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The formulation of moisturizing and hydrating cream based on natural ingredients such as chitosan 以壳聚糖等天然成分为基础的保湿补水霜配方
Pub Date : 2024-02-13 DOI: 10.55124/ijcd.v2i1.234
Mohammadreza Gholibeikian, Zahra Nooriani, Amirhosein Firouzi, Nastaran Samali
The purpose of this work is to make moisturizing and hydrating cream for the skin. the ingredients of moisturizing and hydrating cream are based on natural polysaccharides, such as chitosan and extracted from aquatic organisms such as shrimp.Physical and chemical analysis, identification test of the oils in the cream based on gas chromatography instrument have been done in the reference laboratory of Food and Drug Organization of Iran country. Also, non-sensitizing test of the formulated cream have been done by the rabbit at department of pharmaceutics, school of pharmacy, Shahid Beheshti University of Medical Sciences in Irancountry.
这项工作的目的是为皮肤制作保湿补水面霜。保湿补水面霜的成分以天然多糖为基础,如壳聚糖,是从虾等水生生物中提取的。伊朗食品药品组织的参考实验室利用气相色谱仪对面霜中的油脂进行了理化分析和鉴定测试。此外,伊朗沙希德-贝赫什提医科大学药学院制药系的兔子还对配制的膏霜进行了非致敏性测试。
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引用次数: 0
Manufacturing and formulation of natural products based on the Chitosan as active ingredientin the forms of gel and spray 生产和配制以壳聚糖为活性成分的凝胶和喷雾形式的天然产品
Pub Date : 2024-02-13 DOI: 10.55124/ijcd.v2i1.233
Mohammadreza Gholibeikian, Zahra Nooriani, Amirhosein Firouzi, Nastaran Samali, Somayeh faraji, Afsaneh oshli
The purpose of this work is to make based on natural polysaccharide compounds such as chitosan for the microorganism testwhich led to the destruction of Escherichia coli bacteria, Candida albicans vegetative cells and Aspergillus niger spores and Herpes simplex virus (HSV-1). Chitosan products in the forms of gel and spray have bactericidal, fungicidal and virucidal properties as antiseptic products. Chitosan polysaccharides with high molecular weight are extracted from aquatic organisms such as shrimp.Physical and chemical analysis, identification test of Chitosan as active ingredient and also non-sensitizing test of these products in the forms of gel and spray have been done on the rabbit's skin that did not show no sensitivity and inflammation. It seems that natural products in the forms of gels and sprays based on chitosan, as alternative products for alcohol and chemical compounds, have a useful and promising role as antiseptic in eliminating bacteria, fungi and viruses left on the skin of the hands.
这项工作的目的是以壳聚糖等天然多糖化合物为基础,进行微生物试验,从而消灭大肠杆菌、白色念珠菌无性细胞、黑曲霉孢子和单纯疱疹病毒(HSV-1)。壳聚糖凝胶和喷雾产品具有杀菌、杀真菌和杀病毒特性,可作为防腐产品使用。壳聚糖多糖分子量高,是从虾等水生生物中提取的。理化分析、壳聚糖作为活性成分的鉴定试验以及凝胶和喷雾剂形式的这些产品的无过敏试验都是在兔子的皮肤上进行的,结果显示兔子的皮肤没有出现敏感和炎症。由此看来,以壳聚糖为基础的凝胶和喷雾形式的天然产品,作为酒精和化学物质的替代产品,在消除残留在手部皮肤上的细菌、真菌和病毒的杀菌作用方面,具有实用性和前景。
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引用次数: 0
Vitiligo – Study In view of familial occurence 白癜风的家族性研究
Pub Date : 2021-07-07 DOI: 10.55124/ijcd.v1i1.90
S. Mulla
