The complications following intrathecal baclofen (ITB) surgeries are not uncommon. ITB is an advised method for treating spasticity whether due to cerebral or spinal causes. It has significant improvements with minor complications. It needs special trained multidisciplinary team to manage it.
可编程巴氯芬泵植入用于为患者提供最小的鞘内巴氯芬剂量,以便在患者无法再承受口服允许剂量时提供放松。通过对国内外相关文献的回顾,探讨了可编程巴氯芬泵植入治疗痉挛的有效性。大多数患者均有满意的放松。鞘内巴氯芬手术后的并发症并不少见。ITB是治疗痉挛的建议方法,无论是由于大脑还是脊柱原因。它有显著的改善和轻微的并发症。它需要专门训练的多学科团队来管理。
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引用次数: 0
Hip Surgery in Cerebral Palsy 脑性麻痹的髋关节手术
Pub Date : 2018-12-19 DOI: 10.5772/INTECHOPEN.80442
João Lameiras-Campagnolo
Hip pathology is one of the main orthopedic concerns in cerebral palsy (CP) patients. It has been demonstrated that correctly applied hip screening programs could significantly diminish the incidence of hip pathology. Unfortunately, in several countries, hip dislo- cation is significantly prevalent and is still a major concern in these patients. Depending on the age, the disability grade, the rehabilitation support, and the surgical strategies, results of hip treatment are variable. The ideal outcome of a stable, reduced, and long-lasting pain-free hip are not always achieved. In this chapter, we discuss theoretical and practical strategies used to treat specific CP hip dislocation. In younger children, simple femoral reorientation procedures (tenotomies with or without femoral osteotomies) promote correct acetabular remodeling. Later, surgical hip reduction can be an option even in late adolescents, and the use of capsuloplasty can lead to greater hip stability, in spite of eventual pelvis obliquity caused by associated spine pathology. Several technical tips for hip surgery are presented. It is essential that patients with CP hip problems receive proper follow-up, including rehabilitation medicine, physiotherapy, anti-spastic medication, on-time orthosis availability, and real teamwork concerned with this kind of pathology.
髋关节病理是脑瘫(CP)患者的主要骨科问题之一。已经证明,正确应用髋关节筛查程序可以显著减少髋关节病理的发生率。不幸的是,在一些国家,髋关节脱位非常普遍,仍然是这些患者的主要关注点。取决于年龄、残疾程度、康复支持和手术策略,髋关节治疗的结果是可变的。理想的结果,稳定,减少,持久无痛的髋关节并不总是实现。在本章中,我们讨论了治疗特异性CP髋关节脱位的理论和实践策略。在年幼的儿童中,简单的股骨复位手术(肌腱切断术合并或不合并股骨截骨术)可促进正确的髋臼重塑。后来,即使在青少年晚期,手术髋关节复位也是一种选择,尽管相关脊柱病理最终导致骨盆倾斜,但使用囊成形术可以提高髋关节的稳定性。介绍了髋关节手术的几个技术提示。有CP髋关节问题的患者必须接受适当的随访,包括康复药物、物理治疗、抗痉挛药物、及时提供矫形器,以及与这种病理有关的真正的团队合作。
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引用次数: 0
Plasma Growth Factors in Cerebral Palsy 脑瘫的血浆生长因子
Pub Date : 2018-12-19 DOI: 10.5772/INTECHOPEN.80369
J. A. Rubio, J. López
The use of plasma growth factors is opening a new field of clinical application in medicine, developing a new discipline called regenerative medicine. In many fields such as trauma -tology, dental implantology or anesthesia, the use of this biotechnology is improving the quality of life of patients, through techniques that are not invasive but with extraordinary functional results. A discipline where this type of procedure opens an interesting field of application is undoubtedly neurology, especially those processes of ischemic or hypo-anoxic origin such as cerebral palsy, where recent studies point to an improvement of cognitive abilities in patients, together with specific neurorehabilitation therapies.
