Cuffless blood pressure measuring devices are emerging as alternatives for out-of-office assessment of patients with hypertension. This novel technology promises to deliver continuous or beat-to-beat blood pressure measurement and resolve some of the inconveniences associated with conventional cuff-based devices such as improper cuff fit, discomfort, low adherence to monitoring, and technical challenges. Blood pressure can be estimated based on phenomena related to cardiovascular activity: pulse wave velocity, pulse wave analysis, tonometry, and volume clamping. In this narrative review, we seek to summarize current approaches for nontraditional measurement of blood pressure and discuss some of the benefits and limitations of this technology.
{"title":"Pearls and pitfalls of cuffless blood pressure monitoring devices","authors":"Radu-Alexandru Iacobescu, Bogdan-Danut Florescu, Alina-Mihaela Dimache, Luiza-Elena Corneanu, Elena Adorata Coman","doi":"10.37897/rmj.2023.3.2","DOIUrl":"https://doi.org/10.37897/rmj.2023.3.2","url":null,"abstract":"Cuffless blood pressure measuring devices are emerging as alternatives for out-of-office assessment of patients with hypertension. This novel technology promises to deliver continuous or beat-to-beat blood pressure measurement and resolve some of the inconveniences associated with conventional cuff-based devices such as improper cuff fit, discomfort, low adherence to monitoring, and technical challenges. Blood pressure can be estimated based on phenomena related to cardiovascular activity: pulse wave velocity, pulse wave analysis, tonometry, and volume clamping. In this narrative review, we seek to summarize current approaches for nontraditional measurement of blood pressure and discuss some of the benefits and limitations of this technology.","PeriodicalId":33232,"journal":{"name":"Revista Medicala Romana","volume":"2017 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135131892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicolae Bacalbasa, Irina Balescu, Mihaela Vilcu, Claudia Stoica, Tarig Massawi, Sorin Petrea, Cristina Martac, Adriana Ciuvica, Andrei Voichitoiu, Iulian Brezean, Victor Cauni, Bogdan Gaspar
Red cell distribution width [RDW] represents a new prognostic marker which has been widely studied in malignant tumors including ovarian cancer patients. Therefore, it has been stipulated that RDW can be also used as a prognostic marker and a follow up tool for these patients. The aim of the current paper was to analyze the variations of this parameter on a study group of 31 patients diagnosed with advanced stage ovarian cancer and respectively 48 cases with benign ovarian lesions submitted to surgery between 2017-2020 in “Cantacuzino” Clinical Hospital.
{"title":"Red cell distribution width as a prognostic marker in ovarian cancer patients","authors":"Nicolae Bacalbasa, Irina Balescu, Mihaela Vilcu, Claudia Stoica, Tarig Massawi, Sorin Petrea, Cristina Martac, Adriana Ciuvica, Andrei Voichitoiu, Iulian Brezean, Victor Cauni, Bogdan Gaspar","doi":"10.37897/rmj.2023.3.3","DOIUrl":"https://doi.org/10.37897/rmj.2023.3.3","url":null,"abstract":"Red cell distribution width [RDW] represents a new prognostic marker which has been widely studied in malignant tumors including ovarian cancer patients. Therefore, it has been stipulated that RDW can be also used as a prognostic marker and a follow up tool for these patients. The aim of the current paper was to analyze the variations of this parameter on a study group of 31 patients diagnosed with advanced stage ovarian cancer and respectively 48 cases with benign ovarian lesions submitted to surgery between 2017-2020 in “Cantacuzino” Clinical Hospital.","PeriodicalId":33232,"journal":{"name":"Revista Medicala Romana","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135131897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Internationally, relatively few studies have been undertaken regarding research on non-specific oral burning pain, especially regarding the identification of possible causal factors. Knowledge in this field from a physiopathological and therapeutic perspective is recent, which supports the need for further study and the definition of the disease as an interdisciplinary syndrome. Deepening the research on the etiopathogenesis of burning mouth syndrome (BMS) would be beneficial to medical practice, as it would allow for appropriate therapy and an increased healing rate.
{"title":"Diagnosis of exclusion in Burning Mouth Syndrome (BMS)","authors":"Elena Claudia Coculescu, Bogdan-Ioan Coculescu","doi":"10.37897/rmj.2023.3.1","DOIUrl":"https://doi.org/10.37897/rmj.2023.3.1","url":null,"abstract":"Internationally, relatively few studies have been undertaken regarding research on non-specific oral burning pain, especially regarding the identification of possible causal factors. Knowledge in this field from a physiopathological and therapeutic perspective is recent, which supports the need for further study and the definition of the disease as an interdisciplinary syndrome. Deepening the research on the etiopathogenesis of burning mouth syndrome (BMS) would be beneficial to medical practice, as it would allow for appropriate therapy and an increased healing rate.","PeriodicalId":33232,"journal":{"name":"Revista Medicala Romana","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135132047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irina Balescu, Nicolae Bacalbasa, Mihaela Vilcu, Claudia Stoica, Tarig Massawi, Sorin Petrea, Cristina Martac, Adriana Ciuvica, Andrei Voichitoiu, Victor Cauni, Bogdan Gaspar, Iulian Brezean
Ovarian cancer remains one of the most aggressive malignancies which is frequently diagnosed in advanced stages of the disease, when disseminated lesions are already present. In order to maximize the rates of complete debulking surgery, different prognostic markers have been investigated. The aim of the current paper is to investigate the prognostic value of neutrophil to lymphocyte ratio in advanced stage ovarian cancer patients submitted to debulking surgery.