Vitiligo is a chronic skin disease that causes loss of pigment in the skin. It is caused by a combination of auto-immune, genetic, and environmental factors. This clinical study was carried out to find out the familial tendency in patients of vitiligo. Literary review & clinical study in 60 patients of vitiligo done. The study included the detailed family history with pedigree analysis in patients under study. The conclusion drawn from the study is that the familial occurrence of vitiligo in the studied population is 26.66 % .Younger age group up to 20 Yrs. is predominantly affected. Genetic variations play a significant role in the aetiology of vitiligo. Introduction Historical background: (Rational of the study)-                                                  Vitiligo or leukoderma is a chronic skin disease that causes loss of pigment, resulting in irregular pale patches of skin. It occurs when the melanocytes, the cells responsible for skin pigmentation, die or are unable to function. The precise cause of vitiligo is complex and not fully understood. There is some evidence suggesting it is caused by a combination of auto-immune, genetic, and environmental factors. Vitiligo may also be caused by stress that affects the immune system, leading the body to react and start eliminating skin pigment. It creats a very bad social stigma for the victim, although no other major systemic abnormality is generally present. I have seen number of patients visiting my clinic for the treatment of this problem. So I decided to work on this subject to carry out this clinical study. Epidemiology: The population incidence worldwide is considered to be between 1% and 2%., or as many as 65 million people, have vitiligo.1 Clinical Presentation: In most cases, vitiligo develops early in life, between the ages of 10 and 30 years. Ninety-five percent of those affected will develop the disorder before age of 40 years. Both men and women are equally likely to affected by vitiligo. Vitiligo may run in families; those with a family history of vitiligo or premature graying of the hair are at increased risk for the development of vitiligo. Other risk factors that increase one's chances of developing vitiligo include having autoimmune diseases, such as autoimmune thyroid disease (Hashimoto's thyroiditis). However, most people with vitiligo have no other autoimmune disease. Vitiligo is associated with autoimmune and inflammatory diseases, commonly thyroid over-expression and under-expression.      Vitiligo may also be hereditary; that is, it can run in families. Children whose parents have the disorder are more likely to develop vitiligo (not the rule). In fact, number of people with vitiligo has a family member with the disease. However, only 5 to 7 percent of children will get vitiligo even if a parent has it, and most people with vitiligo do not have a family history of the disorder.9 Clinical classifications of vitiligo10- The most widely used classification of
白癜风是一种慢性皮肤病,会导致皮肤色素流失。它是由自身免疫、遗传和环境因素共同引起的。本临床研究旨在了解白癜风患者的家族性倾向。60例白癜风的文献回顾及临床研究。该研究包括研究患者的详细家族史和系谱分析。研究结果表明,白癜风家族性发病率为26.66%,年龄在20岁以下。主要受影响。遗传变异在白癜风病因学中起重要作用。历史背景:(研究理由)-白癜风或白癜风是一种慢性皮肤病,引起色素丧失,导致皮肤不规则的苍白斑块。当负责皮肤色素沉着的黑色素细胞死亡或无法发挥作用时,就会发生这种情况。白癜风的确切病因很复杂,尚未完全了解。有证据表明,它是由自身免疫、遗传和环境因素共同引起的。白癜风也可能是由影响免疫系统的压力引起的,导致身体反应并开始消除皮肤色素。它给受害者带来了非常糟糕的社会耻辱,尽管通常没有其他主要的系统性异常。我见过很多病人来我的诊所治疗这个问题。所以我决定研究这个课题来开展这个临床研究。流行病学:全球人口发病率被认为在1%至2%之间。美国有多达6500万人患有白癜风临床表现:在大多数情况下,白癜风在生命早期发展,在10到30岁之间。95%的患者会在40岁之前患上这种疾病。男性和女性同样可能受到白癜风的影响。白癜风可能在家族中遗传;那些有白癜风家族史或头发过早变白的人患白癜风的风险增加。其他增加患白癜风几率的风险因素包括自身免疫性疾病,如自身免疫性甲状腺疾病(桥本甲状腺炎)。然而,大多数白癜风患者没有其他自身免疫性疾病。白癜风与自身免疫性和炎症性疾病有关,常见的是甲状腺过表达和过表达。白癜风也可能是遗传性的;也就是说,它可以在家族中遗传。父母患有这种疾病的孩子更有可能患上白癜风(不是规则)。事实上,许多患有白癜风的人都有家庭成员患有这种疾病。然而,即使父母中有一人患有白癜风,也只有5%到7%的孩子会患上白癜风,而且大多数白癜风患者没有家族病史白癜风的临床分类10-白癜风的最广泛使用的分类是局部型,广泛性和普遍型,并基于分布,如下:局部局灶型:这种类型的特征是在一个区域有一个或多个斑点,最常见于三叉神经的分布。