血浆生长因子的使用为医学临床应用开辟了一个新的领域,发展了一门叫做再生医学的新学科。在许多领域,如创伤学、牙科种植学或麻醉,这种生物技术的使用正在通过非侵入性但具有非凡功能结果的技术改善患者的生活质量。毫无疑问,这种类型的手术开辟了一个有趣的应用领域的学科是神经学,特别是那些缺血或缺氧的过程,如脑瘫,最近的研究指出,在特定的神经康复治疗中,患者的认知能力得到改善。
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引用次数: 0
Cerebral Palsy and Epilepsy 脑瘫和癫痫
Pub Date : 2018-12-19 DOI: 10.5772/INTECHOPEN.79565
A. Kholin
The frequency of epilepsy in children with cerebral palsy is 40 times higher than the com- mon population rate. The presence of epilepsy aggravates the clinical course of cerebral palsy, complicates the rehabilitation, affects the prognosis of motor and intellectual func - tions, and could be life-threatening. Another problem is the possibility of aggravation of epileptic seizures and their appearance de novo due to application of some neuro- rehabilitation methods (electrophoresis, acupuncture, nootropic drugs, brain stimula-tors, etc.). Children with cerebral palsy have a broad spectrum of epilepsies—varying from favorable combinations with benign idiopathic forms to extremely severe epileptic encephalopathies. Frequent combination of epileptic and non-epileptic paroxysms causes difficulty in their interpretation and differential diagnosis. Video-EEG monitoring is the “golden standard” for differential diagnostic of epileptic and non-epileptic events, and it is very useful for investigation of patients with cerebral palsy. Treatment of epilepsy in combination with cerebral palsy strictly requires an individual approach due to the form of epilepsy, seizure types, age of the patient, comorbidity, and somatic and mental condition of the patient.
脑瘫儿童癫痫的发病率是普通人群的40倍。癫痫的存在会加重脑瘫的临床病程,使康复复杂化,影响运动和智力功能的预后,并可能危及生命。另一个问题是,由于一些神经康复方法(电泳、针灸、益智药物、脑刺激药物等)的应用,癫痫发作有可能加重和重新出现。脑瘫患儿有广谱的癫痫——从与良性特发性形式的有利组合到极其严重的癫痫性脑病。癫痫性和非癫痫性发作的频繁合并导致其解释和鉴别诊断的困难。视频脑电图监测是鉴别癫痫性和非癫痫性事件的“金标准”,对脑瘫患者的调查非常有用。由于癫痫的形式、发作类型、患者的年龄、合并症以及患者的躯体和精神状况,癫痫合并脑瘫的治疗严格要求个体化治疗。
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引用次数: 1
Oral Health in Children with Cerebral Palsy 脑性麻痹儿童的口腔健康
Pub Date : 2018-12-19 DOI: 10.5772/INTECHOPEN.79452
R. Akhter, N. Hassan, M. Nadkarni, Elizabeth F. Martin, G. Khandaker
Cerebral palsy (CP) is a neurodevelopmental condition comprising a group of permanent disorders of movement and posture that are attributed to nonprogressive disturbances of the developing brain. The neuromuscular problems inherent in CP can affect oral health significantly in several ways. These can include changes in structure of the oro facial region, feeding problems, difficulties with maintaining oral hygiene; additionally, people with CP can encounter barriers in accessing oral health care. Several studies have examined caries rates in individuals who have CP. However, to date, no population- based studies have been published defining the risk factors for dental caries experience among children with CP. There is a high prevalence of orofacial motor dysfunction among people with CP, which can hinder oral hygiene and hence increase dental biofilm formation and retention. Factors such as food consistency, snacking between meals, and associated oromotor dysfunction have also been reported to contribute to the high incidence of caries found in those with CP. Therefore, this chapter will aim to describe the oral health status and factors affecting dental caries experience of children with CP, while also providing preventative and restorative recommendations to combat the prevalence of this disease.