{"title":"Neutrophil to lymphocyte ratio as a prognostic marker for advanced stage ovarian cancer","authors":"Irina Balescu, Nicolae Bacalbasa, Mihaela Vilcu, Claudia Stoica, Tarig Massawi, Sorin Petrea, Cristina Martac, Adriana Ciuvica, Andrei Voichitoiu, Victor Cauni, Bogdan Gaspar, Iulian Brezean","doi":"10.37897/rmj.2023.3.4","DOIUrl":"https://doi.org/10.37897/rmj.2023.3.4","url":null,"abstract":"Ovarian cancer remains one of the most aggressive malignancies which is frequently diagnosed in advanced stages of the disease, when disseminated lesions are already present. In order to maximize the rates of complete debulking surgery, different prognostic markers have been investigated. The aim of the current paper is to investigate the prognostic value of neutrophil to lymphocyte ratio in advanced stage ovarian cancer patients submitted to debulking surgery.","PeriodicalId":33232,"journal":{"name":"Revista Medicala Romana","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135132048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maali Ben Nasr, Nizar Cherni, Abdallah Chaachouaa, Wassim El Ajmi, Arij Zouaoui, Ferjaoui Wael, Samir Ghozzi
Background. Bladder paraganglioma (BPG) is a very rare tumor. Case report: We report the case of a 48-year-old woman with a history of isolated hematuria. Cystoscopy showed a solid mass on the bottom of the bladder. During the intervention the patient experienced a severe hypertensive episode. BPG was then suspected. Pathology findings confirmed the diagnosis.123I-metaiodobenzylguanidine scan showed a pathological tracer accumulation in the left bladder wall consistent with BPG. The patient underwent a transurethral resection of the bladder after drug preparation. The postoperative course was uneventful and our patient was normotensive. Conclusion. Diagnosis of BPG is often made on histological examination of the tumor.
{"title":"Unsuspected paraganglioma of the urinary bladder with intraoperative hypertensive peak: A case report","authors":"Maali Ben Nasr, Nizar Cherni, Abdallah Chaachouaa, Wassim El Ajmi, Arij Zouaoui, Ferjaoui Wael, Samir Ghozzi","doi":"10.37897/rmj.2023.2.7","DOIUrl":"https://doi.org/10.37897/rmj.2023.2.7","url":null,"abstract":"Background. Bladder paraganglioma (BPG) is a very rare tumor. Case report: We report the case of a 48-year-old woman with a history of isolated hematuria. Cystoscopy showed a solid mass on the bottom of the bladder. During the intervention the patient experienced a severe hypertensive episode. BPG was then suspected. Pathology findings confirmed the diagnosis.123I-metaiodobenzylguanidine scan showed a pathological tracer accumulation in the left bladder wall consistent with BPG. The patient underwent a transurethral resection of the bladder after drug preparation. The postoperative course was uneventful and our patient was normotensive. Conclusion. Diagnosis of BPG is often made on histological examination of the tumor.","PeriodicalId":33232,"journal":{"name":"Revista Medicala Romana","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136365714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mihaela Lebedenco, Nicoleta Berbec, Oana Stanca, Anca Roxana Lupu
Hodgkin's lymphoma is the third most common cancer in young people between 15 and 34 years of age, with a lower incidence in other age groups and slightly higher in males. The etiology of Hodgkin's lymphoma is still unknown - although various factors influencing the oncogenesis of the disease have been noted, the mechanism of their influence is poorly understood. This article will present the case of a 41-year-old patient with classic Hodgkin's lymphoma - nodular sclerosis histological subtype - chemorefractory.