节段性:这种类型表现为皮表皮或准表皮型的一个或多个斑点。它最常见于儿童。超过一半的节段性白癜风患者有白头发斑块或脊髓灰质炎。这种类型的白癜风与甲状腺或其他自身免疫性疾病无关。粘膜:仅粘膜受影响。广泛性肩面:脱色发生在手指远端和寻常区周围:其特征是广泛分布的分散斑块。症状:一半的白癜风患者在20多岁之前就会在四肢出现色素脱失的皮肤斑块。斑块可能会增大、缩小或保持大小不变。斑块通常对称地出现在身体两侧。偶尔,当黑素细胞重新定植时,小区域可能会重新着色。随着时间的推移,白癜风影响皮肤的位置会发生变化,一些斑块会重新着色,而另一些则会受到影响。头皮上的白癜风可能会影响头发的颜色(尽管并非总是如此),留下白色斑块或条纹。它同样会影响面部和体毛。症状:一些症状是:皮肤上有白色斑块,包括面部、四肢、躯干和腹股沟,粘膜上有紫色或金棕色斑块,以及眼睛、鼻孔和嘴巴周围,头发过早变白,阳光敏感心理影响白癜风对患者的心理健康有显著影响对于肤色较深的患者尤其如此,因为有色素的皮肤和无色素的皮肤之间的对比非常明显。在某些文化中,白癜风是一种耻辱。 ) 4、5                                                                   的正常序列的DNA代码NALP1 TCACTCCTCTACCAA取代在这些白癜风序列柠檬酸的家庭
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引用次数: 0
Efficacy Of Bastikarma In Vitiligo 白癜风的疗效
Pub Date : 2021-07-06 DOI: 10.55124/ijcd.v1i1.89
S. Mulla
This is a case series study on patients suffering from Vitiligo.  The study was  carried out on  30 outdoor patients taking  regular ayurvedic medicinal  treatment. Patients from both sexes, from age group  10 to 60  years complaining mainly as  white  patches were studied. Patients were treated with  Ayurvedic bodypurification treatment i.e.( Panchakarma) Bastikarma.   Duration of treatment was of 7 days with monthly follow-up for 3 months. The response to treatment was observed in terms of reduction in area of patches after treatment. Most important factor noted was trigger or sudden upsurge of repigmentation  after the treatment. The treatment was effective in all types of vitiligo. The results of internal medications & local treatment were aggrevated specially after Bastikarma. So Bastikarma was very effective in vitiligo.  Introduction Vitiligo, in which whitish patches of skin patches appears on skin is very complex disease. Many a times, it is manifestation of some underlying hormonal or immunological abnormality. It creats a very bad social stigma for the victims. In Ayurveda it is called as ‘shwitra’.1       As per Ayurveda, it has same causative factors as kushtha i.e. leprosy. It is without discharge, vitiated with three doshas i.e.Vata, Pitta, kapha. It is associated with rakta (blood), mansa (Muscle tissue) and meda ( lipid) dhatus.2       Unbalanced diet (Virrudhahara) is also an important cause. It is different from Leprosy (kushtha) in respect that it is non-contagious, non-bacterial, it doesn't destroys body tissues, doesn't have any discharge (vyadhiswabhava). Leprosy (Kushtha) deeply goes up to all Dhatus. Vitiligo (shwitra) occupies only skin, blood, muscle tissue (mansadhatu) and fat (medadhatu). Treatment needs a holistic approach. There is imbalance of regulating hormones for melanin synthesis. For homeostasis or balancing of hormones & body, Ayurvedic body purification treatment i.e. Panchakarma is very useful. In fact in Ayurveda it is described as powerful treatment & should be done before commencing any medical treatment for most of the diseases.1  Prognosis (Sadhyasadhyata)   Madhavanidana describes that Vitiligo (shwitra) in which hairs are black, in small percentage, with diverse spots, new (< 1 year-charak) is curable. Others including developed due to burns , in genitals, hands and feet, lips, with history of inheritance are non – curable or difficult  for cure.2 Treatment (chikitsa) In Ayurveda Body purification i.e. Panchakarma treatment – Therapeutic  Emesis  (vaman), Purgation (virechan),  – purification method for vata, Blood - letting (raktamokshan), Local application (lepachikitsa), sun UV rays exposure (aatapsevan) , internal medications  (abhyantara chikitsa) etc. advised in texts. Treatment is long term and should be continued from months to years.1 Modern (Allopathic Medicine) view According to modern pathophysiology, in generalized vitiligo melanocytes are not found in the affected skin. Mela