脑瘫(CP)是一种神经发育疾病,包括一组永久性的运动和姿势障碍,归因于发育中的大脑的非进行性障碍。CP固有的神经肌肉问题可以在几个方面显著影响口腔健康。这些症状包括口腔面部结构的改变、进食问题、保持口腔卫生的困难;此外,CP患者在获得口腔保健方面可能遇到障碍。几项研究调查了CP患者的龋齿率。然而,迄今为止,还没有发表基于人群的研究来确定CP儿童龋齿经历的危险因素。CP患者中口腔面部运动功能障碍的患病率很高,这可能会妨碍口腔卫生,从而增加牙齿生物膜的形成和保留。食物一致性、两餐之间吃零食以及相关的口腔运动功能障碍等因素也被报道为CP儿童龋齿的高发病率的原因。因此,本章将旨在描述CP儿童的口腔健康状况和影响龋齿经历的因素,同时也提供预防和修复建议,以对抗这种疾病的流行。
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引用次数: 3
Survival, Mortality, and Life Expectancy 生存、死亡率和预期寿命
Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80293
S.M.D. Day, R. Reynolds
Cerebral palsy (CP) is a heterogenous condition, with level of disability ranging from immaterial to profound. In concert with the continuum of level of severity of disability/ independent functioning, health care needs, therapies, medications, surgical interven- tions, costs of care, daily demands on parents and other family members, and expectations for the future in terms of education, employment, and other milestones of life all vary widely. Similarly, life expectancy in CP follows a continuum, from far lower than to potentially as high as general population life expectancy, that parallels the continuum of levels of disability. Here we review the literature documenting this, and examine the specific factors that are known to be strongly associated with mortality and longevity in CP. We also examine the evidence regarding causes of death in CP, and present some new findings related to this. Finally, we outline important methodological considerations for future research in this area.
脑瘫(CP)是一种异质性疾病,其残疾程度从非物质到严重不等。随着残疾/独立功能严重程度的连续变化,保健需求、治疗、药物、手术干预、护理费用、对父母和其他家庭成员的日常需求以及对未来教育、就业和其他生活里程碑的期望都有很大差异。同样,CP患者的预期寿命也遵循一个连续体,从远低于一般人群的预期寿命到可能达到一般人群的预期寿命,这与残疾水平的连续体相对应。在这里,我们回顾了文献记录这一点,并检查了已知与CP死亡率和寿命密切相关的具体因素。我们还检查了关于CP死亡原因的证据,并提出了一些与此相关的新发现。最后,我们概述了该领域未来研究的重要方法学考虑。
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引用次数: 0
Early Markers for Cerebral Palsy 脑瘫的早期标志
Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79466
Ali A. Al-Mayahi
Cerebral palsy (CP) is a term referring to a nonprogressive disease of the brain originating during the antenatal, neonatal, or early postnatal period when brain neuronal connections are still evolving. Secondary effects of spasticity on growth may, however, be progressive. There may be additional disturbances of sensation, perception, cognition, communication, and behavior. Babies who are neurologically abnormal as newborns are at increased risk of neurologic abnormality in later months and years. Being born preterm (born <37 weeks of gestation) or with a very low birth weight (weighing <1500 g/<32 weeks of gestation) or extreme low birth weight (<1000 g/<28 weeks of gestation) is associated with significant motor impairment. Which specific signs in the neonate are of greatest predictive power, what long-term disability these signs predict, and how well they predict it remain unclear? Physician’s major concern is to identify specific risk factors for severe impairment in early infancy so as to predict the developmental outcome of those children that may manifest later on with neurological deficit especially if they have perinatal insult. Parents on the other hand are also concerned about their growing infants, their development, and neurological outcome. Since cerebral palsy is a permanent disorder, early detection of signs of motor impairment is crucial to assist physicians to give close follow-up of those infants and to reassure parents whose children are normal. It has been shown that intervention may be most efficient when the plasticity of the brain is high, and an early detection of brain impairment is therefore crucial. An earlier follow-up and training program can have a positive effect of the motor development of the child with CP, in particular through prevention of limb contractions, and might make a difference in the child’s ability to handle everyday challenges. In addition, an early detection of CP gives the parents more time for adjustment and preparation. Since clinical manifestations of cerebral palsy do not emerge before a child is at least 6 months, the general movement (GM) is considered the most reliable early markers for monitoring of fetal and infant movement. Abnormal General movements and absence of the so-called fidgety movements at 3-5 months post-term carries a high risk of developing cerebral palsy. Beside a high specificity (82–99%) and sensitivity (95–100%), the assessment of the general movements (GMs) is quick, nonintrusive, and easy to acquire.