{"title":"Classic Hodgkin lymphoma-nodular sclerosis – case report","authors":"Mihaela Lebedenco, Nicoleta Berbec, Oana Stanca, Anca Roxana Lupu","doi":"10.37897/rmj.2023.2.8","DOIUrl":"https://doi.org/10.37897/rmj.2023.2.8","url":null,"abstract":"Hodgkin's lymphoma is the third most common cancer in young people between 15 and 34 years of age, with a lower incidence in other age groups and slightly higher in males. The etiology of Hodgkin's lymphoma is still unknown - although various factors influencing the oncogenesis of the disease have been noted, the mechanism of their influence is poorly understood. This article will present the case of a 41-year-old patient with classic Hodgkin's lymphoma - nodular sclerosis histological subtype - chemorefractory.","PeriodicalId":33232,"journal":{"name":"Revista Medicala Romana","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136365715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives. We present a very rare case of incomplete Graham-Little-Piccardi-Lassueur syndrome (GLPLS) overlap with Mixed Connective Tissue Disease (MCTD) versus Multiple Autoimmune Syndrome (MAS). Case Presentation. A 53- year-old female with a long history of more than two years of patchy hair loss on scalp like “footprints in the snow”, partial loss of eyebrows' hair, face erythema, scaly atrophied red/brown patches on face, grouped follicular papules 2-3 mm in diameter with a pointed or hair-like horny spine extending approximately 1-2 mm around the tip of the follicle on lumbar area. The histopathological results from biopsies of scalp and lumbar areas confirmed the clinical diagnosis of cicatricial alopecia induced by lichen plan pilaris (LPP) and also presence of lichen spinulosus (LS) on lumbar area. The description provided by pathologist is however borderline regarding so called interface dermatosis like chronic cutaneous lupus erythematous (CCLE) or Pseudopelade of Brocq (PPB) as the end stage of CCLE or LPP. Blood tests showed both Antinuclear antibodies and U1-nRNP in high titers and the absence of anti-Sm, anti SS-A, anti SS-B and anti-dsDNA antibodies, and also peculiar antibody patterns of MCTD. Outcome. After thorough investigation, MCTD was proven by antibodies results. After one year of treatment a lot of clinical features dramatically responded under therapy. Conclusions. Clinical manifestations in the pathology with strictly cutaneous or systemic localization in conjunction or overlap with other autoimmune diseases (grouped in the MAS) represent a rare diagnostic in daily practice.
目标。我们报告一个非常罕见的不完全graham - little - piccard - lassueur综合征(GLPLS)与混合性结缔组织病(MCTD)和多发性自身免疫性综合征(MAS)重叠的病例。案例演示。女性，53岁，长有两年多的斑状脱发史，如“雪地上的脚印”，眉毛部分脱发，面部红斑，鳞状萎缩的红色/棕色斑块，成组的毛囊丘疹，直径2-3毫米，在腰部毛囊尖端周围延伸约1-2毫米的尖状或头发状角质棘。头皮及腰椎活检病理结果证实临床诊断为毛状苔藓(LPP)及腰椎棘状苔藓(LS)所致瘢痕性脱发。然而，病理学家提供的描述对于所谓的界面皮肤病，如慢性皮肤红斑狼疮(CCLE)或布罗克假性皮炎(PPB)作为CCLE或LPP的终末阶段是模棱两可的。血检显示抗核抗体和U1-nRNP均高滴度，无抗sm、抗SS-A、抗SS-B和抗dsdna抗体，且MCTD特有的抗体模式。结果。经过深入的研究，MCTD得到了抗体结果的证实。经过一年的治疗，许多临床特征在治疗下有显著的反应。结论。临床病理表现为与其他自身免疫性疾病(归类为MAS)合并或重叠的严格皮肤或全身定位，在日常实践中是一种罕见的诊断。
{"title":"Diagnostic dilemma: Multiple Autoimmune Syndrome versus incomplete Graham-Little-Piccardi-Lassueur Syndrome overlap mixed connective tissue disease","authors":"Tudorel Poalelungi, Ana-Maria Olaru, Mihaela Mariuta","doi":"10.37897/rmj.2023.2.6","DOIUrl":"https://doi.org/10.37897/rmj.2023.2.6","url":null,"abstract":"Objectives. We present a very rare case of incomplete Graham-Little-Piccardi-Lassueur syndrome (GLPLS) overlap with Mixed Connective Tissue Disease (MCTD) versus Multiple Autoimmune Syndrome (MAS). Case Presentation. A 53- year-old female with a long history of more than two years of patchy hair loss on scalp like “footprints in the snow”, partial loss of eyebrows' hair, face erythema, scaly atrophied red/brown patches on face, grouped follicular papules 2-3 mm in diameter with a pointed or hair-like horny spine extending approximately 1-2 mm around the tip of the follicle on lumbar area. The histopathological results from biopsies of scalp and lumbar areas confirmed the clinical diagnosis of cicatricial alopecia induced by lichen plan pilaris (LPP) and also presence of lichen spinulosus (LS) on lumbar area. The description provided by pathologist is however borderline regarding so called interface dermatosis like chronic cutaneous lupus erythematous (CCLE) or Pseudopelade of Brocq (PPB) as the end stage of CCLE or LPP. Blood tests showed both Antinuclear antibodies and U1-nRNP in high titers and the absence of anti-Sm, anti SS-A, anti SS-B and anti-dsDNA antibodies, and also peculiar antibody patterns of MCTD. Outcome. After thorough investigation, MCTD was proven by antibodies results. After one year of treatment a lot of clinical features dramatically responded under therapy. Conclusions. Clinical manifestations in the pathology with strictly cutaneous or systemic localization in conjunction or overlap with other autoimmune diseases (grouped in the MAS) represent a rare diagnostic in daily practice.","PeriodicalId":33232,"journal":{"name":"Revista Medicala Romana","volume":"1138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136300558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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