材料Bastidravya——Niruhabasti Dashamoola + Erandamoola(汤)卡拉(粘贴)(Madanphala + Vekhand + Kutaj + Yashtimadhu) kwath (1/8) Chandanbalalakshadi石油- 50毫升Saindhav岩盐大约10 gms蜂蜜10毫升5 - 6 Anuvasan:悉(药用)胡麻油在晚上之前首先Bastikarma Matrabasti——Chandanbalalakshadi石油剂量(马特拉)准备Bastidravya 700到960毫升每巴拉的prakriti & doshaprokopa病人。儿童-根据儿童的年龄和体重调整剂量。Anuvasan basi剂量:120 ml Matrabasti剂量- 60 ml给药方式患者按文献给予外用油液(snehan)和药液蒸汽浴(swedana)。在第一次Niruhabasti的前一天晚上,每位患者服用Anuvasan Basti。然后在清晨空腹服用Niruhabasti。患者被要求在巴斯提卡后洗热水澡。根据经文,Bastikarma遵循特殊的饮食和生活规则(sansarjanakrama)。晚上,在吃完饭后给snehabasti (Matrabasti)。给出了7个这样的设置。适当的(Samyaga) Bastikarma标志Mala, pitta, kapha和vayu doshas被依次疏散,身体的laghuta(轻盈)感觉,Agni(消化能力),味道增加,心灵和indriyas(感觉器官)得到满足,最重要的是症状得到缓解。疗程7天。随访- 15天或每月,为期3个月评估标准确定为-参考' '表,概率< 0.001(实际变异性)。因此,在99.9%的置信限下,它是非常显著的。所以两组观测值的均值之差在1%的水平上是非常显著的。因此,我们拒绝零假设(Ho),接受备择假设(H1)。因此,巴斯蒂卡玛的治疗是造成这种差异的原因这是一项对30例白癜风患者的观察性病例系列研究。阿育吠陀panchakarma治疗即Bastikarma是对服用常规阿育吠陀药物治疗白癜风的患者进行的。观察结果如下:5例患者有遗传史。在这个组中,对治疗的反应是轻微到中度的。致病因素如不平衡的饮食(viruddhahara),过量食用牛奶,大米,非素食食品等注意。大多数患者病因不明。5例(16.66%)患者出现甲状腺激素紊乱,尤其是甲状腺功能减退,13.33%的患者伴有糖尿病。服用对抗疗法药物包括类固醇的历史在相当多的病例中被注意到。发病时间短(几天到几个月)的患者可早期治愈。在大多数病人的症状中都有适当的注意。没有观察到治疗的主要副作用。这种治疗方法对所有类型的白癜风都有效。甲状腺疾病和糖尿病可能在某些情况下被认为是诱发因素 .                                               结论阿育吠陀Panchakarma治疗白癜风疗效显著。内部药物治疗和局部治疗的结果在手术后特别汇总。因此,巴斯蒂卡在白癜风的治疗中具有重要作用。本研究的结果需要通过更大的样本量来验证。还需要做一些实验室研究,比如Bastikarma前后血液中的激素估计。可以进行与抗原-抗体反应变化有关的免疫学研究。这将为治疗的有效性提供有力的证据。Bastikarma通过肠神经系统(ENS)的有效性也是一个单独的问题,阿育吠陀Panchakarma方法是非常有效的身体内稳态和激素平衡工具。这应该在研究所一级进行更多的科学研究来证明。Agnivesh, Charak Charaksamhita, Chikitsathana 7/173, 174, 162, Varanasi, VN: Chaukhambha. 1996。Madhavkar, Madhavanidana 49/41, Varanasi, VN: 1994。福奇、布劳恩瓦尔德、伊塞尔巴赫、威尔逊、马丁、卡斯珀、豪泽、朗戈。哈里森的内科学原理(第14版,第316 - 317页)纽约,纽约:麦格劳-希尔出版社,1998年。Golwala A.F. Golwala的学生医学。(第25版),新德里,ND:Jaypee。1997. Laghuvagbhata, Ashtangahrudaya, sutrasthana 15/3 Varanasi, VN: Chaukhambha, 1982。Bhavamishra, Bhavaprakash (Varanasi, VN: Chaukhambha. 2002)。K. Mahajan,生物统计学方法(第6版,1997),新德里,ND: Jaypee. 1997。萨利姆毛拉。医学和牙科科学研究杂志。2015, 2(6), 8-12。萨利姆毛拉。临床与美容皮肤病学杂志(JCCD)。2017, 2(3), 1-8。
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引用次数: 0
Clinical Role of Oral Vitamin C and E Therapy in Skin and Hair Disorders 口服维生素C和E治疗皮肤和头发疾病的临床作用
Pub Date : 2021-06-28 DOI: 10.55124/ijcd.v1i1.44
F. Casale, Susie Suh, K. Yale, N. Atanaskova Mesinkovska
Article history: Received 20210401 Received in revised form 20210415 Accepted 20210425 Available online 20210515 Introduction: Vitamin C and E are generally recognized as safe dietary supplements that provide benefits for skin and hair health. However, their clinical validity in the treatment of dermatologic conditions has not been explored. It is highly important to review the current evidence on the therapeutic utility of oral vitamin C and E therapy for dermatologic disorders.
简介:维生素C和E通常被认为是安全的膳食补充剂,对皮肤和头发健康有好处。然而,它们在治疗皮肤病方面的临床有效性尚未得到探讨。回顾口服维生素C和E治疗皮肤病的疗效的现有证据是非常重要的。
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引用次数: 1
期刊
International Journal of Cosmetics and Dermatology
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