脑瘫(CP)是指发生在产前、新生儿或出生后早期脑神经连接仍在发育的一种非进行性脑疾病。然而,痉挛对生长的继发性影响可能是进行性的。可能还有感觉、知觉、认知、交流和行为方面的额外障碍。新生儿时神经系统异常的婴儿在以后的几个月和几年中神经系统异常的风险增加。早产(妊娠<37周)或极低出生体重(体重<1500 g/<妊娠32周)或极低出生体重(<1000 g/<妊娠28周)与严重的运动障碍有关。新生儿的哪些具体迹象具有最大的预测能力,这些迹象预示着什么样的长期残疾,以及它们的预测效果如何,这些都还不清楚?医生主要关心的是确定婴儿早期严重损伤的具体风险因素,以便预测这些儿童的发育结果,这些儿童可能在以后表现为神经功能缺陷,特别是如果他们有围产期损伤。另一方面,父母也关心他们正在成长的婴儿,他们的发育和神经系统的结果。由于脑瘫是一种永久性疾病,早期发现运动障碍的迹象对于帮助医生对这些婴儿进行密切随访和让孩子正常的父母放心至关重要。研究表明,当大脑可塑性高时,干预可能是最有效的,因此早期发现脑损伤是至关重要的。早期的随访和训练计划可以对患有CP的儿童的运动发展产生积极影响,特别是通过预防肢体收缩,并且可能对儿童处理日常挑战的能力产生影响。此外,早期发现CP给父母更多的时间来调整和准备。由于脑瘫的临床表现在儿童至少6个月之前不会出现,一般运动(GM)被认为是监测胎儿和婴儿运动的最可靠的早期标志。产后3-5个月的异常一般运动和没有所谓的躁动运动是患脑瘫的高风险。除了高特异性(82-99%)和灵敏度(95-100%)外,一般运动(GMs)的评估快速,非侵入性,易于获得。
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引用次数: 1
Clinical Classification of Cerebral Palsy 脑瘫的临床分型
Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79246
C. C. Ogoke
The classification of cerebral palsy (CP) remains a challenge; hence the presence of so many classifications and a lack of consensus. Each classification used alone is incomplete. Therefore, a multiaxial classification gives a more comprehensive description of a child with CP. The recent WHO International Classification of Functioning, Disability and Health (ICF) emphasizes the importance of focusing on the functional consequences of various states of health and has stimulated the development of newer functional scales in CP. It is widely accepted that the functional classification is the best classification for the patient because it guides management. The objectives of this chapter are to review the various classifications of CP, to highlight the clinical features used in the various classifications, to outline the recent functional classifications of CP and to highlight how these recent classifications guide current management. It is expected that at the end of this chapter, the reader should be able to understand the difficulties in classifying CP, enumerate and discuss the various classifications of CP, understand the merits and short - comings of each classification scheme, clinically evaluate and classify a child with CP multiaxially and understand how functional scales predict current and future needs of children with CP.
脑瘫(CP)的分类仍然是一个挑战;因此存在如此多的分类和缺乏共识。单独使用的每种分类都是不完整的。因此,多轴分类可以更全面地描述儿童CP。最近的WHO国际功能、残疾和健康分类(ICF)强调了关注各种健康状态的功能后果的重要性,并刺激了CP中更新功能量表的发展。人们普遍认为功能分类是对患者最好的分类,因为它指导了管理。本章的目的是回顾脑瘫的各种分类,强调各种分类中使用的临床特征,概述脑瘫的最新功能分类,并强调这些最新分类如何指导当前的管理。期望在本章结束时,读者能够理解脑瘫分类的困难,列举和讨论脑瘫的各种分类,了解每种分类方案的优缺点,临床多轴评价和分类脑瘫儿童,了解功能量表如何预测脑瘫儿童当前和未来的需求。
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引用次数: 10
期刊
Cerebral Palsy - Clinical and Therapeutic Aspects
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